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RcnR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Co(II) Ni(II) RcnA RcnB RcnR rcnAB rcnAB_mRNA rcnR rcnR_mRNA RcnR Co(II) RcnR Ni(II) Ni(II)_Ext Co(II)_Ext


Gensor Unit       
Name: RcnR
Description: Molecular biology level
Detailed: In the absence of cobalt and nickel, RcnR negatively regulates the expression of genes required for their efflux system; under this condition, RcnR repress its own expression and the expression of its regulated genes. In the presence of cobalt or nickel, RcnR is modified to RcnR-Co or RcnR-Ni, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of cobalt or nickel, RcnR negatively regulates the expression of genes needed for detoxification of cobalt and nickel.

Physiology level
Detailed: The presence of cobalt or nickel induces the expression of genes involved with detoxification of cobalt and nickel. Under this condition the genes necessary for efflux of cobalt and nickel are expressed.
Less detailed: The presence of cobalt or nickel induces the expression of genes needfurl for an efflux of cobalt and nickel.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0035784 - nickel cation homeostasis
GO:0035444 - nickel cation transmembrane transport
GO:0032025 - response to cobalt ion
GO:0010045 - response to nickel cation
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cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0046583 - cation efflux transmembrane transporter activity
GO:0005507 - copper ion binding
GO:0015099 - nickel cation transmembrane transporter activity
Components: Show/Hide Components Table (13 more...)
Function Name Type
protein RcnA protein
protein RcnB protein
protein RcnR protein
complex RcnR-cobalt ion complex
complex RcnR-nickel complex
simple_molecule cobalt ion simple_molecule
simple_molecule cobalt ion_Ext simple_molecule
simple_molecule nickel simple_molecule
simple_molecule nickel_Ext simple_molecule
gene rcnAB gene
RNA rcnAB_mRNA RNA
gene rcnR gene
RNA rcnR_mRNA RNA


Reactions       
Showing 9 reactions
RcnR rcnAB rcnAB_mRNA
Name: rcnAB -> rcnAB_mRNA
Description: Transcription of transcription unit rcnAB. Reaction inhibition by RcnR.
Type: transcription
Pathway Components: rcnAB - RcnR -> rcnAB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor RcnR protein nd nd
reactant rcnAB gene nd nd
product rcnAB_mRNA RNA nd nd
RcnR rcnR rcnR_mRNA
Name: rcnR -> rcnR_mRNA
Description: Transcription of transcription unit rcnR. Reaction inhibition by RcnR.
Type: transcription
Pathway Components: rcnR - RcnR -> rcnR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor RcnR protein nd nd
reactant rcnR gene nd nd
product rcnR_mRNA RNA nd nd
cobalt ion + RcnR RcnR-cobalt ion
Name: cobalt ion + RcnR -> RcnR-cobalt ion
Description: Reaction transforming cobalt ion, RcnR into RcnR-cobalt ion
Type: state transition
Pathway Components: cobalt ion + RcnR -> RcnR-cobalt ion
Components:
Function Name Type Evidence Reference(s)
reactant RcnR protein nd nd
product RcnR-cobalt ion complex nd nd
reactant cobalt ion simple_molecule nd nd
nickel + RcnR RcnR-nickel
Name: nickel + RcnR -> RcnR-nickel
Description: Reaction transforming nickel, RcnR into RcnR-nickel
Type: state transition
Pathway Components: nickel + RcnR -> RcnR-nickel
Components:
Function Name Type Evidence Reference(s)
reactant RcnR protein nd nd
product RcnR-nickel complex nd nd
reactant nickel simple_molecule nd nd
rcnR_mRNA RcnR
Name: rcnR_mRNA -> RcnR
Description: Translation of RcnR
Type: translation
Pathway Components: rcnR_mRNA -> RcnR
Components:
Function Name Type Evidence Reference(s)
product RcnR protein nd nd
reactant rcnR_mRNA RNA nd nd
rcnAB_mRNA RcnA
Name: rcnAB_mRNA -> RcnA
Description: Translation of RcnA
Type: translation
Pathway Components: rcnAB_mRNA -> RcnA
Components:
Function Name Type Evidence Reference(s)
product RcnA protein nd nd
reactant rcnAB_mRNA RNA nd nd
RcnA cobalt ion_Ext cobalt ion
Name: cobalt ion_Ext -> cobalt ion
Description: Transport of cobalt ion_Ext through a bacterial membrane, leading to the presence of cobalt ion inside the cell.
Type: transport
Pathway Components: cobalt ion_Ext - RcnA -> cobalt ion
Components:
Function Name Type Evidence Reference(s)
catalyzer RcnA protein nd nd
product cobalt ion simple_molecule nd nd
reactant cobalt ion_Ext simple_molecule nd nd
RcnA nickel_Ext nickel
Name: nickel_Ext -> nickel
Description: Transport of nickel_Ext through a bacterial membrane, leading to the presence of nickel inside the cell.
Type: transport
Pathway Components: nickel_Ext - RcnA -> nickel
Components:
Function Name Type Evidence Reference(s)
catalyzer RcnA protein nd nd
product nickel simple_molecule nd nd
reactant nickel_Ext simple_molecule nd nd
rcnAB_mRNA RcnB
Name: rcnAB_mRNA -> RcnB
Description: Translation of RcnB
Type: translation
Pathway Components: rcnAB_mRNA -> RcnB
Components:
Function Name Type Evidence Reference(s)
product RcnB protein nd nd
reactant rcnAB_mRNA RNA nd nd



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