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RcnR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Co(II) Ni(II) RcnA RcnB RcnR rcnAB rcnAB_mRNA rcnR rcnR_mRNA RcnR Co(II) RcnR Ni(II) Ni(II)_Ext Co(II)_Ext


Gensor Unit       
Name: RcnR
Description: RcnR negatively regulates the expression of genes involved in detoxification of cobalt and nickel in the absence of cobalt/nickel. The presence of cobalt or nickel induces the expression of genes related to an efflux system for cobalt and nickel.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0045892 - negative regulation of transcription, DNA-templated
GO:0046583 - cation efflux transmembrane transporter activity
GO:0016020 - membrane
GO:0035444 - nickel cation transmembrane transport
GO:0042597 - periplasmic space
GO:0005737 - cytoplasm
GO:0005887 - integral component of plasma membrane
GO:0006811 - ion transport
GO:0032025 - response to cobalt ion
GO:0003677 - DNA binding
GO:0015087 - cobalt ion transmembrane transporter activity
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Components:
Function Name Type
RNA rcnR_mRNA RNA


Reactions       
Showing 9 reactions
rcnAB rcnAB_mRNA
Name: rcnAB -> rcnAB_mRNA
Description: Transcription of transcription unit rcnAB; reaction inhibition by Fur-Fe(II).
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant rcnAB gene nd nd
product rcnAB_mRNA RNA nd nd
rcnR rcnR_mRNA
Name: rcnR -> rcnR_mRNA
Description: Transcription of transcription unit rcnR; reaction inhibition by RcnR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product rcnR_mRNA RNA nd nd
reactant rcnR gene nd nd
RcnR + Co2+ RcnR-Co2+
Name: RcnR + Co2+ -> RcnR-Co2+
Description: Reaction transforming RcnR, Co2+ into RcnR-Co2+
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant RcnR protein nd nd
reactant Co2+ simple molecule nd nd
product RcnR-Co2+ complex nd nd
RcnR + Ni2+ RcnR-Ni2+
Name: RcnR + Ni2+ -> RcnR-Ni2+
Description: Reaction transforming RcnR, Ni2+ into RcnR-Ni2+
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant RcnR protein nd nd
reactant Ni2+ simple molecule nd nd
product RcnR-Ni2+ complex nd nd
rcnAB_mRNA RcnB
Name: rcnAB_mRNA -> RcnB
Description: Translation of RcnB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant rcnAB_mRNA RNA nd nd
product RcnB protein nd nd
rcnR_mRNA RcnR
Name: rcnR_mRNA -> RcnR
Description: Translation of RcnR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product RcnR protein nd nd
reactant rcnR_mRNA RNA nd nd
rcnAB_mRNA RcnA
Name: rcnAB_mRNA -> RcnA
Description: Translation of RcnA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant rcnAB_mRNA RNA nd nd
product RcnA protein nd nd
Co2+ Co2+_Ext
Name: Co2+ -> Co2+_Ext
Description: Transport of Co2+ through a bacterial membrane, leading to the presence of Co2+_Ext inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant Co2+ simple molecule nd nd
product Co2+_Ext simple molecule nd nd
Ni2+ Ni2+_Ext
Name: Ni2+ -> Ni2+_Ext
Description: Transport of Ni2+ through a bacterial membrane, leading to the presence of Ni2+_Ext inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant Ni2+ simple molecule nd nd
product Ni2+_Ext simple molecule nd nd



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