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PutA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Sodium_Ext putP glutamate-semialdehyde PutP putA pyrroline 5-carboxylate propanoate L-glutamate ubiquinone propanoate_Ext ubiquinol Sodium putP_mRNA proline_Ext PutA proline putA_mRNA


Gensor Unit       
Name: PutA
Classification:
Groups: Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0006865 - amino acid transport
GO:0006811 - ion transport
GO:0008152 - metabolic process
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0006561 - proline biosynthetic process
GO:0010133 - proline catabolic process to glutamate
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cellular_component GO:0009898 - cytoplasmic side of plasma membrane
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0000986 - bacterial-type cis-regulatory region sequence-specific DNA binding
GO:0003824 - catalytic activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0042802 - identical protein binding
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Components:
  Function Name Type
  simple_molecule L-glutamate simple_molecule
  protein PutA protein
  protein PutP protein
  simple_molecule Sodium simple_molecule
  simple_molecule Sodium_Ext simple_molecule
  simple_molecule glutamate-semialdehyde simple_molecule
  simple_molecule proline simple_molecule
  simple_molecule proline_Ext simple_molecule
  simple_molecule propanoate simple_molecule
  simple_molecule propanoate_Ext simple_molecule
  gene putA gene
  RNA putA_mRNA RNA
  gene putP gene
  RNA putP_mRNA RNA
  simple_molecule pyrroline 5-carboxylate simple_molecule
  simple_molecule ubiquinol simple_molecule
  simple_molecule ubiquinone simple_molecule


Reactions       
Showing 9 reactions
PutA putA putA_mRNA
Name: putA -> putA_mRNA
Description: Transcription of transcription unit putA. Reaction inhibition by PutA.
Type: transcription
Pathway Components: putA - PutA -> putA_mRNA
Components:
Function Name Type
inhibitor PutA protein
reactant putA gene
product putA_mRNA RNA
PutA putP putP_mRNA
Name: putP -> putP_mRNA
Description: Transcription of transcription unit putP. Reaction inhibition by PutA.
Type: transcription
Pathway Components: putP - PutA -> putP_mRNA
Components:
Function Name Type
inhibitor PutA protein
reactant putP gene
product putP_mRNA RNA
putA_mRNA PutA
Name: putA_mRNA -> PutA
Description: Translation of PutA
Type: translation
Pathway Components: putA_mRNA -> PutA
Components:
Function Name Type
product PutA protein
reactant putA_mRNA RNA
PutA ubiquinone + proline pyrroline 5-carboxylate + ubiquinol
Name: ubiquinone + proline -> pyrroline 5-carboxylate + ubiquinol
Description: Reaction transforming ubiquinone, proline into pyrroline 5-carboxylate, ubiquinol
Type: state transition
Pathway Components: ubiquinone + proline - PutA -> pyrroline 5-carboxylate + ubiquinol
Components:
Function Name Type
catalyzer PutA protein
reactant proline simple_molecule
product pyrroline 5-carboxylate simple_molecule
product ubiquinol simple_molecule
reactant ubiquinone simple_molecule
PutA glutamate-semialdehyde L-glutamate
Name: glutamate-semialdehyde -> L-glutamate
Description: Reaction transforming glutamate-semialdehyde into L-glutamate
Type: state transition
Pathway Components: glutamate-semialdehyde - PutA -> L-glutamate
Components:
Function Name Type
product L-glutamate simple_molecule
catalyzer PutA protein
reactant glutamate-semialdehyde simple_molecule
putP_mRNA PutP
Name: putP_mRNA -> PutP
Description: Translation of PutP
Type: translation
Pathway Components: putP_mRNA -> PutP
Components:
Function Name Type
product PutP protein
reactant putP_mRNA RNA
PutP proline_Ext + Sodium_Ext proline + Sodium
Name: proline_Ext + Sodium_Ext -> proline + Sodium
Description: Transport of proline_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of proline, Sodium inside the cell.
Type: transport
Pathway Components: proline_Ext + Sodium_Ext - PutP -> proline + Sodium
Components:
Function Name Type
catalyzer PutP protein
product Sodium simple_molecule
reactant Sodium_Ext simple_molecule
product proline simple_molecule
reactant proline_Ext simple_molecule
PutP propanoate_Ext propanoate
Name: propanoate_Ext -> propanoate
Description: Transport of propanoate_Ext through a bacterial membrane, leading to the presence of propanoate inside the cell.
Type: transport
Pathway Components: propanoate_Ext - PutP -> propanoate
Components:
Function Name Type
catalyzer PutP protein
product propanoate simple_molecule
reactant propanoate_Ext simple_molecule
pyrroline 5-carboxylate glutamate-semialdehyde
Name: pyrroline 5-carboxylate -> glutamate-semialdehyde
Description: Transformation of pyrroline 5-carboxylate into glutamate-semialdehyde by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: pyrroline 5-carboxylate / SPONTPRO-RXN / glutamate-semialdehyde
Components:
Function Name Type
product glutamate-semialdehyde simple_molecule
reactant pyrroline 5-carboxylate simple_molecule



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