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PutA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-proline L-proline_Ext Sodium Sodium_Ext PutA PutP propanoate propanoate_Ext putA putA_mRNA putP putP_mRNA


Gensor Unit       
Name: PutA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0045892 - negative regulation of transcription, DNA-templated
GO:0010133 - proline catabolic process to glutamate
GO:0035524 - proline transmembrane transport
GO:0015824 - proline transport
GO:0015912 - short-chain fatty acid transport
cellular_component GO:0009898 - cytoplasmic side of plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0003677 - DNA binding
GO:0000986 - bacterial-type proximal promoter sequence-specific DNA binding
GO:0050660 - flavin adenine dinucleotide binding
GO:0004657 - proline dehydrogenase activity
GO:0005298 - proline:sodium symporter activity
GO:0043565 - sequence-specific DNA binding
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Components: Show/Hide Components Table (17 more...)
Function Name Type
simple_molecule L-glutamate simple_molecule
protein PutA protein
protein PutP protein
simple_molecule Sodium simple_molecule
simple_molecule Sodium_Ext simple_molecule
simple_molecule glutamate-semialdehyde simple_molecule
simple_molecule proline simple_molecule
simple_molecule proline_Ext simple_molecule
simple_molecule propanoate simple_molecule
simple_molecule propanoate_Ext simple_molecule
gene putA gene
RNA putA_mRNA RNA
gene putP gene
RNA putP_mRNA RNA
simple_molecule pyrroline 5-carboxylate simple_molecule
simple_molecule ubiquinol simple_molecule
simple_molecule ubiquinone simple_molecule


Reactions       
Showing 9 reactions
PutA putA putA_mRNA
Name: putA -> putA_mRNA
Description: Transcription of transcription unit putA. Reaction inhibition by PutA.
Type: transcription
Pathway Components: putA - PutA -> putA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PutA protein nd nd
reactant putA gene nd nd
product putA_mRNA RNA nd nd
PutA putP putP_mRNA
Name: putP -> putP_mRNA
Description: Transcription of transcription unit putP. Reaction inhibition by PutA.
Type: transcription
Pathway Components: putP - PutA -> putP_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PutA protein nd nd
reactant putP gene nd nd
product putP_mRNA RNA nd nd
putP_mRNA PutP
Name: putP_mRNA -> PutP
Description: Translation of PutP
Type: translation
Pathway Components: putP_mRNA -> PutP
Components:
Function Name Type Evidence Reference(s)
product PutP protein nd nd
reactant putP_mRNA RNA nd nd
PutP proline_Ext + Sodium_Ext proline + Sodium
Name: proline_Ext + Sodium_Ext -> proline + Sodium
Description: Transport of proline_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of proline, Sodium inside the cell.
Type: transport
Pathway Components: proline_Ext + Sodium_Ext - PutP -> proline + Sodium
Components:
Function Name Type Evidence Reference(s)
catalyzer PutP protein nd nd
product Sodium simple_molecule nd nd
reactant Sodium_Ext simple_molecule nd nd
product proline simple_molecule nd nd
reactant proline_Ext simple_molecule nd nd
PutP propanoate_Ext propanoate
Name: propanoate_Ext -> propanoate
Description: Transport of propanoate_Ext through a bacterial membrane, leading to the presence of propanoate inside the cell.
Type: transport
Pathway Components: propanoate_Ext - PutP -> propanoate
Components:
Function Name Type Evidence Reference(s)
catalyzer PutP protein nd nd
product propanoate simple_molecule nd nd
reactant propanoate_Ext simple_molecule nd nd
putA_mRNA PutA
Name: putA_mRNA -> PutA
Description: Translation of PutA
Type: translation
Pathway Components: putA_mRNA -> PutA
Components:
Function Name Type Evidence Reference(s)
product PutA protein nd nd
reactant putA_mRNA RNA nd nd
PutA ubiquinone + proline pyrroline 5-carboxylate + ubiquinol
Name: ubiquinone + proline -> pyrroline 5-carboxylate + ubiquinol
Description: Reaction transforming ubiquinone, proline into pyrroline 5-carboxylate, ubiquinol
Type: state transition
Pathway Components: ubiquinone + proline - PutA -> pyrroline 5-carboxylate + ubiquinol
Components:
Function Name Type Evidence Reference(s)
catalyzer PutA protein nd nd
reactant proline simple_molecule nd nd
product pyrroline 5-carboxylate simple_molecule nd nd
product ubiquinol simple_molecule nd nd
reactant ubiquinone simple_molecule nd nd
PutA glutamate-semialdehyde L-glutamate
Name: glutamate-semialdehyde -> L-glutamate
Description: Reaction transforming glutamate-semialdehyde into L-glutamate
Type: state transition
Pathway Components: glutamate-semialdehyde - PutA -> L-glutamate
Components:
Function Name Type Evidence Reference(s)
product L-glutamate simple_molecule nd nd
catalyzer PutA protein nd nd
reactant glutamate-semialdehyde simple_molecule nd nd
pyrroline 5-carboxylate glutamate-semialdehyde
Name: pyrroline 5-carboxylate -> glutamate-semialdehyde
Description: Transformation of pyrroline 5-carboxylate into glutamate-semialdehyde by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: pyrroline 5-carboxylate / SPONTPRO-RXN / glutamate-semialdehyde
Components:
Function Name Type Evidence Reference(s)
product glutamate-semialdehyde simple_molecule nd nd
reactant pyrroline 5-carboxylate simple_molecule nd nd



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