RegulonDB RegulonDB

PurR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
[glycine-cleavage complex H protein] N6-lipoyl-L-lysine carAB_mRNA guanine xanthosine-5-P guanosine-diphosphate CarA PII purR_mRNA purL CodB GcvH Reduced FMN ribose-5P CvpA allo-threonine CodA GlyA CarA cvpA-purF-ubiX_mRNA ubiquinol pyrD_mRNA purA orotate urea GcvT pyrC glyA_mRNA purA_mRNA PurB pyridoxamine phosphate N5-CAIR cytosine 10-formyl-THF mono-L-glutamate PurN carAB guaBA 5-phosphoribosylamine PurR glyA CAIR uracil purEK_mRNA THF polyglutamate PurH electron-transfer quinol methylene-H4PteGlu(n) ala gcvTHP 5-aminoimidazole ribotide Lpd codBA_mRNA ubiquinone PurF FGAR speAB_mRNA Lpd L-glutamate purC HflD diphosphate 5'-p-ribosylglycinamide hypoxanthine purC_mRNA purEK adenylo-succinate vitamin B6 Prs 5'-IMP CarB CarB GcvP gcvTHP_mRNA agmatine CO2 PurD guanylate GcvH aspartate purHD CH-THF mono-L-glutamate GuaA glycine PRPP cytosine_Ext guanine vitamin K2 PyrD GlnB PurA FAICAR glutamine phosphate glnB hflD-purB purR PurK hflD-purB_mRNA speAB pyruvate guanosine-triphosphate AICAR guaBA_mRNA SpeA serine GuaB dimethylallyl phosphate PurC [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine arginine codBA GcvT menaquinol PurR UbiX FGAM prs_mRNA fumarate SpeB SAICAR PurM cvpA-purF-ubiX PurL isoguanine pyrC_mRNA purL_mRNA ammonium folinate allo-thr dihydroorotate carbamyl-aspartate carbamoyl-P putrescine prs electron-transfer quinone pyrD prenylated FMNH2 PurE GcvP xanthine purHD_mRNA hypoxanthine ethanal purMN PurR carbonate glnB_mRNA PyrC purMN_mRNA [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine ala glycine glycine glycine methylene-H4PteGlu(n) THF polyglutamate ammonium CO2 THF polyglutamate adenylo-succinate SAICAR phosphate CAIR aspartate carbamyl-aspartate 5'-IMP PRPP phosphate 5-phosphoribosylamine carbonate FGAM guanosine-triphosphate ammonium guanosine-diphosphate guanylate xanthosine-5-P 5'-IMP glutamine diphosphate L-glutamate phosphate carbonate ammonium carbamoyl-P dihydroorotate CO2


Gensor Unit       
Name: PurR
Description: Molecular biology level
Detailed: In the presence of hypoxanthine PurR negatively regulates the expression of genes required for biosynthesis of purines and pyrimidines and their precursors and polyamines biosynthetic process. Under these conditons, PurR is modified to PurR-hypoxanthine, binds its target sites, preventing its own epression and the expression of its regulated genes. In the absence of hypoxanthine, PurR unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of hypoxanthine PurR negatively regulates the expression of genes needed for biosynthesis of purines and pyrimidines and their precursors and polyamines biosynthetic process.

Physiology level
Detailed: The presence of hypoxanthine inhibits the expression of genes involved with biosynthesis of purines and pyrimidines and their precursors and polyamines biosynthetic process. Under these conditions, the genes necessary for conversion of L-glutamine to carbamoyl-P, conversion of PRPP to 5-phospho-ribosyl-amine, conversion of 5-phospho-ribosyl-amine until to IMP, cyclization of carbamoyl-aspartate to dihydroorotate and its conversion to orotate, conversion of serine to 5, 10-tetrahydrofolate are not expressed.
Less detailed: The presence of hypoxanthine inhibits the expression of genes needful for conversion of L-glutamine to carbamoyl-P, conversion of PRPP to 5-phospho-ribosyl-amine, conversion of 5-phospho-ribosyl-amine until to IMP, cyclization of carbamoyl-aspartate to dihydroorotate and its conversion to orotate, conversion of serine to 5, 10-tetrahydrofolate. Read more >
Classification:
Groups: Mobilome: prophages, transposons
Transcription
Signal transduction mechanisms
Amino acid transport and metabolism
Coenzyme transport and metabolism
Nucleotide transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0044208 - 'de novo' AMP biosynthetic process
GO:0006189 - 'de novo' IMP biosynthetic process
GO:0044205 - 'de novo' UMP biosynthetic process
GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process
GO:0009257 - 10-formyltetrahydrofolate biosynthetic process
GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process
Read more >
cellular_component GO:0005951 - carbamoyl-phosphate synthase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
GO:0005960 - glycine cleavage complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
Read more >
molecular_function GO:0070626 - (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
GO:0034023 - 5-(carboxyamino)imidazole ribonucleotide mutase activity
GO:0034028 - 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0102480 - 5-fluorocytosine deaminase activity
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0010181 - FMN binding
Read more >
Components:
  Function Name Type
  simple_molecule 10-formyl-THF mono-L-glutamate simple_molecule
  simple_molecule 5'-IMP simple_molecule
  simple_molecule 5'-p-ribosylglycinamide simple_molecule
  simple_molecule 5-aminoimidazole ribotide simple_molecule
  simple_molecule 5-phosphoribosylamine simple_molecule
  simple_molecule AICAR simple_molecule
  simple_molecule CAIR simple_molecule
  simple_molecule CH-THF mono-L-glutamate simple_molecule
  simple_molecule CO2 simple_molecule
  protein CarA protein
  protein CarB protein
  complex CarB-CarA complex
  protein CodA protein
  protein CodB protein
  protein CvpA protein
  simple_molecule FAICAR simple_molecule
  simple_molecule FGAM simple_molecule
  simple_molecule FGAR simple_molecule
  protein GcvH protein
  protein GcvP protein
  protein GcvT protein
  protein GlnB protein
  protein GlyA protein
  protein GuaA protein
  protein GuaB protein
  protein HflD protein
  simple_molecule L-glutamate simple_molecule
  protein Lpd protein
  complex Lpd-GcvP-GcvH-GcvT complex
  simple_molecule N5-CAIR simple_molecule
  protein PII protein
  simple_molecule PRPP simple_molecule
  protein Prs protein
  protein PurA protein
  protein PurB protein
  protein PurC protein
  protein PurD protein
  protein PurE protein
  protein PurF protein
  protein PurH protein
  protein PurK protein
  protein PurL protein
  protein PurM protein
  protein PurN protein
  protein PurR protein
  complex PurR-guanine complex
  complex PurR-hypoxanthine complex
  protein PyrC protein
  protein PyrD protein
  simple_molecule Reduced FMN simple_molecule
  simple_molecule SAICAR simple_molecule
  protein SpeA protein
  protein SpeB protein
  simple_molecule THF polyglutamate simple_molecule
  protein UbiX protein
  simple_molecule [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule
  simple_molecule [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule
  simple_molecule [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule
  simple_molecule adenylo-succinate simple_molecule
  simple_molecule agmatine simple_molecule
  simple_molecule ala simple_molecule
  simple_molecule allo-thr simple_molecule
  simple_molecule allo-threonine simple_molecule
  simple_molecule ammonium simple_molecule
  simple_molecule arginine simple_molecule
  simple_molecule aspartate simple_molecule
  gene carAB gene
  RNA carAB_mRNA RNA
  simple_molecule carbamoyl-P simple_molecule
  simple_molecule carbamyl-aspartate simple_molecule
  simple_molecule carbonate simple_molecule
  gene codBA gene
  RNA codBA_mRNA RNA
  gene cvpA-purF-ubiX gene
  RNA cvpA-purF-ubiX_mRNA RNA
  simple_molecule cytosine simple_molecule
  simple_molecule cytosine_Ext simple_molecule
  simple_molecule dihydroorotate simple_molecule
  simple_molecule dimethylallyl phosphate simple_molecule
  simple_molecule diphosphate simple_molecule
  simple_molecule electron-transfer quinol simple_molecule
  simple_molecule electron-transfer quinone simple_molecule
  simple_molecule ethanal simple_molecule
  simple_molecule folinate simple_molecule
  simple_molecule fumarate simple_molecule
  gene gcvTHP gene
  RNA gcvTHP_mRNA RNA
  gene glnB gene
  RNA glnB_mRNA RNA
  simple_molecule glutamine simple_molecule
  gene glyA gene
  RNA glyA_mRNA RNA
  simple_molecule glycine simple_molecule
  gene guaBA gene
  RNA guaBA_mRNA RNA
  simple_molecule guanine simple_molecule
  simple_molecule guanosine-diphosphate simple_molecule
  simple_molecule guanosine-triphosphate simple_molecule
  simple_molecule guanylate simple_molecule
  gene hflD-purB gene
  RNA hflD-purB_mRNA RNA
  simple_molecule hypoxanthine simple_molecule
  simple_molecule isoguanine simple_molecule
  simple_molecule menaquinol simple_molecule
  simple_molecule methylene-H4PteGlu(n) simple_molecule
  simple_molecule orotate simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule prenylated FMNH2 simple_molecule
  gene prs gene
  RNA prs_mRNA RNA
  gene purA gene
  RNA purA_mRNA RNA
  gene purC gene
  RNA purC_mRNA RNA
  gene purEK gene
  RNA purEK_mRNA RNA
  gene purHD gene
  RNA purHD_mRNA RNA
  gene purL gene
  RNA purL_mRNA RNA
  gene purMN gene
  RNA purMN_mRNA RNA
  gene purR gene
  RNA purR_mRNA RNA
  simple_molecule putrescine simple_molecule
  gene pyrC gene
  RNA pyrC_mRNA RNA
  gene pyrD gene
  RNA pyrD_mRNA RNA
  simple_molecule pyridoxamine phosphate simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule ribose-5P simple_molecule
  simple_molecule serine simple_molecule
  gene speAB gene
  RNA speAB_mRNA RNA
  simple_molecule ubiquinol simple_molecule
  simple_molecule ubiquinone simple_molecule
  simple_molecule uracil simple_molecule
  simple_molecule urea simple_molecule
  simple_molecule vitamin B6 simple_molecule
  simple_molecule vitamin K2 simple_molecule
  simple_molecule xanthine simple_molecule
  simple_molecule xanthosine-5-P simple_molecule


Reactions       
Showing 98 reactions
hypoxanthine + PurR PurR-hypoxanthine
Name: hypoxanthine + PurR -> PurR-hypoxanthine
Description: Reaction transforming hypoxanthine, PurR into PurR-hypoxanthine
Type: state transition
Pathway Components: hypoxanthine + PurR -> PurR-hypoxanthine
Components:
Function Name Type
reactant PurR protein
product PurR-hypoxanthine complex
reactant hypoxanthine simple_molecule
PurR-hypoxanthine carAB carAB_mRNA
Name: carAB -> carAB_mRNA
Description: Transcription of transcription unit carAB. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: carAB - PurR-hypoxanthine -> carAB_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant carAB gene
product carAB_mRNA RNA
PurR-hypoxanthine codBA codBA_mRNA
Name: codBA -> codBA_mRNA
Description: Transcription of transcription unit codBA. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: codBA - PurR-hypoxanthine -> codBA_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant codBA gene
product codBA_mRNA RNA
PurR-hypoxanthine cvpA-purF-ubiX cvpA-purF-ubiX_mRNA
Name: cvpA-purF-ubiX -> cvpA-purF-ubiX_mRNA
Description: Transcription of transcription unit cvpA-purF-ubiX. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: cvpA-purF-ubiX - PurR-hypoxanthine -> cvpA-purF-ubiX_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant cvpA-purF-ubiX gene
product cvpA-purF-ubiX_mRNA RNA
PurR-hypoxanthine gcvTHP gcvTHP_mRNA
Name: gcvTHP -> gcvTHP_mRNA
Description: Transcription of transcription unit gcvTHP. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: gcvTHP - PurR-hypoxanthine -> gcvTHP_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant gcvTHP gene
product gcvTHP_mRNA RNA
PurR-hypoxanthine glnB glnB_mRNA
Name: glnB -> glnB_mRNA
Description: Transcription of transcription unit glnB. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: glnB - PurR-hypoxanthine -> glnB_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant glnB gene
product glnB_mRNA RNA
PurR-hypoxanthine glyA glyA_mRNA
Name: glyA -> glyA_mRNA
Description: Transcription of transcription unit glyA. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: glyA - PurR-hypoxanthine -> glyA_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant glyA gene
product glyA_mRNA RNA
PurR-hypoxanthine guaBA guaBA_mRNA
Name: guaBA -> guaBA_mRNA
Description: Transcription of transcription unit guaBA. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: guaBA - PurR-hypoxanthine -> guaBA_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant guaBA gene
product guaBA_mRNA RNA
PurR-hypoxanthine hflD-purB hflD-purB_mRNA
Name: hflD-purB -> hflD-purB_mRNA
Description: Transcription of transcription unit hflD-purB. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: hflD-purB - PurR-hypoxanthine -> hflD-purB_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant hflD-purB gene
product hflD-purB_mRNA RNA
PurR-hypoxanthine prs prs_mRNA
Name: prs -> prs_mRNA
Description: Transcription of transcription unit prs. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: prs - PurR-hypoxanthine -> prs_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant prs gene
product prs_mRNA RNA
PurR-hypoxanthine purA purA_mRNA
Name: purA -> purA_mRNA
Description: Transcription of transcription unit purA. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purA - PurR-hypoxanthine -> purA_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purA gene
product purA_mRNA RNA
PurR-hypoxanthine purC purC_mRNA
Name: purC -> purC_mRNA
Description: Transcription of transcription unit purC. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purC - PurR-hypoxanthine -> purC_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purC gene
product purC_mRNA RNA
PurR-hypoxanthine purEK purEK_mRNA
Name: purEK -> purEK_mRNA
Description: Transcription of transcription unit purEK. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purEK - PurR-hypoxanthine -> purEK_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purEK gene
product purEK_mRNA RNA
PurR-hypoxanthine purHD purHD_mRNA
Name: purHD -> purHD_mRNA
Description: Transcription of transcription unit purHD. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purHD - PurR-hypoxanthine -> purHD_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purHD gene
product purHD_mRNA RNA
PurR-hypoxanthine purL purL_mRNA
Name: purL -> purL_mRNA
Description: Transcription of transcription unit purL. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purL - PurR-hypoxanthine -> purL_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purL gene
product purL_mRNA RNA
PurR-hypoxanthine purMN purMN_mRNA
Name: purMN -> purMN_mRNA
Description: Transcription of transcription unit purMN. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purMN - PurR-hypoxanthine -> purMN_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purMN gene
product purMN_mRNA RNA
PurR-hypoxanthine purR purR_mRNA
Name: purR -> purR_mRNA
Description: Transcription of transcription unit purR. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: purR - PurR-hypoxanthine -> purR_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant purR gene
product purR_mRNA RNA
PurR-hypoxanthine pyrC pyrC_mRNA
Name: pyrC -> pyrC_mRNA
Description: Transcription of transcription unit pyrC. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: pyrC - PurR-hypoxanthine -> pyrC_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant pyrC gene
product pyrC_mRNA RNA
PurR-hypoxanthine pyrD pyrD_mRNA
Name: pyrD -> pyrD_mRNA
Description: Transcription of transcription unit pyrD. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: pyrD - PurR-hypoxanthine -> pyrD_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant pyrD gene
product pyrD_mRNA RNA
PurR-hypoxanthine speAB speAB_mRNA
Name: speAB -> speAB_mRNA
Description: Transcription of transcription unit speAB. Reaction inhibition by PurR-hypoxanthine.
Type: transcription
Pathway Components: speAB - PurR-hypoxanthine -> speAB_mRNA
Components:
Function Name Type
inhibitor PurR-hypoxanthine complex
reactant speAB gene
product speAB_mRNA RNA
guanine + PurR PurR-guanine
Name: guanine + PurR -> PurR-guanine
Description: Reaction transforming guanine, PurR into PurR-guanine
Type: state transition
Pathway Components: guanine + PurR -> PurR-guanine
Components:
Function Name Type
reactant PurR protein
product PurR-guanine complex
reactant guanine simple_molecule
speAB_mRNA SpeA
Name: speAB_mRNA -> SpeA
Description: Translation of SpeA
Type: translation
Pathway Components: speAB_mRNA -> SpeA
Components:
Function Name Type
product SpeA protein
reactant speAB_mRNA RNA
SpeA putrescine arginine agmatine + CO2
Name: arginine -> agmatine + CO2
Description: Reaction transforming arginine into agmatine, CO2
Type: state transition
Pathway Components: arginine - SpeA - putrescine -> agmatine + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer SpeA protein
product agmatine simple_molecule
reactant arginine simple_molecule
inhibitor putrescine simple_molecule
speAB_mRNA SpeB
Name: speAB_mRNA -> SpeB
Description: Translation of SpeB
Type: translation
Pathway Components: speAB_mRNA -> SpeB
Components:
Function Name Type
product SpeB protein
reactant speAB_mRNA RNA
SpeB arginine agmatine putrescine + urea
Name: agmatine -> putrescine + urea
Description: Reaction transforming agmatine into putrescine, urea
Type: state transition
Pathway Components: agmatine - SpeB - arginine -> putrescine + urea
Components:
Function Name Type
catalyzer SpeB protein
reactant agmatine simple_molecule
inhibitor arginine simple_molecule
product putrescine simple_molecule
product urea simple_molecule
glyA_mRNA GlyA
Name: glyA_mRNA -> GlyA
Description: Translation of GlyA
Type: translation
Pathway Components: glyA_mRNA -> GlyA
Components:
Function Name Type
product GlyA protein
reactant glyA_mRNA RNA
GlyA ala THF polyglutamate + serine methylene-H4PteGlu(n) + glycine
Name: THF polyglutamate + serine -> methylene-H4PteGlu(n) + glycine
Description: Reaction transforming THF polyglutamate, serine into methylene-H4PteGlu(n), glycine
Type: state transition
Pathway Components: THF polyglutamate + serine - GlyA - ala -> methylene-H4PteGlu(n) + glycine
Components:
Function Name Type
catalyzer GlyA protein
reactant THF polyglutamate simple_molecule
inhibitor ala simple_molecule
product glycine simple_molecule
product methylene-H4PteGlu(n) simple_molecule
reactant serine simple_molecule
GlyA CH-THF mono-L-glutamate folinate
Name: CH-THF mono-L-glutamate -> folinate
Description: Reaction transforming CH-THF mono-L-glutamate into folinate
Type: state transition
Pathway Components: CH-THF mono-L-glutamate - GlyA -> folinate
Components:
Function Name Type
reactant CH-THF mono-L-glutamate simple_molecule
catalyzer GlyA protein
product folinate simple_molecule
GlyA vitamin B6 + ala pyridoxamine phosphate + pyruvate
Name: vitamin B6 + ala -> pyridoxamine phosphate + pyruvate
Description: Reaction transforming vitamin B6, ala into pyridoxamine phosphate, pyruvate
Type: state transition
Pathway Components: vitamin B6 + ala - GlyA -> pyridoxamine phosphate + pyruvate
Components:
Function Name Type
catalyzer GlyA protein
reactant ala simple_molecule
product pyridoxamine phosphate simple_molecule
product pyruvate simple_molecule
reactant vitamin B6 simple_molecule
GlyA allo-thr glycine + ethanal
Name: allo-thr -> glycine + ethanal
Description: Reaction transforming allo-thr into glycine, ethanal
Type: state transition
Pathway Components: allo-thr - GlyA -> glycine + ethanal
Components:
Function Name Type
catalyzer GlyA protein
reactant allo-thr simple_molecule
product ethanal simple_molecule
product glycine simple_molecule
GlyA allo-threonine ethanal + glycine
Name: allo-threonine -> ethanal + glycine
Description: Reaction transforming allo-threonine into ethanal, glycine
Type: state transition
Pathway Components: allo-threonine - GlyA -> ethanal + glycine
Components:
Function Name Type
catalyzer GlyA protein
reactant allo-threonine simple_molecule
product ethanal simple_molecule
product glycine simple_molecule
purC_mRNA PurC
Name: purC_mRNA -> PurC
Description: Translation of PurC
Type: translation
Pathway Components: purC_mRNA -> PurC
Components:
Function Name Type
product PurC protein
reactant purC_mRNA RNA
5'-IMP PurC aspartate + CAIR phosphate + SAICAR
Name: aspartate + CAIR -> phosphate + SAICAR
Description: Reaction transforming aspartate, CAIR into phosphate, SAICAR
Type: state transition
Pathway Components: aspartate + CAIR - PurC - 5'-IMP -> phosphate + SAICAR
Components:
Function Name Type
inhibitor 5'-IMP simple_molecule
reactant CAIR simple_molecule
catalyzer PurC protein
product SAICAR simple_molecule
reactant aspartate simple_molecule
product phosphate simple_molecule
purHD_mRNA PurH
Name: purHD_mRNA -> PurH
Description: Translation of PurH
Type: translation
Pathway Components: purHD_mRNA -> PurH
Components:
Function Name Type
product PurH protein
reactant purHD_mRNA RNA
PurH 10-formyl-THF mono-L-glutamate + AICAR THF polyglutamate + FAICAR
Name: 10-formyl-THF mono-L-glutamate + AICAR -> THF polyglutamate + FAICAR
Description: Reaction transforming 10-formyl-THF mono-L-glutamate, AICAR into THF polyglutamate, FAICAR
Type: state transition
Pathway Components: 10-formyl-THF mono-L-glutamate + AICAR - PurH -> THF polyglutamate + FAICAR
Components:
Function Name Type
reactant 10-formyl-THF mono-L-glutamate simple_molecule
reactant AICAR simple_molecule
product FAICAR simple_molecule
catalyzer PurH protein
product THF polyglutamate simple_molecule
PurH 5'-IMP FAICAR
Name: 5'-IMP -> FAICAR
Description: Reaction transforming 5'-IMP into FAICAR
Type: state transition
Pathway Components: 5'-IMP - PurH -> FAICAR
Components:
Function Name Type
reactant 5'-IMP simple_molecule
product FAICAR simple_molecule
catalyzer PurH protein
purHD_mRNA PurD
Name: purHD_mRNA -> PurD
Description: Translation of PurD
Type: translation
Pathway Components: purHD_mRNA -> PurD
Components:
Function Name Type
product PurD protein
reactant purHD_mRNA RNA
5-phosphoribosylamine PurD 5-phosphoribosylamine + glycine 5'-p-ribosylglycinamide + phosphate
Name: 5-phosphoribosylamine + glycine -> 5'-p-ribosylglycinamide + phosphate
Description: Reaction transforming 5-phosphoribosylamine, glycine into 5'-p-ribosylglycinamide, phosphate
Type: state transition
Pathway Components: 5-phosphoribosylamine + glycine - PurD - 5-phosphoribosylamine -> 5'-p-ribosylglycinamide + phosphate
Components:
Function Name Type
product 5'-p-ribosylglycinamide simple_molecule
inhibitor 5-phosphoribosylamine simple_molecule
reactant 5-phosphoribosylamine simple_molecule
catalyzer PurD protein
reactant glycine simple_molecule
product phosphate simple_molecule
purL_mRNA PurL
Name: purL_mRNA -> PurL
Description: Translation of PurL
Type: translation
Pathway Components: purL_mRNA -> PurL
Components:
Function Name Type
product PurL protein
reactant purL_mRNA RNA
PurL glutamine + FGAR L-glutamate + phosphate + FGAM
Name: glutamine + FGAR -> L-glutamate + phosphate + FGAM
Description: Reaction transforming glutamine, FGAR into L-glutamate, phosphate , FGAM
Type: state transition
Pathway Components: glutamine + FGAR - PurL -> L-glutamate + phosphate + FGAM
Components:
Function Name Type
product FGAM simple_molecule
reactant FGAR simple_molecule
product L-glutamate simple_molecule
catalyzer PurL protein
reactant glutamine simple_molecule
product phosphate simple_molecule
codBA_mRNA CodB
Name: codBA_mRNA -> CodB
Description: Translation of CodB
Type: translation
Pathway Components: codBA_mRNA -> CodB
Components:
Function Name Type
product CodB protein
reactant codBA_mRNA RNA
CodB cytosine_Ext cytosine
Name: cytosine_Ext -> cytosine
Description: Transport of cytosine_Ext through a bacterial membrane, leading to the presence of cytosine inside the cell.
Type: transport
Pathway Components: cytosine_Ext - CodB -> cytosine
Components:
Function Name Type
catalyzer CodB protein
product cytosine simple_molecule
reactant cytosine_Ext simple_molecule
codBA_mRNA CodA
Name: codBA_mRNA -> CodA
Description: Translation of CodA
Type: translation
Pathway Components: codBA_mRNA -> CodA
Components:
Function Name Type
product CodA protein
reactant codBA_mRNA RNA
CodA cytosine ammonium + uracil
Name: cytosine -> ammonium + uracil
Description: Reaction transforming cytosine into ammonium, uracil
Type: state transition
Pathway Components: cytosine - CodA -> ammonium + uracil
Components:
Function Name Type
catalyzer CodA protein
product ammonium simple_molecule
reactant cytosine simple_molecule
product uracil simple_molecule
CodA isoguanine ammonium + xanthine
Name: isoguanine -> ammonium + xanthine
Description: Reaction transforming isoguanine into ammonium, xanthine
Type: state transition
Pathway Components: isoguanine - CodA -> ammonium + xanthine
Components:
Function Name Type
catalyzer CodA protein
product ammonium simple_molecule
reactant isoguanine simple_molecule
product xanthine simple_molecule
glnB_mRNA GlnB
Name: glnB_mRNA -> GlnB
Description: Translation of GlnB
Type: translation
Pathway Components: glnB_mRNA -> GlnB
Components:
Function Name Type
product GlnB protein
reactant glnB_mRNA RNA
glnB_mRNA PII
Name: glnB_mRNA -> PII
Description: Translation of PII
Type: translation
Pathway Components: glnB_mRNA -> PII
Components:
Function Name Type
product PII protein
reactant glnB_mRNA RNA
purR_mRNA PurR
Name: purR_mRNA -> PurR
Description: Translation of PurR
Type: translation
Pathway Components: purR_mRNA -> PurR
Components:
Function Name Type
product PurR protein
reactant purR_mRNA RNA
purMN_mRNA PurM
Name: purMN_mRNA -> PurM
Description: Translation of PurM
Type: translation
Pathway Components: purMN_mRNA -> PurM
Components:
Function Name Type
product PurM protein
reactant purMN_mRNA RNA
5-aminoimidazole ribotide PurM FGAM 5-aminoimidazole ribotide + phosphate
Name: FGAM -> 5-aminoimidazole ribotide + phosphate
Description: Reaction transforming FGAM into 5-aminoimidazole ribotide, phosphate
Type: state transition
Pathway Components: FGAM - PurM - 5-aminoimidazole ribotide -> 5-aminoimidazole ribotide + phosphate
Components:
Function Name Type
inhibitor 5-aminoimidazole ribotide simple_molecule
product 5-aminoimidazole ribotide simple_molecule
reactant FGAM simple_molecule
catalyzer PurM protein
product phosphate simple_molecule
purMN_mRNA PurN
Name: purMN_mRNA -> PurN
Description: Translation of PurN
Type: translation
Pathway Components: purMN_mRNA -> PurN
Components:
Function Name Type
product PurN protein
reactant purMN_mRNA RNA
PurN Reactants THF polyglutamate + FGAR
Name: 10-formyl-THF mono-L-glutamate + 5'-p-ribosylglycinamide -> THF polyglutamate + FGAR
Description: Reaction transforming 10-formyl-THF mono-L-glutamate, 5'-p-ribosylglycinamide into THF polyglutamate, FGAR
Type: state transition
Pathway Components: 10-formyl-THF mono-L-glutamate + 5'-p-ribosylglycinamide - PurN -> THF polyglutamate + FGAR
Components:
Function Name Type
reactant 10-formyl-THF mono-L-glutamate simple_molecule
reactant 5'-p-ribosylglycinamide simple_molecule
product FGAR simple_molecule
catalyzer PurN protein
product THF polyglutamate simple_molecule
pyrC_mRNA PyrC
Name: pyrC_mRNA -> PyrC
Description: Translation of PyrC
Type: translation
Pathway Components: pyrC_mRNA -> PyrC
Components:
Function Name Type
product PyrC protein
reactant pyrC_mRNA RNA
PyrC dihydroorotate carbamyl-aspartate
Name: dihydroorotate -> carbamyl-aspartate
Description: Reaction transforming dihydroorotate into carbamyl-aspartate
Type: state transition
Pathway Components: dihydroorotate - PyrC -> carbamyl-aspartate
Components:
Function Name Type
catalyzer PyrC protein
product carbamyl-aspartate simple_molecule
reactant dihydroorotate simple_molecule
carAB_mRNA CarA
Name: carAB_mRNA -> CarA
Description: Translation of CarA
Type: translation
Pathway Components: carAB_mRNA -> CarA
Components:
Function Name Type
product CarA protein
reactant