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PrpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
methylisocitrate (2S,3S)-2-methylcitrate 2-methylcitrate PrpB PrpC PrpD PrpE PrpR ac-CoA 2-methylaconitate cit CoA PP oxalacetate propanoate propanoyl-CoA prpBCDE prpBCDE_mRNA prpR prpR_mRNA pyruvate succinate PrpR 2-methylcitrate


Gensor Unit       
Name: PrpR
Description: Molecular biology level
Detailed: In the presence of propanoate, PrpR positively regulates the expression of genes required for propanoate catabolic process. Under these conditions, propanoate is transformed to 2-methylcitrate, PrpR is modified to PrpR-2-methylcitrate, binds its target sites preventing its own expression and enabling the expression of its regulated genes. In the absence of propanoate, PrpR unbinds its target sites enabling its own expression and preventing the expression of its regulated genes.
Less detailed: In the presence of propanoate, PrpR positively regulates the expression of genes needed for propanoate catabolic process.

Physiology level
Detailed: The presence of propanoate induces the expression of genes involved with propanoate catabolic process. Under these conditions the genes necessary for conversion of propanoate to pyruvate and succinate via 2-methylcitrate are expressed.
Less detailed: The presence of propanoate induces the expression of genes needful for conversion of propanoate to pyruvate and succinate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0045892 - negative regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
GO:0019629 - propionate catabolic process, 2-methylcitrate cycle
GO:0019679 - propionate metabolic process, methylcitrate cycle
GO:0009314 - response to radiation
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0047547 - 2-methylcitrate dehydratase activity
GO:0050440 - 2-methylcitrate synthase activity
GO:0003700 - DNA binding transcription factor activity
GO:0004108 - citrate (Si)-synthase activity
GO:0000287 - magnesium ion binding
GO:0046421 - methylisocitrate lyase activity
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Components: Show/Hide Components Table (22 more...)
Function Name Type
simple_molecule (2S,3S)-2-methylcitrate simple_molecule
simple_molecule 2-methylaconitate simple_molecule
protein PrpB protein
protein PrpC protein
protein PrpD protein
protein PrpE protein
protein PrpR protein
complex PrpR-(2S,3S)-2-methylcitrate complex
simple_molecule acetyl-CoA simple_molecule
simple_molecule citrate simple_molecule
simple_molecule coenzyme A simple_molecule
simple_molecule diphosphate simple_molecule
simple_molecule methylisocitrate simple_molecule
simple_molecule oxalacetate simple_molecule
simple_molecule propanoate simple_molecule
simple_molecule propanoyl-CoA simple_molecule
gene prpBCDE gene
RNA prpBCDE_mRNA RNA
gene prpR gene
RNA prpR_mRNA RNA
simple_molecule pyruvate simple_molecule
simple_molecule succinate simple_molecule


Reactions       
Showing 14 reactions
PrpR PrpR-(2S,3S)-2-methylcitrate prpBCDE prpBCDE_mRNA
Name: prpBCDE -> prpBCDE_mRNA
Description: Transcription of transcription unit prpBCDE. Reaction activation by PrpR, and PrpR-(2S,3S)-2-methylcitrate.
Type: transcription
Pathway Components: prpBCDE - PrpR - PrpR-(2S,3S)-2-methylcitrate -> prpBCDE_mRNA
Components:
Function Name Type Evidence Reference(s)
activator PrpR protein nd nd
activator PrpR-(2S,3S)-2-methylcitrate complex nd nd
reactant prpBCDE gene nd nd
product prpBCDE_mRNA RNA nd nd
PrpR PrpR-(2S,3S)-2-methylcitrate prpR prpR_mRNA
Name: prpR -> prpR_mRNA
Description: Transcription of transcription unit prpR. Reaction inhibition by PrpR, and PrpR-(2S,3S)-2-methylcitrate.
Type: transcription
Pathway Components: prpR - PrpR - PrpR-(2S,3S)-2-methylcitrate -> prpR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PrpR protein nd nd
inhibitor PrpR-(2S,3S)-2-methylcitrate complex nd nd
reactant prpR gene nd nd
product prpR_mRNA RNA nd nd
(2S,3S)-2-methylcitrate + PrpR PrpR-(2S,3S)-2-methylcitrate
Name: (2S,3S)-2-methylcitrate + PrpR -> PrpR-(2S,3S)-2-methylcitrate
Description: Reaction transforming (2S,3S)-2-methylcitrate, PrpR into PrpR-(2S,3S)-2-methylcitrate
Type: state transition
Pathway Components: (2S,3S)-2-methylcitrate + PrpR -> PrpR-(2S,3S)-2-methylcitrate
Components:
Function Name Type Evidence Reference(s)
reactant (2S,3S)-2-methylcitrate simple_molecule nd nd
reactant PrpR protein nd nd
product PrpR-(2S,3S)-2-methylcitrate complex nd nd
prpR_mRNA PrpR
Name: prpR_mRNA -> PrpR
Description: Translation of PrpR
Type: translation
Pathway Components: prpR_mRNA -> PrpR
Components:
Function Name Type Evidence Reference(s)
product PrpR protein nd nd
reactant prpR_mRNA RNA nd nd
prpBCDE_mRNA PrpB
Name: prpBCDE_mRNA -> PrpB
Description: Translation of PrpB
Type: translation
Pathway Components: prpBCDE_mRNA -> PrpB
Components:
Function Name Type Evidence Reference(s)
product PrpB protein nd nd
reactant prpBCDE_mRNA RNA nd nd
PrpB methylisocitrate succinate + pyruvate
Name: methylisocitrate -> succinate + pyruvate
Description: Reaction transforming methylisocitrate into succinate, pyruvate
Type: state transition
Pathway Components: methylisocitrate - PrpB -> succinate + pyruvate
Components:
Function Name Type Evidence Reference(s)
catalyzer PrpB protein nd nd
reactant methylisocitrate simple_molecule nd nd
product pyruvate simple_molecule nd nd
product succinate simple_molecule nd nd
prpBCDE_mRNA PrpC
Name: prpBCDE_mRNA -> PrpC
Description: Translation of PrpC
Type: translation
Pathway Components: prpBCDE_mRNA -> PrpC
Components:
Function Name Type Evidence Reference(s)
product PrpC protein nd nd
reactant prpBCDE_mRNA RNA nd nd
PrpC propanoyl-CoA + oxalacetate (2S,3S)-2-methylcitrate + coenzyme A
Name: propanoyl-CoA + oxalacetate -> (2S,3S)-2-methylcitrate + coenzyme A
Description: Reaction transforming propanoyl-CoA, oxalacetate into (2S,3S)-2-methylcitrate, coenzyme A
Type: state transition
Pathway Components: propanoyl-CoA + oxalacetate - PrpC -> (2S,3S)-2-methylcitrate + coenzyme A
Components:
Function Name Type Evidence Reference(s)
product (2S,3S)-2-methylcitrate simple_molecule nd nd
catalyzer PrpC protein nd nd
product coenzyme A simple_molecule nd nd
reactant oxalacetate simple_molecule nd nd
reactant propanoyl-CoA simple_molecule nd nd
PrpC acetyl-CoA oxalacetate propanoyl-CoA oxalacetate + acetyl-CoA coenzyme A + citrate
Name: oxalacetate + acetyl-CoA -> coenzyme A + citrate
Description: Reaction transforming oxalacetate, acetyl-CoA into coenzyme A, citrate
Type: state transition
Pathway Components: oxalacetate + acetyl-CoA - PrpC - acetyl-CoA - oxalacetate - propanoyl-CoA -> coenzyme A + citrate
Components:
Function Name Type Evidence Reference(s)
catalyzer PrpC protein nd nd
inhibitor acetyl-CoA simple_molecule nd nd
reactant acetyl-CoA simple_molecule nd nd
product citrate simple_molecule nd nd
product coenzyme A simple_molecule nd nd
inhibitor oxalacetate simple_molecule nd nd
reactant oxalacetate simple_molecule nd nd
inhibitor propanoyl-CoA simple_molecule nd nd
prpBCDE_mRNA PrpD
Name: prpBCDE_mRNA -> PrpD
Description: Translation of PrpD
Type: translation
Pathway Components: prpBCDE_mRNA -> PrpD
Components:
Function Name Type Evidence Reference(s)
product PrpD protein nd nd
reactant prpBCDE_mRNA RNA nd nd
PrpD (2S,3S)-2-methylcitrate 2-methylaconitate
Name: (2S,3S)-2-methylcitrate -> 2-methylaconitate
Description: Reaction transforming (2S,3S)-2-methylcitrate into 2-methylaconitate
Type: state transition
Pathway Components: (2S,3S)-2-methylcitrate - PrpD -> 2-methylaconitate
Components:
Function Name Type Evidence Reference(s)
reactant (2S,3S)-2-methylcitrate simple_molecule nd nd
product 2-methylaconitate simple_molecule nd nd
catalyzer PrpD protein nd nd
prpBCDE_mRNA PrpE
Name: prpBCDE_mRNA -> PrpE
Description: Translation of PrpE
Type: translation
Pathway Components: prpBCDE_mRNA -> PrpE
Components:
Function Name Type Evidence Reference(s)
product PrpE protein nd nd
reactant prpBCDE_mRNA RNA nd nd
PrpE propanoate + coenzyme A propanoyl-CoA + diphosphate
Name: propanoate + coenzyme A -> propanoyl-CoA + diphosphate
Description: Reaction transforming propanoate, coenzyme A into propanoyl-CoA, diphosphate
Type: state transition
Pathway Components: propanoate + coenzyme A - PrpE -> propanoyl-CoA + diphosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer PrpE protein nd nd
reactant coenzyme A simple_molecule nd nd
product diphosphate simple_molecule nd nd
reactant propanoate simple_molecule nd nd
product propanoyl-CoA simple_molecule nd nd
2-methylaconitate methylisocitrate
Name: 2-methylaconitate -> methylisocitrate
Description: Transformation of 2-methylaconitate into methylisocitrate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 2-methylaconitate / 4.2.1.99-RXN / methylisocitrate
Components:
Function Name Type Evidence Reference(s)
reactant 2-methylaconitate simple_molecule nd nd
product methylisocitrate simple_molecule nd nd



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