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PaaX Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
PaaA PaaH oxepin-CoA coenzyme A PaaE (5Z)-3,8-dioxooct-5-enoyl-CoA PaaG OH-butyryl-CoA crotonyl-CoA PaaE PaaB paaABCDEFGHIJK_mRNA PaaJ paaXY_mRNA 3-oxoadipyl-CoA phenylacetyl-CoA PaaF 3-oxo-5,6-didehydrosuberyl-CoA oxygen PaaG PaaZ PaaX 3,4-dihydroxyphenylacetyl-CoA PaaI PaaX 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA paaXY acetyl-CoA phenylacetyl-CoA PaaK homoprotocatechuate diphosphate 3-hydroxyadipyl-CoA PaaF PaaC PaaA paaZ_mRNA PaaB paaABCDEFGHIJK 2,3-didehydroadipyl-CoA suc-coa paaZ 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA phenylacetate PaaD PaaY PaaC coenzyme A phenylacetyl-CoA coenzyme A


Gensor Unit       
Name: PaaX
Classification:
Groups: General function prediction only
Lipid transport and metabolism
Secondary metabolites biosynthesis, transport and catabolism
Posttranslational modification, protein turnover, chaperones
Transcription
Energy production and conversion
Coenzyme transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0019619 - 3,4-dihydroxybenzoate catabolic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0022900 - electron transport chain
GO:0006635 - fatty acid beta-oxidation
GO:0006631 - fatty acid metabolic process
GO:0006629 - lipid metabolic process
Read more >
cellular_component GO:0005829 - cytosol
GO:0005886 - plasma membrane
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity
GO:0008691 - 3-hydroxybutyryl-CoA dehydrogenase activity
GO:0033812 - 3-oxoadipyl-CoA thiolase activity
GO:0005524 - ATP binding
GO:0016289 - CoA hydrolase activity
GO:0016405 - CoA-ligase activity
Read more >
Components:
  Function Name Type
  simple_molecule (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule
  simple_molecule 2,3-didehydroadipyl-CoA simple_molecule
  simple_molecule 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule
  simple_molecule 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule
  simple_molecule 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate simple_molecule
  simple_molecule 3,4-dihydroxyphenylacetyl-CoA simple_molecule
  simple_molecule 3-hydroxyadipyl-CoA simple_molecule
  simple_molecule 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule
  simple_molecule 3-oxoadipyl-CoA simple_molecule
  simple_molecule OH-butyryl-CoA simple_molecule
  protein PaaA protein
  protein PaaB protein
  protein PaaC protein
  protein PaaD protein
  protein PaaE protein
  complex PaaE-PaaA-PaaC-PaaB complex
  protein PaaF protein
  protein PaaG protein
  complex PaaG-PaaF complex
  protein PaaH protein
  protein PaaI protein
  protein PaaJ protein
  protein PaaK protein
  protein PaaX protein
  complex PaaX-phenylacetyl-CoA complex
  protein PaaY protein
  protein PaaZ protein
  simple_molecule acetyl-CoA simple_molecule
  simple_molecule coenzyme A simple_molecule
  simple_molecule crotonyl-CoA simple_molecule
  simple_molecule diphosphate simple_molecule
  simple_molecule homoprotocatechuate simple_molecule
  simple_molecule oxepin-CoA simple_molecule
  simple_molecule oxygen simple_molecule
  gene paaABCDEFGHIJK gene
  RNA paaABCDEFGHIJK_mRNA RNA
  gene paaXY gene
  RNA paaXY_mRNA RNA
  gene paaZ gene
  RNA paaZ_mRNA RNA
  simple_molecule phenylacetate simple_molecule
  simple_molecule phenylacetyl-CoA simple_molecule
  simple_molecule suc-coa simple_molecule


Reactions       
Showing 33 reactions
PaaX paaABCDEFGHIJK paaABCDEFGHIJK_mRNA
Name: paaABCDEFGHIJK -> paaABCDEFGHIJK_mRNA
Description: Transcription of transcription unit paaABCDEFGHIJK. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaABCDEFGHIJK - PaaX -> paaABCDEFGHIJK_mRNA
Components:
Function Name Type
inhibitor PaaX protein
reactant paaABCDEFGHIJK gene
product paaABCDEFGHIJK_mRNA RNA
PaaX paaXY paaXY_mRNA
Name: paaXY -> paaXY_mRNA
Description: Transcription of transcription unit paaXY. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaXY - PaaX -> paaXY_mRNA
Components:
Function Name Type
inhibitor PaaX protein
reactant paaXY gene
product paaXY_mRNA RNA
PaaX paaZ paaZ_mRNA
Name: paaZ -> paaZ_mRNA
Description: Transcription of transcription unit paaZ. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaZ - PaaX -> paaZ_mRNA
Components:
Function Name Type
inhibitor PaaX protein
reactant paaZ gene
product paaZ_mRNA RNA
phenylacetyl-CoA + PaaX PaaX-phenylacetyl-CoA
Name: phenylacetyl-CoA + PaaX -> PaaX-phenylacetyl-CoA
Description: Reaction transforming phenylacetyl-CoA, PaaX into PaaX-phenylacetyl-CoA
Type: state transition
Pathway Components: phenylacetyl-CoA + PaaX -> PaaX-phenylacetyl-CoA
Components:
Function Name Type
reactant PaaX protein
product PaaX-phenylacetyl-CoA complex
reactant phenylacetyl-CoA simple_molecule
paaZ_mRNA PaaZ
Name: paaZ_mRNA -> PaaZ
Description: Translation of PaaZ
Type: translation
Pathway Components: paaZ_mRNA -> PaaZ
Components:
Function Name Type
product PaaZ protein
reactant paaZ_mRNA RNA
2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA PaaZ oxepin-CoA (5Z)-3,8-dioxooct-5-enoyl-CoA
Name: oxepin-CoA -> (5Z)-3,8-dioxooct-5-enoyl-CoA
Description: Reaction transforming oxepin-CoA into (5Z)-3,8-dioxooct-5-enoyl-CoA
Type: state transition
Pathway Components: oxepin-CoA - PaaZ - 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA -> (5Z)-3,8-dioxooct-5-enoyl-CoA
Components:
Function Name Type
product (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule
inhibitor 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule
catalyzer PaaZ protein
reactant oxepin-CoA simple_molecule
PaaZ (5Z)-3,8-dioxooct-5-enoyl-CoA 3-oxo-5,6-didehydrosuberyl-CoA
Name: (5Z)-3,8-dioxooct-5-enoyl-CoA -> 3-oxo-5,6-didehydrosuberyl-CoA
Description: Reaction transforming (5Z)-3,8-dioxooct-5-enoyl-CoA into 3-oxo-5,6-didehydrosuberyl-CoA
Type: state transition
Pathway Components: (5Z)-3,8-dioxooct-5-enoyl-CoA - PaaZ -> 3-oxo-5,6-didehydrosuberyl-CoA
Components:
Function Name Type
reactant (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule
product 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule
catalyzer PaaZ protein
PaaZ OH-butyryl-CoA crotonyl-CoA
Name: OH-butyryl-CoA -> crotonyl-CoA
Description: Reaction transforming OH-butyryl-CoA into crotonyl-CoA
Type: state transition
Pathway Components: OH-butyryl-CoA - PaaZ -> crotonyl-CoA
Components:
Function Name Type
reactant OH-butyryl-CoA simple_molecule
catalyzer PaaZ protein
product crotonyl-CoA simple_molecule
paaABCDEFGHIJK_mRNA PaaA
Name: paaABCDEFGHIJK_mRNA -> PaaA
Description: Translation of PaaA
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaA
Components:
Function Name Type
product PaaA protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaC + PaaB + PaaE + PaaA PaaE-PaaA-PaaC-PaaB
Name: PaaC + PaaB + PaaE + PaaA -> PaaE-PaaA-PaaC-PaaB
Description: Reaction transforming PaaC, PaaB, PaaE, PaaA into PaaE-PaaA-PaaC-PaaB
Type: state transition
Pathway Components: PaaC + PaaB + PaaE + PaaA -> PaaE-PaaA-PaaC-PaaB
Components:
Function Name Type
reactant PaaA protein
reactant PaaB protein
reactant PaaC protein
reactant PaaE protein
product PaaE-PaaA-PaaC-PaaB complex
PaaE-PaaA-PaaC-PaaB phenylacetyl-CoA + oxygen 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Name: phenylacetyl-CoA + oxygen -> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Description: Reaction transforming phenylacetyl-CoA, oxygen into 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Type: state transition
Pathway Components: phenylacetyl-CoA + oxygen - PaaE-PaaA-PaaC-PaaB -> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Components:
Function Name Type
product 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule
catalyzer PaaE-PaaA-PaaC-PaaB complex
reactant oxygen simple_molecule
reactant phenylacetyl-CoA simple_molecule
paaABCDEFGHIJK_mRNA PaaB
Name: paaABCDEFGHIJK_mRNA -> PaaB
Description: Translation of PaaB
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaB
Components:
Function Name Type
product PaaB protein
reactant paaABCDEFGHIJK_mRNA RNA
paaABCDEFGHIJK_mRNA PaaC
Name: paaABCDEFGHIJK_mRNA -> PaaC
Description: Translation of PaaC
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaC
Components:
Function Name Type
product PaaC protein
reactant paaABCDEFGHIJK_mRNA RNA
paaABCDEFGHIJK_mRNA PaaD
Name: paaABCDEFGHIJK_mRNA -> PaaD
Description: Translation of PaaD
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaD
Components:
Function Name Type
product PaaD protein
reactant paaABCDEFGHIJK_mRNA RNA
paaABCDEFGHIJK_mRNA PaaE
Name: paaABCDEFGHIJK_mRNA -> PaaE
Description: Translation of PaaE
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaE
Components:
Function Name Type
product PaaE protein
reactant paaABCDEFGHIJK_mRNA RNA
paaABCDEFGHIJK_mRNA PaaF
Name: paaABCDEFGHIJK_mRNA -> PaaF
Description: Translation of PaaF
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaF
Components:
Function Name Type
product PaaF protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaG + PaaF PaaG-PaaF
Name: PaaG + PaaF -> PaaG-PaaF
Description: Reaction transforming PaaG, PaaF into PaaG-PaaF
Type: state transition
Pathway Components: PaaG + PaaF -> PaaG-PaaF
Components:
Function Name Type
reactant PaaF protein
reactant PaaG protein
product PaaG-PaaF complex
PaaF 2,3-didehydroadipyl-CoA 3-hydroxyadipyl-CoA
Name: 2,3-didehydroadipyl-CoA -> 3-hydroxyadipyl-CoA
Description: Reaction transforming 2,3-didehydroadipyl-CoA into 3-hydroxyadipyl-CoA
Type: state transition
Pathway Components: 2,3-didehydroadipyl-CoA - PaaF -> 3-hydroxyadipyl-CoA
Components:
Function Name Type
reactant 2,3-didehydroadipyl-CoA simple_molecule
product 3-hydroxyadipyl-CoA simple_molecule
catalyzer PaaF protein
paaABCDEFGHIJK_mRNA PaaG
Name: paaABCDEFGHIJK_mRNA -> PaaG
Description: Translation of PaaG
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaG
Components:
Function Name Type
product PaaG protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaG 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA oxepin-CoA
Name: 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA -> oxepin-CoA
Description: Reaction transforming 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA into oxepin-CoA
Type: state transition
Pathway Components: 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA - PaaG -> oxepin-CoA
Components:
Function Name Type
reactant 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule
catalyzer PaaG protein
product oxepin-CoA simple_molecule
paaABCDEFGHIJK_mRNA PaaH
Name: paaABCDEFGHIJK_mRNA -> PaaH
Description: Translation of PaaH
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaH
Components:
Function Name Type
product PaaH protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaH 3-hydroxyadipyl-CoA 3-oxoadipyl-CoA
Name: 3-hydroxyadipyl-CoA -> 3-oxoadipyl-CoA
Description: Reaction transforming 3-hydroxyadipyl-CoA into 3-oxoadipyl-CoA
Type: state transition
Pathway Components: 3-hydroxyadipyl-CoA - PaaH -> 3-oxoadipyl-CoA
Components:
Function Name Type
reactant 3-hydroxyadipyl-CoA simple_molecule
product 3-oxoadipyl-CoA simple_molecule
catalyzer PaaH protein
paaABCDEFGHIJK_mRNA PaaI
Name: paaABCDEFGHIJK_mRNA -> PaaI
Description: Translation of PaaI
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaI
Components:
Function Name Type
product PaaI protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaI phenylacetyl-CoA phenylacetate + coenzyme A
Name: phenylacetyl-CoA -> phenylacetate + coenzyme A
Description: Reaction transforming phenylacetyl-CoA into phenylacetate, coenzyme A
Type: state transition
Pathway Components: phenylacetyl-CoA - PaaI -> phenylacetate + coenzyme A
Components:
Function Name Type
catalyzer PaaI protein
product coenzyme A simple_molecule
product phenylacetate simple_molecule
reactant phenylacetyl-CoA simple_molecule
PaaI 3,4-dihydroxyphenylacetyl-CoA homoprotocatechuate + coenzyme A
Name: 3,4-dihydroxyphenylacetyl-CoA -> homoprotocatechuate + coenzyme A
Description: Reaction transforming 3,4-dihydroxyphenylacetyl-CoA into homoprotocatechuate, coenzyme A
Type: state transition
Pathway Components: 3,4-dihydroxyphenylacetyl-CoA - PaaI -> homoprotocatechuate + coenzyme A
Components:
Function Name Type
reactant 3,4-dihydroxyphenylacetyl-CoA simple_molecule
catalyzer PaaI protein
product coenzyme A simple_molecule
product homoprotocatechuate simple_molecule
paaABCDEFGHIJK_mRNA PaaJ
Name: paaABCDEFGHIJK_mRNA -> PaaJ
Description: Translation of PaaJ
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaJ
Components:
Function Name Type
product PaaJ protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaJ 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A 2,3-didehydroadipyl-CoA + acetyl-CoA
Name: 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A -> 2,3-didehydroadipyl-CoA + acetyl-CoA
Description: Reaction transforming 3-oxo-5,6-didehydrosuberyl-CoA, coenzyme A into 2,3-didehydroadipyl-CoA, acetyl-CoA
Type: state transition
Pathway Components: 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A - PaaJ -> 2,3-didehydroadipyl-CoA + acetyl-CoA
Components:
Function Name Type
product 2,3-didehydroadipyl-CoA simple_molecule
reactant 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule
catalyzer PaaJ protein
product acetyl-CoA simple_molecule
reactant coenzyme A simple_molecule
PaaJ 3-oxoadipyl-CoA + coenzyme A acetyl-CoA + suc-coa
Name: 3-oxoadipyl-CoA + coenzyme A -> acetyl-CoA + suc-coa
Description: Reaction transforming 3-oxoadipyl-CoA, coenzyme A into acetyl-CoA, suc-coa
Type: state transition
Pathway Components: 3-oxoadipyl-CoA + coenzyme A - PaaJ -> acetyl-CoA + suc-coa
Components:
Function Name Type
reactant 3-oxoadipyl-CoA simple_molecule
catalyzer PaaJ protein
product acetyl-CoA simple_molecule
reactant coenzyme A simple_molecule
product suc-coa simple_molecule
paaABCDEFGHIJK_mRNA PaaK
Name: paaABCDEFGHIJK_mRNA -> PaaK
Description: Translation of PaaK
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaK
Components:
Function Name Type
product PaaK protein
reactant paaABCDEFGHIJK_mRNA RNA
PaaK phenylacetate + coenzyme A phenylacetyl-CoA + diphosphate
Name: phenylacetate + coenzyme A -> phenylacetyl-CoA + diphosphate
Description: Reaction transforming phenylacetate, coenzyme A into phenylacetyl-CoA, diphosphate
Type: state transition
Pathway Components: phenylacetate + coenzyme A - PaaK -> phenylacetyl-CoA + diphosphate
Components:
Function Name Type
catalyzer PaaK protein
reactant coenzyme A simple_molecule
product diphosphate simple_molecule
reactant phenylacetate simple_molecule
product phenylacetyl-CoA simple_molecule
paaXY_mRNA PaaX
Name: paaXY_mRNA -> PaaX
Description: Translation of PaaX
Type: translation
Pathway Components: paaXY_mRNA -> PaaX
Components:
Function Name Type
product PaaX protein
reactant paaXY_mRNA RNA
paaXY_mRNA PaaY
Name: paaXY_mRNA -> PaaY
Description: Translation of PaaY
Type: translation
Pathway Components: paaXY_mRNA -> PaaY
Components:
Function Name Type
product PaaY protein
reactant paaXY_mRNA RNA
PaaY 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA Products
Name: 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA -> 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate + coenzyme A
Description: Reaction transforming 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA into 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate, coenzyme A
Type: state transition
Pathway Components: 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA - PaaY -> 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate + coenzyme A
Components:
Function Name Type
reactant 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule
product 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate simple_molecule
catalyzer PaaY protein
product coenzyme A simple_molecule



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