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PaaX Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2,3-dehydroadipyl-CoA 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA oxepin-CoA homoprotocatechuate 3,4-dihydroxyphenylacetyl-CoA 3-hydroxyadipyl-CoA 3-oxo-5,6-dehydrosuberyl-CoA 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde 3-oxoadipyl-CoA PaaA PaaB PaaC PaaD PaaE PaaF PaaG PaaH PaaI PaaJ PaaK PaaX PaaZ 3-OH-acyl-CoA trans-2,3-dehydroacyl-CoA ac-CoA CoA PP oxygen paaABCDEFGHIJK paaABCDEFGHIJK_mRNA paaZ paaZ_mRNA phenylacetate phenylacetyl-CoA suc-coa PaaE PaaA PaaC PaaB CoA


Gensor Unit       
Name: PaaX
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0006635 - fatty acid beta-oxidation
GO:2000143 - negative regulation of DNA-templated transcription, initiation
GO:0010124 - phenylacetate catabolic process
GO:0006351 - transcription, DNA-templated
cellular_component GO:0005829 - cytosol
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity
GO:0008691 - 3-hydroxybutyryl-CoA dehydrogenase activity
GO:0033812 - 3-oxoadipyl-CoA thiolase activity
GO:0016289 - CoA hydrolase activity
GO:0016405 - CoA-ligase activity
GO:0003988 - acetyl-CoA C-acyltransferase activity
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Components: Show/Hide Components Table (42 more...)
Function Name Type
simple_molecule (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule
simple_molecule 2,3-didehydroadipyl-CoA simple_molecule
simple_molecule 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule
simple_molecule 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule
simple_molecule 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate simple_molecule
simple_molecule 3,4-dihydroxyphenylacetyl-CoA simple_molecule
simple_molecule 3-hydroxyadipyl-CoA simple_molecule
simple_molecule 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule
simple_molecule 3-oxoadipyl-CoA simple_molecule
simple_molecule OH-butyryl-CoA simple_molecule
protein PaaA protein
protein PaaB protein
protein PaaC protein
protein PaaD protein
protein PaaE protein
complex PaaE-PaaA-PaaC-PaaB complex
protein PaaF protein
protein PaaG protein
complex PaaG-PaaF complex
protein PaaH protein
protein PaaI protein
protein PaaJ protein
protein PaaK protein
protein PaaX protein
protein PaaY protein
protein PaaZ protein
simple_molecule acetyl-CoA simple_molecule
simple_molecule coenzyme A simple_molecule
simple_molecule crotonyl-CoA simple_molecule
simple_molecule diphosphate simple_molecule
simple_molecule homoprotocatechuate simple_molecule
simple_molecule oxepin-CoA simple_molecule
simple_molecule oxygen simple_molecule
gene paaABCDEFGHIJK gene
RNA paaABCDEFGHIJK_mRNA RNA
gene paaXY gene
RNA paaXY_mRNA RNA
gene paaZ gene
RNA paaZ_mRNA RNA
simple_molecule phenylacetate simple_molecule
simple_molecule phenylacetyl-CoA simple_molecule
simple_molecule suc-coa simple_molecule


Reactions       
Showing 32 reactions
PaaX paaABCDEFGHIJK paaABCDEFGHIJK_mRNA
Name: paaABCDEFGHIJK -> paaABCDEFGHIJK_mRNA
Description: Transcription of transcription unit paaABCDEFGHIJK. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaABCDEFGHIJK - PaaX -> paaABCDEFGHIJK_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PaaX protein nd nd
reactant paaABCDEFGHIJK gene nd nd
product paaABCDEFGHIJK_mRNA RNA nd nd
PaaX paaXY paaXY_mRNA
Name: paaXY -> paaXY_mRNA
Description: Transcription of transcription unit paaXY. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaXY - PaaX -> paaXY_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PaaX protein nd nd
reactant paaXY gene nd nd
product paaXY_mRNA RNA nd nd
PaaX paaZ paaZ_mRNA
Name: paaZ -> paaZ_mRNA
Description: Transcription of transcription unit paaZ. Reaction inhibition by PaaX.
Type: transcription
Pathway Components: paaZ - PaaX -> paaZ_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor PaaX protein nd nd
reactant paaZ gene nd nd
product paaZ_mRNA RNA nd nd
paaABCDEFGHIJK_mRNA PaaA
Name: paaABCDEFGHIJK_mRNA -> PaaA
Description: Translation of PaaA
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaA
Components:
Function Name Type Evidence Reference(s)
product PaaA protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaB + PaaE + PaaC + PaaA PaaE-PaaA-PaaC-PaaB
Name: PaaB + PaaE + PaaC + PaaA -> PaaE-PaaA-PaaC-PaaB
Description: Reaction transforming PaaB, PaaE, PaaC, PaaA into PaaE-PaaA-PaaC-PaaB
Type: state transition
Pathway Components: PaaB + PaaE + PaaC + PaaA -> PaaE-PaaA-PaaC-PaaB
Components:
Function Name Type Evidence Reference(s)
reactant PaaA protein nd nd
reactant PaaB protein nd nd
reactant PaaC protein nd nd
reactant PaaE protein nd nd
product PaaE-PaaA-PaaC-PaaB complex nd nd
PaaE-PaaA-PaaC-PaaB phenylacetyl-CoA + oxygen 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Name: phenylacetyl-CoA + oxygen -> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Description: Reaction transforming phenylacetyl-CoA, oxygen into 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Type: state transition
Pathway Components: phenylacetyl-CoA + oxygen - PaaE-PaaA-PaaC-PaaB -> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA
Components:
Function Name Type Evidence Reference(s)
product 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule nd nd
catalyzer PaaE-PaaA-PaaC-PaaB complex nd nd
reactant oxygen simple_molecule nd nd
reactant phenylacetyl-CoA simple_molecule nd nd
paaABCDEFGHIJK_mRNA PaaB
Name: paaABCDEFGHIJK_mRNA -> PaaB
Description: Translation of PaaB
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaB
Components:
Function Name Type Evidence Reference(s)
product PaaB protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
paaABCDEFGHIJK_mRNA PaaC
Name: paaABCDEFGHIJK_mRNA -> PaaC
Description: Translation of PaaC
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaC
Components:
Function Name Type Evidence Reference(s)
product PaaC protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
paaABCDEFGHIJK_mRNA PaaD
Name: paaABCDEFGHIJK_mRNA -> PaaD
Description: Translation of PaaD
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaD
Components:
Function Name Type Evidence Reference(s)
product PaaD protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
paaABCDEFGHIJK_mRNA PaaE
Name: paaABCDEFGHIJK_mRNA -> PaaE
Description: Translation of PaaE
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaE
Components:
Function Name Type Evidence Reference(s)
product PaaE protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
paaABCDEFGHIJK_mRNA PaaF
Name: paaABCDEFGHIJK_mRNA -> PaaF
Description: Translation of PaaF
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaF
Components:
Function Name Type Evidence Reference(s)
product PaaF protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaF + PaaG PaaG-PaaF
Name: PaaF + PaaG -> PaaG-PaaF
Description: Reaction transforming PaaF, PaaG into PaaG-PaaF
Type: state transition
Pathway Components: PaaF + PaaG -> PaaG-PaaF
Components:
Function Name Type Evidence Reference(s)
reactant PaaF protein nd nd
reactant PaaG protein nd nd
product PaaG-PaaF complex nd nd
PaaF 3-hydroxyadipyl-CoA 2,3-didehydroadipyl-CoA
Name: 3-hydroxyadipyl-CoA -> 2,3-didehydroadipyl-CoA
Description: Reaction transforming 3-hydroxyadipyl-CoA into 2,3-didehydroadipyl-CoA
Type: state transition
Pathway Components: 3-hydroxyadipyl-CoA - PaaF -> 2,3-didehydroadipyl-CoA
Components:
Function Name Type Evidence Reference(s)
product 2,3-didehydroadipyl-CoA simple_molecule nd nd
reactant 3-hydroxyadipyl-CoA simple_molecule nd nd
catalyzer PaaF protein nd nd
paaABCDEFGHIJK_mRNA PaaG
Name: paaABCDEFGHIJK_mRNA -> PaaG
Description: Translation of PaaG
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaG
Components:
Function Name Type Evidence Reference(s)
product PaaG protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaG 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA oxepin-CoA
Name: 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA -> oxepin-CoA
Description: Reaction transforming 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA into oxepin-CoA
Type: state transition
Pathway Components: 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA - PaaG -> oxepin-CoA
Components:
Function Name Type Evidence Reference(s)
reactant 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA simple_molecule nd nd
catalyzer PaaG protein nd nd
product oxepin-CoA simple_molecule nd nd
paaABCDEFGHIJK_mRNA PaaH
Name: paaABCDEFGHIJK_mRNA -> PaaH
Description: Translation of PaaH
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaH
Components:
Function Name Type Evidence Reference(s)
product PaaH protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaH 3-hydroxyadipyl-CoA 3-oxoadipyl-CoA
Name: 3-hydroxyadipyl-CoA -> 3-oxoadipyl-CoA
Description: Reaction transforming 3-hydroxyadipyl-CoA into 3-oxoadipyl-CoA
Type: state transition
Pathway Components: 3-hydroxyadipyl-CoA - PaaH -> 3-oxoadipyl-CoA
Components:
Function Name Type Evidence Reference(s)
reactant 3-hydroxyadipyl-CoA simple_molecule nd nd
product 3-oxoadipyl-CoA simple_molecule nd nd
catalyzer PaaH protein nd nd
paaABCDEFGHIJK_mRNA PaaI
Name: paaABCDEFGHIJK_mRNA -> PaaI
Description: Translation of PaaI
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaI
Components:
Function Name Type Evidence Reference(s)
product PaaI protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaI phenylacetyl-CoA phenylacetate + coenzyme A
Name: phenylacetyl-CoA -> phenylacetate + coenzyme A
Description: Reaction transforming phenylacetyl-CoA into phenylacetate, coenzyme A
Type: state transition
Pathway Components: phenylacetyl-CoA - PaaI -> phenylacetate + coenzyme A
Components:
Function Name Type Evidence Reference(s)
catalyzer PaaI protein nd nd
product coenzyme A simple_molecule nd nd
product phenylacetate simple_molecule nd nd
reactant phenylacetyl-CoA simple_molecule nd nd
PaaI 3,4-dihydroxyphenylacetyl-CoA homoprotocatechuate + coenzyme A
Name: 3,4-dihydroxyphenylacetyl-CoA -> homoprotocatechuate + coenzyme A
Description: Reaction transforming 3,4-dihydroxyphenylacetyl-CoA into homoprotocatechuate, coenzyme A
Type: state transition
Pathway Components: 3,4-dihydroxyphenylacetyl-CoA - PaaI -> homoprotocatechuate + coenzyme A
Components:
Function Name Type Evidence Reference(s)
reactant 3,4-dihydroxyphenylacetyl-CoA simple_molecule nd nd
catalyzer PaaI protein nd nd
product coenzyme A simple_molecule nd nd
product homoprotocatechuate simple_molecule nd nd
paaABCDEFGHIJK_mRNA PaaJ
Name: paaABCDEFGHIJK_mRNA -> PaaJ
Description: Translation of PaaJ
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaJ
Components:
Function Name Type Evidence Reference(s)
product PaaJ protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaJ 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A 2,3-didehydroadipyl-CoA + acetyl-CoA
Name: 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A -> 2,3-didehydroadipyl-CoA + acetyl-CoA
Description: Reaction transforming 3-oxo-5,6-didehydrosuberyl-CoA, coenzyme A into 2,3-didehydroadipyl-CoA, acetyl-CoA
Type: state transition
Pathway Components: 3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A - PaaJ -> 2,3-didehydroadipyl-CoA + acetyl-CoA
Components:
Function Name Type Evidence Reference(s)
product 2,3-didehydroadipyl-CoA simple_molecule nd nd
reactant 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule nd nd
catalyzer PaaJ protein nd nd
product acetyl-CoA simple_molecule nd nd
reactant coenzyme A simple_molecule nd nd
PaaJ 3-oxoadipyl-CoA + coenzyme A acetyl-CoA + suc-coa
Name: 3-oxoadipyl-CoA + coenzyme A -> acetyl-CoA + suc-coa
Description: Reaction transforming 3-oxoadipyl-CoA, coenzyme A into acetyl-CoA, suc-coa
Type: state transition
Pathway Components: 3-oxoadipyl-CoA + coenzyme A - PaaJ -> acetyl-CoA + suc-coa
Components:
Function Name Type Evidence Reference(s)
reactant 3-oxoadipyl-CoA simple_molecule nd nd
catalyzer PaaJ protein nd nd
product acetyl-CoA simple_molecule nd nd
reactant coenzyme A simple_molecule nd nd
product suc-coa simple_molecule nd nd
paaABCDEFGHIJK_mRNA PaaK
Name: paaABCDEFGHIJK_mRNA -> PaaK
Description: Translation of PaaK
Type: translation
Pathway Components: paaABCDEFGHIJK_mRNA -> PaaK
Components:
Function Name Type Evidence Reference(s)
product PaaK protein nd nd
reactant paaABCDEFGHIJK_mRNA RNA nd nd
PaaK phenylacetate + coenzyme A phenylacetyl-CoA + diphosphate
Name: phenylacetate + coenzyme A -> phenylacetyl-CoA + diphosphate
Description: Reaction transforming phenylacetate, coenzyme A into phenylacetyl-CoA, diphosphate
Type: state transition
Pathway Components: phenylacetate + coenzyme A - PaaK -> phenylacetyl-CoA + diphosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer PaaK protein nd nd
reactant coenzyme A simple_molecule nd nd
product diphosphate simple_molecule nd nd
reactant phenylacetate simple_molecule nd nd
product phenylacetyl-CoA simple_molecule nd nd
paaXY_mRNA PaaX
Name: paaXY_mRNA -> PaaX
Description: Translation of PaaX
Type: translation
Pathway Components: paaXY_mRNA -> PaaX
Components:
Function Name Type Evidence Reference(s)
product PaaX protein nd nd
reactant paaXY_mRNA RNA nd nd
paaXY_mRNA PaaY
Name: paaXY_mRNA -> PaaY
Description: Translation of PaaY
Type: translation
Pathway Components: paaXY_mRNA -> PaaY
Components:
Function Name Type Evidence Reference(s)
product PaaY protein nd nd
reactant paaXY_mRNA RNA nd nd
PaaY 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA Products
Name: 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA -> 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate + coenzyme A
Description: Reaction transforming 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA into 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate, coenzyme A
Type: state transition
Pathway Components: 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA - PaaY -> 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate + coenzyme A
Components:
Function Name Type Evidence Reference(s)
reactant 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule nd nd
product 2-hydroxycyclohepta-1,4,6-triene-1-carboxylate simple_molecule nd nd
catalyzer PaaY protein nd nd
product coenzyme A simple_molecule nd nd
paaZ_mRNA PaaZ
Name: paaZ_mRNA -> PaaZ
Description: Translation of PaaZ
Type: translation
Pathway Components: paaZ_mRNA -> PaaZ
Components:
Function Name Type Evidence Reference(s)
product PaaZ protein nd nd
reactant paaZ_mRNA RNA nd nd
2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA PaaZ oxepin-CoA (5Z)-3,8-dioxooct-5-enoyl-CoA
Name: oxepin-CoA -> (5Z)-3,8-dioxooct-5-enoyl-CoA
Description: Reaction transforming oxepin-CoA into (5Z)-3,8-dioxooct-5-enoyl-CoA
Type: state transition
Pathway Components: oxepin-CoA - PaaZ - 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA -> (5Z)-3,8-dioxooct-5-enoyl-CoA
Components:
Function Name Type Evidence Reference(s)
product (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule nd nd
inhibitor 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA simple_molecule nd nd
catalyzer PaaZ protein nd nd
reactant oxepin-CoA simple_molecule nd nd
PaaZ (5Z)-3,8-dioxooct-5-enoyl-CoA 3-oxo-5,6-didehydrosuberyl-CoA
Name: (5Z)-3,8-dioxooct-5-enoyl-CoA -> 3-oxo-5,6-didehydrosuberyl-CoA
Description: Reaction transforming (5Z)-3,8-dioxooct-5-enoyl-CoA into 3-oxo-5,6-didehydrosuberyl-CoA
Type: state transition
Pathway Components: (5Z)-3,8-dioxooct-5-enoyl-CoA - PaaZ -> 3-oxo-5,6-didehydrosuberyl-CoA
Components:
Function Name Type Evidence Reference(s)
reactant (5Z)-3,8-dioxooct-5-enoyl-CoA simple_molecule nd nd
product 3-oxo-5,6-didehydrosuberyl-CoA simple_molecule nd nd
catalyzer PaaZ protein nd nd
PaaZ OH-butyryl-CoA crotonyl-CoA
Name: OH-butyryl-CoA -> crotonyl-CoA
Description: Reaction transforming OH-butyryl-CoA into crotonyl-CoA
Type: state transition
Pathway Components: OH-butyryl-CoA - PaaZ -> crotonyl-CoA
Components:
Function Name Type Evidence Reference(s)
reactant OH-butyryl-CoA simple_molecule nd nd
catalyzer PaaZ protein nd nd
product crotonyl-CoA simple_molecule nd nd



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