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NrdR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
5'-deoxyadenosine CDP CTP GDP GTP L-methionine NrdA NrdB NrdD NrdE NrdF NrdG NrdH NrdI NrdR S-adenosyl-L-methionine Udp UTP YfaE Zn a 2'-deoxyribonucleoside 5'-diphosphate a deoxynucleoside triphosphate a reduced NrdH glutaredoxin-like protein a reduced flavodoxin a reduced thioredoxin nucleoside diphosphate nucleoside triphosphate an active ribonucleoside triphosphate reductase an inactive ribonucleoside triphosphate reductase NrdHox an oxidized flavodoxin oxidized thioredoxin dADP dATP dCDP dCTP dGDP dGTP dUDP dUTP nrdAB-yfaE nrdAB-yfaE_mRNA nrdDG nrdDG_mRNA nrdHIEF nrdHIEF_mRNA NrdR Zn NrdE NrdF NrdA NrdB oxidized thioredoxin a reduced thioredoxin a reduced NrdH glutaredoxin-like protein a reduced thioredoxin oxidized thioredoxin a reduced thioredoxin NrdHox a reduced flavodoxin


Gensor Unit       
Name: NrdR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0051065 - CTP reductase activity
GO:0010181 - FMN binding
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0008270 - zinc ion binding
GO:0016491 - oxidoreductase activity
GO:0003824 - catalytic activity
GO:0009186 - deoxyribonucleoside diphosphate metabolic process
GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0006464 - cellular protein modification process
GO:0005737 - cytoplasm
GO:0005971 - ribonucleoside-diphosphate reductase complex
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Components:
Function Name Type
RNA nrdHIEF_mRNA RNA


Reactions       
Showing 39 reactions
NrdR + Zn NrdR-Zn
Name: NrdR + Zn -> NrdR-Zn
Description: Reaction transforming NrdR, Zn into NrdR-Zn
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant NrdR protein nd nd
reactant Zn simple molecule nd nd
product NrdR-Zn complex nd nd
nrdAB-yfaE nrdAB-yfaE_mRNA
Name: nrdAB-yfaE -> nrdAB-yfaE_mRNA
Description: Transcription of transcription unit nrdAB-yfaE; reaction activation by ArgP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product nrdAB-yfaE_mRNA RNA nd nd
reactant nrdAB-yfaE gene nd nd
nrdDG nrdDG_mRNA
Name: nrdDG -> nrdDG_mRNA
Description: Transcription of transcription unit nrdDG; reaction inhibition by NrdR-Zn.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant nrdDG gene nd nd
product nrdDG_mRNA RNA nd nd
nrdHIEF nrdHIEF_mRNA
Name: nrdHIEF -> nrdHIEF_mRNA
Description: Transcription of transcription unit nrdHIEF; reaction inhibition by Fur-Fe(II).
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product nrdHIEF_mRNA RNA nd nd
reactant nrdHIEF gene nd nd
nrdDG_mRNA NrdD
Name: nrdDG_mRNA -> NrdD
Description: Translation of NrdD
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdD protein nd nd
reactant nrdDG_mRNA RNA nd nd
dATP + an oxidized flavodoxin a reduced flavodoxin
Name: dATP + an oxidized flavodoxin -> a reduced flavodoxin
Description: Reaction transforming dATP, an oxidized flavodoxin into a reduced flavodoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a reduced flavodoxin simple molecule nd nd
reactant an oxidized flavodoxin simple molecule nd nd
reactant dATP simple molecule nd nd
dGTP + an oxidized flavodoxin GTP + a reduced flavodoxin
Name: dGTP + an oxidized flavodoxin -> GTP + a reduced flavodoxin
Description: Reaction transforming dGTP, an oxidized flavodoxin into GTP, a reduced flavodoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product GTP simple molecule nd nd
reactant an oxidized flavodoxin simple molecule nd nd
reactant dGTP simple molecule nd nd
product a reduced flavodoxin simple molecule nd nd
dUTP + an oxidized flavodoxin UTP + a reduced flavodoxin
Name: dUTP + an oxidized flavodoxin -> UTP + a reduced flavodoxin
Description: Reaction transforming dUTP, an oxidized flavodoxin into UTP, a reduced flavodoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product UTP simple molecule nd nd
product a reduced flavodoxin simple molecule nd nd
reactant dUTP simple molecule nd nd
reactant an oxidized flavodoxin simple molecule nd nd
dCTP + an oxidized flavodoxin CTP + a reduced flavodoxin
Name: dCTP + an oxidized flavodoxin -> CTP + a reduced flavodoxin
Description: Reaction transforming dCTP, an oxidized flavodoxin into CTP, a reduced flavodoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a reduced flavodoxin simple molecule nd nd
product CTP simple molecule nd nd
reactant dCTP simple molecule nd nd
reactant an oxidized flavodoxin simple molecule nd nd
a reduced flavodoxin + nucleoside triphosphate an oxidized flavodoxin + deoxyribonucleoside triphosphate
Name: a reduced flavodoxin + nucleoside triphosphate -> an oxidized flavodoxin + deoxyribonucleoside triphosphate
Description: Reaction transforming a reduced flavodoxin, nucleoside triphosphate into an oxidized flavodoxin, deoxyribonucleoside triphosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a reduced flavodoxin simple molecule nd nd
product deoxyribonucleoside triphosphate simple molecule nd nd
product an oxidized flavodoxin simple molecule nd nd
reactant nucleoside triphosphate simple molecule nd nd
nrdHIEF_mRNA NrdH
Name: nrdHIEF_mRNA -> NrdH
Description: Translation of NrdH
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdH protein nd nd
reactant nrdHIEF_mRNA RNA nd nd
nrdAB-yfaE_mRNA YfaE
Name: nrdAB-yfaE_mRNA -> YfaE
Description: Translation of YfaE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product YfaE protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
nrdHIEF_mRNA NrdF
Name: nrdHIEF_mRNA -> NrdF
Description: Translation of NrdF
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant nrdHIEF_mRNA RNA nd nd
product NrdF protein nd nd
NrdE + NrdF NrdE-NrdF
Name: NrdE + NrdF -> NrdE-NrdF
Description: Reaction transforming NrdE, NrdF into NrdE-NrdF
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant NrdE protein nd nd
product NrdE-NrdF complex nd nd
reactant NrdF protein nd nd
dCDP + NrdHox CDP + a reduced NrdH glutaredoxin-like protein
Name: dCDP + NrdHox -> CDP + a reduced NrdH glutaredoxin-like protein
Description: Reaction transforming dCDP, NrdHox into CDP, a reduced NrdH glutaredoxin-like protein
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a reduced NrdH glutaredoxin-like protein simple molecule nd nd
reactant dCDP simple molecule nd nd
reactant NrdHox simple molecule nd nd
product CDP simple molecule nd nd
dGDP + NrdHox GDP + a reduced NrdH glutaredoxin-like protein
Name: dGDP + NrdHox -> GDP + a reduced NrdH glutaredoxin-like protein
Description: Reaction transforming dGDP, NrdHox into GDP, a reduced NrdH glutaredoxin-like protein
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a reduced NrdH glutaredoxin-like protein simple molecule nd nd
product GDP simple molecule nd nd
reactant dGDP simple molecule nd nd
reactant NrdHox simple molecule nd nd
dADP + NrdHox a reduced NrdH glutaredoxin-like protein
Name: dADP + NrdHox -> a reduced NrdH glutaredoxin-like protein
Description: Reaction transforming dADP, NrdHox into a reduced NrdH glutaredoxin-like protein
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a reduced NrdH glutaredoxin-like protein simple molecule nd nd
reactant NrdHox simple molecule nd nd
reactant dADP simple molecule nd nd
dUDP + NrdHox UDP + a reduced NrdH glutaredoxin-like protein
Name: dUDP + NrdHox -> UDP + a reduced NrdH glutaredoxin-like protein
Description: Reaction transforming dUDP, NrdHox into UDP, a reduced NrdH glutaredoxin-like protein
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product UDP simple molecule nd nd
product a reduced NrdH glutaredoxin-like protein simple molecule nd nd
reactant NrdHox simple molecule nd nd
reactant dUDP simple molecule nd nd
oxidized thioredoxin + deoxynucleoside diphosphate reduced thioredoxin + nucleoside diphosphate
Name: oxidized thioredoxin + deoxynucleoside diphosphate -> reduced thioredoxin + nucleoside diphosphate
Description: Reaction transforming oxidized thioredoxin, deoxynucleoside diphosphate into reduced thioredoxin, nucleoside diphosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant oxidized thioredoxin simple molecule nd nd
product reduced thioredoxin simple molecule nd nd
product nucleoside diphosphate simple molecule nd nd
reactant deoxynucleoside diphosphate simple molecule nd nd
dADP + oxidized thioredoxin reduced thioredoxin
Name: dADP + oxidized thioredoxin -> reduced thioredoxin
Description: Reaction transforming dADP, oxidized thioredoxin into reduced thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant oxidized thioredoxin simple molecule nd nd
product reduced thioredoxin simple molecule nd nd
reactant dADP simple molecule nd nd
dGDP + oxidized thioredoxin GDP + reduced thioredoxin
Name: dGDP + oxidized thioredoxin -> GDP + reduced thioredoxin
Description: Reaction transforming dGDP, oxidized thioredoxin into GDP, reduced thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product GDP simple molecule nd nd
product reduced thioredoxin simple molecule nd nd
reactant dGDP simple molecule nd nd
reactant oxidized thioredoxin simple molecule nd nd
dCDP + oxidized thioredoxin CDP + reduced thioredoxin
Name: dCDP + oxidized thioredoxin -> CDP + reduced thioredoxin
Description: Reaction transforming dCDP, oxidized thioredoxin into CDP, reduced thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant dCDP simple molecule nd nd
reactant oxidized thioredoxin simple molecule nd nd
product reduced thioredoxin simple molecule nd nd
product CDP simple molecule nd nd
dUDP + oxidized thioredoxin UDP + reduced thioredoxin
Name: dUDP + oxidized thioredoxin -> UDP + reduced thioredoxin
Description: Reaction transforming dUDP, oxidized thioredoxin into UDP, reduced thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product reduced thioredoxin simple molecule nd nd
reactant dUDP simple molecule nd nd
reactant oxidized thioredoxin simple molecule nd nd
product UDP simple molecule nd nd
nrdHIEF_mRNA NrdI
Name: nrdHIEF_mRNA -> NrdI
Description: Translation of NrdI
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant nrdHIEF_mRNA RNA nd nd
product NrdI protein nd nd
nrdAB-yfaE_mRNA NrdA
Name: nrdAB-yfaE_mRNA -> NrdA
Description: Translation of NrdA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdA protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
NrdA + NrdB NrdA-NrdB
Name: NrdA + NrdB -> NrdA-NrdB
Description: Reaction transforming NrdA, NrdB into NrdA-NrdB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant NrdB protein nd nd
reactant NrdA protein nd nd
product NrdA-NrdB complex nd nd
nrdAB-yfaE_mRNA NrdB
Name: nrdAB-yfaE_mRNA -> NrdB
Description: Translation of NrdB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdB protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
nrdDG_mRNA NrdG
Name: nrdDG_mRNA -> NrdG
Description: Translation of NrdG
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant nrdDG_mRNA RNA nd nd
product NrdG protein nd nd
S-adenosyl-L-methionine + an inactive ribonucleoside triphosphate reductase 5′-deoxyadenosine + an active ribonucleoside triphosphate reductase + L-methionine
Name: S-adenosyl-L-methionine + an inactive ribonucleoside triphosphate reductase -> 5′-deoxyadenosine + an active ribonucleoside triphosphate reductase + L-methionine
Description: Reaction transforming S-adenosyl-L-methionine, an inactive ribonucleoside triphosphate reductase into 5′-deoxyadenosine, an active ribonucleoside triphosphate reductase , L-methionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-methionine simple molecule nd nd
product 5′-deoxyadenosine simple molecule nd nd
reactant S-adenosyl-L-methionine simple molecule nd nd
reactant an inactive ribonucleoside triphosphate reductase simple molecule nd nd
product an active ribonucleoside triphosphate reductase simple molecule nd nd
nrdHIEF_mRNA NrdE
Name: nrdHIEF_mRNA -> NrdE
Description: Translation of NrdE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdE protein nd nd
reactant nrdHIEF_mRNA RNA nd nd
dADP dATP
Name: dADP -> dATP
Description: Transformation of dADP into dATP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant dADP simple molecule nd nd
product dADP simple molecule nd nd
dCDP dCTP
Name: dCDP -> dCTP
Description: Transformation of dCDP into dCTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product dCTP simple molecule nd nd
reactant dCDP simple molecule nd nd
dCTP dUTP
Name: dCTP -> dUTP
Description: Transformation of dCTP into dUTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product dUTP simple molecule nd nd
reactant dCTP simple molecule nd nd
dUDP dUTP
Name: dUDP -> dUTP
Description: Transformation of dUDP into dUTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product dUTP simple molecule nd nd
reactant dUDP simple molecule nd nd
dGDP dGTP
Name: dGDP -> dGTP
Description: Transformation of dGDP into dGTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant dGDP simple molecule nd nd
product dGTP simple molecule nd nd
GDP GTP
Name: GDP -> GTP
Description: Transformation of GDP into GTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant GDP simple molecule nd nd
product GTP simple molecule nd nd
UDP UTP
Name: UDP -> UTP
Description: Transformation of UDP into UTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product UTP simple molecule nd nd
reactant UDP simple molecule nd nd
UTP CTP
Name: UTP -> CTP
Description: Transformation of UTP into CTP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant UTP simple molecule nd nd
product CTP simple molecule nd nd
CTP CDP
Name: CTP -> CDP
Description: Transformation of CTP into CDP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant CTP simple molecule nd nd
product CDP simple molecule nd nd



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