RegulonDB RegulonDB

NhaR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
ROOH OsmC uridine-diphosphate acetate Sodium_Ext alcohol partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext osmC nhaAR UDP-GlcNAc poly-beta-1,6-N-acetyl-D-glucosamine_Ext poly-beta-1,6-N-acetyl-D-glucosamine PgaD NhaA pgaABCD_mRNA PgaC NhaR NhaR lithium ion_Ext thioredoxin disulfide PgaD pgaABCD Sodium PgaC PgaB lithium ion reduced thioredoxin osmC_mRNA Sodium partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine PgaA NAcGlc nhaAR_mRNA


Gensor Unit       
Name: NhaR
Description: Molecular biology level
Detailed: In the presence of sodium, NhaR positively regulates the expression of genes required for sodium transport, cell adhesi?n, biofilm formation and response to oxidative and osmotic stresses. Under these conditions, NhaR is modified to NhaR-sodium, binds its target sites enabling its own expression and the expression of its regulated genes. In the absence of sodium, NhaR unbinds its target sites, preventing the expression of its regulated genes.
Less detailed: In the presence of sodium, NhaR positively regulates the expression of genes needed for sodium transport, cell adhesi?n, biofilm formation and response to oxidative and osmotic stresses.

Physiology level
Detailed: The presence of sodium induces the expression of genes involved with sodium transport, cell adhesi?n, biofilm formation and response to oxidative and osmotic stresses. Under these conditions, the genes necessary for transport of sodium into cell, PGA transport, polimerization and deacetylation are expresed.
Less detailed: The presence of sodium induces the expression of genes needful for transport of sodium into cell, PGA transport, polimerization and deacetylation.
Classification:
Groups: Cell motility
General function prediction only
Transcription
Carbohydrate transport and metabolism
Energy production and conversion
Defense mechanisms
Gene Ontology Terms (GO): biological_process GO:0001121 - bacterial transcription
GO:0042710 - biofilm formation
GO:0005975 - carbohydrate metabolic process
GO:0043708 - cell adhesion involved in biofilm formation
GO:0098869 - cellular oxidant detoxification
GO:0006883 - cellular sodium ion homeostasis
Read more >
cellular_component GO:0009279 - cell outer membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0045203 - integral component of cell outer membrane
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031246 - intrinsic component of periplasmic side of cell outer membrane
Read more >
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008375 - acetylglucosaminyltransferase activity
GO:0016209 - antioxidant activity
GO:0015297 - antiporter activity
GO:1901612 - cardiolipin binding
GO:0003824 - catalytic activity
Read more >
Components:
  Function Name Type
  simple_molecule NAcGlc simple_molecule
  protein NhaA protein
  protein NhaR protein
  complex NhaR-Sodium complex
  protein OsmC protein
  protein PgaA protein
  protein PgaB protein
  protein PgaC protein
  protein PgaD protein
  complex PgaD-PgaC complex
  simple_molecule ROOH simple_molecule
  simple_molecule Sodium simple_molecule
  simple_molecule Sodium_Ext simple_molecule
  simple_molecule UDP-GlcNAc simple_molecule
  simple_molecule acetate simple_molecule
  simple_molecule alcohol simple_molecule
  simple_molecule lithium ion simple_molecule
  simple_molecule lithium ion_Ext simple_molecule
  gene nhaAR gene
  RNA nhaAR_mRNA RNA
  gene osmC gene
  RNA osmC_mRNA RNA
  simple_molecule partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
  simple_molecule partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
  gene pgaABCD gene
  RNA pgaABCD_mRNA RNA
  simple_molecule poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
  simple_molecule poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
  simple_molecule reduced thioredoxin simple_molecule
  simple_molecule thioredoxin disulfide simple_molecule
  simple_molecule uridine-diphosphate simple_molecule


Reactions       
Showing 19 reactions
Sodium + NhaR NhaR-Sodium
Name: Sodium + NhaR -> NhaR-Sodium
Description: Reaction transforming Sodium, NhaR into NhaR-Sodium
Type: state transition
Pathway Components: Sodium + NhaR -> NhaR-Sodium
Components:
Function Name Type
reactant NhaR protein
product NhaR-Sodium complex
reactant Sodium simple_molecule
NhaR-Sodium nhaAR nhaAR_mRNA
Name: nhaAR -> nhaAR_mRNA
Description: Transcription of transcription unit nhaAR. Reaction activation by NhaR-Sodium, and NhaR-Sodium.
Type: transcription
Pathway Components: nhaAR - NhaR-Sodium -> nhaAR_mRNA
Components:
Function Name Type
activator NhaR-Sodium complex
reactant nhaAR gene
product nhaAR_mRNA RNA
NhaR-Sodium osmC osmC_mRNA
Name: osmC -> osmC_mRNA
Description: Transcription of transcription unit osmC. Reaction activation by NhaR-Sodium.
Type: transcription
Pathway Components: osmC - NhaR-Sodium -> osmC_mRNA
Components:
Function Name Type
activator NhaR-Sodium complex
reactant osmC gene
product osmC_mRNA RNA
NhaR-Sodium pgaABCD pgaABCD_mRNA
Name: pgaABCD -> pgaABCD_mRNA
Description: Transcription of transcription unit pgaABCD. Reaction activation by NhaR-Sodium.
Type: transcription
Pathway Components: pgaABCD - NhaR-Sodium -> pgaABCD_mRNA
Components:
Function Name Type
activator NhaR-Sodium complex
reactant pgaABCD gene
product pgaABCD_mRNA RNA
nhaAR_mRNA NhaA
Name: nhaAR_mRNA -> NhaA
Description: Translation of NhaA
Type: translation
Pathway Components: nhaAR_mRNA -> NhaA
Components:
Function Name Type
product NhaA protein
reactant nhaAR_mRNA RNA
NhaA Sodium_Ext Sodium
Name: Sodium_Ext -> Sodium
Description: Transport of Sodium_Ext through a bacterial membrane, leading to the presence of Sodium inside the cell.
Type: transport
Pathway Components: Sodium_Ext - NhaA -> Sodium
Components:
Function Name Type
catalyzer NhaA protein
product Sodium simple_molecule
reactant Sodium_Ext simple_molecule
NhaA lithium ion_Ext lithium ion
Name: lithium ion_Ext -> lithium ion
Description: Transport of lithium ion_Ext through a bacterial membrane, leading to the presence of lithium ion inside the cell.
Type: transport
Pathway Components: lithium ion_Ext - NhaA -> lithium ion
Components:
Function Name Type
catalyzer NhaA protein
product lithium ion simple_molecule
reactant lithium ion_Ext simple_molecule
nhaAR_mRNA NhaR
Name: nhaAR_mRNA -> NhaR
Description: Translation of NhaR
Type: translation
Pathway Components: nhaAR_mRNA -> NhaR
Components:
Function Name Type
product NhaR protein
reactant nhaAR_mRNA RNA
osmC_mRNA OsmC
Name: osmC_mRNA -> OsmC
Description: Translation of OsmC
Type: translation
Pathway Components: osmC_mRNA -> OsmC
Components:
Function Name Type
product OsmC protein
reactant osmC_mRNA RNA
OsmC reduced thioredoxin + ROOH thioredoxin disulfide + alcohol
Name: reduced thioredoxin + ROOH -> thioredoxin disulfide + alcohol
Description: Reaction transforming reduced thioredoxin, ROOH into thioredoxin disulfide, alcohol
Type: state transition
Pathway Components: reduced thioredoxin + ROOH - OsmC -> thioredoxin disulfide + alcohol
Components:
Function Name Type
catalyzer OsmC protein
reactant ROOH simple_molecule
product alcohol simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
pgaABCD_mRNA PgaA
Name: pgaABCD_mRNA -> PgaA
Description: Translation of PgaA
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaA
Components:
Function Name Type
product PgaA protein
reactant pgaABCD_mRNA RNA
PgaA Reactants Products
Name: partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
Description: Transport of partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext through a bacterial membrane, leading to the presence of partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine inside the cell.
Type: transport
Pathway Components: partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext - PgaA -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
Components:
Function Name Type
catalyzer PgaA protein
product partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
reactant partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
pgaABCD_mRNA PgaB
Name: pgaABCD_mRNA -> PgaB
Description: Translation of PgaB
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaB
Components:
Function Name Type
product PgaB protein
reactant pgaABCD_mRNA RNA
PgaB poly-beta-1,6-N-acetyl-D-glucosamine Products
Name: poly-beta-1,6-N-acetyl-D-glucosamine -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine + acetate
Description: Reaction transforming poly-beta-1,6-N-acetyl-D-glucosamine into partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine, acetate
Type: state transition
Pathway Components: poly-beta-1,6-N-acetyl-D-glucosamine - PgaB -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine + acetate
Components:
Function Name Type
catalyzer PgaB protein
product acetate simple_molecule
product partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
reactant poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
pgaABCD_mRNA PgaC
Name: pgaABCD_mRNA -> PgaC
Description: Translation of PgaC
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaC
Components:
Function Name Type
product PgaC protein
reactant pgaABCD_mRNA RNA
PgaC + PgaD PgaD-PgaC
Name: PgaC + PgaD -> PgaD-PgaC
Description: Reaction transforming PgaC, PgaD into PgaD-PgaC
Type: state transition
Pathway Components: PgaC + PgaD -> PgaD-PgaC
Components:
Function Name Type
reactant PgaC protein
reactant PgaD protein
product PgaD-PgaC complex
PgaD-PgaC poly-beta-1,6-N-acetyl-D-glucosamine_Ext poly-beta-1,6-N-acetyl-D-glucosamine
Name: poly-beta-1,6-N-acetyl-D-glucosamine_Ext -> poly-beta-1,6-N-acetyl-D-glucosamine
Description: Transport of poly-beta-1,6-N-acetyl-D-glucosamine_Ext through a bacterial membrane, leading to the presence of poly-beta-1,6-N-acetyl-D-glucosamine inside the cell.
Type: transport
Pathway Components: poly-beta-1,6-N-acetyl-D-glucosamine_Ext - PgaD-PgaC -> poly-beta-1,6-N-acetyl-D-glucosamine
Components:
Function Name Type
catalyzer PgaD-PgaC complex
product poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
reactant poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
PgaD-PgaC UDP-GlcNAc + NAcGlc Products
Name: UDP-GlcNAc + NAcGlc -> poly-beta-1,6-N-acetyl-D-glucosamine + uridine-diphosphate
Description: Reaction transforming UDP-GlcNAc, NAcGlc into poly-beta-1,6-N-acetyl-D-glucosamine, uridine-diphosphate
Type: state transition
Pathway Components: UDP-GlcNAc + NAcGlc - PgaD-PgaC -> poly-beta-1,6-N-acetyl-D-glucosamine + uridine-diphosphate
Components:
Function Name Type
reactant NAcGlc simple_molecule
catalyzer PgaD-PgaC complex
reactant UDP-GlcNAc simple_molecule
product poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
product uridine-diphosphate simple_molecule
pgaABCD_mRNA PgaD
Name: pgaABCD_mRNA -> PgaD
Description: Translation of PgaD
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaD
Components:
Function Name Type
product PgaD protein
reactant pgaABCD_mRNA RNA



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