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NhaR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: NhaR
Description: Molecular biology level
Detailed: In the presence of sodium, NhaR positively regulates the expression of genes required for sodium transport, cell adhesión, biofilm formation and response to oxidative and osmotic stresses. Under these conditions, NhaR is modified to NhaR-sodium, binds its target sites enabling its own expression and the expression of its regulated genes. In the absence of sodium, NhaR unbinds its target sites, preventing the expression of its regulated genes.
Less detailed: In the presence of sodium, NhaR positively regulates the expression of genes needed for sodium transport, cell adhesión, biofilm formation and response to oxidative and osmotic stresses.

Physiology level
Detailed: The presence of sodium induces the expression of genes involved with sodium transport, cell adhesión, biofilm formation and response to oxidative and osmotic stresses. Under these conditions, the genes necessary for transport of sodium into cell, PGA transport, polimerization and deacetylation are expresed.
Less detailed: The presence of sodium induces the expression of genes needful for transport of sodium into cell, PGA transport, polimerization and deacetylation.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0042710 - biofilm formation
GO:0098655 - cation transmembrane transport
GO:0043708 - cell adhesion involved in biofilm formation
GO:0098869 - cellular oxidant detoxification
GO:0006883 - cellular sodium ion homeostasis
GO:0006972 - hyperosmotic response
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031246 - intrinsic component of periplasmic side of cell outer membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008375 - acetylglucosaminyltransferase activity
GO:0015297 - antiporter activity
GO:1901612 - cardiolipin binding
GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0004601 - peroxidase activity
GO:0051920 - peroxiredoxin activity
GO:0005515 - protein binding
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Components: Show/Hide Components Table (28 more...)
Function Name Type
protein NhaA protein
protein NhaR protein
complex NhaR-Sodium complex
protein OsmC protein
protein PgaA protein
protein PgaB protein
protein PgaC protein
protein PgaD protein
complex PgaD-PgaC complex
simple_molecule ROOH simple_molecule
simple_molecule Sodium simple_molecule
simple_molecule Sodium_Ext simple_molecule
simple_molecule UDP-GlcNAc simple_molecule
simple_molecule acetate simple_molecule
simple_molecule alcohol simple_molecule
gene nhaAR gene
RNA nhaAR_mRNA RNA
gene osmC gene
RNA osmC_mRNA RNA
simple_molecule partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
simple_molecule partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
gene pgaABCD gene
RNA pgaABCD_mRNA RNA
simple_molecule poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule
simple_molecule poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule
simple_molecule reduced thioredoxin simple_molecule
simple_molecule thioredoxin disulfide simple_molecule
simple_molecule uridine-diphosphate simple_molecule


Reactions       
Showing 18 reactions
Sodium + NhaR NhaR-Sodium
Name: Sodium + NhaR -> NhaR-Sodium
Description: Reaction transforming Sodium, NhaR into NhaR-Sodium
Type: state transition
Pathway Components: Sodium + NhaR -> NhaR-Sodium
Components:
Function Name Type Evidence Reference(s)
reactant NhaR protein nd nd
product NhaR-Sodium complex nd nd
reactant Sodium simple_molecule nd nd
NhaR-Sodium osmC osmC_mRNA
Name: osmC -> osmC_mRNA
Description: Transcription of transcription unit osmC. Reaction activation by NhaR-Sodium.
Type: transcription
Pathway Components: osmC - NhaR-Sodium -> osmC_mRNA
Components:
Function Name Type Evidence Reference(s)
activator NhaR-Sodium complex nd nd
reactant osmC gene nd nd
product osmC_mRNA RNA nd nd
NhaR-Sodium pgaABCD pgaABCD_mRNA
Name: pgaABCD -> pgaABCD_mRNA
Description: Transcription of transcription unit pgaABCD. Reaction activation by NhaR-Sodium.
Type: transcription
Pathway Components: pgaABCD - NhaR-Sodium -> pgaABCD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator NhaR-Sodium complex nd nd
reactant pgaABCD gene nd nd
product pgaABCD_mRNA RNA nd nd
NhaR-Sodium nhaAR nhaAR_mRNA
Name: nhaAR -> nhaAR_mRNA
Description: Transcription of transcription unit nhaAR. Reaction activation by NhaR-Sodium.
Type: transcription
Pathway Components: nhaAR - NhaR-Sodium -> nhaAR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator NhaR-Sodium complex nd nd
reactant nhaAR gene nd nd
product nhaAR_mRNA RNA nd nd
nhaAR_mRNA NhaA
Name: nhaAR_mRNA -> NhaA
Description: Translation of NhaA
Type: translation
Pathway Components: nhaAR_mRNA -> NhaA
Components:
Function Name Type Evidence Reference(s)
product NhaA protein nd nd
reactant nhaAR_mRNA RNA nd nd
NhaA Sodium_Ext Sodium
Name: Sodium_Ext -> Sodium
Description: Transport of Sodium_Ext through a bacterial membrane, leading to the presence of Sodium inside the cell.
Type: transport
Pathway Components: Sodium_Ext - NhaA -> Sodium
Components:
Function Name Type Evidence Reference(s)
catalyzer NhaA protein nd nd
product Sodium simple_molecule nd nd
reactant Sodium_Ext simple_molecule nd nd
nhaAR_mRNA NhaR
Name: nhaAR_mRNA -> NhaR
Description: Translation of NhaR
Type: translation
Pathway Components: nhaAR_mRNA -> NhaR
Components:
Function Name Type Evidence Reference(s)
product NhaR protein nd nd
reactant nhaAR_mRNA RNA nd nd
osmC_mRNA OsmC
Name: osmC_mRNA -> OsmC
Description: Translation of OsmC
Type: translation
Pathway Components: osmC_mRNA -> OsmC
Components:
Function Name Type Evidence Reference(s)
product OsmC protein nd nd
reactant osmC_mRNA RNA nd nd
OsmC reduced thioredoxin + ROOH thioredoxin disulfide + alcohol
Name: reduced thioredoxin + ROOH -> thioredoxin disulfide + alcohol
Description: Reaction transforming reduced thioredoxin, ROOH into thioredoxin disulfide, alcohol
Type: state transition
Pathway Components: reduced thioredoxin + ROOH - OsmC -> thioredoxin disulfide + alcohol
Components:
Function Name Type Evidence Reference(s)
catalyzer OsmC protein nd nd
reactant ROOH simple_molecule nd nd
product alcohol simple_molecule nd nd
reactant reduced thioredoxin simple_molecule nd nd
product thioredoxin disulfide simple_molecule nd nd
pgaABCD_mRNA PgaA
Name: pgaABCD_mRNA -> PgaA
Description: Translation of PgaA
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaA
Components:
Function Name Type Evidence Reference(s)
product PgaA protein nd nd
reactant pgaABCD_mRNA RNA nd nd
PgaA Reactants Products
Name: partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
Description: Transport of partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext through a bacterial membrane, leading to the presence of partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine inside the cell.
Type: transport
Pathway Components: partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext - PgaA -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
Components:
Function Name Type Evidence Reference(s)
catalyzer PgaA protein nd nd
product partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule nd nd
reactant partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule nd nd
pgaABCD_mRNA PgaB
Name: pgaABCD_mRNA -> PgaB
Description: Translation of PgaB
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaB
Components:
Function Name Type Evidence Reference(s)
product PgaB protein nd nd
reactant pgaABCD_mRNA RNA nd nd
PgaB poly-beta-1,6-N-acetyl-D-glucosamine Products
Name: poly-beta-1,6-N-acetyl-D-glucosamine -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine + acetate
Description: Reaction transforming poly-beta-1,6-N-acetyl-D-glucosamine into partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine, acetate
Type: state transition
Pathway Components: poly-beta-1,6-N-acetyl-D-glucosamine - PgaB -> partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine + acetate
Components:
Function Name Type Evidence Reference(s)
catalyzer PgaB protein nd nd
product acetate simple_molecule nd nd
product partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule nd nd
reactant poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule nd nd
pgaABCD_mRNA PgaC
Name: pgaABCD_mRNA -> PgaC
Description: Translation of PgaC
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaC
Components:
Function Name Type Evidence Reference(s)
product PgaC protein nd nd
reactant pgaABCD_mRNA RNA nd nd
PgaC + PgaD PgaD-PgaC
Name: PgaC + PgaD -> PgaD-PgaC
Description: Reaction transforming PgaC, PgaD into PgaD-PgaC
Type: state transition
Pathway Components: PgaC + PgaD -> PgaD-PgaC
Components:
Function Name Type Evidence Reference(s)
reactant PgaC protein nd nd
reactant PgaD protein nd nd
product PgaD-PgaC complex nd nd
PgaD-PgaC poly-beta-1,6-N-acetyl-D-glucosamine_Ext poly-beta-1,6-N-acetyl-D-glucosamine
Name: poly-beta-1,6-N-acetyl-D-glucosamine_Ext -> poly-beta-1,6-N-acetyl-D-glucosamine
Description: Transport of poly-beta-1,6-N-acetyl-D-glucosamine_Ext through a bacterial membrane, leading to the presence of poly-beta-1,6-N-acetyl-D-glucosamine inside the cell.
Type: transport
Pathway Components: poly-beta-1,6-N-acetyl-D-glucosamine_Ext - PgaD-PgaC -> poly-beta-1,6-N-acetyl-D-glucosamine
Components:
Function Name Type Evidence Reference(s)
catalyzer PgaD-PgaC complex nd nd
product poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule nd nd
reactant poly-beta-1,6-N-acetyl-D-glucosamine_Ext simple_molecule nd nd
PgaD-PgaC UDP-GlcNAc Products
Name: UDP-GlcNAc -> poly-beta-1,6-N-acetyl-D-glucosamine + uridine-diphosphate
Description: Reaction transforming UDP-GlcNAc into poly-beta-1,6-N-acetyl-D-glucosamine, uridine-diphosphate
Type: state transition
Pathway Components: UDP-GlcNAc - PgaD-PgaC -> poly-beta-1,6-N-acetyl-D-glucosamine + uridine-diphosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer PgaD-PgaC complex nd nd
reactant UDP-GlcNAc simple_molecule nd nd
product poly-beta-1,6-N-acetyl-D-glucosamine simple_molecule nd nd
product uridine-diphosphate simple_molecule nd nd
pgaABCD_mRNA PgaD
Name: pgaABCD_mRNA -> PgaD
Description: Translation of PgaD
Type: translation
Pathway Components: pgaABCD_mRNA -> PgaD
Components:
Function Name Type Evidence Reference(s)
product PgaD protein nd nd
reactant pgaABCD_mRNA RNA nd nd



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