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NanR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
FimB N-acetyl-D-glucosamine-6-phosphate N-acetyl-beta-D-mannosamine N-acetyl-D-mannosamine-6-phosphate alpha-Neu5Ac beta-Neu5Ac NANA NANA_Ext NanA NanC NanE NanK NanM NanR NanT YhcH fimB fimB_mRNA nanATEK-yhcH nanATEK-yhcH_mRNA nanCM nanCM_mRNA pyruvate NanR NANA


Gensor Unit       
Name: NanR
Description: Molecular biology level
Detailed: In the absence of N-acetylneuraminate, NanR positively regulates the expression of a gene required for regulation of pilus assembly and negatively regulates the expression of the genes required for N-acetylneuraminate (NANA) transport and catabolic process. Under these conditions, NanR remains unmodified, binds its target sites enabling in some cases and preventing in other cases the expression of its regulated genes. (In the presence of N-acetylneuraminate, NanR unbinds its target sites preventing some genes expression and enabling other genes expression.
Less detailed: In the absence of N-acetylneuraminate, NanR positively regulates the expression of genes needed for regulation of pilus assembly and negatively regulates the expression of genes needed for N-acetylneuraminate transport and catabolic process.

Physiology level
Detailed: The presence of N-acetylneuraminate inhbits the expression of genes involved with regulation of pilus assembly and induces the expression of genes necessary for N-acetylneuraminate transport and catabolic process. Under these conditions the genes necessary for N-acetylneuraminate transport and its conversion to N-acetyl-D-glucosamine-6-phosphate, and conversion of N-acetyl-alfa-neuraminate to N-acetyl-beta-neuraminate are expressed.
Less detailed: The presence of N-acetylneuraminate induces the expression of genes needful for N-acetylneuraminate transport and its conversion to N-acetyl-D-glucosamine-6-phosphate, and conversion of N-acetyl-alfa-neuraminate to N-acetyl-beta-neuraminate. Read more >
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0015074 - DNA integration
GO:0006310 - DNA recombination
GO:0006053 - N-acetylmannosamine catabolic process
GO:0019262 - N-acetylneuraminate catabolic process
GO:0098656 - anion transmembrane transport
GO:1901264 - carbohydrate derivative transport
Read more >
cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:0045203 - integral component of cell outer membrane
GO:0005887 - integral component of plasma membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0008747 - N-acetylneuraminate lyase activity
GO:0047465 - N-acylglucosamine-6-phosphate 2-epimerase activity
GO:0009384 - N-acylmannosamine kinase activity
GO:0015144 - carbohydrate transmembrane transporter activity
GO:0005351 - carbohydrate:proton symporter activity
GO:0046943 - carboxylic acid transmembrane transporter activity
GO:0042802 - identical protein binding
Read more >
Components: Show/Hide Components Table (34 more...)
Function Name Type
simple_molecule α-Neu5Ac simple_molecule
protein FimB protein
simple_molecule ManNAc-6-P simple_molecule
simple_molecule N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
simple_molecule N-acetyl-beta-D-mannosamine simple_molecule
simple_molecule N-acetylneuraminate simple_molecule
simple_molecule N-acetylneuraminate_Ext simple_molecule
protein NanA protein
protein NanC protein
protein NanE protein
protein NanK protein
protein NanM protein
protein NanR protein
complex NanR-N-acetylneuraminate complex
protein NanS protein
protein NanT protein
protein YhcH protein
protein YjhB protein
protein YjhC protein
simple_molecule beta-Neu5Ac simple_molecule
simple_molecule beta-Neu5Ac_Ext simple_molecule
gene fimB gene
RNA fimB_mRNA RNA
gene nanA gene
gene nanATEK-yhcH gene
RNA nanATEK-yhcH_mRNA RNA
RNA nanA_mRNA RNA
gene nanCM gene
gene nanCMS gene
RNA nanCMS_mRNA RNA
RNA nanCM_mRNA RNA
simple_molecule pyruvate simple_molecule
gene yjhBC gene
RNA yjhBC_mRNA RNA


Reactions       
Showing 28 reactions
NanR fimB fimB_mRNA
Name: fimB -> fimB_mRNA
Description: Transcription of transcription unit fimB. Reaction activation by NanR.
Type: transcription
Pathway Components: fimB - NanR -> fimB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator NanR protein nd nd
reactant fimB gene nd nd
product fimB_mRNA RNA nd nd
NanR nanATEK-yhcH nanATEK-yhcH_mRNA
Name: nanATEK-yhcH -> nanATEK-yhcH_mRNA
Description: Transcription of transcription unit nanATEK-yhcH. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanATEK-yhcH - NanR -> nanATEK-yhcH_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NanR protein nd nd
reactant nanATEK-yhcH gene nd nd
product nanATEK-yhcH_mRNA RNA nd nd
NanR nanCMS nanCMS_mRNA
Name: nanCMS -> nanCMS_mRNA
Description: Transcription of transcription unit nanCMS. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanCMS - NanR -> nanCMS_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NanR protein nd nd
reactant nanCMS gene nd nd
product nanCMS_mRNA RNA nd nd
NanR yjhBC yjhBC_mRNA
Name: yjhBC -> yjhBC_mRNA
Description: Transcription of transcription unit yjhBC. Reaction inhibition by NanR.
Type: transcription
Pathway Components: yjhBC - NanR -> yjhBC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NanR protein nd nd
reactant yjhBC gene nd nd
product yjhBC_mRNA RNA nd nd
N-acetylneuraminate + NanR NanR-N-acetylneuraminate
Name: N-acetylneuraminate + NanR -> NanR-N-acetylneuraminate
Description: Reaction transforming N-acetylneuraminate, NanR into NanR-N-acetylneuraminate
Type: state transition
Pathway Components: N-acetylneuraminate + NanR -> NanR-N-acetylneuraminate
Components:
Function Name Type Evidence Reference(s)
reactant N-acetylneuraminate simple_molecule nd nd
reactant NanR protein nd nd
product NanR-N-acetylneuraminate complex nd nd
NanR nanA nanA_mRNA
Name: nanA -> nanA_mRNA
Description: Transcription of transcription unit nanA. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanA - NanR -> nanA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NanR protein nd nd
reactant nanA gene nd nd
product nanA_mRNA RNA nd nd
NanR nanCM nanCM_mRNA
Name: nanCM -> nanCM_mRNA
Description: Transcription of transcription unit nanCM. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanCM - NanR -> nanCM_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NanR protein nd nd
reactant nanCM gene nd nd
product nanCM_mRNA RNA nd nd
fimB_mRNA FimB
Name: fimB_mRNA -> FimB
Description: Translation of FimB
Type: translation
Pathway Components: fimB_mRNA -> FimB
Components:
Function Name Type Evidence Reference(s)
product FimB protein nd nd
reactant fimB_mRNA RNA nd nd
nanCMS_mRNA NanC
Name: nanCMS_mRNA -> NanC
Description: Translation of NanC
Type: translation
Pathway Components: nanCMS_mRNA -> NanC
Components:
Function Name Type Evidence Reference(s)
product NanC protein nd nd
reactant nanCMS_mRNA RNA nd nd
NanC NanT N-acetylneuraminate_Ext N-acetylneuraminate
Name: N-acetylneuraminate_Ext -> N-acetylneuraminate
Description: Transport of N-acetylneuraminate_Ext through a bacterial membrane, leading to the presence of N-acetylneuraminate inside the cell.
Type: transport
Pathway Components: N-acetylneuraminate_Ext - NanC - NanT -> N-acetylneuraminate
Components:
Function Name Type Evidence Reference(s)
product N-acetylneuraminate simple_molecule nd nd
reactant N-acetylneuraminate_Ext simple_molecule nd nd
catalyzer NanC protein nd nd
catalyzer NanT protein nd nd
NanC NanT beta-Neu5Ac_Ext beta-Neu5Ac
Name: beta-Neu5Ac_Ext -> beta-Neu5Ac
Description: Transport of beta-Neu5Ac_Ext through a bacterial membrane, leading to the presence of beta-Neu5Ac inside the cell.
Type: transport
Pathway Components: beta-Neu5Ac_Ext - NanC - NanT -> beta-Neu5Ac
Components:
Function Name Type Evidence Reference(s)
catalyzer NanC protein nd nd
catalyzer NanT protein nd nd
product beta-Neu5Ac simple_molecule nd nd
reactant beta-Neu5Ac_Ext simple_molecule nd nd
nanCMS_mRNA NanM
Name: nanCMS_mRNA -> NanM
Description: Translation of NanM
Type: translation
Pathway Components: nanCMS_mRNA -> NanM
Components:
Function Name Type Evidence Reference(s)
product NanM protein nd nd
reactant nanCMS_mRNA RNA nd nd
NanM α-Neu5Ac beta-Neu5Ac
Name: α-Neu5Ac -> beta-Neu5Ac
Description: Reaction transforming α-Neu5Ac into beta-Neu5Ac
Type: state transition
Pathway Components: α-Neu5Ac - NanM -> beta-Neu5Ac
Components:
Function Name Type Evidence Reference(s)
reactant α-Neu5Ac simple_molecule nd nd
catalyzer NanM protein nd nd
product beta-Neu5Ac simple_molecule nd nd
nanCMS_mRNA NanS
Name: nanCMS_mRNA -> NanS
Description: Translation of NanS
Type: translation
Pathway Components: nanCMS_mRNA -> NanS
Components:
Function Name Type Evidence Reference(s)
product NanS protein nd nd
reactant nanCMS_mRNA RNA nd nd
nanATEK-yhcH_mRNA NanA
Name: nanATEK-yhcH_mRNA -> NanA
Description: Translation of NanA
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanA
Components:
Function Name Type Evidence Reference(s)
product NanA protein nd nd
reactant nanATEK-yhcH_mRNA RNA nd nd
NanA pyruvate N-acetylneuraminate N-acetyl-beta-D-mannosamine + pyruvate
Name: N-acetylneuraminate -> N-acetyl-beta-D-mannosamine + pyruvate
Description: Reaction transforming N-acetylneuraminate into N-acetyl-beta-D-mannosamine, pyruvate
Type: state transition
Pathway Components: N-acetylneuraminate - NanA - pyruvate -> N-acetyl-beta-D-mannosamine + pyruvate
Components:
Function Name Type Evidence Reference(s)
product N-acetyl-beta-D-mannosamine simple_molecule nd nd
reactant N-acetylneuraminate simple_molecule nd nd
catalyzer NanA protein nd nd
inhibitor pyruvate simple_molecule nd nd
product pyruvate simple_molecule nd nd
NanA pyruvate beta-Neu5Ac N-acetyl-beta-D-mannosamine + pyruvate
Name: beta-Neu5Ac -> N-acetyl-beta-D-mannosamine + pyruvate
Description: Reaction transforming beta-Neu5Ac into N-acetyl-beta-D-mannosamine, pyruvate
Type: state transition
Pathway Components: beta-Neu5Ac - NanA - pyruvate -> N-acetyl-beta-D-mannosamine + pyruvate
Components:
Function Name Type Evidence Reference(s)
product N-acetyl-beta-D-mannosamine simple_molecule nd nd
catalyzer NanA protein nd nd
reactant beta-Neu5Ac simple_molecule nd nd
inhibitor pyruvate simple_molecule nd nd
product pyruvate simple_molecule nd nd
nanATEK-yhcH_mRNA NanT
Name: nanATEK-yhcH_mRNA -> NanT
Description: Translation of NanT
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanT
Components:
Function Name Type Evidence Reference(s)
product NanT protein nd nd
reactant nanATEK-yhcH_mRNA RNA nd nd
nanATEK-yhcH_mRNA NanE
Name: nanATEK-yhcH_mRNA -> NanE
Description: Translation of NanE
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanE
Components:
Function Name Type Evidence Reference(s)
product NanE protein nd nd
reactant nanATEK-yhcH_mRNA RNA nd nd
NanE ManNAc-6-P N-acetyl-α-D-glucosamine 6-phosphate
Name: ManNAc-6-P -> N-acetyl-α-D-glucosamine 6-phosphate
Description: Reaction transforming ManNAc-6-P into N-acetyl-α-D-glucosamine 6-phosphate
Type: state transition
Pathway Components: ManNAc-6-P - NanE -> N-acetyl-α-D-glucosamine 6-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant ManNAc-6-P simple_molecule nd nd
product N-acetyl-α-D-glucosamine 6-phosphate simple_molecule nd nd
catalyzer NanE protein nd nd
nanATEK-yhcH_mRNA NanK
Name: nanATEK-yhcH_mRNA -> NanK
Description: Translation of NanK
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanK
Components:
Function Name Type Evidence Reference(s)
product NanK protein nd nd
reactant nanATEK-yhcH_mRNA RNA nd nd
NanK N-acetyl-beta-D-mannosamine ManNAc-6-P
Name: N-acetyl-beta-D-mannosamine -> ManNAc-6-P
Description: Reaction transforming N-acetyl-beta-D-mannosamine into ManNAc-6-P
Type: state transition
Pathway Components: N-acetyl-beta-D-mannosamine - NanK -> ManNAc-6-P
Components:
Function Name Type Evidence Reference(s)
product ManNAc-6-P simple_molecule nd nd
reactant N-acetyl-beta-D-mannosamine simple_molecule nd nd
catalyzer NanK protein nd nd
nanATEK-yhcH_mRNA YhcH
Name: nanATEK-yhcH_mRNA -> YhcH
Description: Translation of YhcH
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> YhcH
Components:
Function Name Type Evidence Reference(s)
product YhcH protein nd nd
reactant nanATEK-yhcH_mRNA RNA nd nd
yjhBC_mRNA YjhB
Name: yjhBC_mRNA -> YjhB
Description: Translation of YjhB
Type: translation
Pathway Components: yjhBC_mRNA -> YjhB
Components:
Function Name Type Evidence Reference(s)
product YjhB protein nd nd
reactant yjhBC_mRNA RNA nd nd
yjhBC_mRNA YjhC
Name: yjhBC_mRNA -> YjhC
Description: Translation of YjhC
Type: translation
Pathway Components: yjhBC_mRNA -> YjhC
Components:
Function Name Type Evidence Reference(s)
product YjhC protein nd nd
reactant yjhBC_mRNA RNA nd nd
nanA_mRNA NanA
Name: nanA_mRNA -> NanA
Description: Translation of NanA
Type: translation
Pathway Components: nanA_mRNA -> NanA
Components:
Function Name Type Evidence Reference(s)
product NanA protein nd nd
reactant nanA_mRNA RNA nd nd
nanCM_mRNA NanC
Name: nanCM_mRNA -> NanC
Description: Translation of NanC
Type: translation
Pathway Components: nanCM_mRNA -> NanC
Components:
Function Name Type Evidence Reference(s)
product NanC protein nd nd
reactant nanCM_mRNA RNA nd nd
nanCM_mRNA NanM
Name: nanCM_mRNA -> NanM
Description: Translation of NanM
Type: translation
Pathway Components: nanCM_mRNA -> NanM
Components:
Function Name Type Evidence Reference(s)
product NanM protein nd nd
reactant nanCM_mRNA RNA nd nd



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