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NemR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
N-EM NemR glutathione nemRA-gloA nemRA_mRNA nemRA-gloA_mRNA GloA NemR NemA nemRA oxopropanal ethylsuccinimide oxopropanal lactoylglutathione


Gensor Unit       
Name: NemR
Classification:
Groups: Secondary metabolites biosynthesis, transport and catabolism
Transcription
Energy production and conversion
Gene Ontology Terms (GO): biological_process GO:0046256 - 2,4,6-trinitrotoluene catabolic process
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0018937 - nitroglycerin metabolic process
GO:0006355 - regulation of transcription, DNA-templated
GO:0051595 - response to methylglyoxal
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cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0010181 - FMN binding
GO:0008748 - N-ethylmaleimide reductase activity
GO:0003824 - catalytic activity
GO:0034567 - chromate reductase activity
GO:0004462 - lactoylglutathione lyase activity
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Components:
  Function Name Type
  protein GloA protein
  simple_molecule N-EM simple_molecule
  protein NemA protein
  protein NemR protein
  complex NemR-oxopropanal complex
  simple_molecule ethylsuccinimide simple_molecule
  simple_molecule glutathione simple_molecule
  simple_molecule lactoylglutathione simple_molecule
  gene nemRA gene
  gene nemRA-gloA gene
  RNA nemRA-gloA_mRNA RNA
  RNA nemRA_mRNA RNA
  simple_molecule oxopropanal simple_molecule


Reactions       
Showing 10 reactions
NemR nemRA nemRA_mRNA
Name: nemRA -> nemRA_mRNA
Description: Transcription of transcription unit nemRA. Reaction inhibition by NemR.
Type: transcription
Pathway Components: nemRA - NemR -> nemRA_mRNA
Components:
Function Name Type
inhibitor NemR protein
reactant nemRA gene
product nemRA_mRNA RNA
NemR nemRA-gloA nemRA-gloA_mRNA
Name: nemRA-gloA -> nemRA-gloA_mRNA
Description: Transcription of transcription unit nemRA-gloA. Reaction inhibition by NemR.
Type: transcription
Pathway Components: nemRA-gloA - NemR -> nemRA-gloA_mRNA
Components:
Function Name Type
inhibitor NemR protein
reactant nemRA-gloA gene
product nemRA-gloA_mRNA RNA
oxopropanal + NemR NemR-oxopropanal
Name: oxopropanal + NemR -> NemR-oxopropanal
Description: Reaction transforming oxopropanal, NemR into NemR-oxopropanal
Type: state transition
Pathway Components: oxopropanal + NemR -> NemR-oxopropanal
Components:
Function Name Type
reactant NemR protein
product NemR-oxopropanal complex
reactant oxopropanal simple_molecule
nemRA_mRNA NemR
Name: nemRA_mRNA -> NemR
Description: Translation of NemR
Type: translation
Pathway Components: nemRA_mRNA -> NemR
Components:
Function Name Type
product NemR protein
reactant nemRA_mRNA RNA
nemRA_mRNA NemA
Name: nemRA_mRNA -> NemA
Description: Translation of NemA
Type: translation
Pathway Components: nemRA_mRNA -> NemA
Components:
Function Name Type
product NemA protein
reactant nemRA_mRNA RNA
NemA N-EM ethylsuccinimide
Name: N-EM -> ethylsuccinimide
Description: Reaction transforming N-EM into ethylsuccinimide
Type: state transition
Pathway Components: N-EM - NemA -> ethylsuccinimide
Components:
Function Name Type
reactant N-EM simple_molecule
catalyzer NemA protein
product ethylsuccinimide simple_molecule
nemRA-gloA_mRNA NemR
Name: nemRA-gloA_mRNA -> NemR
Description: Translation of NemR
Type: translation
Pathway Components: nemRA-gloA_mRNA -> NemR
Components:
Function Name Type
product NemR protein
reactant nemRA-gloA_mRNA RNA
nemRA-gloA_mRNA NemA
Name: nemRA-gloA_mRNA -> NemA
Description: Translation of NemA
Type: translation
Pathway Components: nemRA-gloA_mRNA -> NemA
Components:
Function Name Type
product NemA protein
reactant nemRA-gloA_mRNA RNA
nemRA-gloA_mRNA GloA
Name: nemRA-gloA_mRNA -> GloA
Description: Translation of GloA
Type: translation
Pathway Components: nemRA-gloA_mRNA -> GloA
Components:
Function Name Type
product GloA protein
reactant nemRA-gloA_mRNA RNA
GloA oxopropanal + glutathione lactoylglutathione
Name: oxopropanal + glutathione -> lactoylglutathione
Description: Reaction transforming oxopropanal, glutathione into lactoylglutathione
Type: state transition
Pathway Components: oxopropanal + glutathione - GloA -> lactoylglutathione
Components:
Function Name Type
catalyzer GloA protein
reactant glutathione simple_molecule
product lactoylglutathione simple_molecule
reactant oxopropanal simple_molecule



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