RegulonDB RegulonDB

MurR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-lactate Crr MurP MurQ MurR N-acetyl-D-glucosamine-6-phosphate MurNAc-6-P MurNAc_Ext murQP murQP_mRNA murR murR_mRNA PEP_Ext pyruvate MurR MurNAc-6-P MurP Crr


Gensor Unit       
Name: MurR
Description: Molecular biology level
Detailed: In the absence of N-acetylmuramate, MurR negatively regulates the expression of genes required for N-acetylmuramic transport and catabolic process and dually regulates its own expression. Under these conditons MurR binds its target sites, enabling and preventing its own expression and preventing the expression of its regulated genes. In the presence of N-acetylmuramate, it is transported and transformed to N-acetylmuramate-6-phosphate, MurR is modified to MurR-MurNAc-6-P, unbinds its target sites in some cases enabling and at others preventing its own expression and enabling the expression of other of its regulated genes.
Less detailed: In the absence of N-acetylmuramate-6-phosphate MurR dually regulates its own expression and negatively regulates the expression of the genes needed for N-acetylmuramic transport and catabolic process.

Physiology level
Detailed: The presence of N-acetylmuramate-6-phosphate induces the expression of genes involved with N-acetylmuramic transport and catabolic process. Under these conditions, the genes necessary for conversion of N-acetylmuramate-6-phosphate to N-acetyl-D-glucosamine-6-phosphate and lactate are expressed.
Less detailed: The presence of N-acetylmuramate-6-phosphate induces the expression of genes needful for its conversion to N-acetyl-D-glucosamine-6-phosphate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0046348 - amino sugar catabolic process
GO:1901135 - carbohydrate derivative metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006096 - glycolytic process
GO:0045892 - negative regulation of transcription, DNA-templated
Read more >
cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003700 - DNA binding transcription factor activity
GO:0097367 - carbohydrate derivative binding
GO:0016835 - carbon-oxygen lyase activity
GO:0016803 - ether hydrolase activity
GO:0004340 - glucokinase activity
GO:0016301 - kinase activity
GO:0005515 - protein binding
Read more >
Components: Show/Hide Components Table (24 more...)
Function Name Type
simple_molecule 1,6-anhMurNAc simple_molecule
simple_molecule 1,6-anhMurNAc_Ext simple_molecule
protein Crr protein
simple_molecule HPr - phosphorylated_Ext simple_molecule
simple_molecule MurNAc-6-P simple_molecule
simple_molecule MurNAc_Ext simple_molecule
protein MurP protein
complex MurP-Crr complex
protein MurQ protein
protein MurR protein
complex MurR-MurNAc-6-P complex
simple_molecule N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
simple_molecule PtsH simple_molecule
protein YfeW protein
simple_molecule ala simple_molecule
simple_molecule lactate simple_molecule
gene murQP gene
gene murQP-yfeW gene
RNA murQP-yfeW_mRNA RNA
RNA murQP_mRNA RNA
gene murR gene
RNA murR_mRNA RNA
simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule
simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule


Reactions       
Showing 15 reactions
MurR MurR murR murR_mRNA
Name: murR -> murR_mRNA
Description: Transcription of transcription unit murR. Reaction activation by MurR. Reaction inhibition by MurR.
Type: transcription
Pathway Components: murR - MurR - MurR -> murR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MurR protein nd nd
inhibitor MurR protein nd nd
reactant murR gene nd nd
product murR_mRNA RNA nd nd
MurR murQP-yfeW murQP-yfeW_mRNA
Name: murQP-yfeW -> murQP-yfeW_mRNA
Description: Transcription of transcription unit murQP-yfeW. Reaction inhibition by MurR.
Type: transcription
Pathway Components: murQP-yfeW - MurR -> murQP-yfeW_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MurR protein nd nd
reactant murQP-yfeW gene nd nd
product murQP-yfeW_mRNA RNA nd nd
MurNAc-6-P + MurR MurR-MurNAc-6-P
Name: MurNAc-6-P + MurR -> MurR-MurNAc-6-P
Description: Reaction transforming MurNAc-6-P, MurR into MurR-MurNAc-6-P
Type: state transition
Pathway Components: MurNAc-6-P + MurR -> MurR-MurNAc-6-P
Components:
Function Name Type Evidence Reference(s)
reactant MurNAc-6-P simple_molecule nd nd
reactant MurR protein nd nd
product MurR-MurNAc-6-P complex nd nd
MurR murQP murQP_mRNA
Name: murQP -> murQP_mRNA
Description: Transcription of transcription unit murQP. Reaction inhibition by MurR.
Type: transcription
Pathway Components: murQP - MurR -> murQP_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MurR protein nd nd
reactant murQP gene nd nd
product murQP_mRNA RNA nd nd
murR_mRNA MurR
Name: murR_mRNA -> MurR
Description: Translation of MurR
Type: translation
Pathway Components: murR_mRNA -> MurR
Components:
Function Name Type Evidence Reference(s)
product MurR protein nd nd
reactant murR_mRNA RNA nd nd
murQP-yfeW_mRNA MurQ
Name: murQP-yfeW_mRNA -> MurQ
Description: Translation of MurQ
Type: translation
Pathway Components: murQP-yfeW_mRNA -> MurQ
Components:
Function Name Type Evidence Reference(s)
product MurQ protein nd nd
reactant murQP-yfeW_mRNA RNA nd nd
MurQ MurNAc-6-P Products
Name: MurNAc-6-P -> N-acetyl-α-D-glucosamine 6-phosphate + lactate
Description: Reaction transforming MurNAc-6-P into N-acetyl-α-D-glucosamine 6-phosphate, lactate
Type: state transition
Pathway Components: MurNAc-6-P - MurQ -> N-acetyl-α-D-glucosamine 6-phosphate + lactate
Components:
Function Name Type Evidence Reference(s)
reactant MurNAc-6-P simple_molecule nd nd
catalyzer MurQ protein nd nd
product N-acetyl-α-D-glucosamine 6-phosphate simple_molecule nd nd
product lactate simple_molecule nd nd
murQP-yfeW_mRNA MurP
Name: murQP-yfeW_mRNA -> MurP
Description: Translation of MurP
Type: translation
Pathway Components: murQP-yfeW_mRNA -> MurP
Components:
Function Name Type Evidence Reference(s)
product MurP protein nd nd
reactant murQP-yfeW_mRNA RNA nd nd
MurP + Crr MurP-Crr
Name: MurP + Crr -> MurP-Crr
Description: Reaction transforming MurP, Crr into MurP-Crr
Type: state transition
Pathway Components: MurP + Crr -> MurP-Crr
Components:
Function Name Type Evidence Reference(s)
reactant Crr protein nd nd
reactant MurP protein nd nd
product MurP-Crr complex nd nd
MurP-Crr HPr - phosphorylated_Ext + MurNAc_Ext MurNAc-6-P + PtsH
Name: HPr - phosphorylated_Ext + MurNAc_Ext -> MurNAc-6-P + PtsH
Description: Transport of HPr - phosphorylated_Ext, MurNAc_Ext through a bacterial membrane, leading to the presence of MurNAc-6-P, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + MurNAc_Ext - MurP-Crr -> MurNAc-6-P + PtsH
Components:
Function Name Type Evidence Reference(s)
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product MurNAc-6-P simple_molecule nd nd
reactant MurNAc_Ext simple_molecule nd nd
catalyzer MurP-Crr complex nd nd
product PtsH simple_molecule nd nd
MurP 1,6-anhMurNAc_Ext 1,6-anhMurNAc
Name: 1,6-anhMurNAc_Ext -> 1,6-anhMurNAc
Description: Transport of 1,6-anhMurNAc_Ext through a bacterial membrane, leading to the presence of 1,6-anhMurNAc inside the cell.
Type: transport
Pathway Components: 1,6-anhMurNAc_Ext - MurP -> 1,6-anhMurNAc
Components:
Function Name Type Evidence Reference(s)
product 1,6-anhMurNAc simple_molecule nd nd
reactant 1,6-anhMurNAc_Ext simple_molecule nd nd
catalyzer MurP protein nd nd
murQP-yfeW_mRNA YfeW
Name: murQP-yfeW_mRNA -> YfeW
Description: Translation of YfeW
Type: translation
Pathway Components: murQP-yfeW_mRNA -> YfeW
Components:
Function Name Type Evidence Reference(s)
product YfeW protein nd nd
reactant murQP-yfeW_mRNA RNA nd nd
YfeW Reactants Products
Name: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Description: Reaction transforming nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide into nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide, ala
Type: state transition
Pathway Components: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide - YfeW -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Components:
Function Name Type Evidence Reference(s)
catalyzer YfeW protein nd nd
product ala simple_molecule nd nd
product nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule nd nd
reactant nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule nd nd
murQP_mRNA MurQ
Name: murQP_mRNA -> MurQ
Description: Translation of MurQ
Type: translation
Pathway Components: murQP_mRNA -> MurQ
Components:
Function Name Type Evidence Reference(s)
product MurQ protein nd nd
reactant murQP_mRNA RNA nd nd
murQP_mRNA MurP
Name: murQP_mRNA -> MurP
Description: Translation of MurP
Type: translation
Pathway Components: murQP_mRNA -> MurP
Components:
Function Name Type Evidence Reference(s)
product MurP protein nd nd
reactant murQP_mRNA RNA nd nd



RegulonDB