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NadR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: NadR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0034628 - 'de novo' NAD biosynthetic process from aspartate
GO:0009435 - NAD biosynthetic process
GO:0034355 - NAD salvage
GO:0034258 - nicotinamide riboside transport
GO:0019805 - quinolinate biosynthetic process
GO:0009408 - response to heat
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0008734 - L-aspartate oxidase activity
GO:0044318 - L-aspartate:fumarate oxidoreductase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0016879 - ligase activity, forming carbon-nitrogen bonds
GO:0034257 - nicotinamide riboside transmembrane transporter activity
GO:0004516 - nicotinate phosphoribosyltransferase activity
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Components: Show/Hide Components Table (26 more...)
Function Name Type
simple_molecule DHAP simple_molecule
simple_molecule NaMN simple_molecule
protein NadA protein
protein NadB protein
protein NadR protein
simple_molecule PRPP simple_molecule
protein PncB protein
protein PnuC protein
simple_molecule aspartate simple_molecule
simple_molecule diphosphate simple_molecule
simple_molecule fumarate simple_molecule
simple_molecule iminoaspartate simple_molecule
gene nadA-pnuC gene
RNA nadA-pnuC_mRNA RNA
gene nadB gene
RNA nadB_mRNA RNA
simple_molecule niacin simple_molecule
simple_molecule nicotinamide ribose simple_molecule
simple_molecule nicotinamide ribose_Ext simple_molecule
simple_molecule oxygen simple_molecule
simple_molecule perhydrol simple_molecule
simple_molecule phosphate simple_molecule
gene pncB gene
RNA pncB_mRNA RNA
simple_molecule quinolinate simple_molecule
simple_molecule succinate simple_molecule


Reactions       
Showing 12 reactions
NadR nadA-pnuC nadA-pnuC_mRNA
Name: nadA-pnuC -> nadA-pnuC_mRNA
Description: Transcription of transcription unit nadA-pnuC. Reaction inhibition by NadR.
Type: transcription
Pathway Components: nadA-pnuC - NadR -> nadA-pnuC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NadR protein nd nd
reactant nadA-pnuC gene nd nd
product nadA-pnuC_mRNA RNA nd nd
NadR nadB nadB_mRNA
Name: nadB -> nadB_mRNA
Description: Transcription of transcription unit nadB. Reaction inhibition by NadR.
Type: transcription
Pathway Components: nadB - NadR -> nadB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NadR protein nd nd
reactant nadB gene nd nd
product nadB_mRNA RNA nd nd
NadR pncB pncB_mRNA
Name: pncB -> pncB_mRNA
Description: Transcription of transcription unit pncB. Reaction inhibition by NadR.
Type: transcription
Pathway Components: pncB - NadR -> pncB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor NadR protein nd nd
reactant pncB gene nd nd
product pncB_mRNA RNA nd nd
nadB_mRNA NadB
Name: nadB_mRNA -> NadB
Description: Translation of NadB
Type: translation
Pathway Components: nadB_mRNA -> NadB
Components:
Function Name Type Evidence Reference(s)
product NadB protein nd nd
reactant nadB_mRNA RNA nd nd
NadB aspartate + fumarate iminoaspartate + succinate
Name: aspartate + fumarate -> iminoaspartate + succinate
Description: Reaction transforming aspartate, fumarate into iminoaspartate, succinate
Type: state transition
Pathway Components: aspartate + fumarate - NadB -> iminoaspartate + succinate
Components:
Function Name Type Evidence Reference(s)
catalyzer NadB protein nd nd
reactant aspartate simple_molecule nd nd
reactant fumarate simple_molecule nd nd
product iminoaspartate simple_molecule nd nd
product succinate simple_molecule nd nd
NadB iminoaspartate aspartate + oxygen iminoaspartate + perhydrol
Name: aspartate + oxygen -> iminoaspartate + perhydrol
Description: Reaction transforming aspartate, oxygen into iminoaspartate, perhydrol
Type: state transition
Pathway Components: aspartate + oxygen - NadB - iminoaspartate -> iminoaspartate + perhydrol
Components:
Function Name Type Evidence Reference(s)
catalyzer NadB protein nd nd
reactant aspartate simple_molecule nd nd
inhibitor iminoaspartate simple_molecule nd nd
product iminoaspartate simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product perhydrol simple_molecule nd nd
nadA-pnuC_mRNA NadA
Name: nadA-pnuC_mRNA -> NadA
Description: Translation of NadA
Type: translation
Pathway Components: nadA-pnuC_mRNA -> NadA
Components:
Function Name Type Evidence Reference(s)
product NadA protein nd nd
reactant nadA-pnuC_mRNA RNA nd nd
NadA oxygen iminoaspartate + DHAP quinolinate + phosphate
Name: iminoaspartate + DHAP -> quinolinate + phosphate
Description: Reaction transforming iminoaspartate, DHAP into quinolinate, phosphate
Type: state transition
Pathway Components: iminoaspartate + DHAP - NadA - oxygen -> quinolinate + phosphate
Components:
Function Name Type Evidence Reference(s)
reactant DHAP simple_molecule nd nd
catalyzer NadA protein nd nd
reactant iminoaspartate simple_molecule nd nd
inhibitor oxygen simple_molecule nd nd
product phosphate simple_molecule nd nd
product quinolinate simple_molecule nd nd
nadA-pnuC_mRNA PnuC
Name: nadA-pnuC_mRNA -> PnuC
Description: Translation of PnuC
Type: translation
Pathway Components: nadA-pnuC_mRNA -> PnuC
Components:
Function Name Type Evidence Reference(s)
product PnuC protein nd nd
reactant nadA-pnuC_mRNA RNA nd nd
PnuC nicotinamide ribose_Ext nicotinamide ribose
Name: nicotinamide ribose_Ext -> nicotinamide ribose
Description: Transport of nicotinamide ribose_Ext through a bacterial membrane, leading to the presence of nicotinamide ribose inside the cell.
Type: transport
Pathway Components: nicotinamide ribose_Ext - PnuC -> nicotinamide ribose
Components:
Function Name Type Evidence Reference(s)
catalyzer PnuC protein nd nd
product nicotinamide ribose simple_molecule nd nd
reactant nicotinamide ribose_Ext simple_molecule nd nd
pncB_mRNA PncB
Name: pncB_mRNA -> PncB
Description: Translation of PncB
Type: translation
Pathway Components: pncB_mRNA -> PncB
Components:
Function Name Type Evidence Reference(s)
product PncB protein nd nd
reactant pncB_mRNA RNA nd nd
PncB niacin + PRPP diphosphate + phosphate + NaMN
Name: niacin + PRPP -> diphosphate + phosphate + NaMN
Description: Reaction transforming niacin, PRPP into diphosphate, phosphate , NaMN
Type: state transition
Pathway Components: niacin + PRPP - PncB -> diphosphate + phosphate + NaMN
Components:
Function Name Type Evidence Reference(s)
product NaMN simple_molecule nd nd
reactant PRPP simple_molecule nd nd
catalyzer PncB protein nd nd
product diphosphate simple_molecule nd nd
reactant niacin simple_molecule nd nd
product phosphate simple_molecule nd nd



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