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MtlR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-fructose 6-phosphate D-mannitol_Ext MtlA MtlD MtlR mannitol-1-phosphate mtlADR mtlADR_mRNA PEP_Ext pyruvate


Gensor Unit       
Name: MtlR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0019592 - mannitol catabolic process
GO:0015797 - mannitol transport
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0016301 - kinase activity
GO:0008926 - mannitol-1-phosphate 5-dehydrogenase activity
GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0022872 - protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
GO:0008982 - protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0090565 - protein-phosphocysteine-mannitol phosphotransferase system transporter activity
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Components: Show/Hide Components Table (13 more...)
Function Name Type
protein EIIMtl protein
simple_molecule HPr - phosphorylated_Ext simple_molecule
protein MtlA protein
protein MtlD protein
protein MtlR protein
simple_molecule PtsH simple_molecule
simple_molecule fructose-6-P simple_molecule
simple_molecule gulitol_Ext simple_molecule
simple_molecule mannitol-1-P simple_molecule
simple_molecule mannitol_Ext simple_molecule
gene mtlADR gene
RNA mtlADR_mRNA RNA
simple_molecule sorbitol 6-phosphate simple_molecule


Reactions       
Showing 8 reactions
MtlR mtlADR mtlADR_mRNA
Name: mtlADR -> mtlADR_mRNA
Description: Transcription of transcription unit mtlADR. Reaction inhibition by MtlR.
Type: transcription
Pathway Components: mtlADR - MtlR -> mtlADR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MtlR protein nd nd
reactant mtlADR gene nd nd
product mtlADR_mRNA RNA nd nd
mtlADR_mRNA MtlA
Name: mtlADR_mRNA -> MtlA
Description: Translation of MtlA
Type: translation
Pathway Components: mtlADR_mRNA -> MtlA
Components:
Function Name Type Evidence Reference(s)
product MtlA protein nd nd
reactant mtlADR_mRNA RNA nd nd
EIIMtl MtlA HPr - phosphorylated_Ext + mannitol_Ext mannitol-1-P + PtsH
Name: HPr - phosphorylated_Ext + mannitol_Ext -> mannitol-1-P + PtsH
Description: Transport of HPr - phosphorylated_Ext, mannitol_Ext through a bacterial membrane, leading to the presence of mannitol-1-P, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + mannitol_Ext - EIIMtl - MtlA -> mannitol-1-P + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer EIIMtl protein nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
catalyzer MtlA protein nd nd
product PtsH simple_molecule nd nd
product mannitol-1-P simple_molecule nd nd
reactant mannitol_Ext simple_molecule nd nd
EIIMtl MtlA HPr - phosphorylated_Ext + gulitol_Ext sorbitol 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + gulitol_Ext -> sorbitol 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, gulitol_Ext through a bacterial membrane, leading to the presence of sorbitol 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + gulitol_Ext - EIIMtl - MtlA -> sorbitol 6-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer EIIMtl protein nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
catalyzer MtlA protein nd nd
product PtsH simple_molecule nd nd
reactant gulitol_Ext simple_molecule nd nd
product sorbitol 6-phosphate simple_molecule nd nd
mtlADR_mRNA EIIMtl
Name: mtlADR_mRNA -> EIIMtl
Description: Translation of EIIMtl
Type: translation
Pathway Components: mtlADR_mRNA -> EIIMtl
Components:
Function Name Type Evidence Reference(s)
product EIIMtl protein nd nd
reactant mtlADR_mRNA RNA nd nd
mtlADR_mRNA MtlD
Name: mtlADR_mRNA -> MtlD
Description: Translation of MtlD
Type: translation
Pathway Components: mtlADR_mRNA -> MtlD
Components:
Function Name Type Evidence Reference(s)
product MtlD protein nd nd
reactant mtlADR_mRNA RNA nd nd
MtlD mannitol-1-P fructose-6-P
Name: mannitol-1-P -> fructose-6-P
Description: Reaction transforming mannitol-1-P into fructose-6-P
Type: state transition
Pathway Components: mannitol-1-P - MtlD -> fructose-6-P
Components:
Function Name Type Evidence Reference(s)
catalyzer MtlD protein nd nd
product fructose-6-P simple_molecule nd nd
reactant mannitol-1-P simple_molecule nd nd
mtlADR_mRNA MtlR
Name: mtlADR_mRNA -> MtlR
Description: Translation of MtlR
Type: translation
Pathway Components: mtlADR_mRNA -> MtlR
Components:
Function Name Type Evidence Reference(s)
product MtlR protein nd nd
reactant mtlADR_mRNA RNA nd nd



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