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MntR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Dps Fe+2 Fe+2_Ext Mn(II) Mn(II)_Ext MntH MntP MntR MntS This Gensor Unit is not yet available dps dps_mRNA mntH mntH_mRNA mntP mntP_mRNA rybA-mntS rybA-mntS_mRNA MntR Mn(II)


Gensor Unit       
Name: MntR
Description: Molecular biology level
Detailed: In the presence of Mn(II), MntR positively regulates the expression of genes required for manganese transport and negatively regulates the expression of genes required for iron transport. Under these conditions, MntR is modified to MntR-Mn(II), binds its target sites preventing the expression of some of its regulated genes and enabling the expression of others. (Conversely,) in the absence of Mn(II), MntR unbinds its target sites enabling in some cases and preventing in others the expression of its regulated genes.
Less detailed: In the presence of Mn(II), MntR positively regulates the expression of genes needed for manganese and iron transport.

Physiology level
Detailed: The presence of Mn(II) induces the expression of genes involved with manganese transport. Under these conditions the genes necessary for transport of Mn(II) and Fe+2 into cell are expressed.
Less detailed: The presence of Mn(II) induces the expression of genes needful for manganese and iron transport into the cell.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0070574 - cadmium ion transmembrane transport
GO:0015691 - cadmium ion transport
GO:0030026 - cellular manganese ion homeostasis
GO:0071287 - cellular response to manganese ion
GO:0034599 - cellular response to oxidative stress
GO:0006824 - cobalt ion transport
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cellular_component GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0015086 - cadmium ion transmembrane transporter activity
GO:0008199 - ferric iron binding
GO:0042802 - identical protein binding
GO:0005384 - manganese ion transmembrane transporter activity
GO:0005515 - protein binding
GO:0015078 - proton transmembrane transporter activity
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Components: Show/Hide Components Table (21 more...)
Function Name Type
simple_molecule Cadmium simple_molecule
protein Dps protein
simple_molecule Fe+2 simple_molecule
simple_molecule Fe+2_Ext simple_molecule
simple_molecule Mn(II) simple_molecule
simple_molecule Mn(II)_Ext simple_molecule
protein MntH protein
protein MntP protein
protein MntR protein
complex MntR-Cadmium complex
complex MntR-Mn(II) complex
protein MntS protein
protein RNA:RybA protein
gene dps gene
RNA dps_mRNA RNA
gene mntH gene
RNA mntH_mRNA RNA
gene mntP gene
RNA mntP_mRNA RNA
gene rybA-mntS gene
RNA rybA-mntS_mRNA RNA


Reactions       
Showing 13 reactions
Cadmium + MntR MntR-Cadmium
Name: Cadmium + MntR -> MntR-Cadmium
Description: Reaction transforming Cadmium, MntR into MntR-Cadmium
Type: state transition
Pathway Components: Cadmium + MntR -> MntR-Cadmium
Components:
Function Name Type Evidence Reference(s)
reactant Cadmium simple_molecule nd nd
reactant MntR protein nd nd
product MntR-Cadmium complex nd nd
MntR-Cadmium MntR-Mn(II) mntP mntP_mRNA
Name: mntP -> mntP_mRNA
Description: Transcription of transcription unit mntP. Reaction activation by MntR-Cadmium, and MntR-Mn(II).
Type: transcription
Pathway Components: mntP - MntR-Cadmium - MntR-Mn(II) -> mntP_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MntR-Cadmium complex nd nd
activator MntR-Mn(II) complex nd nd
reactant mntP gene nd nd
product mntP_mRNA RNA nd nd
MntR-Cadmium MntR-Mn(II) dps dps_mRNA
Name: dps -> dps_mRNA
Description: Transcription of transcription unit dps. Reaction inhibition by MntR-Cadmium, and MntR-Mn(II).
Type: transcription
Pathway Components: dps - MntR-Cadmium - MntR-Mn(II) -> dps_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MntR-Cadmium complex nd nd
inhibitor MntR-Mn(II) complex nd nd
reactant dps gene nd nd
product dps_mRNA RNA nd nd
MntR-Cadmium MntR-Mn(II) mntH mntH_mRNA
Name: mntH -> mntH_mRNA
Description: Transcription of transcription unit mntH. Reaction inhibition by MntR-Cadmium, and MntR-Mn(II).
Type: transcription
Pathway Components: mntH - MntR-Cadmium - MntR-Mn(II) -> mntH_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MntR-Cadmium complex nd nd
inhibitor MntR-Mn(II) complex nd nd
reactant mntH gene nd nd
product mntH_mRNA RNA nd nd
MntR-Cadmium MntR-Mn(II) rybA-mntS rybA-mntS_mRNA
Name: rybA-mntS -> rybA-mntS_mRNA
Description: Transcription of transcription unit rybA-mntS. Reaction inhibition by MntR-Cadmium, and MntR-Mn(II).
Type: transcription
Pathway Components: rybA-mntS - MntR-Cadmium - MntR-Mn(II) -> rybA-mntS_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MntR-Cadmium complex nd nd
inhibitor MntR-Mn(II) complex nd nd
reactant rybA-mntS gene nd nd
product rybA-mntS_mRNA RNA nd nd
Mn(II) + MntR MntR-Mn(II)
Name: Mn(II) + MntR -> MntR-Mn(II)
Description: Reaction transforming Mn(II), MntR into MntR-Mn(II)
Type: state transition
Pathway Components: Mn(II) + MntR -> MntR-Mn(II)
Components:
Function Name Type Evidence Reference(s)
reactant Mn(II) simple_molecule nd nd
reactant MntR protein nd nd
product MntR-Mn(II) complex nd nd
dps_mRNA Dps
Name: dps_mRNA -> Dps
Description: Translation of Dps
Type: translation
Pathway Components: dps_mRNA -> Dps
Components:
Function Name Type Evidence Reference(s)
product Dps protein nd nd
reactant dps_mRNA RNA nd nd
mntH_mRNA MntH
Name: mntH_mRNA -> MntH
Description: Translation of MntH
Type: translation
Pathway Components: mntH_mRNA -> MntH
Components:
Function Name Type Evidence Reference(s)
product MntH protein nd nd
reactant mntH_mRNA RNA nd nd
MntH Fe+2_Ext Fe+2
Name: Fe+2_Ext -> Fe+2
Description: Transport of Fe+2_Ext through a bacterial membrane, leading to the presence of Fe+2 inside the cell.
Type: transport
Pathway Components: Fe+2_Ext - MntH -> Fe+2
Components:
Function Name Type Evidence Reference(s)
product Fe+2 simple_molecule nd nd
reactant Fe+2_Ext simple_molecule nd nd
catalyzer MntH protein nd nd
MntH MntP Mn(II)_Ext Mn(II)
Name: Mn(II)_Ext -> Mn(II)
Description: Transport of Mn(II)_Ext through a bacterial membrane, leading to the presence of Mn(II) inside the cell.
Type: transport
Pathway Components: Mn(II)_Ext - MntH - MntP -> Mn(II)
Components:
Function Name Type Evidence Reference(s)
product Mn(II) simple_molecule nd nd
reactant Mn(II)_Ext simple_molecule nd nd
catalyzer MntH protein nd nd
catalyzer MntP protein nd nd
rybA-mntS_mRNA MntS
Name: rybA-mntS_mRNA -> MntS
Description: Translation of MntS
Type: translation
Pathway Components: rybA-mntS_mRNA -> MntS
Components:
Function Name Type Evidence Reference(s)
product MntS protein nd nd
reactant rybA-mntS_mRNA RNA nd nd
rybA-mntS_mRNA RNA:RybA
Name: rybA-mntS_mRNA -> RNA:RybA
Description: Translation of RNA:RybA
Type: translation
Pathway Components: rybA-mntS_mRNA -> RNA:RybA
Components:
Function Name Type Evidence Reference(s)
product RNA:RybA protein nd nd
reactant rybA-mntS_mRNA RNA nd nd
mntP_mRNA MntP
Name: mntP_mRNA -> MntP
Description: Translation of MntP
Type: translation
Pathway Components: mntP_mRNA -> MntP
Components:
Function Name Type Evidence Reference(s)
product MntP protein nd nd
reactant mntP_mRNA RNA nd nd



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