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MprA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2,4-DNP AcrA AcrB AcrD Carbonyl cyanide m-chlorophenylhydrazone (CCCP) Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone EmrA EmrB MprA NmpC TolC a drug a drug_Ext acrAB acrAB_mRNA mprA-emrAB mprA-emrAB_mRNA nmpC nmpC_mRNA MprA Carbonyl cyanide m-chlorophenylhydrazone (CCCP) Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone MprA 2,4-DNP AcrA TolC AcrB AcrD AcrA TolC EmrA EmrB TolC MprA


Gensor Unit       
Name: MprA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0045892 - negative regulation of transcription, DNA-templated
GO:0046930 - pore complex
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0005622 - intracellular
GO:0016020 - membrane
GO:0005887 - integral component of plasma membrane
GO:0006811 - ion transport
GO:0009276 - Gram-negative-bacterium-type cell wall
GO:0055085 - transmembrane transport
GO:0046677 - response to antibiotic
GO:0003677 - DNA binding
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Components:
Function Name Type
RNA nmpC_mRNA RNA


Reactions       
Showing 16 reactions
acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB; reaction inhibition by AcrR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant acrAB gene nd nd
product acrAB_mRNA RNA nd nd
mprA-emrAB mprA-emrAB_mRNA
Name: mprA-emrAB -> mprA-emrAB_mRNA
Description: Transcription of transcription unit mprA-emrAB; reaction inhibition by MprA.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product mprA-emrAB_mRNA RNA nd nd
reactant mprA-emrAB gene nd nd
nmpC nmpC_mRNA
Name: nmpC -> nmpC_mRNA
Description: Transcription of transcription unit nmpC; reaction inhibition by MprA.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product nmpC_mRNA RNA nd nd
reactant nmpC gene nd nd
MprA + Carbonyl cyanide m-chlorophenylhydrazone (CCCP) MprA-Carbonyl cyanide m-chlorophenylhydrazone (CCCP)
Name: MprA + Carbonyl cyanide m-chlorophenylhydrazone (CCCP) -> MprA-Carbonyl cyanide m-chlorophenylhydrazone (CCCP)
Description: Reaction transforming MprA, Carbonyl cyanide m-chlorophenylhydrazone (CCCP) into MprA-Carbonyl cyanide m-chlorophenylhydrazone (CCCP)
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MprA protein nd nd
product MprA-Carbonyl cyanide m-chlorophenylhydrazone (CCCP) complex nd nd
reactant Carbonyl cyanide m-chlorophenylhydrazone (CCCP) simple molecule nd nd
MprA + Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Name: MprA + Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone -> MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Description: Reaction transforming MprA, Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone into MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MprA protein nd nd
reactant Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone simple molecule nd nd
product MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone complex nd nd
MprA + 2,4-DNP MprA-2,4-DNP
Name: MprA + 2,4-DNP -> MprA-2,4-DNP
Description: Reaction transforming MprA, 2,4-DNP into MprA-2,4-DNP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MprA protein nd nd
reactant 2,4-DNP simple molecule nd nd
product MprA-2,4-DNP complex nd nd
mprA-emrAB_mRNA MprA
Name: mprA-emrAB_mRNA -> MprA
Description: Translation of MprA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant mprA-emrAB_mRNA RNA nd nd
product MprA protein nd nd
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant acrAB_mRNA RNA nd nd
product AcrA protein nd nd
AcrA + TolC + AcrB AcrA-TolC-AcrB
Name: AcrA + TolC + AcrB -> AcrA-TolC-AcrB
Description: Reaction transforming AcrA, TolC, AcrB into AcrA-TolC-AcrB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product AcrA-TolC-AcrB complex nd nd
reactant AcrB protein nd nd
reactant AcrA protein nd nd
reactant TolC protein nd nd
a drug_Ext a drug
Name: a drug_Ext -> a drug
Description: Transport of a drug_Ext through a bacterial membrane, leading to the presence of a drug inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant a drug_Ext simple molecule nd nd
product a drug simple molecule nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant TolC protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
mprA-emrAB_mRNA EmrA
Name: mprA-emrAB_mRNA -> EmrA
Description: Translation of EmrA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product EmrA protein nd nd
reactant mprA-emrAB_mRNA RNA nd nd
EmrA + EmrB + TolC EmrA-EmrB-TolC
Name: EmrA + EmrB + TolC -> EmrA-EmrB-TolC
Description: Reaction transforming EmrA, EmrB, TolC into EmrA-EmrB-TolC
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant EmrB protein nd nd
product EmrA-EmrB-TolC complex nd nd
reactant TolC protein nd nd
reactant EmrA protein nd nd
mprA-emrAB_mRNA EmrB
Name: mprA-emrAB_mRNA -> EmrB
Description: Translation of EmrB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product EmrB protein nd nd
reactant mprA-emrAB_mRNA RNA nd nd
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant acrAB_mRNA RNA nd nd
product AcrB protein nd nd
nmpC_mRNA NmpC
Name: nmpC_mRNA -> NmpC
Description: Translation of NmpC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant nmpC_mRNA RNA nd nd
product NmpC protein nd nd



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