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MprA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2,4-DNP AcrA AcrB AcrD Carbonyl cyanide m-chlorophenylhydrazone (CCCP) Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone EmrA EmrB MprA NmpC TolC a drug a drug_Ext acrAB acrAB_mRNA mprA-emrAB mprA-emrAB_mRNA nmpC nmpC_mRNA MprA Carbonyl cyanide m-chlorophenylhydrazone (CCCP) Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone MprA 2,4-DNP AcrA TolC AcrB AcrD AcrA TolC EmrA EmrB TolC MprA


Gensor Unit       
Name: MprA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0015721 - bile acid and bile salt transport
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0046677 - response to antibiotic
GO:0042493 - response to drug
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cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:1990281 - efflux pump complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031237 - intrinsic component of periplasmic side of plasma membrane
GO:0031226 - intrinsic component of plasma membrane
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molecular_function GO:0003677 - DNA binding
GO:0015238 - drug transmembrane transporter activity
GO:0015307 - drug:proton antiporter activity
GO:0042802 - identical protein binding
GO:0015288 - porin activity
GO:0005515 - protein binding
GO:0044212 - transcription regulatory region DNA binding
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Components: Show/Hide Components Table (27 more...)
Function Name Type
simple_molecule 2,4-DNP simple_molecule
protein AcrA protein
complex AcrA-TolC-AcrB complex
protein AcrB protein
protein AcrD protein
complex AcrD-AcrA-TolC complex
simple_molecule CCCP simple_molecule
simple_molecule Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone simple_molecule
protein EmrA protein
complex EmrA-EmrB-TolC complex
protein EmrB protein
protein MprA protein
complex MprA-2,4-DNP complex
complex MprA-CCCP complex
complex MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone complex
protein NmpC protein
protein TolC protein
gene acrAB gene
RNA acrAB_mRNA RNA
simple_molecule chenodiol simple_molecule
simple_molecule chenodiol_Ext simple_molecule
simple_molecule drug simple_molecule
simple_molecule drug_Ext simple_molecule
gene mprA-emrAB gene
RNA mprA-emrAB_mRNA RNA
gene nmpC gene
RNA nmpC_mRNA RNA


Reactions       
Showing 17 reactions
MprA acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB. Reaction inhibition by MprA.
Type: transcription
Pathway Components: acrAB - MprA -> acrAB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MprA protein nd nd
reactant acrAB gene nd nd
product acrAB_mRNA RNA nd nd
MprA mprA-emrAB mprA-emrAB_mRNA
Name: mprA-emrAB -> mprA-emrAB_mRNA
Description: Transcription of transcription unit mprA-emrAB. Reaction inhibition by MprA.
Type: transcription
Pathway Components: mprA-emrAB - MprA -> mprA-emrAB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MprA protein nd nd
reactant mprA-emrAB gene nd nd
product mprA-emrAB_mRNA RNA nd nd
MprA nmpC nmpC_mRNA
Name: nmpC -> nmpC_mRNA
Description: Transcription of transcription unit nmpC. Reaction inhibition by MprA.
Type: transcription
Pathway Components: nmpC - MprA -> nmpC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MprA protein nd nd
reactant nmpC gene nd nd
product nmpC_mRNA RNA nd nd
2,4-DNP + MprA MprA-2,4-DNP
Name: 2,4-DNP + MprA -> MprA-2,4-DNP
Description: Reaction transforming 2,4-DNP, MprA into MprA-2,4-DNP
Type: state transition
Pathway Components: 2,4-DNP + MprA -> MprA-2,4-DNP
Components:
Function Name Type Evidence Reference(s)
reactant 2,4-DNP simple_molecule nd nd
reactant MprA protein nd nd
product MprA-2,4-DNP complex nd nd
MprA + CCCP MprA-CCCP
Name: MprA + CCCP -> MprA-CCCP
Description: Reaction transforming MprA, CCCP into MprA-CCCP
Type: state transition
Pathway Components: MprA + CCCP -> MprA-CCCP
Components:
Function Name Type Evidence Reference(s)
reactant CCCP simple_molecule nd nd
reactant MprA protein nd nd
product MprA-CCCP complex nd nd
TF + effector TF - effector Complex
Name: Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone + MprA -> MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Description: Reaction transforming Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone, MprA into MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Type: state transition
Pathway Components: Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone + MprA -> MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Components:
Function Name Type Evidence Reference(s)
reactant Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone simple_molecule nd nd
reactant MprA protein nd nd
product MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone complex nd nd
mprA-emrAB_mRNA MprA
Name: mprA-emrAB_mRNA -> MprA
Description: Translation of MprA
Type: translation
Pathway Components: mprA-emrAB_mRNA -> MprA
Components:
Function Name Type Evidence Reference(s)
product MprA protein nd nd
reactant mprA-emrAB_mRNA RNA nd nd
mprA-emrAB_mRNA EmrA
Name: mprA-emrAB_mRNA -> EmrA
Description: Translation of EmrA
Type: translation
Pathway Components: mprA-emrAB_mRNA -> EmrA
Components:
Function Name Type Evidence Reference(s)
product EmrA protein nd nd
reactant mprA-emrAB_mRNA RNA nd nd
EmrB + TolC + EmrA EmrA-EmrB-TolC
Name: EmrB + TolC + EmrA -> EmrA-EmrB-TolC
Description: Reaction transforming EmrB, TolC, EmrA into EmrA-EmrB-TolC
Type: state transition
Pathway Components: EmrB + TolC + EmrA -> EmrA-EmrB-TolC
Components:
Function Name Type Evidence Reference(s)
reactant EmrA protein nd nd
product EmrA-EmrB-TolC complex nd nd
reactant EmrB protein nd nd
reactant TolC protein nd nd
AcrA-TolC-AcrB AcrD-AcrA-TolC EmrA-EmrB-TolC drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrA-TolC-AcrB - AcrD-AcrA-TolC - EmrA-EmrB-TolC -> drug
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrA-TolC-AcrB complex nd nd
catalyzer AcrD-AcrA-TolC complex nd nd
catalyzer EmrA-EmrB-TolC complex nd nd
product drug simple_molecule nd nd
reactant drug_Ext simple_molecule nd nd
mprA-emrAB_mRNA EmrB
Name: mprA-emrAB_mRNA -> EmrB
Description: Translation of EmrB
Type: translation
Pathway Components: mprA-emrAB_mRNA -> EmrB
Components:
Function Name Type Evidence Reference(s)
product EmrB protein nd nd
reactant mprA-emrAB_mRNA RNA nd nd
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Pathway Components: acrAB_mRNA -> AcrA
Components:
Function Name Type Evidence Reference(s)
product AcrA protein nd nd
reactant acrAB_mRNA RNA nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
reactant TolC protein nd nd
AcrB + AcrA + TolC AcrA-TolC-AcrB
Name: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Description: Reaction transforming AcrB, AcrA, TolC into AcrA-TolC-AcrB
Type: state transition
Pathway Components: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
product AcrA-TolC-AcrB complex nd nd
reactant AcrB protein nd nd
reactant TolC protein nd nd
AcrA-TolC-AcrB chenodiol_Ext chenodiol
Name: chenodiol_Ext -> chenodiol
Description: Transport of chenodiol_Ext through a bacterial membrane, leading to the presence of chenodiol inside the cell.
Type: transport
Pathway Components: chenodiol_Ext - AcrA-TolC-AcrB -> chenodiol
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrA-TolC-AcrB complex nd nd
product chenodiol simple_molecule nd nd
reactant chenodiol_Ext simple_molecule nd nd
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Pathway Components: acrAB_mRNA -> AcrB
Components:
Function Name Type Evidence Reference(s)
product AcrB protein nd nd
reactant acrAB_mRNA RNA nd nd
nmpC_mRNA NmpC
Name: nmpC_mRNA -> NmpC
Description: Translation of NmpC
Type: translation
Pathway Components: nmpC_mRNA -> NmpC
Components:
Function Name Type Evidence Reference(s)
product NmpC protein nd nd
reactant nmpC_mRNA RNA nd nd



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