RegulonDB RegulonDB

MngR Genetic Sensory Response Unit in Escherichia coli K-12 genome

Gensor Unit Map          
mngAB 2(alpha-D-mannosyl-6-phosphate)-D-glycerate mannosylglycerate_Ext mngAB_mRNA glycerate mngR MngA mannopyranose-6-P HPr - phosphorylated_Ext MngB MngR mngR_mRNA PtsH

Gensor Unit       
Name: MngR
Groups: Transcription
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0015755 - fructose transmembrane transport
GO:0006013 - mannose metabolic process
GO:0051476 - mannosylglycerate transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004559 - alpha-mannosidase activity
GO:0030246 - carbohydrate binding
GO:0005351 - carbohydrate:proton symporter activity
GO:0003824 - catalytic activity
GO:0016787 - hydrolase activity
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  Function Name Type
  simple_molecule 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule
  simple_molecule HPr - phosphorylated_Ext simple_molecule
  protein MngA protein
  protein MngB protein
  protein MngR protein
  simple_molecule PtsH simple_molecule
  simple_molecule glycerate simple_molecule
  simple_molecule mannopyranose-6-P simple_molecule
  simple_molecule mannosylglycerate_Ext simple_molecule
  gene mngAB gene
  gene mngR gene

Showing 7 reactions
MngR mngAB mngAB_mRNA
Name: mngAB -> mngAB_mRNA
Description: Transcription of transcription unit mngAB. Reaction inhibition by MngR.
Type: transcription
Pathway Components: mngAB - MngR -> mngAB_mRNA
Function Name Type
inhibitor MngR protein
reactant mngAB gene
product mngAB_mRNA RNA
MngR mngR mngR_mRNA
Name: mngR -> mngR_mRNA
Description: Transcription of transcription unit mngR. Reaction inhibition by MngR.
Type: transcription
Pathway Components: mngR - MngR -> mngR_mRNA
Function Name Type
inhibitor MngR protein
reactant mngR gene
product mngR_mRNA RNA
mngAB_mRNA MngA
Name: mngAB_mRNA -> MngA
Description: Translation of MngA
Type: translation
Pathway Components: mngAB_mRNA -> MngA
Function Name Type
product MngA protein
reactant mngAB_mRNA RNA
MngA HPr - phosphorylated_Ext + mannosylglycerate_Ext Products
Name: HPr - phosphorylated_Ext + mannosylglycerate_Ext -> 2(α-D-mannosyl-6-phosphate)-D-glycerate + PtsH
Description: Transport of HPr - phosphorylated_Ext, mannosylglycerate_Ext through a bacterial membrane, leading to the presence of 2(α-D-mannosyl-6-phosphate)-D-glycerate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + mannosylglycerate_Ext - MngA -> 2(α-D-mannosyl-6-phosphate)-D-glycerate + PtsH
Function Name Type
product 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule
reactant HPr - phosphorylated_Ext simple_molecule
catalyzer MngA protein
product PtsH simple_molecule
reactant mannosylglycerate_Ext simple_molecule
mngAB_mRNA MngB
Name: mngAB_mRNA -> MngB
Description: Translation of MngB
Type: translation
Pathway Components: mngAB_mRNA -> MngB
Function Name Type
product MngB protein
reactant mngAB_mRNA RNA
MngB 2(α-D-mannosyl-6-phosphate)-D-glycerate mannopyranose-6-P + glycerate
Name: 2(α-D-mannosyl-6-phosphate)-D-glycerate -> mannopyranose-6-P + glycerate
Description: Reaction transforming 2(α-D-mannosyl-6-phosphate)-D-glycerate into mannopyranose-6-P, glycerate
Type: state transition
Pathway Components: 2(α-D-mannosyl-6-phosphate)-D-glycerate - MngB -> mannopyranose-6-P + glycerate
Function Name Type
reactant 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule
catalyzer MngB protein
product glycerate simple_molecule
product mannopyranose-6-P simple_molecule
mngR_mRNA MngR
Name: mngR_mRNA -> MngR
Description: Translation of MngR
Type: translation
Pathway Components: mngR_mRNA -> MngR
Function Name Type
product MngR protein
reactant mngR_mRNA RNA