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MngR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2(alpha-D-mannosyl-6-phosphate)-D-glycerate mannosylglycerate_Ext D-glycerate MngA MngB MngR alpha-D-mannose-6-phosphate mngAB mngAB_mRNA mngR mngR_mRNA PEP_Ext pyruvate


Gensor Unit       
Name: MngR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0034219 - carbohydrate transmembrane transport
GO:0015755 - fructose transmembrane transport
GO:0006013 - mannose metabolic process
GO:0051476 - mannosylglycerate transport
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
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cellular_component GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0003700 - DNA binding transcription factor activity
GO:0004559 - alpha-mannosidase activity
GO:0005515 - protein binding
GO:0090581 - protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity
GO:0090563 - protein-phosphocysteine-sugar phosphotransferase activity
Components: Show/Hide Components Table (13 more...)
Function Name Type
simple_molecule 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule
simple_molecule HPr - phosphorylated_Ext simple_molecule
protein MngA protein
protein MngB protein
protein MngR protein
simple_molecule PtsH simple_molecule
simple_molecule glycerate simple_molecule
simple_molecule mannopyranose-6-P simple_molecule
simple_molecule mannosylglycerate_Ext simple_molecule
gene mngAB gene
RNA mngAB_mRNA RNA
gene mngR gene
RNA mngR_mRNA RNA


Reactions       
Showing 7 reactions
MngR mngAB mngAB_mRNA
Name: mngAB -> mngAB_mRNA
Description: Transcription of transcription unit mngAB. Reaction inhibition by MngR.
Type: transcription
Pathway Components: mngAB - MngR -> mngAB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MngR protein nd nd
reactant mngAB gene nd nd
product mngAB_mRNA RNA nd nd
MngR mngR mngR_mRNA
Name: mngR -> mngR_mRNA
Description: Transcription of transcription unit mngR. Reaction inhibition by MngR.
Type: transcription
Pathway Components: mngR - MngR -> mngR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MngR protein nd nd
reactant mngR gene nd nd
product mngR_mRNA RNA nd nd
mngAB_mRNA MngA
Name: mngAB_mRNA -> MngA
Description: Translation of MngA
Type: translation
Pathway Components: mngAB_mRNA -> MngA
Components:
Function Name Type Evidence Reference(s)
product MngA protein nd nd
reactant mngAB_mRNA RNA nd nd
MngA HPr - phosphorylated_Ext + mannosylglycerate_Ext Products
Name: HPr - phosphorylated_Ext + mannosylglycerate_Ext -> 2(α-D-mannosyl-6-phosphate)-D-glycerate + PtsH
Description: Transport of HPr - phosphorylated_Ext, mannosylglycerate_Ext through a bacterial membrane, leading to the presence of 2(α-D-mannosyl-6-phosphate)-D-glycerate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + mannosylglycerate_Ext - MngA -> 2(α-D-mannosyl-6-phosphate)-D-glycerate + PtsH
Components:
Function Name Type Evidence Reference(s)
product 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
catalyzer MngA protein nd nd
product PtsH simple_molecule nd nd
reactant mannosylglycerate_Ext simple_molecule nd nd
mngAB_mRNA MngB
Name: mngAB_mRNA -> MngB
Description: Translation of MngB
Type: translation
Pathway Components: mngAB_mRNA -> MngB
Components:
Function Name Type Evidence Reference(s)
product MngB protein nd nd
reactant mngAB_mRNA RNA nd nd
MngB 2(α-D-mannosyl-6-phosphate)-D-glycerate mannopyranose-6-P + glycerate
Name: 2(α-D-mannosyl-6-phosphate)-D-glycerate -> mannopyranose-6-P + glycerate
Description: Reaction transforming 2(α-D-mannosyl-6-phosphate)-D-glycerate into mannopyranose-6-P, glycerate
Type: state transition
Pathway Components: 2(α-D-mannosyl-6-phosphate)-D-glycerate - MngB -> mannopyranose-6-P + glycerate
Components:
Function Name Type Evidence Reference(s)
reactant 2(α-D-mannosyl-6-phosphate)-D-glycerate simple_molecule nd nd
catalyzer MngB protein nd nd
product glycerate simple_molecule nd nd
product mannopyranose-6-P simple_molecule nd nd
mngR_mRNA MngR
Name: mngR_mRNA -> MngR
Description: Translation of MngR
Type: translation
Pathway Components: mngR_mRNA -> MngR
Components:
Function Name Type Evidence Reference(s)
product MngR protein nd nd
reactant mngR_mRNA RNA nd nd



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