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MetR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
5,10-methenyltetrahydrofolate 5,10-methylenetetrahydrofolate 5,6,7,8-tetrahydropteridine 5-formyl-tetrahydrofolate 5-methyl-tetrahydrofolate 5-methyltetrahydropteroyltri-L-glutamate 6,7-dihydropteridine D-ala allo-thr GlyA Hmp L-allo-threonine homo-cys L-methionine L-serine MetE MetH MetR acetaldehyde glyA glyA_mRNA glycine hmp hmp_mRNA metE metE_mRNA metH metH_mRNA metR metR_mRNA nitrate NO oxygen pyridoxal 5'-phosphate pyridoxamine 5'-phosphate pyruvate THF H4PteGlu(n) MetR homo-cys


Gensor Unit       
Name: MetR
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): GO:0032843 - hydroperoxide reductase activity
GO:0008270 - zinc ion binding
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016491 - oxidoreductase activity
GO:0016020 - membrane
GO:0009086 - methionine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0005622 - intracellular
GO:0003824 - catalytic activity
GO:0015671 - oxygen transport
GO:0005344 - oxygen transporter activity
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Components:
Function Name Type
simple molecule H4PteGlu(n) simple molecule


Reactions       
Showing 20 reactions
hmp hmp_mRNA
Name: hmp -> hmp_mRNA
Description: Transcription of transcription unit hmp; reaction inhibition by Fur-Fe(II).
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product hmp_mRNA RNA nd nd
reactant hmp gene nd nd
metH metH_mRNA
Name: metH -> metH_mRNA
Description: Transcription of transcription unit metH; reaction inhibition by Fur-Fe(II).
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metH_mRNA RNA nd nd
reactant metH gene nd nd
MetR + homo-cys MetR-homo-cys
Name: MetR + homo-cys -> MetR-homo-cys
Description: Reaction transforming MetR, homo-cys into MetR-homo-cys
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MetR protein nd nd
reactant homo-cys simple molecule nd nd
product MetR-homo-cys complex nd nd
glyA glyA_mRNA
Name: glyA -> glyA_mRNA
Description: Transcription of transcription unit glyA; reaction inhibition by MetR-homo-cys.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product glyA_mRNA RNA nd nd
reactant glyA gene nd nd
metE metE_mRNA
Name: metE -> metE_mRNA
Description: Transcription of transcription unit metE; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metE_mRNA RNA nd nd
reactant metE gene nd nd
metR metR_mRNA
Name: metR -> metR_mRNA
Description: Transcription of transcription unit metR; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant metR gene nd nd
product metR_mRNA RNA nd nd
hmp_mRNA Hmp
Name: hmp_mRNA -> Hmp
Description: Translation of Hmp
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Hmp protein nd nd
reactant hmp_mRNA RNA nd nd
NO + oxygen nitrate
Name: NO + oxygen -> nitrate
Description: Reaction transforming NO, oxygen into nitrate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant NO simple molecule nd nd
product nitrate simple molecule nd nd
reactant oxygen simple molecule nd nd
5,6,7,8-tetrahydropteridine 6,7-dihydropteridine
Name: 5,6,7,8-tetrahydropteridine -> 6,7-dihydropteridine
Description: Reaction transforming 5,6,7,8-tetrahydropteridine into 6,7-dihydropteridine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 5,6,7,8-tetrahydropteridine simple molecule nd nd
product 6,7-dihydropteridine simple molecule nd nd
metR_mRNA MetR
Name: metR_mRNA -> MetR
Description: Translation of MetR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetR protein nd nd
reactant metR_mRNA RNA nd nd
metH_mRNA MetH
Name: metH_mRNA -> MetH
Description: Translation of MetH
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metH_mRNA RNA nd nd
product MetH protein nd nd
homo-cys + 5-methyl-tetrahydrofolate L-methionine + THF
Name: homo-cys + 5-methyl-tetrahydrofolate -> L-methionine + THF
Description: Reaction transforming homo-cys, 5-methyl-tetrahydrofolate into L-methionine, THF
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product THF simple molecule nd nd
reactant homo-cys simple molecule nd nd
product L-methionine simple molecule nd nd
reactant 5-methyl-tetrahydrofolate simple molecule nd nd
metE_mRNA MetE
Name: metE_mRNA -> MetE
Description: Translation of MetE
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metE_mRNA RNA nd nd
product MetE protein nd nd
5-methyltetrahydropteroyltri-L-glutamate + homo-cys L-methionine + H4PteGlu(n)
Name: 5-methyltetrahydropteroyltri-L-glutamate + homo-cys -> L-methionine + H4PteGlu(n)
Description: Reaction transforming 5-methyltetrahydropteroyltri-L-glutamate, homo-cys into L-methionine, H4PteGlu(n)
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product H4PteGlu(n) simple molecule nd nd
reactant homo-cys simple molecule nd nd
product L-methionine simple molecule nd nd
reactant 5-methyltetrahydropteroyltri-L-glutamate simple molecule nd nd
glyA_mRNA GlyA
Name: glyA_mRNA -> GlyA
Description: Translation of GlyA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant glyA_mRNA RNA nd nd
product GlyA protein nd nd
L-serine + THF 5,10-methylenetetrahydrofolate + glycine
Name: L-serine + THF -> 5,10-methylenetetrahydrofolate + glycine
Description: Reaction transforming L-serine, THF into 5,10-methylenetetrahydrofolate, glycine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-serine simple molecule nd nd
product glycine simple molecule nd nd
reactant THF simple molecule nd nd
product 5,10-methylenetetrahydrofolate simple molecule nd nd
5,10-methenyltetrahydrofolate 5-formyl-tetrahydrofolate
Name: 5,10-methenyltetrahydrofolate -> 5-formyl-tetrahydrofolate
Description: Reaction transforming 5,10-methenyltetrahydrofolate into 5-formyl-tetrahydrofolate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 5,10-methenyltetrahydrofolate simple molecule nd nd
product 5-formyl-tetrahydrofolate simple molecule nd nd
D-ala + PLP pyruvate + PMP
Name: D-ala + PLP -> pyruvate + PMP
Description: Reaction transforming D-ala, PLP into pyruvate, PMP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product PMP simple molecule nd nd
product pyruvate simple molecule nd nd
reactant D-ala simple molecule nd nd
reactant PLP simple molecule nd nd
allo-thr acetaldehyde + glycine
Name: allo-thr -> acetaldehyde + glycine
Description: Reaction transforming allo-thr into acetaldehyde, glycine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product glycine simple molecule nd nd
reactant allo-thr simple molecule nd nd
product acetaldehyde simple molecule nd nd
L-allo-threonine glycine + acetaldehyde
Name: L-allo-threonine -> glycine + acetaldehyde
Description: Reaction transforming L-allo-threonine into glycine, acetaldehyde
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-allo-threonine simple molecule nd nd
product acetaldehyde simple molecule nd nd
product glycine simple molecule nd nd



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