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MetR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
5,10-methenyltetrahydrofolate 5,10-methylenetetrahydrofolate 5,6,7,8-tetrahydropteridine 5-formyl-tetrahydrofolate 5-methyl-tetrahydrofolate 5-methyltetrahydropteroyltri-L-glutamate 6,7-dihydropteridine D-ala allo-thr GlyA Hmp L-allo-threonine homo-cys L-methionine L-serine MetE MetH MetR acetaldehyde glyA glyA_mRNA glycine hmp hmp_mRNA metE metE_mRNA metH metH_mRNA metR metR_mRNA nitrate NO oxygen pyridoxal 5'-phosphate pyridoxamine 5'-phosphate pyruvate THF H4PteGlu(n) MetR homo-cys


Gensor Unit       
Name: MetR
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): biological_process GO:0006565 - L-serine catabolic process
GO:0071500 - cellular response to nitrosative stress
GO:0019264 - glycine biosynthetic process from serine
GO:0006546 - glycine catabolic process
GO:0050667 - homocysteine metabolic process
GO:0009086 - methionine biosynthetic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005576 - extracellular region
GO:0005622 - intracellular
GO:0016020 - membrane
molecular_function GO:0003871 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0003677 - DNA binding
GO:0071949 - FAD binding
GO:0016597 - amino acid binding
GO:0031419 - cobalamin binding
GO:0005504 - fatty acid binding
GO:0004372 - glycine hydroxymethyltransferase activity
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Components: Show/Hide Components Table (39 more...)
Function Name Type
simple_molecule 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule
simple_molecule 6,7-dihydropteridine simple_molecule
simple_molecule CH-THF mono-L-glutamate simple_molecule
protein GlyA protein
simple_molecule H4PteGlu(n) simple_molecule
protein Hmp protein
protein MetE protein
protein MetH protein
protein MetR protein
complex MetR-homo-cys complex
simple_molecule N5-methyl-tetrahydrofolate simple_molecule
simple_molecule THF polyglutamate simple_molecule
simple_molecule ala simple_molecule
simple_molecule allo-thr simple_molecule
simple_molecule allo-threonine simple_molecule
simple_molecule ethanal simple_molecule
simple_molecule folinate simple_molecule
gene glyA gene
RNA glyA_mRNA RNA
simple_molecule glycine simple_molecule
gene hmp gene
RNA hmp_mRNA RNA
simple_molecule homo-cys simple_molecule
gene metE gene
RNA metE_mRNA RNA
gene metH gene
RNA metH_mRNA RNA
gene metR gene
RNA metR_mRNA RNA
simple_molecule methionine simple_molecule
simple_molecule methylene-H4PteGlu(n) simple_molecule
simple_molecule nitrate simple_molecule
simple_molecule nitric oxide simple_molecule
simple_molecule oxygen simple_molecule
simple_molecule pyridoxamine phosphate simple_molecule
simple_molecule pyruvate simple_molecule
simple_molecule serine simple_molecule
simple_molecule tetrahydropteridine simple_molecule
simple_molecule vitamin B6 simple_molecule


Reactions       
Showing 22 reactions
homo-cys + MetR MetR-homo-cys
Name: homo-cys + MetR -> MetR-homo-cys
Description: Reaction transforming homo-cys, MetR into MetR-homo-cys
Type: state transition
Pathway Components: homo-cys + MetR -> MetR-homo-cys
Components:
Function Name Type Evidence Reference(s)
reactant MetR protein nd nd
product MetR-homo-cys complex nd nd
reactant homo-cys simple_molecule nd nd
MetR-homo-cys hmp hmp_mRNA
Name: hmp -> hmp_mRNA
Description: Transcription of transcription unit hmp. Reaction activation by MetR-homo-cys.
Type: transcription
Pathway Components: hmp - MetR-homo-cys -> hmp_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MetR-homo-cys complex nd nd
reactant hmp gene nd nd
product hmp_mRNA RNA nd nd
MetR-homo-cys metE metE_mRNA
Name: metE -> metE_mRNA
Description: Transcription of transcription unit metE. Reaction activation by MetR-homo-cys.
Type: transcription
Pathway Components: metE - MetR-homo-cys -> metE_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MetR-homo-cys complex nd nd
reactant metE gene nd nd
product metE_mRNA RNA nd nd
MetR-homo-cys metH metH_mRNA
Name: metH -> metH_mRNA
Description: Transcription of transcription unit metH. Reaction activation by MetR-homo-cys.
Type: transcription
Pathway Components: metH - MetR-homo-cys -> metH_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MetR-homo-cys complex nd nd
reactant metH gene nd nd
product metH_mRNA RNA nd nd
MetR-homo-cys MetR-homo-cys glyA glyA_mRNA
Name: glyA -> glyA_mRNA
Description: Transcription of transcription unit glyA. Reaction activation by MetR-homo-cys. Reaction inhibition by MetR-homo-cys.
Type: transcription
Pathway Components: glyA - MetR-homo-cys - MetR-homo-cys -> glyA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MetR-homo-cys complex nd nd
inhibitor MetR-homo-cys complex nd nd
reactant glyA gene nd nd
product glyA_mRNA RNA nd nd
MetR-homo-cys metR metR_mRNA
Name: metR -> metR_mRNA
Description: Transcription of transcription unit metR. Reaction inhibition by MetR-homo-cys.
Type: transcription
Pathway Components: metR - MetR-homo-cys -> metR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor MetR-homo-cys complex nd nd
reactant metR gene nd nd
product metR_mRNA RNA nd nd
hmp_mRNA Hmp
Name: hmp_mRNA -> Hmp
Description: Translation of Hmp
Type: translation
Pathway Components: hmp_mRNA -> Hmp
Components:
Function Name Type Evidence Reference(s)
product Hmp protein nd nd
reactant hmp_mRNA RNA nd nd
Hmp nitric oxide + oxygen nitrate
Name: nitric oxide + oxygen -> nitrate
Description: Reaction transforming nitric oxide, oxygen into nitrate
Type: state transition
Pathway Components: nitric oxide + oxygen - Hmp -> nitrate
Components:
Function Name Type Evidence Reference(s)
catalyzer Hmp protein nd nd
product nitrate simple_molecule nd nd
reactant nitric oxide simple_molecule nd nd
reactant oxygen simple_molecule nd nd
Hmp tetrahydropteridine 6,7-dihydropteridine
Name: tetrahydropteridine -> 6,7-dihydropteridine
Description: Reaction transforming tetrahydropteridine into 6,7-dihydropteridine
Type: state transition
Pathway Components: tetrahydropteridine - Hmp -> 6,7-dihydropteridine
Components:
Function Name Type Evidence Reference(s)
product 6,7-dihydropteridine simple_molecule nd nd
catalyzer Hmp protein nd nd
reactant tetrahydropteridine simple_molecule nd nd
metR_mRNA MetR
Name: metR_mRNA -> MetR
Description: Translation of MetR
Type: translation
Pathway Components: metR_mRNA -> MetR
Components:
Function Name Type Evidence Reference(s)
product MetR protein nd nd
reactant metR_mRNA RNA nd nd
metE_mRNA MetE
Name: metE_mRNA -> MetE
Description: Translation of MetE
Type: translation
Pathway Components: metE_mRNA -> MetE
Components:
Function Name Type Evidence Reference(s)
product MetE protein nd nd
reactant metE_mRNA RNA nd nd
MetE MetH Reactants H4PteGlu(n) + methionine
Name: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys -> H4PteGlu(n) + methionine
Description: Reaction transforming 5-methyltetrahydropteroyl tri-L-glutamate, homo-cys into H4PteGlu(n), methionine
Type: state transition
Pathway Components: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys - MetE - MetH -> H4PteGlu(n) + methionine
Components:
Function Name Type Evidence Reference(s)
reactant 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule nd nd
product H4PteGlu(n) simple_molecule nd nd
catalyzer MetE protein nd nd
catalyzer MetH protein nd nd
reactant homo-cys simple_molecule nd nd
product methionine simple_molecule nd nd
metH_mRNA MetH
Name: metH_mRNA -> MetH
Description: Translation of MetH
Type: translation
Pathway Components: metH_mRNA -> MetH
Components:
Function Name Type Evidence Reference(s)
product MetH protein nd nd
reactant metH_mRNA RNA nd nd
MetH methionine N5-methyl-tetrahydrofolate + homo-cys THF polyglutamate + methionine
Name: N5-methyl-tetrahydrofolate + homo-cys -> THF polyglutamate + methionine
Description: Reaction transforming N5-methyl-tetrahydrofolate, homo-cys into THF polyglutamate, methionine
Type: state transition
Pathway Components: N5-methyl-tetrahydrofolate + homo-cys - MetH - methionine -> THF polyglutamate + methionine
Components:
Function Name Type Evidence Reference(s)
catalyzer MetH protein nd nd
reactant N5-methyl-tetrahydrofolate simple_molecule nd nd
product THF polyglutamate simple_molecule nd nd
reactant homo-cys simple_molecule nd nd
inhibitor methionine simple_molecule nd nd
product methionine simple_molecule nd nd
glyA_mRNA GlyA
Name: glyA_mRNA -> GlyA
Description: Translation of GlyA
Type: translation
Pathway Components: glyA_mRNA -> GlyA
Components:
Function Name Type Evidence Reference(s)
product GlyA protein nd nd
reactant glyA_mRNA RNA nd nd
GlyA ala THF polyglutamate + serine methylene-H4PteGlu(n) + glycine
Name: THF polyglutamate + serine -> methylene-H4PteGlu(n) + glycine
Description: Reaction transforming THF polyglutamate, serine into methylene-H4PteGlu(n), glycine
Type: state transition
Pathway Components: THF polyglutamate + serine - GlyA - ala -> methylene-H4PteGlu(n) + glycine
Components:
Function Name Type Evidence Reference(s)
catalyzer GlyA protein nd nd
reactant THF polyglutamate simple_molecule nd nd
inhibitor ala simple_molecule nd nd
product glycine simple_molecule nd nd
product methylene-H4PteGlu(n) simple_molecule nd nd
reactant serine simple_molecule nd nd
GlyA CH-THF mono-L-glutamate folinate
Name: CH-THF mono-L-glutamate -> folinate
Description: Reaction transforming CH-THF mono-L-glutamate into folinate
Type: state transition
Pathway Components: CH-THF mono-L-glutamate - GlyA -> folinate
Components:
Function Name Type Evidence Reference(s)
reactant CH-THF mono-L-glutamate simple_molecule nd nd
catalyzer GlyA protein nd nd
product folinate simple_molecule nd nd
GlyA vitamin B6 + ala pyridoxamine phosphate + pyruvate
Name: vitamin B6 + ala -> pyridoxamine phosphate + pyruvate
Description: Reaction transforming vitamin B6, ala into pyridoxamine phosphate, pyruvate
Type: state transition
Pathway Components: vitamin B6 + ala - GlyA -> pyridoxamine phosphate + pyruvate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlyA protein nd nd
reactant ala simple_molecule nd nd
product pyridoxamine phosphate simple_molecule nd nd
product pyruvate simple_molecule nd nd
reactant vitamin B6 simple_molecule nd nd
GlyA allo-thr ethanal + glycine
Name: allo-thr -> ethanal + glycine
Description: Reaction transforming allo-thr into ethanal, glycine
Type: state transition
Pathway Components: allo-thr - GlyA -> ethanal + glycine
Components:
Function Name Type Evidence Reference(s)
catalyzer GlyA protein nd nd
reactant allo-thr simple_molecule nd nd
product ethanal simple_molecule nd nd
product glycine simple_molecule nd nd
GlyA allo-threonine ethanal + glycine
Name: allo-threonine -> ethanal + glycine
Description: Reaction transforming allo-threonine into ethanal, glycine
Type: state transition
Pathway Components: allo-threonine - GlyA -> ethanal + glycine
Components:
Function Name Type Evidence Reference(s)
catalyzer GlyA protein nd nd
reactant allo-threonine simple_molecule nd nd
product ethanal simple_molecule nd nd
product glycine simple_molecule nd nd
glycine + THF polyglutamate N5-methyl-tetrahydrofolate
Name: glycine + THF polyglutamate -> N5-methyl-tetrahydrofolate
Description: Transformation of glycine, THF polyglutamate into N5-methyl-tetrahydrofolate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: glycine / GCVMULTI-RXN / 1.5.1.20-RXN / N5-methyl-tetrahydrofolate
Components:
Function Name Type Evidence Reference(s)
product N5-methyl-tetrahydrofolate simple_molecule nd nd
reactant THF polyglutamate simple_molecule nd nd
reactant glycine simple_molecule nd nd
THF polyglutamate methylene-H4PteGlu(n)
Name: THF polyglutamate -> methylene-H4PteGlu(n)
Description: Transformation of THF polyglutamate into methylene-H4PteGlu(n) by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: THF polyglutamate / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / methylene-H4PteGlu(n)
Components:
Function Name Type Evidence Reference(s)
reactant THF polyglutamate simple_molecule nd nd
product methylene-H4PteGlu(n) simple_molecule nd nd



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