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MetR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
vitamin B6 metR_mRNA methionine pyridoxamine phosphate MetR GlyA S-Ribosylhomocysteine allo-threonine ethanal folinate 5-methyltetrahydropteroyl tri-L-glutamate metE pyruvate allo-thr THF polyglutamate homo-cys oxygen glycine homo-cys metE_mRNA methylene-H4PteGlu(n) hmp_mRNA CH-THF mono-L-glutamate nitric oxide glyA Hmp hmp ala tetrahydropteridine metH_mRNA metH serine N5-methyl-tetrahydrofolate MetR metR H4PteGlu(n) MetH nitrate MetE glyA_mRNA 6,7-dihydropteridine glycine homo-cys homo-cys MetR


Gensor Unit       
Name: MetR
Classification:
Groups: Transcription
Energy production and conversion
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0006565 - L-serine catabolic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0044237 - cellular metabolic process
GO:0071500 - cellular response to nitrosative stress
GO:0006545 - glycine biosynthetic process
GO:0019264 - glycine biosynthetic process from serine
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005576 - extracellular region
GO:0005622 - intracellular
GO:0030288 - outer membrane-bounded periplasmic space
molecular_function GO:0003871 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0071949 - FAD binding
GO:0016597 - amino acid binding
GO:0003824 - catalytic activity
GO:0031419 - cobalamin binding
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Components:
  Function Name Type
  simple_molecule 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule
  simple_molecule 6,7-dihydropteridine simple_molecule
  simple_molecule CH-THF mono-L-glutamate simple_molecule
  protein GlyA protein
  simple_molecule H4PteGlu(n) simple_molecule
  protein Hmp protein
  protein MetE protein
  protein MetH protein
  protein MetR protein
  complex MetR-homo-cys complex
  simple_molecule N5-methyl-tetrahydrofolate simple_molecule
  simple_molecule S-Ribosylhomocysteine simple_molecule
  simple_molecule THF polyglutamate simple_molecule
  simple_molecule ala simple_molecule
  simple_molecule allo-thr simple_molecule
  simple_molecule allo-threonine simple_molecule
  simple_molecule ethanal simple_molecule
  simple_molecule folinate simple_molecule
  gene glyA gene
  RNA glyA_mRNA RNA
  simple_molecule glycine simple_molecule
  gene hmp gene
  RNA hmp_mRNA RNA
  simple_molecule homo-cys simple_molecule
  gene metE gene
  RNA metE_mRNA RNA
  gene metH gene
  RNA metH_mRNA RNA
  gene metR gene
  RNA metR_mRNA RNA
  simple_molecule methionine simple_molecule
  simple_molecule methylene-H4PteGlu(n) simple_molecule
  simple_molecule nitrate simple_molecule
  simple_molecule nitric oxide simple_molecule
  simple_molecule oxygen simple_molecule
  simple_molecule pyridoxamine phosphate simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule serine simple_molecule
  simple_molecule tetrahydropteridine simple_molecule
  simple_molecule vitamin B6 simple_molecule


Reactions       
Showing 23 reactions
homo-cys + MetR MetR-homo-cys
Name: homo-cys + MetR -> MetR-homo-cys
Description: Reaction transforming homo-cys, MetR into MetR-homo-cys
Type: state transition
Pathway Components: homo-cys + MetR -> MetR-homo-cys
Components:
Function Name Type
reactant MetR protein
product MetR-homo-cys complex
reactant homo-cys simple_molecule
MetR-homo-cys MetR-homo-cys glyA glyA_mRNA
Name: glyA -> glyA_mRNA
Description: Transcription of transcription unit glyA. Reaction activation by MetR-homo-cys. Reaction inhibition by MetR-homo-cys.
Type: transcription
Pathway Components: glyA - MetR-homo-cys - MetR-homo-cys -> glyA_mRNA
Components:
Function Name Type
activator MetR-homo-cys complex
inhibitor MetR-homo-cys complex
reactant glyA gene
product glyA_mRNA RNA
MetR-homo-cys metE metE_mRNA
Name: metE -> metE_mRNA
Description: Transcription of transcription unit metE. Reaction activation by MetR-homo-cys.
Type: transcription
Pathway Components: metE - MetR-homo-cys -> metE_mRNA
Components:
Function Name Type
activator MetR-homo-cys complex
reactant metE gene
product metE_mRNA RNA
MetR-homo-cys metR metR_mRNA
Name: metR -> metR_mRNA
Description: Transcription of transcription unit metR. Reaction inhibition by MetR-homo-cys.
Type: transcription
Pathway Components: metR - MetR-homo-cys -> metR_mRNA
Components:
Function Name Type
inhibitor MetR-homo-cys complex
reactant metR gene
product metR_mRNA RNA
MetR hmp hmp_mRNA
Name: hmp -> hmp_mRNA
Description: Transcription of transcription unit hmp. Reaction activation by MetR.
Type: transcription
Pathway Components: hmp - MetR -> hmp_mRNA
Components:
Function Name Type
activator MetR protein
reactant hmp gene
product hmp_mRNA RNA
MetR metH metH_mRNA
Name: metH -> metH_mRNA
Description: Transcription of transcription unit metH. Reaction activation by MetR.
Type: transcription
Pathway Components: metH - MetR -> metH_mRNA
Components:
Function Name Type
activator MetR protein
reactant metH gene
product metH_mRNA RNA
hmp_mRNA Hmp
Name: hmp_mRNA -> Hmp
Description: Translation of Hmp
Type: translation
Pathway Components: hmp_mRNA -> Hmp
Components:
Function Name Type
product Hmp protein
reactant hmp_mRNA RNA
Hmp nitric oxide + oxygen nitrate
Name: nitric oxide + oxygen -> nitrate
Description: Reaction transforming nitric oxide, oxygen into nitrate
Type: state transition
Pathway Components: nitric oxide + oxygen - Hmp -> nitrate
Components:
Function Name Type
catalyzer Hmp protein
product nitrate simple_molecule
reactant nitric oxide simple_molecule
reactant oxygen simple_molecule
Hmp 6,7-dihydropteridine tetrahydropteridine
Name: 6,7-dihydropteridine -> tetrahydropteridine
Description: Reaction transforming 6,7-dihydropteridine into tetrahydropteridine
Type: state transition
Pathway Components: 6,7-dihydropteridine - Hmp -> tetrahydropteridine
Components:
Function Name Type
reactant 6,7-dihydropteridine simple_molecule
catalyzer Hmp protein
product tetrahydropteridine simple_molecule
metE_mRNA MetE
Name: metE_mRNA -> MetE
Description: Translation of MetE
Type: translation
Pathway Components: metE_mRNA -> MetE
Components:
Function Name Type
product MetE protein
reactant metE_mRNA RNA
MetE MetH Reactants H4PteGlu(n) + methionine
Name: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys -> H4PteGlu(n) + methionine
Description: Reaction transforming 5-methyltetrahydropteroyl tri-L-glutamate, homo-cys into H4PteGlu(n), methionine
Type: state transition
Pathway Components: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys - MetE - MetH -> H4PteGlu(n) + methionine
Components:
Function Name Type
reactant 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule
product H4PteGlu(n) simple_molecule
catalyzer MetE protein
catalyzer MetH protein
reactant homo-cys simple_molecule
product methionine simple_molecule
metH_mRNA MetH
Name: metH_mRNA -> MetH
Description: Translation of MetH
Type: translation
Pathway Components: metH_mRNA -> MetH
Components:
Function Name Type
product MetH protein
reactant metH_mRNA RNA
MetH methionine N5-methyl-tetrahydrofolate + homo-cys THF polyglutamate + methionine
Name: N5-methyl-tetrahydrofolate + homo-cys -> THF polyglutamate + methionine
Description: Reaction transforming N5-methyl-tetrahydrofolate, homo-cys into THF polyglutamate, methionine
Type: state transition
Pathway Components: N5-methyl-tetrahydrofolate + homo-cys - MetH - methionine -> THF polyglutamate + methionine
Components:
Function Name Type
catalyzer MetH protein
reactant N5-methyl-tetrahydrofolate simple_molecule
product THF polyglutamate simple_molecule
reactant homo-cys simple_molecule
inhibitor methionine simple_molecule
product methionine simple_molecule
glyA_mRNA GlyA
Name: glyA_mRNA -> GlyA
Description: Translation of GlyA
Type: translation
Pathway Components: glyA_mRNA -> GlyA
Components:
Function Name Type
product GlyA protein
reactant glyA_mRNA RNA
GlyA ala THF polyglutamate + serine methylene-H4PteGlu(n) + glycine
Name: THF polyglutamate + serine -> methylene-H4PteGlu(n) + glycine
Description: Reaction transforming THF polyglutamate, serine into methylene-H4PteGlu(n), glycine
Type: state transition
Pathway Components: THF polyglutamate + serine - GlyA - ala -> methylene-H4PteGlu(n) + glycine
Components:
Function Name Type
catalyzer GlyA protein
reactant THF polyglutamate simple_molecule
inhibitor ala simple_molecule
product glycine simple_molecule
product methylene-H4PteGlu(n) simple_molecule
reactant serine simple_molecule
GlyA CH-THF mono-L-glutamate folinate
Name: CH-THF mono-L-glutamate -> folinate
Description: Reaction transforming CH-THF mono-L-glutamate into folinate
Type: state transition
Pathway Components: CH-THF mono-L-glutamate - GlyA -> folinate
Components:
Function Name Type
reactant CH-THF mono-L-glutamate simple_molecule
catalyzer GlyA protein
product folinate simple_molecule
GlyA vitamin B6 + ala pyridoxamine phosphate + pyruvate
Name: vitamin B6 + ala -> pyridoxamine phosphate + pyruvate
Description: Reaction transforming vitamin B6, ala into pyridoxamine phosphate, pyruvate
Type: state transition
Pathway Components: vitamin B6 + ala - GlyA -> pyridoxamine phosphate + pyruvate
Components:
Function Name Type
catalyzer GlyA protein
reactant ala simple_molecule
product pyridoxamine phosphate simple_molecule
product pyruvate simple_molecule
reactant vitamin B6 simple_molecule
GlyA allo-thr glycine + ethanal
Name: allo-thr -> glycine + ethanal
Description: Reaction transforming allo-thr into glycine, ethanal
Type: state transition
Pathway Components: allo-thr - GlyA -> glycine + ethanal
Components:
Function Name Type
catalyzer GlyA protein
reactant allo-thr simple_molecule
product ethanal simple_molecule
product glycine simple_molecule
GlyA allo-threonine ethanal + glycine
Name: allo-threonine -> ethanal + glycine
Description: Reaction transforming allo-threonine into ethanal, glycine
Type: state transition
Pathway Components: allo-threonine - GlyA -> ethanal + glycine
Components:
Function Name Type
catalyzer GlyA protein
reactant allo-threonine simple_molecule
product ethanal simple_molecule
product glycine simple_molecule
metR_mRNA MetR
Name: metR_mRNA -> MetR
Description: Translation of MetR
Type: translation
Pathway Components: metR_mRNA -> MetR
Components:
Function Name Type
product MetR protein
reactant metR_mRNA RNA
glycine + THF polyglutamate N5-methyl-tetrahydrofolate
Name: glycine + THF polyglutamate -> N5-methyl-tetrahydrofolate
Description: Transformation of glycine, THF polyglutamate into N5-methyl-tetrahydrofolate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: glycine / GCVMULTI-RXN / 1.5.1.20-RXN / N5-methyl-tetrahydrofolate
Components:
Function Name Type
product N5-methyl-tetrahydrofolate simple_molecule
reactant THF polyglutamate simple_molecule
reactant glycine simple_molecule
THF polyglutamate methylene-H4PteGlu(n)
Name: THF polyglutamate -> methylene-H4PteGlu(n)
Description: Transformation of THF polyglutamate into methylene-H4PteGlu(n) by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: THF polyglutamate / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / 1.5.1.20-RXN / HOMOCYSMETB12-RXN / GCVMULTI-RXN / methylene-H4PteGlu(n)
Components:
Function Name Type
reactant THF polyglutamate simple_molecule
product methylene-H4PteGlu(n) simple_molecule
methionine S-Ribosylhomocysteine
Name: methionine -> S-Ribosylhomocysteine
Description: Transformation of methionine into S-Ribosylhomocysteine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: methionine / S-ADENMETSYN-RXN / RXN-7605 / ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN / S-Ribosylhomocysteine
Components:
Function Name Type
product S-Ribosylhomocysteine simple_molecule
reactant methionine simple_molecule



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