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MelR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
lithium ion lithium ion_Ext MelA MelB MelR Sodium Sodium_Ext alpha-D-galactose beta-glucose melAB melAB_mRNA melR melR_mRNA melibiose melibiose_Ext a-methyl-D-galactoside a-methyl-D-galactoside_Ext b-methyl-D-galactoside b-methyl-D-galactoside_Ext melibiose MelR MelR melibiose


Gensor Unit       
Name: MelR
Description: Molecular biology level
Detailed: In the presence but also in the absence of melibiose, MelR dually regulates the expression of genes required for methylgalactoside transport and melibiose transport and catabolism. In the presence of melibiose, MelR is modified to MelR-melibiose, binds its target sites enabling or preventing its own expression and the expression of its regulated genes. In the absence of melibiose, MelR can also binds its target sites enabling or preventing its own expression and the expression of its regulated genes.
Less detailed: In the presence but also in the absence of melibiose, MelR dually regulates the expression of genes needed for methyl galactoside transport, and melibiose transport and catabolic process.

Physiology level
Detailed: The presence of melibiose induces in some case and inhibits in others the expression of genes involved with methylgalactoside transport and melibiose transport and catabolism. Under this condition the genes necessary for methylgalactoside and melibiose transport, and for conversion of melibiose to galactose and glucose are in some cases expressed and repressed in other.
Less detailed: The presence of melibiose induce and inhibits the expression of genes needful for methylgalactoside and melibiose transport, and for conversion of melibiose to galactose and glucose
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0034219 - carbohydrate transmembrane transport
GO:0098655 - cation transmembrane transport
GO:0005995 - melibiose catabolic process
GO:0015769 - melibiose transport
GO:0015765 - methylgalactoside transport
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
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cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA binding transcription factor activity
GO:0070403 - NAD+ binding
GO:0004557 - alpha-galactosidase activity
GO:0015486 - glycoside-pentoside-hexuronide:cation symporter activity
GO:0019172 - glyoxalase III activity
GO:0030145 - manganese ion binding
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Components: Show/Hide Components Table (20 more...)
Function Name Type
protein MelA protein
protein MelB protein
protein MelR protein
complex MelR-melibiose complex
simple_molecule Sodium simple_molecule
simple_molecule Sodium_Ext simple_molecule
simple_molecule a-methyl-D-galactoside simple_molecule
simple_molecule a-methyl-D-galactoside_Ext simple_molecule
simple_molecule b-methyl-D-galactoside simple_molecule
simple_molecule b-methyl-D-galactoside_Ext simple_molecule
simple_molecule galactopyranose simple_molecule
simple_molecule glucopyranose simple_molecule
simple_molecule lithium ion simple_molecule
simple_molecule lithium ion_Ext simple_molecule
gene melAB gene
RNA melAB_mRNA RNA
gene melR gene
RNA melR_mRNA RNA
simple_molecule melibiose simple_molecule
simple_molecule melibiose_Ext simple_molecule


Reactions       
Showing 12 reactions
MelR MelR MelR-melibiose MelR-melibiose melAB melAB_mRNA
Name: melAB -> melAB_mRNA
Description: Transcription of transcription unit melAB. Reaction activation by MelR, and MelR-melibiose. Reaction inhibition by MelR, and MelR-melibiose.
Type: transcription
Pathway Components: melAB - MelR - MelR-melibiose - MelR - MelR-melibiose -> melAB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MelR protein nd nd
inhibitor MelR protein nd nd
activator MelR-melibiose complex nd nd
inhibitor MelR-melibiose complex nd nd
reactant melAB gene nd nd
product melAB_mRNA RNA nd nd
MelR MelR MelR-melibiose MelR-melibiose melR melR_mRNA
Name: melR -> melR_mRNA
Description: Transcription of transcription unit melR. Reaction activation by MelR, and MelR-melibiose. Reaction inhibition by MelR, and MelR-melibiose.
Type: transcription
Pathway Components: melR - MelR - MelR-melibiose - MelR - MelR-melibiose -> melR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator MelR protein nd nd
inhibitor MelR protein nd nd
activator MelR-melibiose complex nd nd
inhibitor MelR-melibiose complex nd nd
reactant melR gene nd nd
product melR_mRNA RNA nd nd
melibiose + MelR MelR-melibiose
Name: melibiose + MelR -> MelR-melibiose
Description: Reaction transforming melibiose, MelR into MelR-melibiose
Type: state transition
Pathway Components: melibiose + MelR -> MelR-melibiose
Components:
Function Name Type Evidence Reference(s)
reactant MelR protein nd nd
product MelR-melibiose complex nd nd
reactant melibiose simple_molecule nd nd
melR_mRNA MelR
Name: melR_mRNA -> MelR
Description: Translation of MelR
Type: translation
Pathway Components: melR_mRNA -> MelR
Components:
Function Name Type Evidence Reference(s)
product MelR protein nd nd
reactant melR_mRNA RNA nd nd
melAB_mRNA MelA
Name: melAB_mRNA -> MelA
Description: Translation of MelA
Type: translation
Pathway Components: melAB_mRNA -> MelA
Components:
Function Name Type Evidence Reference(s)
product MelA protein nd nd
reactant melAB_mRNA RNA nd nd
MelA melibiose galactopyranose + glucopyranose
Name: melibiose -> galactopyranose + glucopyranose
Description: Reaction transforming melibiose into galactopyranose, glucopyranose
Type: state transition
Pathway Components: melibiose - MelA -> galactopyranose + glucopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer MelA protein nd nd
product galactopyranose simple_molecule nd nd
product glucopyranose simple_molecule nd nd
reactant melibiose simple_molecule nd nd
melAB_mRNA MelB
Name: melAB_mRNA -> MelB
Description: Translation of MelB
Type: translation
Pathway Components: melAB_mRNA -> MelB
Components:
Function Name Type Evidence Reference(s)
product MelB protein nd nd
reactant melAB_mRNA RNA nd nd
MelB lithium ion_Ext + melibiose_Ext lithium ion + melibiose
Name: lithium ion_Ext + melibiose_Ext -> lithium ion + melibiose
Description: Transport of lithium ion_Ext, melibiose_Ext through a bacterial membrane, leading to the presence of lithium ion, melibiose inside the cell.
Type: transport
Pathway Components: lithium ion_Ext + melibiose_Ext - MelB -> lithium ion + melibiose
Components:
Function Name Type Evidence Reference(s)
catalyzer MelB protein nd nd
product lithium ion simple_molecule nd nd
reactant lithium ion_Ext simple_molecule nd nd
product melibiose simple_molecule nd nd
reactant melibiose_Ext simple_molecule nd nd
MelB melibiose_Ext + Sodium_Ext melibiose + Sodium
Name: melibiose_Ext + Sodium_Ext -> melibiose + Sodium
Description: Transport of melibiose_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of melibiose, Sodium inside the cell.
Type: transport
Pathway Components: melibiose_Ext + Sodium_Ext - MelB -> melibiose + Sodium
Components:
Function Name Type Evidence Reference(s)
catalyzer MelB protein nd nd
product Sodium simple_molecule nd nd
reactant Sodium_Ext simple_molecule nd nd
product melibiose simple_molecule nd nd
reactant melibiose_Ext simple_molecule nd nd
MelB b-methyl-D-galactoside_Ext + Sodium_Ext b-methyl-D-galactoside + Sodium
Name: b-methyl-D-galactoside_Ext + Sodium_Ext -> b-methyl-D-galactoside + Sodium
Description: Transport of b-methyl-D-galactoside_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside, Sodium inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext + Sodium_Ext - MelB -> b-methyl-D-galactoside + Sodium
Components:
Function Name Type Evidence Reference(s)
catalyzer MelB protein nd nd
product Sodium simple_molecule nd nd
reactant Sodium_Ext simple_molecule nd nd
product b-methyl-D-galactoside simple_molecule nd nd
reactant b-methyl-D-galactoside_Ext simple_molecule nd nd
MelB a-methyl-D-galactoside_Ext a-methyl-D-galactoside
Name: a-methyl-D-galactoside_Ext -> a-methyl-D-galactoside
Description: Transport of a-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of a-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: a-methyl-D-galactoside_Ext - MelB -> a-methyl-D-galactoside
Components:
Function Name Type Evidence Reference(s)
catalyzer MelB protein nd nd
product a-methyl-D-galactoside simple_molecule nd nd
reactant a-methyl-D-galactoside_Ext simple_molecule nd nd
MelB melibiose_Ext melibiose
Name: melibiose_Ext -> melibiose
Description: Transport of melibiose_Ext through a bacterial membrane, leading to the presence of melibiose inside the cell.
Type: transport
Pathway Components: melibiose_Ext - MelB -> melibiose
Components:
Function Name Type Evidence Reference(s)
catalyzer MelB protein nd nd
product melibiose simple_molecule nd nd
reactant melibiose_Ext simple_molecule nd nd



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