RegulonDB RegulonDB

MetJ Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
methionine metC_mRNA 5-methyltetrahydropteroyl tri-L-glutamate MetN suc-coa methionine-(S)-S-oxide Methionine S-oxide_Ext MetJ MetI MetC MetL folE-yeiB AhpF methionine-R-sulfoxide_Ext AhpC methionine_Ext 2-oxobutyrate ahpCF N5-methyl-tetrahydrofolate metA pyruvate ROOH folE-yeiB_mRNA SAM (2Z)-2-aminobut-2-enoate MetE MetB MetA phosphate dehydroalanine AhpC MetQ MetR metK_mRNA Methionine S-oxide methionine-R-sulfoxide MetI metBL MetN MetQ MetK sulfide metF_mRNA aspartyl-4-P metNIQ_mRNA acetyl-DL-methionine_Ext metK formate metE_mRNA YeiB metNIQ MetJ FolE metR_mRNA homo-ser diphosphate cystathionine metC acetyl-DL-methionine H4PteGlu(n) ahpCF_mRNA methylene-H4PteGlu(n) metR alcohol H2NTP ammonium metBL_mRNA MetF methionine-(S)-S-oxide_Ext guanosine-triphosphate coenzyme A homo-cys succinate aspartate metF succinyl-homoserine AhpF SAM cysteine aspartate-semialdehyde metA_mRNA metE homo-cys SAM SAM methionine cysteine succinate


Gensor Unit       
Name: MetJ
Description: Molecular biology level
Detailed: In the presence of S-adenosyl-L-methionine, MetJ negatively regulates the expression of genes required for methionine, S-adenosylmethionine and tetrahydrofolate biosynthetic processes and response to hydroperoxide. Under this condition, MetJ is modified to MetJ-S-adenosyl-L-methionine, binds its target sites preventing the expression of its regulated genes. In the absence of S-adenosyl-L-methionine, MetJ unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of S-adenosyl-L-methionine, MetJ negatively regulates the expression of genes needed for methionine, S-adenosylmethionine, and tetrahydrofolate biosynthesis and the genes required in response to hydroperoxide.

Physiology level
Detailed: The presence of S-adenosyl-L-methionine inhibits the expression of genes involved with methionine, S-adenosylmethionine and tetrahydrofolate biosynthesis and the genes necessary to respond to hydroperoxide. Under this condition, the genes necessary for methionine transport, conversion of homocysteine to methionine, conversion of L-cysteine to dehydroalanine are not expressed.
Less detailed: The presence of S-adenosyl-L-methionine inhibits the expression of genes needful for methionine, S-adenosylmethionine and tetrahydrofolate biosynthesis and the genes necessary to respond to hydroperoxide.
Classification:
Groups: Inorganic ion transport and metabolism
Transcription
Amino acid transport and metabolism
Coenzyme transport and metabolism
Defense mechanisms
Gene Ontology Terms (GO): biological_process GO:0035998 - 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0048473 - D-methionine transport
GO:1902475 - L-alpha-amino acid transmembrane transport
GO:0019450 - L-cysteine catabolic process to pyruvate
GO:0019281 - L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO:0006556 - S-adenosylmethionine biosynthetic process
Read more >
cellular_component GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:0009276 - Gram-negative-bacterium-type cell wall
GO:0009321 - alkyl hydroperoxide reductase complex
GO:0046658 - anchored component of plasma membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005576 - extracellular region
Read more >
molecular_function GO:0003871 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0048474 - D-methionine transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
Read more >
Components:
  Function Name Type
  simple_molecule (2Z)-2-aminobut-2-enoate simple_molecule
  simple_molecule 2-oxobutyrate simple_molecule
  simple_molecule 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule
  protein AhpC protein
  complex AhpC-AhpF complex
  protein AhpF protein
  protein FolE protein
  simple_molecule H2NTP simple_molecule
  simple_molecule H4PteGlu(n) simple_molecule
  protein MetA protein
  protein MetB protein
  protein MetC protein
  protein MetE protein
  protein MetF protein
  protein MetI protein
  protein MetJ protein
  complex MetJ-SAM complex
  protein MetK protein
  protein MetL protein
  protein MetN protein
  complex MetN-MetI-MetQ complex
  protein MetQ protein
  protein MetR protein
  simple_molecule Methionine S-oxide simple_molecule
  simple_molecule Methionine S-oxide_Ext simple_molecule
  simple_molecule N5-methyl-tetrahydrofolate simple_molecule
  simple_molecule ROOH simple_molecule
  simple_molecule SAM simple_molecule
  protein YeiB protein
  simple_molecule acetyl-DL-methionine simple_molecule
  simple_molecule acetyl-DL-methionine_Ext simple_molecule
  gene ahpCF gene
  RNA ahpCF_mRNA RNA
  simple_molecule alcohol simple_molecule
  simple_molecule ammonium simple_molecule
  simple_molecule aspartate simple_molecule
  simple_molecule aspartate-semialdehyde simple_molecule
  simple_molecule aspartyl-4-P simple_molecule
  simple_molecule coenzyme A simple_molecule
  simple_molecule cystathionine simple_molecule
  simple_molecule cysteine simple_molecule
  simple_molecule dehydroalanine simple_molecule
  simple_molecule diphosphate simple_molecule
  gene folE-yeiB gene
  RNA folE-yeiB_mRNA RNA
  simple_molecule formate simple_molecule
  simple_molecule guanosine-triphosphate simple_molecule
  simple_molecule homo-cys simple_molecule
  simple_molecule homo-ser simple_molecule
  gene metA gene
  RNA metA_mRNA RNA
  gene metBL gene
  RNA metBL_mRNA RNA
  gene metC gene
  RNA metC_mRNA RNA
  gene metE gene
  RNA metE_mRNA RNA
  gene metF gene
  RNA metF_mRNA RNA
  gene metK gene
  RNA metK_mRNA RNA
  gene metNIQ gene
  RNA metNIQ_mRNA RNA
  gene metR gene
  RNA metR_mRNA RNA
  simple_molecule methionine simple_molecule
  simple_molecule methionine-(S)-S-oxide simple_molecule
  simple_molecule methionine-(S)-S-oxide_Ext simple_molecule
  simple_molecule methionine-R-sulfoxide simple_molecule
  simple_molecule methionine-R-sulfoxide_Ext simple_molecule
  simple_molecule methionine_Ext simple_molecule
  simple_molecule methylene-H4PteGlu(n) simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule suc-coa simple_molecule
  simple_molecule succinate simple_molecule
  simple_molecule succinyl-homoserine simple_molecule
  simple_molecule sulfide simple_molecule


Reactions       
Showing 51 reactions
MetJ + SAM MetJ-SAM
Name: MetJ + SAM -> MetJ-SAM
Description: Reaction transforming MetJ, SAM into MetJ-SAM
Type: state transition
Pathway Components: MetJ + SAM -> MetJ-SAM
Components:
Function Name Type
reactant MetJ protein
product MetJ-SAM complex
reactant SAM simple_molecule
MetJ-SAM ahpCF ahpCF_mRNA
Name: ahpCF -> ahpCF_mRNA
Description: Transcription of transcription unit ahpCF. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: ahpCF - MetJ-SAM -> ahpCF_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant ahpCF gene
product ahpCF_mRNA RNA
MetJ-SAM folE-yeiB folE-yeiB_mRNA
Name: folE-yeiB -> folE-yeiB_mRNA
Description: Transcription of transcription unit folE-yeiB. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: folE-yeiB - MetJ-SAM -> folE-yeiB_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant folE-yeiB gene
product folE-yeiB_mRNA RNA
MetJ-SAM metA metA_mRNA
Name: metA -> metA_mRNA
Description: Transcription of transcription unit metA. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metA - MetJ-SAM -> metA_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metA gene
product metA_mRNA RNA
MetJ-SAM metBL metBL_mRNA
Name: metBL -> metBL_mRNA
Description: Transcription of transcription unit metBL. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metBL - MetJ-SAM -> metBL_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metBL gene
product metBL_mRNA RNA
MetJ-SAM metC metC_mRNA
Name: metC -> metC_mRNA
Description: Transcription of transcription unit metC. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metC - MetJ-SAM -> metC_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metC gene
product metC_mRNA RNA
MetJ-SAM metE metE_mRNA
Name: metE -> metE_mRNA
Description: Transcription of transcription unit metE. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metE - MetJ-SAM -> metE_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metE gene
product metE_mRNA RNA
MetJ-SAM metF metF_mRNA
Name: metF -> metF_mRNA
Description: Transcription of transcription unit metF. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metF - MetJ-SAM -> metF_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metF gene
product metF_mRNA RNA
MetJ-SAM metK metK_mRNA
Name: metK -> metK_mRNA
Description: Transcription of transcription unit metK. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metK - MetJ-SAM -> metK_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metK gene
product metK_mRNA RNA
MetJ-SAM metNIQ metNIQ_mRNA
Name: metNIQ -> metNIQ_mRNA
Description: Transcription of transcription unit metNIQ. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metNIQ - MetJ-SAM -> metNIQ_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metNIQ gene
product metNIQ_mRNA RNA
MetJ-SAM metR metR_mRNA
Name: metR -> metR_mRNA
Description: Transcription of transcription unit metR. Reaction inhibition by MetJ-SAM.
Type: transcription
Pathway Components: metR - MetJ-SAM -> metR_mRNA
Components:
Function Name Type
inhibitor MetJ-SAM complex
reactant metR gene
product metR_mRNA RNA
metA_mRNA MetA
Name: metA_mRNA -> MetA
Description: Translation of MetA
Type: translation
Pathway Components: metA_mRNA -> MetA
Components:
Function Name Type
product MetA protein
reactant metA_mRNA RNA
MetA SAM methionine homo-ser + suc-coa succinyl-homoserine + coenzyme A
Name: homo-ser + suc-coa -> succinyl-homoserine + coenzyme A
Description: Reaction transforming homo-ser, suc-coa into succinyl-homoserine, coenzyme A
Type: state transition
Pathway Components: homo-ser + suc-coa - MetA - SAM - methionine -> succinyl-homoserine + coenzyme A
Components:
Function Name Type
catalyzer MetA protein
inhibitor SAM simple_molecule
product coenzyme A simple_molecule
reactant homo-ser simple_molecule
inhibitor methionine simple_molecule
reactant suc-coa simple_molecule
product succinyl-homoserine simple_molecule
metR_mRNA MetR
Name: metR_mRNA -> MetR
Description: Translation of MetR
Type: translation
Pathway Components: metR_mRNA -> MetR
Components:
Function Name Type
product MetR protein
reactant metR_mRNA RNA
metK_mRNA MetK
Name: metK_mRNA -> MetK
Description: Translation of MetK
Type: translation
Pathway Components: metK_mRNA -> MetK
Components:
Function Name Type
product MetK protein
reactant metK_mRNA RNA
MetK SAM methionine diphosphate + phosphate + SAM
Name: methionine -> diphosphate + phosphate + SAM
Description: Reaction transforming methionine into diphosphate, phosphate , SAM
Type: state transition
Pathway Components: methionine - MetK - SAM -> diphosphate + phosphate + SAM
Components:
Function Name Type
catalyzer MetK protein
inhibitor SAM simple_molecule
product SAM simple_molecule
product diphosphate simple_molecule
reactant methionine simple_molecule
product phosphate simple_molecule
metF_mRNA MetF
Name: metF_mRNA -> MetF
Description: Translation of MetF
Type: translation
Pathway Components: metF_mRNA -> MetF
Components:
Function Name Type
product MetF protein
reactant metF_mRNA RNA
MetF methylene-H4PteGlu(n) N5-methyl-tetrahydrofolate
Name: methylene-H4PteGlu(n) -> N5-methyl-tetrahydrofolate
Description: Reaction transforming methylene-H4PteGlu(n) into N5-methyl-tetrahydrofolate
Type: state transition
Pathway Components: methylene-H4PteGlu(n) - MetF -> N5-methyl-tetrahydrofolate
Components:
Function Name Type
catalyzer MetF protein
product N5-methyl-tetrahydrofolate simple_molecule
reactant methylene-H4PteGlu(n) simple_molecule
ahpCF_mRNA AhpC
Name: ahpCF_mRNA -> AhpC
Description: Translation of AhpC
Type: translation
Pathway Components: ahpCF_mRNA -> AhpC
Components:
Function Name Type
product AhpC protein
reactant ahpCF_mRNA RNA
AhpC + AhpF AhpC-AhpF
Name: AhpC + AhpF -> AhpC-AhpF
Description: Reaction transforming AhpC, AhpF into AhpC-AhpF
Type: state transition
Pathway Components: AhpC + AhpF -> AhpC-AhpF
Components:
Function Name Type
reactant AhpC protein
product AhpC-AhpF complex
reactant AhpF protein
AhpC-AhpF ROOH alcohol
Name: ROOH -> alcohol
Description: Reaction transforming ROOH into alcohol
Type: state transition
Pathway Components: ROOH - AhpC-AhpF -> alcohol
Components:
Function Name Type
catalyzer AhpC-AhpF complex
reactant ROOH simple_molecule
product alcohol simple_molecule
ahpCF_mRNA AhpF
Name: ahpCF_mRNA -> AhpF
Description: Translation of AhpF
Type: translation
Pathway Components: ahpCF_mRNA -> AhpF
Components:
Function Name Type
product AhpF protein
reactant ahpCF_mRNA RNA
folE-yeiB_mRNA FolE
Name: folE-yeiB_mRNA -> FolE
Description: Translation of FolE
Type: translation
Pathway Components: folE-yeiB_mRNA -> FolE
Components:
Function Name Type
product FolE protein
reactant folE-yeiB_mRNA RNA
FolE guanosine-triphosphate formate + H2NTP
Name: guanosine-triphosphate -> formate + H2NTP
Description: Reaction transforming guanosine-triphosphate into formate, H2NTP
Type: state transition
Pathway Components: guanosine-triphosphate - FolE -> formate + H2NTP
Components:
Function Name Type
catalyzer FolE protein
product H2NTP simple_molecule
product formate simple_molecule
reactant guanosine-triphosphate simple_molecule
folE-yeiB_mRNA YeiB
Name: folE-yeiB_mRNA -> YeiB
Description: Translation of YeiB
Type: translation
Pathway Components: folE-yeiB_mRNA -> YeiB
Components:
Function Name Type
product YeiB protein
reactant folE-yeiB_mRNA RNA
metC_mRNA MetC
Name: metC_mRNA -> MetC
Description: Translation of MetC
Type: translation
Pathway Components: metC_mRNA -> MetC
Components:
Function Name Type
product MetC protein
reactant metC_mRNA RNA
MetC cysteine cystathionine homo-cys + pyruvate + ammonium
Name: cystathionine -> homo-cys + pyruvate + ammonium
Description: Reaction transforming cystathionine into homo-cys, pyruvate , ammonium
Type: state transition
Pathway Components: cystathionine - MetC - cysteine -> homo-cys + pyruvate + ammonium
Components:
Function Name Type
catalyzer MetC protein
product ammonium simple_molecule
reactant cystathionine simple_molecule
inhibitor cysteine simple_molecule
product homo-cys simple_molecule
product pyruvate simple_molecule
MetC cystathionine dehydroalanine + homo-cys
Name: cystathionine -> dehydroalanine + homo-cys
Description: Reaction transforming cystathionine into dehydroalanine, homo-cys
Type: state transition
Pathway Components: cystathionine - MetC -> dehydroalanine + homo-cys
Components:
Function Name Type
catalyzer MetC protein
reactant cystathionine simple_molecule
product dehydroalanine simple_molecule
product homo-cys simple_molecule
MetC cysteine ammonium + pyruvate + sulfide
Name: cysteine -> ammonium + pyruvate + sulfide
Description: Reaction transforming cysteine into ammonium, pyruvate , sulfide
Type: state transition
Pathway Components: cysteine - MetC -> ammonium + pyruvate + sulfide
Components:
Function Name Type
catalyzer MetC protein
product ammonium simple_molecule
reactant cysteine simple_molecule
product pyruvate simple_molecule
product sulfide simple_molecule
MetC cysteine dehydroalanine + sulfide
Name: cysteine -> dehydroalanine + sulfide
Description: Reaction transforming cysteine into dehydroalanine, sulfide
Type: state transition
Pathway Components: cysteine - MetC -> dehydroalanine + sulfide
Components:
Function Name Type
catalyzer MetC protein
reactant cysteine simple_molecule
product dehydroalanine simple_molecule
product sulfide simple_molecule
metBL_mRNA MetB
Name: metBL_mRNA -> MetB
Description: Translation of MetB
Type: translation
Pathway Components: metBL_mRNA -> MetB
Components:
Function Name Type
product MetB protein
reactant metBL_mRNA RNA
MetB succinyl-homoserine + cysteine cystathionine + succinate
Name: succinyl-homoserine + cysteine -> cystathionine + succinate
Description: Reaction transforming succinyl-homoserine, cysteine into cystathionine, succinate
Type: state transition
Pathway Components: succinyl-homoserine + cysteine - MetB -> cystathionine + succinate
Components:
Function Name Type
catalyzer MetB protein
product cystathionine simple_molecule
reactant cysteine simple_molecule
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
MetB succinyl-homoserine 2-oxobutyrate + succinate + ammonium
Name: succinyl-homoserine -> 2-oxobutyrate + succinate + ammonium
Description: Reaction transforming succinyl-homoserine into 2-oxobutyrate, succinate , ammonium
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> 2-oxobutyrate + succinate + ammonium
Components:
Function Name Type
product 2-oxobutyrate simple_molecule
catalyzer MetB protein
product ammonium simple_molecule
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
MetB succinyl-homoserine (2Z)-2-aminobut-2-enoate + succinate
Name: succinyl-homoserine -> (2Z)-2-aminobut-2-enoate + succinate
Description: Reaction transforming succinyl-homoserine into (2Z)-2-aminobut-2-enoate, succinate
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> (2Z)-2-aminobut-2-enoate + succinate
Components:
Function Name Type
product (2Z)-2-aminobut-2-enoate simple_molecule
catalyzer MetB protein
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
metBL_mRNA MetL
Name: metBL_mRNA -> MetL
Description: Translation of MetL
Type: translation
Pathway Components: metBL_mRNA -> MetL
Components:
Function Name Type
product MetL protein
reactant metBL_mRNA RNA
MetL homo-ser aspartate aspartyl-4-P
Name: aspartate -> aspartyl-4-P
Description: Reaction transforming aspartate into aspartyl-4-P
Type: state transition
Pathway Components: aspartate - MetL - homo-ser -> aspartyl-4-P
Components:
Function Name Type
catalyzer MetL protein
reactant aspartate simple_molecule
product aspartyl-4-P simple_molecule
inhibitor homo-ser simple_molecule
MetL aspartate-semialdehyde homo-ser
Name: aspartate-semialdehyde -> homo-ser
Description: Reaction transforming aspartate-semialdehyde into homo-ser
Type: state transition
Pathway Components: aspartate-semialdehyde - MetL -> homo-ser
Components:
Function Name Type
catalyzer MetL protein
reactant aspartate-semialdehyde simple_molecule
product homo-ser simple_molecule
metNIQ_mRNA MetN
Name: metNIQ_mRNA -> MetN
Description: Translation of MetN
Type: translation
Pathway Components: metNIQ_mRNA -> MetN
Components:
Function Name Type
product MetN protein
reactant metNIQ_mRNA RNA
MetQ + MetI + MetN MetN-MetI-MetQ
Name: MetQ + MetI + MetN -> MetN-MetI-MetQ
Description: Reaction transforming MetQ, MetI, MetN into MetN-MetI-MetQ
Type: state transition
Pathway Components: MetQ + MetI + MetN -> MetN-MetI-MetQ
Components:
Function Name Type
reactant MetI protein
reactant MetN protein
product MetN-MetI-MetQ complex
reactant MetQ protein
MetN-MetI-MetQ methionine_Ext methionine
Name: methionine_Ext -> methionine
Description: Transport of methionine_Ext through a bacterial membrane, leading to the presence of methionine inside the cell.
Type: transport
Pathway Components: methionine_Ext - MetN-MetI-MetQ -> methionine
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine simple_molecule
reactant methionine_Ext simple_molecule
MetN-MetI-MetQ Methionine S-oxide_Ext Methionine S-oxide
Name: Methionine S-oxide_Ext -> Methionine S-oxide
Description: Transport of Methionine S-oxide_Ext through a bacterial membrane, leading to the presence of Methionine S-oxide inside the cell.
Type: transport
Pathway Components: Methionine S-oxide_Ext - MetN-MetI-MetQ -> Methionine S-oxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product Methionine S-oxide simple_molecule
reactant Methionine S-oxide_Ext simple_molecule
MetN-MetI-MetQ methionine-R-sulfoxide_Ext methionine-R-sulfoxide
Name: methionine-R-sulfoxide_Ext -> methionine-R-sulfoxide
Description: Transport of methionine-R-sulfoxide_Ext through a bacterial membrane, leading to the presence of methionine-R-sulfoxide inside the cell.
Type: transport
Pathway Components: methionine-R-sulfoxide_Ext - MetN-MetI-MetQ -> methionine-R-sulfoxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine-R-sulfoxide simple_molecule
reactant methionine-R-sulfoxide_Ext simple_molecule
MetN-MetI-MetQ methionine-(S)-S-oxide_Ext methionine-(S)-S-oxide
Name: methionine-(S)-S-oxide_Ext -> methionine-(S)-S-oxide
Description: Transport of methionine-(S)-S-oxide_Ext through a bacterial membrane, leading to the presence of methionine-(S)-S-oxide inside the cell.
Type: transport
Pathway Components: methionine-(S)-S-oxide_Ext - MetN-MetI-MetQ -> methionine-(S)-S-oxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine-(S)-S-oxide simple_molecule
reactant methionine-(S)-S-oxide_Ext simple_molecule
MetN-MetI-MetQ acetyl-DL-methionine_Ext acetyl-DL-methionine
Name: acetyl-DL-methionine_Ext -> acetyl-DL-methionine
Description: Transport of acetyl-DL-methionine_Ext through a bacterial membrane, leading to the presence of acetyl-DL-methionine inside the cell.
Type: transport
Pathway Components: acetyl-DL-methionine_Ext - MetN-MetI-MetQ -> acetyl-DL-methionine
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product acetyl-DL-methionine simple_molecule
reactant acetyl-DL-methionine_Ext simple_molecule
metNIQ_mRNA MetI
Name: metNIQ_mRNA -> MetI
Description: Translation of MetI
Type: translation
Pathway Components: metNIQ_mRNA -> MetI
Components:
Function Name Type
product MetI protein
reactant metNIQ_mRNA RNA
metNIQ_mRNA MetQ
Name: metNIQ_mRNA -> MetQ
Description: Translation of MetQ
Type: translation
Pathway Components: metNIQ_mRNA -> MetQ
Components:
Function Name Type
product MetQ protein
reactant metNIQ_mRNA RNA
metE_mRNA MetE
Name: metE_mRNA -> MetE
Description: Translation of MetE
Type: translation
Pathway Components: metE_mRNA -> MetE
Components:
Function Name Type
product MetE protein
reactant metE_mRNA RNA
MetE Reactants H4PteGlu(n) + methionine
Name: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys -> H4PteGlu(n) + methionine
Description: Reaction transforming 5-methyltetrahydropteroyl tri-L-glutamate, homo-cys into H4PteGlu(n), methionine
Type: state transition
Pathway Components: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys - MetE -> H4PteGlu(n) + methionine
Components:
Function Name Type
reactant 5-methyltetrahydropteroyl tri-L-glutamate simple_molecule
product H4PteGlu(n) simple_molecule
catalyzer MetE protein
reactant homo-cys simple_molecule
product methionine simple_molecule
homo-cys methionine
Name: homo-cys -> methionine
Description: Transformation of homo-cys into methionine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: homo-cys / HOMOCYSMETB12-RXN / methionine
Components:
Function Name Type
reactant homo-cys simple_molecule
product methionine simple_molecule
SAM homo-cys
Name: SAM -> homo-cys
Description: Transformation of SAM into homo-cys by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: SAM / RXN-7605 / ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN / RIBOSYLHOMOCYSTEINASE-RXN / homo-cys
Components:
Function Name Type
reactant SAM simple_molecule
product homo-cys simple_molecule
aspartyl-4-P aspartate-semialdehyde
Name: aspartyl-4-P -> aspartate-semialdehyde
Description: Transformation of aspartyl-4-P into aspartate-semialdehyde by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: aspartyl-4-P / ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN / aspartate-semialdehyde
Components:
Function Name Type
product aspartate-semialdehyde simple_molecule
reactant aspartyl-4-P simple_molecule



RegulonDB