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MetJ Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
(2Z)-2-aminobut-2-enoate dehydroalanine 2-oxobutyrate 5,10-methylenetetrahydrofolate 5-methyl-tetrahydrofolate 5-methyltetrahydropteroyl tri-L-glutamate H2NTP AhpC AhpF D-methionine D-methionine_Ext FolE GTP asp L-aspartate-semialdehyde L-aspartyl-4-P cystathionine L-cysteine homo-cys homo-ser L-methionine Methionine S-oxide Methionine S-oxide_Ext L-methionine_Ext MetA MetB MetC MetE MetF MetI MetJ MetK MetL MetN MetQ MetR acetyl-DL-methionine acetyl-DL-methionine_Ext azaserine S-adenosyl-L-methionine S-adenosyl-L-methionine YeiB ahpCF ahpCF_mRNA ammonium ROH ROOH CoA PP folE-yeiB folE-yeiB_mRNA formate sulfide metA metA_mRNA metBL metBL_mRNA metC metC_mRNA metE metE_mRNA metF metF_mRNA metK metK_mRNA metNIQ metNIQ_mRNA metR metR_mRNA phosphate succinate suc-coa H4PteGlu(n) MetJ S-adenosyl-L-methionine MetN MetI MetQ AhpC AhpF phosphate phosphate phosphate


Gensor Unit       
Name: MetJ
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): GO:0008785 - alkyl hydroperoxide reductase activity
GO:0033214 - iron assimilation by chelation and transport
GO:0032843 - hydroperoxide reductase activity
GO:0015821 - methionine transport
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0015424 - amino acid-transporting ATPase activity
GO:0008270 - zinc ion binding
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016491 - oxidoreductase activity
GO:0016020 - membrane
GO:0009086 - methionine biosynthetic process
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Components:
Function Name Type
simple molecule H4PteGlu(n) simple molecule


Reactions       
Showing 47 reactions
MetJ + S-adenosyl-L-methionine MetJ-S-adenosyl-L-methionine
Name: MetJ + S-adenosyl-L-methionine -> MetJ-S-adenosyl-L-methionine
Description: Reaction transforming MetJ, S-adenosyl-L-methionine into MetJ-S-adenosyl-L-methionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant S-adenosyl-L-methionine simple molecule nd nd
reactant MetJ protein nd nd
product MetJ-S-adenosyl-L-methionine complex nd nd
ahpCF ahpCF_mRNA
Name: ahpCF -> ahpCF_mRNA
Description: Transcription of transcription unit ahpCF; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant ahpCF gene nd nd
product ahpCF_mRNA RNA nd nd
folE-yeiB folE-yeiB_mRNA
Name: folE-yeiB -> folE-yeiB_mRNA
Description: Transcription of transcription unit folE-yeiB; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product folE-yeiB_mRNA RNA nd nd
reactant folE-yeiB gene nd nd
metA metA_mRNA
Name: metA -> metA_mRNA
Description: Transcription of transcription unit metA; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant metA gene nd nd
product metA_mRNA RNA nd nd
metBL metBL_mRNA
Name: metBL -> metBL_mRNA
Description: Transcription of transcription unit metBL; reaction activation by HypT-Met-oxidized.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metBL_mRNA RNA nd nd
reactant metBL gene nd nd
metC metC_mRNA
Name: metC -> metC_mRNA
Description: Transcription of transcription unit metC; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant metC gene nd nd
product metC_mRNA RNA nd nd
metE metE_mRNA
Name: metE -> metE_mRNA
Description: Transcription of transcription unit metE; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metE_mRNA RNA nd nd
reactant metE gene nd nd
metF metF_mRNA
Name: metF -> metF_mRNA
Description: Transcription of transcription unit metF; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metF_mRNA RNA nd nd
reactant metF gene nd nd
metK metK_mRNA
Name: metK -> metK_mRNA
Description: Transcription of transcription unit metK; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metK_mRNA RNA nd nd
reactant metK gene nd nd
metNIQ metNIQ_mRNA
Name: metNIQ -> metNIQ_mRNA
Description: Transcription of transcription unit metNIQ; reaction activation by HypT-Met-oxidized.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ gene nd nd
product metNIQ_mRNA RNA nd nd
metR metR_mRNA
Name: metR -> metR_mRNA
Description: Transcription of transcription unit metR; reaction inhibition by MetJ-S-adenosyl-L-methionine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant metR gene nd nd
product metR_mRNA RNA nd nd
metK_mRNA MetK
Name: metK_mRNA -> MetK
Description: Translation of MetK
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetK protein nd nd
reactant metK_mRNA RNA nd nd
L-methionine phosphate + PP + S-adenosyl-L-methionine
Name: L-methionine -> phosphate + PP + S-adenosyl-L-methionine
Description: Reaction transforming L-methionine into phosphate, PP , S-adenosyl-L-methionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-methionine simple molecule nd nd
product PP simple molecule nd nd
product S-adenosyl-L-methionine simple molecule nd nd
product phosphate simple molecule nd nd
metNIQ_mRNA MetN
Name: metNIQ_mRNA -> MetN
Description: Translation of MetN
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ_mRNA RNA nd nd
product MetN protein nd nd
MetN + MetI + MetQ MetN-MetI-MetQ
Name: MetN + MetI + MetQ -> MetN-MetI-MetQ
Description: Reaction transforming MetN, MetI, MetQ into MetN-MetI-MetQ
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MetN protein nd nd
reactant MetQ protein nd nd
product MetN-MetI-MetQ complex nd nd
reactant MetI protein nd nd
Methionine S-oxide_Ext Methionine S-oxide + phosphate
Name: Methionine S-oxide_Ext -> Methionine S-oxide + phosphate
Description: Transport of Methionine S-oxide_Ext through a bacterial membrane, leading to the presence of Methionine S-oxide, phosphate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant Methionine S-oxide_Ext simple molecule nd nd
product phosphate simple molecule nd nd
product Methionine S-oxide simple molecule nd nd
acetyl-DL-methionine_Ext acetyl-DL-methionine + phosphate
Name: acetyl-DL-methionine_Ext -> acetyl-DL-methionine + phosphate
Description: Transport of acetyl-DL-methionine_Ext through a bacterial membrane, leading to the presence of acetyl-DL-methionine, phosphate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product phosphate simple molecule nd nd
reactant acetyl-DL-methionine_Ext simple molecule nd nd
product acetyl-DL-methionine simple molecule nd nd
L-methionine_Ext phosphate + L-methionine
Name: L-methionine_Ext -> phosphate + L-methionine
Description: Transport of L-methionine_Ext through a bacterial membrane, leading to the presence of phosphate, L-methionine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product L-methionine simple molecule nd nd
product phosphate simple molecule nd nd
reactant L-methionine_Ext simple molecule nd nd
D-methionine_Ext phosphate + D-methionine
Name: D-methionine_Ext -> phosphate + D-methionine
Description: Transport of D-methionine_Ext through a bacterial membrane, leading to the presence of phosphate, D-methionine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant D-methionine_Ext simple molecule nd nd
product phosphate simple molecule nd nd
product D-methionine simple molecule nd nd
metBL_mRNA MetB
Name: metBL_mRNA -> MetB
Description: Translation of MetB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metBL_mRNA RNA nd nd
product MetB protein nd nd
L-cysteine + azaserine suc + cystathionine
Name: L-cysteine + azaserine -> suc + cystathionine
Description: Reaction transforming L-cysteine, azaserine into suc, cystathionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-cysteine simple molecule nd nd
product suc simple molecule nd nd
reactant azaserine simple molecule nd nd
product cystathionine simple molecule nd nd
azaserine 2-oxobutyrate + suc + ammonium
Name: azaserine -> 2-oxobutyrate + suc + ammonium
Description: Reaction transforming azaserine into 2-oxobutyrate, suc , ammonium
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product ammonium simple molecule nd nd
product 2-oxobutyrate simple molecule nd nd
reactant azaserine simple molecule nd nd
product suc simple molecule nd nd
azaserine suc + (2Z)-2-aminobut-2-enoate
Name: azaserine -> suc + (2Z)-2-aminobut-2-enoate
Description: Reaction transforming azaserine into suc, (2Z)-2-aminobut-2-enoate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant azaserine simple molecule nd nd
product (2Z)-2-aminobut-2-enoate simple molecule nd nd
product suc simple molecule nd nd
metBL_mRNA MetL
Name: metBL_mRNA -> MetL
Description: Translation of MetL
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metBL_mRNA RNA nd nd
product MetL protein nd nd
asp L-aspartyl-4-P
Name: asp -> L-aspartyl-4-P
Description: Reaction transforming asp into L-aspartyl-4-P
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-aspartyl-4-P simple molecule nd nd
reactant asp simple molecule nd nd
homo-ser L-aspartate-semialdehyde
Name: homo-ser -> L-aspartate-semialdehyde
Description: Reaction transforming homo-ser into L-aspartate-semialdehyde
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-aspartate-semialdehyde simple molecule nd nd
reactant homo-ser simple molecule nd nd
metF_mRNA MetF
Name: metF_mRNA -> MetF
Description: Translation of MetF
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metF_mRNA RNA nd nd
product MetF protein nd nd
5-methyl-tetrahydrofolate 5,10-methylenetetrahydrofolate
Name: 5-methyl-tetrahydrofolate -> 5,10-methylenetetrahydrofolate
Description: Reaction transforming 5-methyl-tetrahydrofolate into 5,10-methylenetetrahydrofolate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 5-methyl-tetrahydrofolate simple molecule nd nd
product 5,10-methylenetetrahydrofolate simple molecule nd nd
folE-yeiB_mRNA YeiB
Name: folE-yeiB_mRNA -> YeiB
Description: Translation of YeiB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant folE-yeiB_mRNA RNA nd nd
product YeiB protein nd nd
metC_mRNA MetC
Name: metC_mRNA -> MetC
Description: Translation of MetC
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetC protein nd nd
reactant metC_mRNA RNA nd nd
cystathionine dehydroalanine + homo-cys
Name: cystathionine -> dehydroalanine + homo-cys
Description: Reaction transforming cystathionine into dehydroalanine, homo-cys
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product dehydroalanine simple molecule nd nd
reactant cystathionine simple molecule nd nd
product homo-cys simple molecule nd nd
L-cysteine dehydroalanine + sulfide
Name: L-cysteine -> dehydroalanine + sulfide
Description: Reaction transforming L-cysteine into dehydroalanine, sulfide
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product sulfide simple molecule nd nd
reactant L-cysteine simple molecule nd nd
product dehydroalanine simple molecule nd nd
metE_mRNA MetE
Name: metE_mRNA -> MetE
Description: Translation of MetE
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metE_mRNA RNA nd nd
product MetE protein nd nd
5-methyltetrahydropteroyl tri-L-glutamate + homo-cys L-methionine + H4PteGlu(n)
Name: 5-methyltetrahydropteroyl tri-L-glutamate + homo-cys -> L-methionine + H4PteGlu(n)
Description: Reaction transforming 5-methyltetrahydropteroyl tri-L-glutamate, homo-cys into L-methionine, H4PteGlu(n)
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product H4PteGlu(n) simple molecule nd nd
product L-methionine simple molecule nd nd
reactant 5-methyltetrahydropteroyl tri-L-glutamate simple molecule nd nd
reactant homo-cys simple molecule nd nd
metNIQ_mRNA MetQ
Name: metNIQ_mRNA -> MetQ
Description: Translation of MetQ
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ_mRNA RNA nd nd
product MetQ protein nd nd
ahpCF_mRNA AhpC
Name: ahpCF_mRNA -> AhpC
Description: Translation of AhpC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant ahpCF_mRNA RNA nd nd
product AhpC protein nd nd
AhpC + AhpF AhpC-AhpF
Name: AhpC + AhpF -> AhpC-AhpF
Description: Reaction transforming AhpC, AhpF into AhpC-AhpF
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant AhpF protein nd nd
product AhpC-AhpF complex nd nd
reactant AhpC protein nd nd
ROH ROOH
Name: ROH -> ROOH
Description: Reaction transforming ROH into ROOH
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant ROH simple molecule nd nd
product ROOH simple molecule nd nd
folE-yeiB_mRNA FolE
Name: folE-yeiB_mRNA -> FolE
Description: Translation of FolE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product FolE protein nd nd
reactant folE-yeiB_mRNA RNA nd nd
GTP formate + H2NTP
Name: GTP -> formate + H2NTP
Description: Reaction transforming GTP into formate, H2NTP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product formate simple molecule nd nd
product H2NTP simple molecule nd nd
reactant GTP simple molecule nd nd
metNIQ_mRNA MetI
Name: metNIQ_mRNA -> MetI
Description: Translation of MetI
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ_mRNA RNA nd nd
product MetI protein nd nd
metR_mRNA MetR
Name: metR_mRNA -> MetR
Description: Translation of MetR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetR protein nd nd
reactant metR_mRNA RNA nd nd
metA_mRNA MetA
Name: metA_mRNA -> MetA
Description: Translation of MetA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetA protein nd nd
reactant metA_mRNA RNA nd nd
homo-ser + suc-coa azaserine + CoA
Name: homo-ser + suc-coa -> azaserine + CoA
Description: Reaction transforming homo-ser, suc-coa into azaserine, CoA
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product CoA simple molecule nd nd
product azaserine simple molecule nd nd
reactant homo-ser simple molecule nd nd
reactant suc-coa simple molecule nd nd
ahpCF_mRNA AhpF
Name: ahpCF_mRNA -> AhpF
Description: Translation of AhpF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AhpF protein nd nd
reactant ahpCF_mRNA RNA nd nd
L-aspartyl-4-P L-aspartate-semialdehyde
Name: L-aspartyl-4-P -> L-aspartate-semialdehyde
Description: Transformation of L-aspartyl-4-P into L-aspartate-semialdehyde by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant L-aspartyl-4-P simple molecule nd nd
product L-aspartate-semialdehyde simple molecule nd nd
S-adenosyl-L-methionine homo-cys
Name: S-adenosyl-L-methionine -> homo-cys
Description: Transformation of S-adenosyl-L-methionine into homo-cys by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant S-adenosyl-L-methionine simple molecule nd nd
product homo-cys simple molecule nd nd



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