RegulonDB RegulonDB

MalT Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
maltoheptaose ADP-Maltotriose MalG MalZ MalT MalG MalK malZ maltotetraose maltotriose MalM D-glucose 1-phosphate non-specific ion/solute MalY phosphate amylose Aes MalT malPQ_mRNA malEFG malK-lamB-malM MalY MalP LamB ADP-Maltotriose malS_mRNA non-specific ion/solute_Ext MalF maltohexaose MalK MalE MalT maltotriose-ATP malZ_mRNA glucopyranose MalT MalS malPQ MalT debranched alpha-limit dextrin malK-lamB-malM_mRNA MalF MalQ maltotriose_Ext maltotetraose_Ext maltopentaose MalK maltose_Ext malS MalT maltotriose-ATP Aes MalE malEFG_mRNA maltose maltose phosphate glucopyranose amylose


Gensor Unit       
Name: MalT
Description: Molecular biology level
Detailed: In the presence of maltotriose, MalT dually regulates the expression of genes required for maltodextrin and maltose transport and catabolic processes. Under these conditions, maltotriose is directly transported into cell or generated from maltoteraose transport and coversion to maltotriose, MalT is modified to MalT-maltotriose, binds its target sites enabling and preventing the expression of its regulated genes. In the absence of maltotriose, MalT is modified to MalT-Aes, MalT-MalY and MalT-MalK, and unbinds its target sites, enabling in some cases and preventing in others, the expression of its regulated genes.
Less detailed: In the presence of maltotriose, MalT dually regulates the expression of genes needed for maltodextrin and maltose transport and catabolic processes.

Physiology level
Detailed: The presence of maltotriose induces and inhibits the expression of genes involved with maltodextrin and maltose transport and catabolic processes. Under these conditions, the genes necessary for maltodextrin conversion to α-D-glucose-1-phosphate and beta-glucose are in some cases expressed and not expressed in other cases.
Less detailed: The presence of maltotriose induces and inhibits the expression of genes needful for maltodextrin conversion to α-D-glucose-1-phosphate and beta-glucose.
Classification:
Groups: Carbohydrate transport and metabolism
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0030980 - alpha-glucan catabolic process
GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0060326 - cell chemotaxis
GO:0051692 - cellular oligosaccharide catabolic process
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cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:0009279 - cell outer membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
GO:0045203 - integral component of cell outer membrane
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molecular_function GO:0004645 - 1,4-alpha-oligoglucan phosphorylase activity
GO:0004134 - 4-alpha-glucanotransferase activity
GO:0015423 - ABC-type maltose transporter activity
GO:0005524 - ATP binding
GO:0016887 - ATP hydrolysis activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0102499 - SHG alpha-glucan phosphorylase activity
Read more >
Components:
  Function Name Type
  simple_molecule ADP-Maltotriose simple_molecule
  protein Aes protein
  simple_molecule D-glucose 1-phosphate simple_molecule
  protein LamB protein
  protein MalE protein
  protein MalF protein
  protein MalG protein
  protein MalK protein
  complex MalK-MalF-MalG-MalE complex
  protein MalM protein
  protein MalP protein
  protein MalQ protein
  protein MalS protein
  protein MalT protein
  complex MalT-ADP-Maltotriose complex
  complex MalT-Aes complex
  complex MalT-MalK complex
  complex MalT-MalY complex
  complex MalT-maltotriose-ATP complex
  protein MalY protein
  protein MalZ protein
  simple_molecule amylose simple_molecule
  simple_molecule debranched α-limit dextrin simple_molecule
  simple_molecule glucopyranose simple_molecule
  gene malEFG gene
  RNA malEFG_mRNA RNA
  gene malK-lamB-malM gene
  RNA malK-lamB-malM_mRNA RNA
  gene malPQ gene
  RNA malPQ_mRNA RNA
  gene malS gene
  RNA malS_mRNA RNA
  gene malZ gene
  RNA malZ_mRNA RNA
  simple_molecule maltoheptaose simple_molecule
  simple_molecule maltohexaose simple_molecule
  simple_molecule maltopentaose simple_molecule
  simple_molecule maltose simple_molecule
  simple_molecule maltose_Ext simple_molecule
  simple_molecule maltotetraose simple_molecule
  simple_molecule maltotetraose_Ext simple_molecule
  simple_molecule maltotriose simple_molecule
  simple_molecule maltotriose-ATP simple_molecule
  simple_molecule maltotriose_Ext simple_molecule
  simple_molecule non-specific ion/solute simple_molecule
  simple_molecule non-specific ion/solute_Ext simple_molecule
  simple_molecule phosphate simple_molecule


Reactions       
Showing 41 reactions
maltotriose-ATP + MalT MalT-maltotriose-ATP
Name: maltotriose-ATP + MalT -> MalT-maltotriose-ATP
Description: Reaction transforming maltotriose-ATP, MalT into MalT-maltotriose-ATP
Type: state transition
Pathway Components: maltotriose-ATP + MalT -> MalT-maltotriose-ATP
Components:
Function Name Type
reactant MalT protein
product MalT-maltotriose-ATP complex
reactant maltotriose-ATP simple_molecule
MalT-maltotriose-ATP malEFG malEFG_mRNA
Name: malEFG -> malEFG_mRNA
Description: Transcription of transcription unit malEFG. Reaction activation by MalT-maltotriose-ATP.
Type: transcription
Pathway Components: malEFG - MalT-maltotriose-ATP -> malEFG_mRNA
Components:
Function Name Type
activator MalT-maltotriose-ATP complex
reactant malEFG gene
product malEFG_mRNA RNA
MalT-maltotriose-ATP malK-lamB-malM malK-lamB-malM_mRNA
Name: malK-lamB-malM -> malK-lamB-malM_mRNA
Description: Transcription of transcription unit malK-lamB-malM. Reaction activation by MalT-maltotriose-ATP.
Type: transcription
Pathway Components: malK-lamB-malM - MalT-maltotriose-ATP -> malK-lamB-malM_mRNA
Components:
Function Name Type
activator MalT-maltotriose-ATP complex
reactant malK-lamB-malM gene
product malK-lamB-malM_mRNA RNA
MalT-maltotriose-ATP malPQ malPQ_mRNA
Name: malPQ -> malPQ_mRNA
Description: Transcription of transcription unit malPQ. Reaction activation by MalT-maltotriose-ATP.
Type: transcription
Pathway Components: malPQ - MalT-maltotriose-ATP -> malPQ_mRNA
Components:
Function Name Type
activator MalT-maltotriose-ATP complex
reactant malPQ gene
product malPQ_mRNA RNA
MalT-maltotriose-ATP malS malS_mRNA
Name: malS -> malS_mRNA
Description: Transcription of transcription unit malS. Reaction activation by MalT-maltotriose-ATP.
Type: transcription
Pathway Components: malS - MalT-maltotriose-ATP -> malS_mRNA
Components:
Function Name Type
activator MalT-maltotriose-ATP complex
reactant malS gene
product malS_mRNA RNA
MalT-maltotriose-ATP malZ malZ_mRNA
Name: malZ -> malZ_mRNA
Description: Transcription of transcription unit malZ. Reaction activation by MalT-maltotriose-ATP.
Type: transcription
Pathway Components: malZ - MalT-maltotriose-ATP -> malZ_mRNA
Components:
Function Name Type
activator MalT-maltotriose-ATP complex
reactant malZ gene
product malZ_mRNA RNA
MalT + Aes MalT-Aes
Name: MalT + Aes -> MalT-Aes
Description: Reaction transforming MalT, Aes into MalT-Aes
Type: state transition
Pathway Components: MalT + Aes -> MalT-Aes
Components:
Function Name Type
reactant Aes protein
reactant MalT protein
product MalT-Aes complex
MalK + MalT MalT-MalK
Name: MalK + MalT -> MalT-MalK
Description: Reaction transforming MalK, MalT into MalT-MalK
Type: state transition
Pathway Components: MalK + MalT -> MalT-MalK
Components:
Function Name Type
reactant MalK protein
reactant MalT protein
product MalT-MalK complex
MalT + MalY MalT-MalY
Name: MalT + MalY -> MalT-MalY
Description: Reaction transforming MalT, MalY into MalT-MalY
Type: state transition
Pathway Components: MalT + MalY -> MalT-MalY
Components:
Function Name Type
reactant MalT protein
product MalT-MalY complex
reactant MalY protein
ADP-Maltotriose + MalT MalT-ADP-Maltotriose
Name: ADP-Maltotriose + MalT -> MalT-ADP-Maltotriose
Description: Reaction transforming ADP-Maltotriose, MalT into MalT-ADP-Maltotriose
Type: state transition
Pathway Components: ADP-Maltotriose + MalT -> MalT-ADP-Maltotriose
Components:
Function Name Type
reactant ADP-Maltotriose simple_molecule
reactant MalT protein
product MalT-ADP-Maltotriose complex
malEFG_mRNA MalE
Name: malEFG_mRNA -> MalE
Description: Translation of MalE
Type: translation
Pathway Components: malEFG_mRNA -> MalE
Components:
Function Name Type
product MalE protein
reactant malEFG_mRNA RNA
MalE + MalF + MalG + MalK MalK-MalF-MalG-MalE
Name: MalE + MalF + MalG + MalK -> MalK-MalF-MalG-MalE
Description: Reaction transforming MalE, MalF, MalG, MalK into MalK-MalF-MalG-MalE
Type: state transition
Pathway Components: MalE + MalF + MalG + MalK -> MalK-MalF-MalG-MalE
Components:
Function Name Type
reactant MalE protein
reactant MalF protein
reactant MalG protein
reactant MalK protein
product MalK-MalF-MalG-MalE complex
LamB MalK-MalF-MalG-MalE maltose_Ext maltose
Name: maltose_Ext -> maltose
Description: Transport of maltose_Ext through a bacterial membrane, leading to the presence of maltose inside the cell.
Type: transport
Pathway Components: maltose_Ext - LamB - MalK-MalF-MalG-MalE -> maltose
Components:
Function Name Type
catalyzer LamB protein
catalyzer MalK-MalF-MalG-MalE complex
product maltose simple_molecule
reactant maltose_Ext simple_molecule
MalK-MalF-MalG-MalE maltotetraose_Ext maltotetraose
Name: maltotetraose_Ext -> maltotetraose
Description: Transport of maltotetraose_Ext through a bacterial membrane, leading to the presence of maltotetraose inside the cell.
Type: transport
Pathway Components: maltotetraose_Ext - MalK-MalF-MalG-MalE -> maltotetraose
Components:
Function Name Type
catalyzer MalK-MalF-MalG-MalE complex
product maltotetraose simple_molecule
reactant maltotetraose_Ext simple_molecule
MalK-MalF-MalG-MalE maltotriose_Ext maltotriose
Name: maltotriose_Ext -> maltotriose
Description: Transport of maltotriose_Ext through a bacterial membrane, leading to the presence of maltotriose inside the cell.
Type: transport
Pathway Components: maltotriose_Ext - MalK-MalF-MalG-MalE -> maltotriose
Components:
Function Name Type
catalyzer MalK-MalF-MalG-MalE complex
product maltotriose simple_molecule
reactant maltotriose_Ext simple_molecule
malEFG_mRNA MalF
Name: malEFG_mRNA -> MalF
Description: Translation of MalF
Type: translation
Pathway Components: malEFG_mRNA -> MalF
Components:
Function Name Type
product MalF protein
reactant malEFG_mRNA RNA
malEFG_mRNA MalG
Name: malEFG_mRNA -> MalG
Description: Translation of MalG
Type: translation
Pathway Components: malEFG_mRNA -> MalG
Components:
Function Name Type
product MalG protein
reactant malEFG_mRNA RNA
malZ_mRNA MalZ
Name: malZ_mRNA -> MalZ
Description: Translation of MalZ
Type: translation
Pathway Components: malZ_mRNA -> MalZ
Components:
Function Name Type
product MalZ protein
reactant malZ_mRNA RNA
MalZ maltotriose glucopyranose + maltose
Name: maltotriose -> glucopyranose + maltose
Description: Reaction transforming maltotriose into glucopyranose, maltose
Type: state transition
Pathway Components: maltotriose - MalZ -> glucopyranose + maltose
Components:
Function Name Type
catalyzer MalZ protein
product glucopyranose simple_molecule
product maltose simple_molecule
reactant maltotriose simple_molecule
MalZ amylose glucopyranose + amylose
Name: amylose -> glucopyranose + amylose
Description: Reaction transforming amylose into glucopyranose, amylose
Type: state transition
Pathway Components: amylose - MalZ -> glucopyranose + amylose
Components:
Function Name Type
catalyzer MalZ protein
product amylose simple_molecule
reactant amylose simple_molecule
product glucopyranose simple_molecule
MalZ maltopentaose maltotetraose + glucopyranose
Name: maltopentaose -> maltotetraose + glucopyranose
Description: Reaction transforming maltopentaose into maltotetraose, glucopyranose
Type: state transition
Pathway Components: maltopentaose - MalZ -> maltotetraose + glucopyranose
Components:
Function Name Type
catalyzer MalZ protein
product glucopyranose simple_molecule
reactant maltopentaose simple_molecule
product maltotetraose simple_molecule
MalZ maltohexaose glucopyranose + maltopentaose
Name: maltohexaose -> glucopyranose + maltopentaose
Description: Reaction transforming maltohexaose into glucopyranose, maltopentaose
Type: state transition
Pathway Components: maltohexaose - MalZ -> glucopyranose + maltopentaose
Components:
Function Name Type
catalyzer MalZ protein
product glucopyranose simple_molecule
reactant maltohexaose simple_molecule
product maltopentaose simple_molecule
MalZ maltoheptaose glucopyranose + maltohexaose
Name: maltoheptaose -> glucopyranose + maltohexaose
Description: Reaction transforming maltoheptaose into glucopyranose, maltohexaose
Type: state transition
Pathway Components: maltoheptaose - MalZ -> glucopyranose + maltohexaose
Components:
Function Name Type
catalyzer MalZ protein
product glucopyranose simple_molecule
reactant maltoheptaose simple_molecule
product maltohexaose simple_molecule
malPQ_mRNA MalP
Name: malPQ_mRNA -> MalP
Description: Translation of MalP
Type: translation
Pathway Components: malPQ_mRNA -> MalP
Components:
Function Name Type
product MalP protein
reactant malPQ_mRNA RNA
MalP debranched α-limit dextrin + phosphate D-glucose 1-phosphate
Name: debranched α-limit dextrin + phosphate -> D-glucose 1-phosphate
Description: Reaction transforming debranched α-limit dextrin, phosphate into D-glucose 1-phosphate
Type: state transition
Pathway Components: debranched α-limit dextrin + phosphate - MalP -> D-glucose 1-phosphate
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
reactant debranched α-limit dextrin simple_molecule
reactant phosphate simple_molecule
MalP maltoheptaose + phosphate D-glucose 1-phosphate + maltohexaose
Name: maltoheptaose + phosphate -> D-glucose 1-phosphate + maltohexaose
Description: Reaction transforming maltoheptaose, phosphate into D-glucose 1-phosphate, maltohexaose
Type: state transition
Pathway Components: maltoheptaose + phosphate - MalP -> D-glucose 1-phosphate + maltohexaose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
reactant maltoheptaose simple_molecule
product maltohexaose simple_molecule
reactant phosphate simple_molecule
MalP maltohexaose + phosphate D-glucose 1-phosphate + maltopentaose
Name: maltohexaose + phosphate -> D-glucose 1-phosphate + maltopentaose
Description: Reaction transforming maltohexaose, phosphate into D-glucose 1-phosphate, maltopentaose
Type: state transition
Pathway Components: maltohexaose + phosphate - MalP -> D-glucose 1-phosphate + maltopentaose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
reactant maltohexaose simple_molecule
product maltopentaose simple_molecule
reactant phosphate simple_molecule
MalP maltopentaose + phosphate D-glucose 1-phosphate + maltotetraose
Name: maltopentaose + phosphate -> D-glucose 1-phosphate + maltotetraose
Description: Reaction transforming maltopentaose, phosphate into D-glucose 1-phosphate, maltotetraose
Type: state transition
Pathway Components: maltopentaose + phosphate - MalP -> D-glucose 1-phosphate + maltotetraose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
reactant maltopentaose simple_molecule
product maltotetraose simple_molecule
reactant phosphate simple_molecule
MalP maltotetraose + phosphate D-glucose 1-phosphate + maltotriose
Name: maltotetraose + phosphate -> D-glucose 1-phosphate + maltotriose
Description: Reaction transforming maltotetraose, phosphate into D-glucose 1-phosphate, maltotriose
Type: state transition
Pathway Components: maltotetraose + phosphate - MalP -> D-glucose 1-phosphate + maltotriose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
reactant maltotetraose simple_molecule
product maltotriose simple_molecule
reactant phosphate simple_molecule
MalP phosphate + amylose D-glucose 1-phosphate + amylose
Name: phosphate + amylose -> D-glucose 1-phosphate + amylose
Description: Reaction transforming phosphate, amylose into D-glucose 1-phosphate, amylose
Type: state transition
Pathway Components: phosphate + amylose - MalP -> D-glucose 1-phosphate + amylose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer MalP protein
product amylose simple_molecule
reactant amylose simple_molecule
reactant phosphate simple_molecule
malPQ_mRNA MalQ
Name: malPQ_mRNA -> MalQ
Description: Translation of MalQ
Type: translation
Pathway Components: malPQ_mRNA -> MalQ
Components:
Function Name Type
product MalQ protein
reactant malPQ_mRNA RNA
MalQ glucopyranose + maltohexaose maltopentaose + maltose
Name: glucopyranose + maltohexaose -> maltopentaose + maltose
Description: Reaction transforming glucopyranose, maltohexaose into maltopentaose, maltose
Type: state transition
Pathway Components: glucopyranose + maltohexaose - MalQ -> maltopentaose + maltose
Components:
Function Name Type
catalyzer MalQ protein
reactant glucopyranose simple_molecule
reactant maltohexaose simple_molecule
product maltopentaose simple_molecule
product maltose simple_molecule
MalQ maltopentaose + glucopyranose maltotetraose + maltose
Name: maltopentaose + glucopyranose -> maltotetraose + maltose
Description: Reaction transforming maltopentaose, glucopyranose into maltotetraose, maltose
Type: state transition
Pathway Components: maltopentaose + glucopyranose - MalQ -> maltotetraose + maltose
Components:
Function Name Type
catalyzer MalQ protein
reactant glucopyranose simple_molecule
reactant maltopentaose simple_molecule
product maltose simple_molecule
product maltotetraose simple_molecule
MalQ maltohexaose + maltose glucopyranose + maltoheptaose
Name: maltohexaose + maltose -> glucopyranose + maltoheptaose
Description: Reaction transforming maltohexaose, maltose into glucopyranose, maltoheptaose
Type: state transition
Pathway Components: maltohexaose + maltose - MalQ -> glucopyranose + maltoheptaose
Components:
Function Name Type
catalyzer MalQ protein
product glucopyranose simple_molecule
product maltoheptaose simple_molecule
reactant maltohexaose simple_molecule
reactant maltose simple_molecule
MalQ maltotetraose + glucopyranose maltotriose + maltose
Name: maltotetraose + glucopyranose -> maltotriose + maltose
Description: Reaction transforming maltotetraose, glucopyranose into maltotriose, maltose
Type: state transition
Pathway Components: maltotetraose + glucopyranose - MalQ -> maltotriose + maltose
Components:
Function Name Type
catalyzer MalQ protein
reactant glucopyranose simple_molecule
product maltose simple_molecule
reactant maltotetraose simple_molecule
product maltotriose simple_molecule
malS_mRNA MalS
Name: malS_mRNA -> MalS
Description: Translation of MalS
Type: translation
Pathway Components: malS_mRNA -> MalS
Components:
Function Name Type
product MalS protein
reactant malS_mRNA RNA
MalS amylose maltohexaose + amylose
Name: amylose -> maltohexaose + amylose
Description: Reaction transforming amylose into maltohexaose, amylose
Type: state transition
Pathway Components: amylose - MalS -> maltohexaose + amylose
Components:
Function Name Type
catalyzer MalS protein
product amylose simple_molecule
reactant amylose simple_molecule
product maltohexaose simple_molecule
malK-lamB-malM_mRNA MalK
Name: malK-lamB-malM_mRNA -> MalK
Description: Translation of MalK
Type: translation
Pathway Components: malK-lamB-malM_mRNA -> MalK
Components:
Function Name Type
product MalK protein
reactant malK-lamB-malM_mRNA RNA
malK-lamB-malM_mRNA LamB
Name: malK-lamB-malM_mRNA -> LamB
Description: Translation of LamB
Type: translation
Pathway Components: malK-lamB-malM_mRNA -> LamB
Components:
Function Name Type
product LamB protein
reactant malK-lamB-malM_mRNA RNA
LamB non-specific ion/solute_Ext non-specific ion/solute
Name: non-specific ion/solute_Ext -> non-specific ion/solute
Description: Transport of non-specific ion/solute_Ext through a bacterial membrane, leading to the presence of non-specific ion/solute inside the cell.
Type: transport
Pathway Components: non-specific ion / solute_Ext - LamB -> non-specific ion / solute
Components:
Function Name Type
catalyzer LamB protein
product non-specific ion/solute simple_molecule
reactant non-specific ion/solute_Ext simple_molecule
malK-lamB-malM_mRNA MalM
Name: malK-lamB-malM_mRNA -> MalM
Description: Translation of MalM
Type: translation
Pathway Components: malK-lamB-malM_mRNA -> MalM
Components:
Function Name Type
product MalM protein
reactant malK-lamB-malM_mRNA RNA



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