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LldR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
(R)-lactate (R)-lactate_Ext (S)-lactate (S)-lactate_Ext L-lactose LldD LldP LldR a reduced electron acceptor an oxidized electron acceptor glycolate glycolate_Ext lldPRD lldPRD_mRNA pyruvate LldR L-lactose LldR


Gensor Unit       
Name: LldR
Description: Molecular biology level
Detailed: In the presence of lactose, LldR dually regulates the expression of genes required for lactate and glycolate transport and lactate oxidation. Under these conditions, LldR is modified to LldR-L-lactose, binds its target sites both enabling in some cases and preventing its own expression and the expression of its regulated genes. In the absence of of L-lactose, LldR is also able to bind to its target sites enabling in some cases and preventing in others the expression of its regulated genes.
Less detailed: In the presence but also in the absence of L-lactose, LldR dually regulates the expression of genes needed for lactate and glycolate transport and lactate oxidation.

Physiology level
Detailed: The presence of L-lactose dually regulates the expression of genes involved with glycolate and lactate transport and lactate oxidation. Under these conditions the genes necessary for tranport of glycolate and lactate into cell and lactate conversion to pyruvate are expressed in some cases and not expressed in other cases.
Less detailed: The presence of L-lactose induces in some cases and inhibits in other the expression of genes needful for lactate and glycolate transport into cell and lactate conversion of pyruvate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0042355 - L-fucose catabolic process
GO:0009060 - aerobic respiration
GO:0009061 - anaerobic respiration
GO:0042710 - biofilm formation
GO:0045990 - carbon catabolite regulation of transcription
GO:0006974 - cellular response to DNA damage stimulus
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cellular_component GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0010181 - FMN binding
GO:0004459 - L-lactate dehydrogenase activity
GO:0043879 - glycolate transmembrane transporter activity
GO:0015129 - lactate transmembrane transporter activity
GO:0043565 - sequence-specific DNA binding
GO:0015295 - solute:proton symporter activity
Components: Show/Hide Components Table (13 more...)
Function Name Type
simple_molecule A(H2) simple_molecule
protein LldD protein
protein LldP protein
protein LldR protein
complex LldR-lactate complex
simple_molecule acceptors simple_molecule
simple_molecule glycolate simple_molecule
simple_molecule glycolate_Ext simple_molecule
simple_molecule lactate simple_molecule
simple_molecule lactate_Ext simple_molecule
gene lldPRD gene
RNA lldPRD_mRNA RNA
simple_molecule pyruvate simple_molecule


Reactions       
Showing 8 reactions
LldR LldR LldR-lactate LldR-lactate lldPRD lldPRD_mRNA
Name: lldPRD -> lldPRD_mRNA
Description: Transcription of transcription unit lldPRD. Reaction activation by LldR, and LldR-lactate. Reaction inhibition by LldR, and LldR-lactate.
Type: transcription
Pathway Components: lldPRD - LldR - LldR-lactate - LldR - LldR-lactate -> lldPRD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator LldR protein nd nd
inhibitor LldR protein nd nd
activator LldR-lactate complex nd nd
inhibitor LldR-lactate complex nd nd
reactant lldPRD gene nd nd
product lldPRD_mRNA RNA nd nd
lactate + LldR LldR-lactate
Name: lactate + LldR -> LldR-lactate
Description: Reaction transforming lactate, LldR into LldR-lactate
Type: state transition
Pathway Components: lactate + LldR -> LldR-lactate
Components:
Function Name Type Evidence Reference(s)
reactant LldR protein nd nd
product LldR-lactate complex nd nd
reactant lactate simple_molecule nd nd
lldPRD_mRNA LldP
Name: lldPRD_mRNA -> LldP
Description: Translation of LldP
Type: translation
Pathway Components: lldPRD_mRNA -> LldP
Components:
Function Name Type Evidence Reference(s)
product LldP protein nd nd
reactant lldPRD_mRNA RNA nd nd
LldP glycolate_Ext glycolate
Name: glycolate_Ext -> glycolate
Description: Transport of glycolate_Ext through a bacterial membrane, leading to the presence of glycolate inside the cell.
Type: transport
Pathway Components: glycolate_Ext - LldP -> glycolate
Components:
Function Name Type Evidence Reference(s)
catalyzer LldP protein nd nd
product glycolate simple_molecule nd nd
reactant glycolate_Ext simple_molecule nd nd
LldP lactate_Ext lactate
Name: lactate_Ext -> lactate
Description: Transport of lactate_Ext through a bacterial membrane, leading to the presence of lactate inside the cell.
Type: transport
Pathway Components: lactate_Ext - LldP -> lactate
Components:
Function Name Type Evidence Reference(s)
catalyzer LldP protein nd nd
product lactate simple_molecule nd nd
reactant lactate_Ext simple_molecule nd nd
lldPRD_mRNA LldR
Name: lldPRD_mRNA -> LldR
Description: Translation of LldR
Type: translation
Pathway Components: lldPRD_mRNA -> LldR
Components:
Function Name Type Evidence Reference(s)
product LldR protein nd nd
reactant lldPRD_mRNA RNA nd nd
lldPRD_mRNA LldD
Name: lldPRD_mRNA -> LldD
Description: Translation of LldD
Type: translation
Pathway Components: lldPRD_mRNA -> LldD
Components:
Function Name Type Evidence Reference(s)
product LldD protein nd nd
reactant lldPRD_mRNA RNA nd nd
LldD acceptors + lactate pyruvate + A(H2)
Name: acceptors + lactate -> pyruvate + A(H2)
Description: Reaction transforming acceptors, lactate into pyruvate, A(H2)
Type: state transition
Pathway Components: acceptors + lactate - LldD -> pyruvate + A(H2)
Components:
Function Name Type Evidence Reference(s)
product A(H2) simple_molecule nd nd
catalyzer LldD protein nd nd
reactant acceptors simple_molecule nd nd
reactant lactate simple_molecule nd nd
product pyruvate simple_molecule nd nd



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