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LacI Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
LacA LacI LacY LacZ 6-acetyl-b-D-galactoside b-D-galactoside ac-CoA allolactose b-D-galactose b-D-glucose CoA lacZYA lacZYA_mRNA a-D-lactose a-D-lactose_Ext a-D-melibiose a-D-melibiose_Ext LacI allolactose


Gensor Unit       
Name: LacI
Description: LacI negatively regulates the expression of genes involved in the transport and catabolism of ?-D-lactose in the absence of allolactose. The presence of allolactose induces the expression of genes related to the entry into the cell of D-lactose and its degradation to D-galactose and D-glucose.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): GO:0003824 - catalytic activity
GO:0005989 - lactose biosynthetic process
GO:0008870 - galactoside O-acetyltransferase activity
GO:0016020 - membrane
GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005737 - cytoplasm
GO:0005887 - integral component of plasma membrane
GO:0005990 - lactose catabolic process
GO:0016798 - hydrolase activity, acting on glycosyl bonds
GO:0009341 - beta-galactosidase complex
GO:0016407 - acetyltransferase activity
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Components:
Function Name Type
simple molecule melibiose_Ext simple molecule


Reactions       
Showing 10 reactions
lacZYA lacZYA_mRNA
Name: lacZYA -> lacZYA_mRNA
Description: Transcription of transcription unit lacZYA; reaction inhibition by LacI.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant lacZYA gene nd nd
product lacZYA_mRNA RNA nd nd
LacI + Allolactose LacI-Allolactose
Name: LacI + Allolactose -> LacI-Allolactose
Description: Reaction transforming LacI, Allolactose into LacI-Allolactose
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product LacI-Allolactose complex nd nd
reactant LacI protein nd nd
reactant Allolactose simple molecule nd nd
lacZYA_mRNA LacZ
Name: lacZYA_mRNA -> LacZ
Description: Translation of LacZ
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant lacZYA_mRNA RNA nd nd
product LacZ protein nd nd
lactose allolactose
Name: lactose -> allolactose
Description: Reaction transforming lactose into allolactose
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant lactose simple molecule nd nd
product allolactose simple molecule nd nd
lactose beta-D-galactose + beta-D-glucose
Name: lactose -> beta-D-galactose + beta-D-glucose
Description: Reaction transforming lactose into beta-D-galactose, beta-D-glucose
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product beta-D-glucose simple molecule nd nd
reactant lactose simple molecule nd nd
product beta-D-galactose simple molecule nd nd
lacZYA_mRNA LacY
Name: lacZYA_mRNA -> LacY
Description: Translation of LacY
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant lacZYA_mRNA RNA nd nd
product LacY protein nd nd
melibiose_Ext melibiose
Name: melibiose_Ext -> melibiose
Description: Transport of melibiose_Ext through a bacterial membrane, leading to the presence of melibiose inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product melibiose simple molecule nd nd
reactant melibiose_Ext simple molecule nd nd
lactose_Ext lactose
Name: lactose_Ext -> lactose
Description: Transport of lactose_Ext through a bacterial membrane, leading to the presence of lactose inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product lactose simple molecule nd nd
reactant lactose_Ext simple molecule nd nd
lacZYA_mRNA LacA
Name: lacZYA_mRNA -> LacA
Description: Translation of LacA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product LacA protein nd nd
reactant lacZYA_mRNA RNA nd nd
a beta-D-galactoside + acetyl-CoA a 6-acetyl-beta-D-galactoside + coenzyme A
Name: a beta-D-galactoside + acetyl-CoA -> a 6-acetyl-beta-D-galactoside + coenzyme A
Description: Reaction transforming a beta-D-galactoside, acetyl-CoA into a 6-acetyl-beta-D-galactoside, coenzyme A
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product coenzyme A simple molecule nd nd
product a 6-acetyl-beta-D-galactoside simple molecule nd nd
reactant acetyl-CoA simple molecule nd nd
reactant a beta-D-galactoside simple molecule nd nd



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