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IlvY Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
(S)-2-acetolactate (R)-2,3-dihydroxy-isovalerate (R)-2,3-dihydroxy-3-methylvalerate (S)-2-aceto-2-hydroxybutanoate (S)-2-acetolactate IlvC IlvY ilvC ilvC_mRNA ilvY ilvY_mRNA IlvY (S)-2-acetolactate 2-dehydropantoate (R)-pantoate


Gensor Unit       
Name: IlvY
Description: IlvY positively regulates the expression of genes involved in reactions that are part of the L-isoleucine, L-valine, and phosphopantothenate biosynthesis pathways in the presence or absence of (S)-2-acetolactate. The reactions entail transformation of 2-dehydropantoate to (R)pantoate, of (S)-2-acetolactate to (R)-2,3-dihydroxy-isovalerate, and of (S)-2-aceto-2-hydroxybutanoate to (R)-2,3-dihydroxy-3-methylvalerate; these intermediates correspond to the phosphopantothenate, L-valine, and L-isoleucine biosynthetic pathways, respectively.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0050662 - coenzyme binding
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016491 - oxidoreductase activity
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0005737 - cytoplasm
GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0005829 - cytosol
GO:0003677 - DNA binding
GO:0000287 - magnesium ion binding
GO:0050661 - NADP binding
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Components:
Function Name Type
RNA ilvY_mRNA RNA


Reactions       
Showing 8 reactions
ilvC ilvC_mRNA
Name: ilvC -> ilvC_mRNA
Description: Transcription of transcription unit ilvC; reaction activation by IlvY.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product ilvC_mRNA RNA nd nd
reactant ilvC gene nd nd
ilvY ilvY_mRNA
Name: ilvY -> ilvY_mRNA
Description: Transcription of transcription unit ilvY; reaction inhibition by IlvY.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product ilvY_mRNA RNA nd nd
reactant ilvY gene nd nd
IlvY + 2-acetolactate IlvY-2-acetolactate
Name: IlvY + 2-acetolactate -> IlvY-2-acetolactate
Description: Reaction transforming IlvY, 2-acetolactate into IlvY-2-acetolactate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant IlvY protein nd nd
product IlvY-2-acetolactate complex nd nd
reactant 2-acetolactate simple molecule nd nd
ilvC_mRNA IlvC
Name: ilvC_mRNA -> IlvC
Description: Translation of IlvC
Type: translation
Components:
Function Name Type Evidence Reference(s)
product IlvC protein nd nd
reactant ilvC_mRNA RNA nd nd
2-aceto-2-hydroxy-butanoate 2,3-dihydroxy-3-methylvalerate
Name: 2-aceto-2-hydroxy-butanoate -> 2,3-dihydroxy-3-methylvalerate
Description: Reaction transforming 2-aceto-2-hydroxy-butanoate into 2,3-dihydroxy-3-methylvalerate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product 2,3-dihydroxy-3-methylvalerate simple molecule nd nd
reactant 2-aceto-2-hydroxy-butanoate simple molecule nd nd
(S)-2-acetolactate 2,3-dihydroxy-3-methylbutanoate
Name: (S)-2-acetolactate -> 2,3-dihydroxy-3-methylbutanoate
Description: Reaction transforming (S)-2-acetolactate into 2,3-dihydroxy-3-methylbutanoate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant (S)-2-acetolactate simple molecule nd nd
product 2,3-dihydroxy-3-methylbutanoate simple molecule nd nd
ilvY_mRNA IlvY
Name: ilvY_mRNA -> IlvY
Description: Translation of IlvY
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant ilvY_mRNA RNA nd nd
product IlvY protein nd nd
2-dehydropantoate (R)-pantoate
Name: 2-dehydropantoate -> (R)-pantoate
Description: Reaction transforming 2-dehydropantoate into (R)-pantoate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product (R)-pantoate simple molecule nd nd
reactant 2-dehydropantoate simple molecule nd nd



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