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HypT Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2-oxobutyrate CydA CydB CysH D-methionine D-methionine_Ext ExbB ExbD FecA FecB FecC FecD FecE HypT asp L-aspartate-semialdehyde L-aspartyl-4-P cystathionine L-cysteine homo-ser L-methionine Methionine S-oxide Methionine S-oxide_Ext L-methionine_Ext Met-oxidized MetB MetI MetL MetN MetQ acetyl-DL-methionine acetyl-DL-methionine_Ext azaserine TonB a reduced thioredoxin adenosine 3',5'-bisphosphate ammonia oxidized thioredoxin an ubiquinol_Ext ubiquinone cydAB cydAB_mRNA This Gensor Unit is not yet available This Gensor Unit is not yet available fecABCDE fecABCDE_mRNA iron dicitrate iron dicitrate_Ext metBL metBL_mRNA metNIQ metNIQ_mRNA oxygen_Ext phosphate phosphoadenosine-5'-phosphosulfate succinate sulfite HypT Met-oxidized FecB FecD FecC FecE TonB ExbB ExbD FecA FecE FecC FecD FecB MetN MetI MetQ CydA CydB FecA ExbD ExbB TonB phosphate phosphate


Gensor Unit       
Name: HypT
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0071266 - 'de novo' L-methionine biosynthetic process
GO:0048473 - D-methionine transport
GO:0019646 - aerobic electron transport chain
GO:0006865 - amino acid transport
GO:0015682 - ferric iron transport
GO:0009090 - homoserine biosynthetic process
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cellular_component GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:0009276 - Gram-negative-bacterium-type cell wall
GO:0046658 - anchored component of plasma membrane
GO:0009279 - cell outer membrane
GO:0070069 - cytochrome complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
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molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0043492 - ATPase activity, coupled to movement of substances
GO:0042626 - ATPase activity, coupled to transmembrane movement of substances
GO:0048474 - D-methionine transmembrane transporter activity
GO:0015191 - L-methionine transmembrane transporter activity
GO:0004072 - aspartate kinase activity
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Components: Show/Hide Components Table (61 more...)
Function Name Type
simple_molecule (2Z)-2-aminobut-2-enoate simple_molecule
simple_molecule 2-oxobutyrate simple_molecule
simple_molecule 3',5'-ADP simple_molecule
protein CydA protein
complex CydA-CydB-CydX complex
protein CydB protein
protein CydX protein
protein CysH protein
protein ExbB protein
protein ExbD protein
protein FecA protein
complex FecA-ExbD-ExbB-TonB complex
complex FecA-FecR complex
protein FecB protein
protein FecC protein
protein FecD protein
protein FecE protein
complex FecE-FecC-FecD-FecB complex
protein FecR protein
protein HypT protein
protein MetB protein
protein MetI protein
protein MetL protein
protein MetN protein
complex MetN-MetI-MetQ complex
protein MetQ protein
simple_molecule Methionine S-oxide simple_molecule
simple_molecule Methionine S-oxide_Ext simple_molecule
simple_molecule PAPS simple_molecule
protein TonB protein
simple_molecule acetyl-DL-methionine simple_molecule
simple_molecule acetyl-DL-methionine_Ext simple_molecule
simple_molecule ammonium simple_molecule
simple_molecule aspartate simple_molecule
simple_molecule aspartate-semialdehyde simple_molecule
simple_molecule aspartyl-4-P simple_molecule
gene cydAB gene
RNA cydAB_mRNA RNA
gene cysH gene
RNA cysH_mRNA RNA
simple_molecule cystathionine simple_molecule
simple_molecule cysteine simple_molecule
gene fecABCDE gene
RNA fecABCDE_mRNA RNA
simple_molecule homo-ser simple_molecule
simple_molecule iron dicitrate simple_molecule
simple_molecule iron dicitrate_Ext simple_molecule
gene metBL gene
RNA metBL_mRNA RNA
gene metNIQ gene
RNA metNIQ_mRNA RNA
simple_molecule methionine simple_molecule
simple_molecule methionine_Ext simple_molecule
simple_molecule oxygen_Ext simple_molecule
simple_molecule reduced thioredoxin simple_molecule
simple_molecule succinate simple_molecule
simple_molecule succinyl-homoserine simple_molecule
simple_molecule sulfite simple_molecule
simple_molecule thioredoxin disulfide simple_molecule
simple_molecule ubiquinol_Ext simple_molecule
simple_molecule ubiquinone simple_molecule


Reactions       
Showing 36 reactions
HypT cydAB cydAB_mRNA
Name: cydAB -> cydAB_mRNA
Description: Transcription of transcription unit cydAB. Reaction activation by HypT.
Type: transcription
Pathway Components: cydAB - HypT -> cydAB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator HypT protein nd nd
reactant cydAB gene nd nd
product cydAB_mRNA RNA nd nd
HypT cysH cysH_mRNA
Name: cysH -> cysH_mRNA
Description: Transcription of transcription unit cysH. Reaction activation by HypT.
Type: transcription
Pathway Components: cysH - HypT -> cysH_mRNA
Components:
Function Name Type Evidence Reference(s)
activator HypT protein nd nd
reactant cysH gene nd nd
product cysH_mRNA RNA nd nd
HypT fecABCDE fecABCDE_mRNA
Name: fecABCDE -> fecABCDE_mRNA
Description: Transcription of transcription unit fecABCDE. Reaction inhibition by HypT.
Type: transcription
Pathway Components: fecABCDE - HypT -> fecABCDE_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HypT protein nd nd
reactant fecABCDE gene nd nd
product fecABCDE_mRNA RNA nd nd
HypT metBL metBL_mRNA
Name: metBL -> metBL_mRNA
Description: Transcription of transcription unit metBL. Reaction activation by HypT.
Type: transcription
Pathway Components: metBL - HypT -> metBL_mRNA
Components:
Function Name Type Evidence Reference(s)
activator HypT protein nd nd
reactant metBL gene nd nd
product metBL_mRNA RNA nd nd
HypT metNIQ metNIQ_mRNA
Name: metNIQ -> metNIQ_mRNA
Description: Transcription of transcription unit metNIQ. Reaction activation by HypT.
Type: transcription
Pathway Components: metNIQ - HypT -> metNIQ_mRNA
Components:
Function Name Type Evidence Reference(s)
activator HypT protein nd nd
reactant metNIQ gene nd nd
product metNIQ_mRNA RNA nd nd
cysH_mRNA CysH
Name: cysH_mRNA -> CysH
Description: Translation of CysH
Type: translation
Pathway Components: cysH_mRNA -> CysH
Components:
Function Name Type Evidence Reference(s)
product CysH protein nd nd
reactant cysH_mRNA RNA nd nd
3',5'-ADP CysH reduced thioredoxin + PAPS Products
Name: reduced thioredoxin + PAPS -> thioredoxin disulfide + 3',5'-ADP + sulfite
Description: Reaction transforming reduced thioredoxin, PAPS into thioredoxin disulfide, 3',5'-ADP , sulfite
Type: state transition
Pathway Components: reduced thioredoxin + PAPS - CysH - 3',5'-ADP -> thioredoxin disulfide + 3',5'-ADP + sulfite
Components:
Function Name Type Evidence Reference(s)
inhibitor 3',5'-ADP simple_molecule nd nd
product 3',5'-ADP simple_molecule nd nd
catalyzer CysH protein nd nd
reactant PAPS simple_molecule nd nd
reactant reduced thioredoxin simple_molecule nd nd
product sulfite simple_molecule nd nd
product thioredoxin disulfide simple_molecule nd nd
cydAB_mRNA CydA
Name: cydAB_mRNA -> CydA
Description: Translation of CydA
Type: translation
Pathway Components: cydAB_mRNA -> CydA
Components:
Function Name Type Evidence Reference(s)
product CydA protein nd nd
reactant cydAB_mRNA RNA nd nd
CydX + CydA + CydB CydA-CydB-CydX
Name: CydX + CydA + CydB -> CydA-CydB-CydX
Description: Reaction transforming CydX, CydA, CydB into CydA-CydB-CydX
Type: state transition
Pathway Components: CydX + CydA + CydB -> CydA-CydB-CydX
Components:
Function Name Type Evidence Reference(s)
reactant CydA protein nd nd
product CydA-CydB-CydX complex nd nd
reactant CydB protein nd nd
reactant CydX protein nd nd
CydA-CydB-CydX ubiquinol_Ext + oxygen_Ext ubiquinone
Name: ubiquinol_Ext + oxygen_Ext -> ubiquinone
Description: Transport of ubiquinol_Ext, oxygen_Ext through a bacterial membrane, leading to the presence of ubiquinone inside the cell.
Type: transport
Pathway Components: ubiquinol_Ext + oxygen_Ext - CydA-CydB-CydX -> ubiquinone
Components:
Function Name Type Evidence Reference(s)
catalyzer CydA-CydB-CydX complex nd nd
reactant oxygen_Ext simple_molecule nd nd
reactant ubiquinol_Ext simple_molecule nd nd
product ubiquinone simple_molecule nd nd
cydAB_mRNA CydB
Name: cydAB_mRNA -> CydB
Description: Translation of CydB
Type: translation
Pathway Components: cydAB_mRNA -> CydB
Components:
Function Name Type Evidence Reference(s)
product CydB protein nd nd
reactant cydAB_mRNA RNA nd nd
fecABCDE_mRNA FecA
Name: fecABCDE_mRNA -> FecA
Description: Translation of FecA
Type: translation
Pathway Components: fecABCDE_mRNA -> FecA
Components:
Function Name Type Evidence Reference(s)
product FecA protein nd nd
reactant fecABCDE_mRNA RNA nd nd
FecR + FecA FecA-FecR
Name: FecR + FecA -> FecA-FecR
Description: Reaction transforming FecR, FecA into FecA-FecR
Type: state transition
Pathway Components: FecR + FecA -> FecA-FecR
Components:
Function Name Type Evidence Reference(s)
reactant FecA protein nd nd
product FecA-FecR complex nd nd
reactant FecR protein nd nd
ExbD + TonB + ExbB + FecA FecA-ExbD-ExbB-TonB
Name: ExbD + TonB + ExbB + FecA -> FecA-ExbD-ExbB-TonB
Description: Reaction transforming ExbD, TonB, ExbB, FecA into FecA-ExbD-ExbB-TonB
Type: state transition
Pathway Components: ExbD + TonB + ExbB + FecA -> FecA-ExbD-ExbB-TonB
Components:
Function Name Type Evidence Reference(s)
reactant ExbB protein nd nd
reactant ExbD protein nd nd
reactant FecA protein nd nd
product FecA-ExbD-ExbB-TonB complex nd nd
reactant TonB protein nd nd
FecA-ExbD-ExbB-TonB FecE-FecC-FecD-FecB iron dicitrate_Ext iron dicitrate
Name: iron dicitrate_Ext -> iron dicitrate
Description: Transport of iron dicitrate_Ext through a bacterial membrane, leading to the presence of iron dicitrate inside the cell.
Type: transport
Pathway Components: iron dicitrate_Ext - FecA-ExbD-ExbB-TonB - FecE-FecC-FecD-FecB -> iron dicitrate
Components:
Function Name Type Evidence Reference(s)
catalyzer FecA-ExbD-ExbB-TonB complex nd nd
catalyzer FecE-FecC-FecD-FecB complex nd nd
product iron dicitrate simple_molecule nd nd
reactant iron dicitrate_Ext simple_molecule nd nd
fecABCDE_mRNA FecB
Name: fecABCDE_mRNA -> FecB
Description: Translation of FecB
Type: translation
Pathway Components: fecABCDE_mRNA -> FecB
Components:
Function Name Type Evidence Reference(s)
product FecB protein nd nd
reactant fecABCDE_mRNA RNA nd nd
FecC + FecB + FecE + FecD FecE-FecC-FecD-FecB
Name: FecC + FecB + FecE + FecD -> FecE-FecC-FecD-FecB
Description: Reaction transforming FecC, FecB, FecE, FecD into FecE-FecC-FecD-FecB
Type: state transition
Pathway Components: FecC + FecB + FecE + FecD -> FecE-FecC-FecD-FecB
Components:
Function Name Type Evidence Reference(s)
reactant FecB protein nd nd
reactant FecC protein nd nd
reactant FecD protein nd nd
reactant FecE protein nd nd
product FecE-FecC-FecD-FecB complex nd nd
fecABCDE_mRNA FecC
Name: fecABCDE_mRNA -> FecC
Description: Translation of FecC
Type: translation
Pathway Components: fecABCDE_mRNA -> FecC
Components:
Function Name Type Evidence Reference(s)
product FecC protein nd nd
reactant fecABCDE_mRNA RNA nd nd
fecABCDE_mRNA FecD
Name: fecABCDE_mRNA -> FecD
Description: Translation of FecD
Type: translation
Pathway Components: fecABCDE_mRNA -> FecD
Components:
Function Name Type Evidence Reference(s)
product FecD protein nd nd
reactant fecABCDE_mRNA RNA nd nd
fecABCDE_mRNA FecE
Name: fecABCDE_mRNA -> FecE
Description: Translation of FecE
Type: translation
Pathway Components: fecABCDE_mRNA -> FecE
Components:
Function Name Type Evidence Reference(s)
product FecE protein nd nd
reactant fecABCDE_mRNA RNA nd nd
metBL_mRNA MetB
Name: metBL_mRNA -> MetB
Description: Translation of MetB
Type: translation
Pathway Components: metBL_mRNA -> MetB
Components:
Function Name Type Evidence Reference(s)
product MetB protein nd nd
reactant metBL_mRNA RNA nd nd
MetB succinyl-homoserine + cysteine cystathionine + succinate
Name: succinyl-homoserine + cysteine -> cystathionine + succinate
Description: Reaction transforming succinyl-homoserine, cysteine into cystathionine, succinate
Type: state transition
Pathway Components: succinyl-homoserine + cysteine - MetB -> cystathionine + succinate
Components:
Function Name Type Evidence Reference(s)
catalyzer MetB protein nd nd
product cystathionine simple_molecule nd nd
reactant cysteine simple_molecule nd nd
product succinate simple_molecule nd nd
reactant succinyl-homoserine simple_molecule nd nd
MetB succinyl-homoserine 2-oxobutyrate + succinate + ammonium
Name: succinyl-homoserine -> 2-oxobutyrate + succinate + ammonium
Description: Reaction transforming succinyl-homoserine into 2-oxobutyrate, succinate , ammonium
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> 2-oxobutyrate + succinate + ammonium
Components:
Function Name Type Evidence Reference(s)
product 2-oxobutyrate simple_molecule nd nd
catalyzer MetB protein nd nd
product ammonium simple_molecule nd nd
product succinate simple_molecule nd nd
reactant succinyl-homoserine simple_molecule nd nd
MetB succinyl-homoserine (2Z)-2-aminobut-2-enoate + succinate
Name: succinyl-homoserine -> (2Z)-2-aminobut-2-enoate + succinate
Description: Reaction transforming succinyl-homoserine into (2Z)-2-aminobut-2-enoate, succinate
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> (2Z)-2-aminobut-2-enoate + succinate
Components:
Function Name Type Evidence Reference(s)
product (2Z)-2-aminobut-2-enoate simple_molecule nd nd
catalyzer MetB protein nd nd
product succinate simple_molecule nd nd
reactant succinyl-homoserine simple_molecule nd nd
metBL_mRNA MetL
Name: metBL_mRNA -> MetL
Description: Translation of MetL
Type: translation
Pathway Components: metBL_mRNA -> MetL
Components:
Function Name Type Evidence Reference(s)
product MetL protein nd nd
reactant metBL_mRNA RNA nd nd
MetL homo-ser aspartate aspartyl-4-P
Name: aspartate -> aspartyl-4-P
Description: Reaction transforming aspartate into aspartyl-4-P
Type: state transition
Pathway Components: aspartate - MetL - homo-ser -> aspartyl-4-P
Components:
Function Name Type Evidence Reference(s)
catalyzer MetL protein nd nd
reactant aspartate simple_molecule nd nd
product aspartyl-4-P simple_molecule nd nd
inhibitor homo-ser simple_molecule nd nd
MetL aspartate-semialdehyde homo-ser
Name: aspartate-semialdehyde -> homo-ser
Description: Reaction transforming aspartate-semialdehyde into homo-ser
Type: state transition
Pathway Components: aspartate-semialdehyde - MetL -> homo-ser
Components:
Function Name Type Evidence Reference(s)
catalyzer MetL protein nd nd
reactant aspartate-semialdehyde simple_molecule nd nd
product homo-ser simple_molecule nd nd
metNIQ_mRNA MetN
Name: metNIQ_mRNA -> MetN
Description: Translation of MetN
Type: translation
Pathway Components: metNIQ_mRNA -> MetN
Components:
Function Name Type Evidence Reference(s)
product MetN protein nd nd
reactant metNIQ_mRNA RNA nd nd
MetI + MetN + MetQ MetN-MetI-MetQ
Name: MetI + MetN + MetQ -> MetN-MetI-MetQ
Description: Reaction transforming MetI, MetN, MetQ into MetN-MetI-MetQ
Type: state transition
Pathway Components: MetI + MetN + MetQ -> MetN-MetI-MetQ
Components:
Function Name Type Evidence Reference(s)
reactant MetI protein nd nd
reactant MetN protein nd nd
product MetN-MetI-MetQ complex nd nd
reactant MetQ protein nd nd
MetN-MetI-MetQ Methionine S-oxide_Ext Methionine S-oxide
Name: Methionine S-oxide_Ext -> Methionine S-oxide
Description: Transport of Methionine S-oxide_Ext through a bacterial membrane, leading to the presence of Methionine S-oxide inside the cell.
Type: transport
Pathway Components: Methionine S-oxide_Ext - MetN-MetI-MetQ -> Methionine S-oxide
Components:
Function Name Type Evidence Reference(s)
catalyzer MetN-MetI-MetQ complex nd nd
product Methionine S-oxide simple_molecule nd nd
reactant Methionine S-oxide_Ext simple_molecule nd nd
MetN-MetI-MetQ acetyl-DL-methionine_Ext acetyl-DL-methionine
Name: acetyl-DL-methionine_Ext -> acetyl-DL-methionine
Description: Transport of acetyl-DL-methionine_Ext through a bacterial membrane, leading to the presence of acetyl-DL-methionine inside the cell.
Type: transport
Pathway Components: acetyl-DL-methionine_Ext - MetN-MetI-MetQ -> acetyl-DL-methionine
Components:
Function Name Type Evidence Reference(s)
catalyzer MetN-MetI-MetQ complex nd nd
product acetyl-DL-methionine simple_molecule nd nd
reactant acetyl-DL-methionine_Ext simple_molecule nd nd
MetN-MetI-MetQ methionine_Ext methionine
Name: methionine_Ext -> methionine
Description: Transport of methionine_Ext through a bacterial membrane, leading to the presence of methionine inside the cell.
Type: transport
Pathway Components: methionine_Ext - MetN-MetI-MetQ -> methionine
Components:
Function Name Type Evidence Reference(s)
catalyzer MetN-MetI-MetQ complex nd nd
product methionine simple_molecule nd nd
reactant methionine_Ext simple_molecule nd nd
metNIQ_mRNA MetI
Name: metNIQ_mRNA -> MetI
Description: Translation of MetI
Type: translation
Pathway Components: metNIQ_mRNA -> MetI
Components:
Function Name Type Evidence Reference(s)
product MetI protein nd nd
reactant metNIQ_mRNA RNA nd nd
metNIQ_mRNA MetQ
Name: metNIQ_mRNA -> MetQ
Description: Translation of MetQ
Type: translation
Pathway Components: metNIQ_mRNA -> MetQ
Components:
Function Name Type Evidence Reference(s)
product MetQ protein nd nd
reactant metNIQ_mRNA RNA nd nd
homo-ser succinyl-homoserine
Name: homo-ser -> succinyl-homoserine
Description: Transformation of homo-ser into succinyl-homoserine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: homo-ser / HOMSUCTRAN-RXN / succinyl-homoserine
Components:
Function Name Type Evidence Reference(s)
reactant homo-ser simple_molecule nd nd
product succinyl-homoserine simple_molecule nd nd
aspartyl-4-P aspartate-semialdehyde
Name: aspartyl-4-P -> aspartate-semialdehyde
Description: Transformation of aspartyl-4-P into aspartate-semialdehyde by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: aspartyl-4-P / ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN / aspartate-semialdehyde
Components:
Function Name Type Evidence Reference(s)
product aspartate-semialdehyde simple_molecule nd nd
reactant aspartyl-4-P simple_molecule nd nd



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