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HypT Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2-oxobutyrate CydA CydB CysH D-methionine D-methionine_Ext ExbB ExbD FecA FecB FecC FecD FecE HypT asp L-aspartate-semialdehyde L-aspartyl-4-P cystathionine L-cysteine homo-ser L-methionine Methionine S-oxide Methionine S-oxide_Ext L-methionine_Ext Met-oxidized MetB MetI MetL MetN MetQ acetyl-DL-methionine acetyl-DL-methionine_Ext azaserine TonB a reduced thioredoxin adenosine 3',5'-bisphosphate ammonia oxidized thioredoxin an ubiquinol_Ext ubiquinone cydAB cydAB_mRNA This Gensor Unit is not yet available This Gensor Unit is not yet available fecABCDE fecABCDE_mRNA iron dicitrate iron dicitrate_Ext metBL metBL_mRNA metNIQ metNIQ_mRNA oxygen_Ext phosphate phosphoadenosine-5'-phosphosulfate succinate sulfite HypT Met-oxidized FecB FecD FecC FecE TonB ExbB ExbD FecA FecE FecC FecD FecB MetN MetI MetQ CydA CydB FecA ExbD ExbB TonB phosphate phosphate


Gensor Unit       
Name: HypT
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0055072 - iron ion homeostasis
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0015821 - methionine transport
GO:0019344 - cysteine biosynthetic process
GO:0003824 - catalytic activity
GO:0015424 - amino acid-transporting ATPase activity
GO:0008652 - cellular amino acid biosynthetic process
GO:0016020 - membrane
GO:0016682 - oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO:0016491 - oxidoreductase activity
GO:0009086 - methionine biosynthetic process
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Components:
Function Name Type
simple molecule sulfite simple molecule


Reactions       
Showing 38 reactions
HypT + Met-oxidized HypT-Met-oxidized
Name: HypT + Met-oxidized -> HypT-Met-oxidized
Description: Reaction transforming HypT, Met-oxidized into HypT-Met-oxidized
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant Met-oxidized simple molecule nd nd
reactant HypT protein nd nd
product HypT-Met-oxidized complex nd nd
cydAB cydAB_mRNA
Name: cydAB -> cydAB_mRNA
Description: Transcription of transcription unit cydAB; reaction activation by Cra.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product cydAB_mRNA RNA nd nd
reactant cydAB gene nd nd
cysH cysH_mRNA
Name: cysH -> cysH_mRNA
Description: Transcription of transcription unit cysH; reaction activation by HypT-Met-oxidized.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant cysH gene nd nd
product cysH_mRNA RNA nd nd
fecABCDE fecABCDE_mRNA
Name: fecABCDE -> fecABCDE_mRNA
Description: Transcription of transcription unit fecABCDE; reaction inhibition by Fur-Fe(II).
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product fecABCDE_mRNA RNA nd nd
reactant fecABCDE gene nd nd
metBL metBL_mRNA
Name: metBL -> metBL_mRNA
Description: Transcription of transcription unit metBL; reaction activation by HypT-Met-oxidized.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metBL_mRNA RNA nd nd
reactant metBL gene nd nd
metNIQ metNIQ_mRNA
Name: metNIQ -> metNIQ_mRNA
Description: Transcription of transcription unit metNIQ; reaction activation by HypT-Met-oxidized.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product metNIQ_mRNA RNA nd nd
reactant metNIQ gene nd nd
cysH_mRNA CysH
Name: cysH_mRNA -> CysH
Description: Translation of CysH
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant cysH_mRNA RNA nd nd
product CysH protein nd nd
PAP + sulfite + oxidized thioredoxin PAPS + reduced thioredoxin
Name: PAP + sulfite + oxidized thioredoxin -> PAPS + reduced thioredoxin
Description: Reaction transforming PAP, sulfite, oxidized thioredoxin into PAPS, reduced thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product reduced thioredoxin simple molecule nd nd
reactant oxidized thioredoxin simple molecule nd nd
product PAPS simple molecule nd nd
reactant sulfite simple molecule nd nd
reactant PAP simple molecule nd nd
fecABCDE_mRNA FecD
Name: fecABCDE_mRNA -> FecD
Description: Translation of FecD
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fecABCDE_mRNA RNA nd nd
product FecD protein nd nd
FecB + FecD + FecC + FecE + TonB + ExbB + ExbD + FecA FecB-FecD-FecC-FecE-TonB-ExbB-ExbD-FecA
Name: FecB + FecD + FecC + FecE + TonB + ExbB + ExbD + FecA -> FecB-FecD-FecC-FecE-TonB-ExbB-ExbD-FecA
Description: Reaction transforming FecB, FecD, FecC, FecE, TonB, ExbB, ExbD, FecA into FecB-FecD-FecC-FecE-TonB-ExbB-ExbD-FecA
Type: state transition
Components: Show/Hide Components Table
Function Name Type Evidence Reference(s)
reactant FecA protein nd nd
reactant FecE protein nd nd
reactant ExbD protein nd nd
reactant FecD protein nd nd
product FecB-FecD-FecC-FecE-TonB-ExbB-ExbD-FecA complex nd nd
reactant ExbB protein nd nd
reactant FecB protein nd nd
reactant FecC protein nd nd
reactant TonB protein nd nd
iron dicitrate_Ext iron dicitrate
Name: iron dicitrate_Ext -> iron dicitrate
Description: Transport of iron dicitrate_Ext through a bacterial membrane, leading to the presence of iron dicitrate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant iron dicitrate_Ext simple molecule nd nd
product iron dicitrate simple molecule nd nd
FecE + FecC + FecD + FecB FecE-FecC-FecD-FecB
Name: FecE + FecC + FecD + FecB -> FecE-FecC-FecD-FecB
Description: Reaction transforming FecE, FecC, FecD, FecB into FecE-FecC-FecD-FecB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product FecE-FecC-FecD-FecB complex nd nd
reactant FecC protein nd nd
reactant FecB protein nd nd
reactant FecD protein nd nd
reactant FecE protein nd nd
iron dicitrate_Ext phosphate + iron dicitrate
Name: iron dicitrate_Ext -> phosphate + iron dicitrate
Description: Transport of iron dicitrate_Ext through a bacterial membrane, leading to the presence of phosphate, iron dicitrate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product phosphate simple molecule nd nd
product iron dicitrate simple molecule nd nd
reactant iron dicitrate_Ext simple molecule nd nd
fecABCDE_mRNA FecE
Name: fecABCDE_mRNA -> FecE
Description: Translation of FecE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product FecE protein nd nd
reactant fecABCDE_mRNA RNA nd nd
metNIQ_mRNA MetN
Name: metNIQ_mRNA -> MetN
Description: Translation of MetN
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ_mRNA RNA nd nd
product MetN protein nd nd
MetN + MetI + MetQ MetN-MetI-MetQ
Name: MetN + MetI + MetQ -> MetN-MetI-MetQ
Description: Reaction transforming MetN, MetI, MetQ into MetN-MetI-MetQ
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant MetN protein nd nd
reactant MetQ protein nd nd
reactant MetI protein nd nd
product MetN-MetI-MetQ complex nd nd
Methionine S-oxide_Ext Methionine S-oxide + phosphate
Name: Methionine S-oxide_Ext -> Methionine S-oxide + phosphate
Description: Transport of Methionine S-oxide_Ext through a bacterial membrane, leading to the presence of Methionine S-oxide, phosphate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant Methionine S-oxide_Ext simple molecule nd nd
product phosphate simple molecule nd nd
product Methionine S-oxide simple molecule nd nd
acetyl-DL-methionine_Ext acetyl-DL-methionine + phosphate
Name: acetyl-DL-methionine_Ext -> acetyl-DL-methionine + phosphate
Description: Transport of acetyl-DL-methionine_Ext through a bacterial membrane, leading to the presence of acetyl-DL-methionine, phosphate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant acetyl-DL-methionine_Ext simple molecule nd nd
product acetyl-DL-methionine simple molecule nd nd
product phosphate simple molecule nd nd
L-methionine_Ext phosphate + L-methionine
Name: L-methionine_Ext -> phosphate + L-methionine
Description: Transport of L-methionine_Ext through a bacterial membrane, leading to the presence of phosphate, L-methionine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product phosphate simple molecule nd nd
reactant L-methionine_Ext simple molecule nd nd
product L-methionine simple molecule nd nd
D-methionine_Ext phosphate + D-methionine
Name: D-methionine_Ext -> phosphate + D-methionine
Description: Transport of D-methionine_Ext through a bacterial membrane, leading to the presence of phosphate, D-methionine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product D-methionine simple molecule nd nd
reactant D-methionine_Ext simple molecule nd nd
product phosphate simple molecule nd nd
metBL_mRNA MetB
Name: metBL_mRNA -> MetB
Description: Translation of MetB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetB protein nd nd
reactant metBL_mRNA RNA nd nd
2-oxobutyrate + suc + ammonia azaserine
Name: 2-oxobutyrate + suc + ammonia -> azaserine
Description: Reaction transforming 2-oxobutyrate, suc, ammonia into azaserine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant ammonia simple molecule nd nd
reactant 2-oxobutyrate simple molecule nd nd
reactant suc simple molecule nd nd
product azaserine simple molecule nd nd
L-cysteine + azaserine suc + cystathionine
Name: L-cysteine + azaserine -> suc + cystathionine
Description: Reaction transforming L-cysteine, azaserine into suc, cystathionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant azaserine simple molecule nd nd
product cystathionine simple molecule nd nd
product suc simple molecule nd nd
reactant L-cysteine simple molecule nd nd
metBL_mRNA MetL
Name: metBL_mRNA -> MetL
Description: Translation of MetL
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metBL_mRNA RNA nd nd
product MetL protein nd nd
asp L-aspartyl-4-P
Name: asp -> L-aspartyl-4-P
Description: Reaction transforming asp into L-aspartyl-4-P
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-aspartyl-4-P simple molecule nd nd
reactant asp simple molecule nd nd
homo-ser L-aspartate-semialdehyde
Name: homo-ser -> L-aspartate-semialdehyde
Description: Reaction transforming homo-ser into L-aspartate-semialdehyde
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant homo-ser simple molecule nd nd
product L-aspartate-semialdehyde simple molecule nd nd
cydAB_mRNA CydA
Name: cydAB_mRNA -> CydA
Description: Translation of CydA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant cydAB_mRNA RNA nd nd
product CydA protein nd nd
CydA + CydB CydA-CydB
Name: CydA + CydB -> CydA-CydB
Description: Reaction transforming CydA, CydB into CydA-CydB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant CydB protein nd nd
product CydA-CydB complex nd nd
reactant CydA protein nd nd
oxygen_Ext + an ubiquinol_Ext ubiquinone
Name: oxygen_Ext + an ubiquinol_Ext -> ubiquinone
Description: Transport of oxygen_Ext, an ubiquinol_Ext through a bacterial membrane, leading to the presence of ubiquinone inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant an ubiquinol_Ext simple molecule nd nd
reactant oxygen_Ext simple molecule nd nd
product ubiquinone simple molecule nd nd
metNIQ_mRNA MetQ
Name: metNIQ_mRNA -> MetQ
Description: Translation of MetQ
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant metNIQ_mRNA RNA nd nd
product MetQ protein nd nd
fecABCDE_mRNA FecB
Name: fecABCDE_mRNA -> FecB
Description: Translation of FecB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fecABCDE_mRNA RNA nd nd
product FecB protein nd nd
fecABCDE_mRNA FecA
Name: fecABCDE_mRNA -> FecA
Description: Translation of FecA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fecABCDE_mRNA RNA nd nd
product FecA protein nd nd
FecA + ExbD + ExbB + TonB FecA-ExbD-ExbB-TonB
Name: FecA + ExbD + ExbB + TonB -> FecA-ExbD-ExbB-TonB
Description: Reaction transforming FecA, ExbD, ExbB, TonB into FecA-ExbD-ExbB-TonB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant ExbB protein nd nd
reactant FecA protein nd nd
reactant TonB protein nd nd
reactant ExbD protein nd nd
product FecA-ExbD-ExbB-TonB complex nd nd
metNIQ_mRNA MetI
Name: metNIQ_mRNA -> MetI
Description: Translation of MetI
Type: translation
Components:
Function Name Type Evidence Reference(s)
product MetI protein nd nd
reactant metNIQ_mRNA RNA nd nd
cydAB_mRNA CydB
Name: cydAB_mRNA -> CydB
Description: Translation of CydB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product CydB protein nd nd
reactant cydAB_mRNA RNA nd nd
fecABCDE_mRNA FecC
Name: fecABCDE_mRNA -> FecC
Description: Translation of FecC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fecABCDE_mRNA RNA nd nd
product FecC protein nd nd
L-aspartyl-4-P L-aspartate-semialdehyde
Name: L-aspartyl-4-P -> L-aspartate-semialdehyde
Description: Transformation of L-aspartyl-4-P into L-aspartate-semialdehyde by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant L-aspartyl-4-P simple molecule nd nd
product L-aspartate-semialdehyde simple molecule nd nd
homo-ser azaserine
Name: homo-ser -> azaserine
Description: Transformation of homo-ser into azaserine by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant homo-ser simple molecule nd nd
product azaserine simple molecule nd nd



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