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HipB Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
HipA HipB hipBA hipBA_mRNA HipA HipA


Gensor Unit       
Name: HipB
Description: Molecular biology level
Detailed: HipB negatively regulates the expression of genes required for dormancy process, biofilm formation and antibiotic tolerance. HipB binds its target site preventing its own expression and the expression of HipA.
Less detailed: HipB negatively regulates the expression of genes needed for dormancy process.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0022611 - dormancy process
GO:0033543 - fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
GO:0015969 - guanosine tetraphosphate metabolic process
GO:0006402 - mRNA catabolic process
GO:0043086 - negative regulation of catalytic activity
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cellular_component GO:0005618 - cell wall
GO:0005829 - cytosol
GO:0005886 - plasma membrane
molecular_function GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0071949 - FAD binding
GO:0010181 - FMN binding
GO:0008728 - GTP diphosphokinase activity
GO:0000985 - bacterial-type RNA polymerase core promoter sequence-specific DNA binding
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Components: Show/Hide Components Table (20 more...)
Function Name Type
simple_molecule 2E-decenoyl-CoA simple_molecule
protein FadH protein
simple_molecule HipA simple_molecule
protein HipB protein
complex HipB-HipA complex
protein MazE protein
protein MazF protein
complex MazF-MazE complex
protein RelA protein
gene fadH gene
RNA fadH_mRNA RNA
simple_molecule guanosine-diphosphate simple_molecule
simple_molecule guanosine-triphosphate simple_molecule
gene hipBA gene
RNA hipBA_mRNA RNA
simple_molecule ppGpp simple_molecule
simple_molecule pppGpp simple_molecule
gene relA-mazEF gene
RNA relA-mazEF_mRNA RNA
simple_molecule trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule


Reactions       
Showing 16 reactions
HipB fadH fadH_mRNA
Name: fadH -> fadH_mRNA
Description: Transcription of transcription unit fadH. Reaction inhibition by HipB.
Type: transcription
Pathway Components: fadH - HipB -> fadH_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HipB protein nd nd
reactant fadH gene nd nd
product fadH_mRNA RNA nd nd
HipB hipBA hipBA_mRNA
Name: hipBA -> hipBA_mRNA
Description: Transcription of transcription unit hipBA. Reaction inhibition by HipB.
Type: transcription
Pathway Components: hipBA - HipB -> hipBA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HipB protein nd nd
reactant hipBA gene nd nd
product hipBA_mRNA RNA nd nd
HipB relA-mazEF relA-mazEF_mRNA
Name: relA-mazEF -> relA-mazEF_mRNA
Description: Transcription of transcription unit relA-mazEF. Reaction inhibition by HipB.
Type: transcription
Pathway Components: relA-mazEF - HipB -> relA-mazEF_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HipB protein nd nd
reactant relA-mazEF gene nd nd
product relA-mazEF_mRNA RNA nd nd
hipBA_mRNA HipB
Name: hipBA_mRNA -> HipB
Description: Translation of HipB
Type: translation
Pathway Components: hipBA_mRNA -> HipB
Components:
Function Name Type Evidence Reference(s)
product HipB protein nd nd
reactant hipBA_mRNA RNA nd nd
HipA + HipB HipB-HipA
Name: HipA + HipB -> HipB-HipA
Description: Reaction transforming HipA, HipB into HipB-HipA
Type: state transition
Pathway Components: HipA + HipB -> HipB-HipA
Components:
Function Name Type Evidence Reference(s)
reactant HipA simple_molecule nd nd
reactant HipB protein nd nd
product HipB-HipA complex nd nd
hipBA_mRNA HipA
Name: hipBA_mRNA -> HipA
Description: Translation of HipA
Type: translation
Pathway Components: hipBA_mRNA -> HipA
Components:
Function Name Type Evidence Reference(s)
product HipA simple_molecule nd nd
reactant hipBA_mRNA RNA nd nd
HipA HipA HipA
Name: HipA -> HipA
Description: Reaction transforming HipA into HipA
Type: state transition
Pathway Components: HipA - HipA -> HipA
Components:
Function Name Type Evidence Reference(s)
catalyzer HipA simple_molecule nd nd
product HipA simple_molecule nd nd
reactant HipA simple_molecule nd nd
relA-mazEF_mRNA RelA
Name: relA-mazEF_mRNA -> RelA
Description: Translation of RelA
Type: translation
Pathway Components: relA-mazEF_mRNA -> RelA
Components:
Function Name Type Evidence Reference(s)
product RelA protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
RelA ppGpp guanosine-diphosphate ppGpp
Name: guanosine-diphosphate -> ppGpp
Description: Reaction transforming guanosine-diphosphate into ppGpp
Type: state transition
Pathway Components: guanosine-diphosphate - RelA - ppGpp -> ppGpp
Components:
Function Name Type Evidence Reference(s)
catalyzer RelA protein nd nd
reactant guanosine-diphosphate simple_molecule nd nd
inhibitor ppGpp simple_molecule nd nd
product ppGpp simple_molecule nd nd
RelA guanosine-triphosphate pppGpp
Name: guanosine-triphosphate -> pppGpp
Description: Reaction transforming guanosine-triphosphate into pppGpp
Type: state transition
Pathway Components: guanosine-triphosphate - RelA -> pppGpp
Components:
Function Name Type Evidence Reference(s)
catalyzer RelA protein nd nd
reactant guanosine-triphosphate simple_molecule nd nd
product pppGpp simple_molecule nd nd
relA-mazEF_mRNA MazE
Name: relA-mazEF_mRNA -> MazE
Description: Translation of MazE
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazE
Components:
Function Name Type Evidence Reference(s)
product MazE protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
MazF + MazE MazF-MazE
Name: MazF + MazE -> MazF-MazE
Description: Reaction transforming MazF, MazE into MazF-MazE
Type: state transition
Pathway Components: MazF + MazE -> MazF-MazE
Components:
Function Name Type Evidence Reference(s)
reactant MazE protein nd nd
reactant MazF protein nd nd
product MazF-MazE complex nd nd
relA-mazEF_mRNA MazF
Name: relA-mazEF_mRNA -> MazF
Description: Translation of MazF
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazF
Components:
Function Name Type Evidence Reference(s)
product MazF protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
fadH_mRNA FadH
Name: fadH_mRNA -> FadH
Description: Translation of FadH
Type: translation
Pathway Components: fadH_mRNA -> FadH
Components:
Function Name Type Evidence Reference(s)
product FadH protein nd nd
reactant fadH_mRNA RNA nd nd
FadH trans-Δ2, cis-Δ4-decadienoyl-CoA trans-Δ2, cis-Δ4-decadienoyl-CoA 2E-decenoyl-CoA
Name: trans-Δ2, cis-Δ4-decadienoyl-CoA -> 2E-decenoyl-CoA
Description: Reaction transforming trans-Δ2, cis-Δ4-decadienoyl-CoA into 2E-decenoyl-CoA
Type: state transition
Pathway Components: trans-Δ2, cis-Δ4-decadienoyl-CoA - FadH - trans-Δ2, cis-Δ4-decadienoyl-CoA -> 2E-decenoyl-CoA
Components:
Function Name Type Evidence Reference(s)
product 2E-decenoyl-CoA simple_molecule nd nd
catalyzer FadH protein nd nd
inhibitor trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule nd nd
reactant trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule nd nd
pppGpp guanosine-diphosphate
Name: pppGpp -> guanosine-diphosphate
Description: Transformation of pppGpp into guanosine-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: pppGpp / PPPGPPHYDRO-RXN / PPGPPSYN-RXN / guanosine-diphosphate
Components:
Function Name Type Evidence Reference(s)
product guanosine-diphosphate simple_molecule nd nd
reactant pppGpp simple_molecule nd nd



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