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HipAB Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
HipA HipAB HipB hipBA hipBA_mRNA HipA HipA


Gensor Unit       
Name: HipAB
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0022611 - dormancy process
GO:0015969 - guanosine tetraphosphate metabolic process
GO:0006402 - mRNA catabolic process
GO:0043086 - negative regulation of catalytic activity
GO:0030308 - negative regulation of cell growth
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cellular_component GO:0005618 - cell wall
GO:0005829 - cytosol
GO:0005886 - plasma membrane
molecular_function GO:0005524 - ATP binding
GO:0008728 - GTP diphosphokinase activity
GO:0000985 - bacterial-type RNA polymerase core promoter sequence-specific DNA binding
GO:0004521 - endoribonuclease activity
GO:0008893 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0000287 - magnesium ion binding
GO:0005515 - protein binding
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Components: Show/Hide Components Table (16 more...)
Function Name Type
simple_molecule HipA simple_molecule
protein HipAB protein
protein HipB protein
complex HipB-HipA complex
protein MazE protein
protein MazF protein
complex MazF-MazE complex
protein RelA protein
simple_molecule guanosine-diphosphate simple_molecule
simple_molecule guanosine-triphosphate simple_molecule
gene hipBA gene
RNA hipBA_mRNA RNA
simple_molecule ppGpp simple_molecule
simple_molecule pppGpp simple_molecule
gene relA-mazEF gene
RNA relA-mazEF_mRNA RNA


Reactions       
Showing 13 reactions
HipAB hipBA hipBA_mRNA
Name: hipBA -> hipBA_mRNA
Description: Transcription of transcription unit hipBA. Reaction inhibition by HipAB.
Type: transcription
Pathway Components: hipBA - HipAB -> hipBA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HipAB protein nd nd
reactant hipBA gene nd nd
product hipBA_mRNA RNA nd nd
HipAB relA-mazEF relA-mazEF_mRNA
Name: relA-mazEF -> relA-mazEF_mRNA
Description: Transcription of transcription unit relA-mazEF. Reaction inhibition by HipAB.
Type: transcription
Pathway Components: relA-mazEF - HipAB -> relA-mazEF_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor HipAB protein nd nd
reactant relA-mazEF gene nd nd
product relA-mazEF_mRNA RNA nd nd
hipBA_mRNA HipB
Name: hipBA_mRNA -> HipB
Description: Translation of HipB
Type: translation
Pathway Components: hipBA_mRNA -> HipB
Components:
Function Name Type Evidence Reference(s)
product HipB protein nd nd
reactant hipBA_mRNA RNA nd nd
HipA + HipB HipB-HipA
Name: HipA + HipB -> HipB-HipA
Description: Reaction transforming HipA, HipB into HipB-HipA
Type: state transition
Pathway Components: HipA + HipB -> HipB-HipA
Components:
Function Name Type Evidence Reference(s)
reactant HipA simple_molecule nd nd
reactant HipB protein nd nd
product HipB-HipA complex nd nd
hipBA_mRNA HipA
Name: hipBA_mRNA -> HipA
Description: Translation of HipA
Type: translation
Pathway Components: hipBA_mRNA -> HipA
Components:
Function Name Type Evidence Reference(s)
product HipA simple_molecule nd nd
reactant hipBA_mRNA RNA nd nd
HipA HipA HipA
Name: HipA -> HipA
Description: Reaction transforming HipA into HipA
Type: state transition
Pathway Components: HipA - HipA -> HipA
Components:
Function Name Type Evidence Reference(s)
catalyzer HipA simple_molecule nd nd
product HipA simple_molecule nd nd
reactant HipA simple_molecule nd nd
relA-mazEF_mRNA RelA
Name: relA-mazEF_mRNA -> RelA
Description: Translation of RelA
Type: translation
Pathway Components: relA-mazEF_mRNA -> RelA
Components:
Function Name Type Evidence Reference(s)
product RelA protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
RelA ppGpp guanosine-diphosphate ppGpp
Name: guanosine-diphosphate -> ppGpp
Description: Reaction transforming guanosine-diphosphate into ppGpp
Type: state transition
Pathway Components: guanosine-diphosphate - RelA - ppGpp -> ppGpp
Components:
Function Name Type Evidence Reference(s)
catalyzer RelA protein nd nd
reactant guanosine-diphosphate simple_molecule nd nd
inhibitor ppGpp simple_molecule nd nd
product ppGpp simple_molecule nd nd
RelA guanosine-triphosphate pppGpp
Name: guanosine-triphosphate -> pppGpp
Description: Reaction transforming guanosine-triphosphate into pppGpp
Type: state transition
Pathway Components: guanosine-triphosphate - RelA -> pppGpp
Components:
Function Name Type Evidence Reference(s)
catalyzer RelA protein nd nd
reactant guanosine-triphosphate simple_molecule nd nd
product pppGpp simple_molecule nd nd
relA-mazEF_mRNA MazE
Name: relA-mazEF_mRNA -> MazE
Description: Translation of MazE
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazE
Components:
Function Name Type Evidence Reference(s)
product MazE protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
MazF + MazE MazF-MazE
Name: MazF + MazE -> MazF-MazE
Description: Reaction transforming MazF, MazE into MazF-MazE
Type: state transition
Pathway Components: MazF + MazE -> MazF-MazE
Components:
Function Name Type Evidence Reference(s)
reactant MazE protein nd nd
reactant MazF protein nd nd
product MazF-MazE complex nd nd
relA-mazEF_mRNA MazF
Name: relA-mazEF_mRNA -> MazF
Description: Translation of MazF
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazF
Components:
Function Name Type Evidence Reference(s)
product MazF protein nd nd
reactant relA-mazEF_mRNA RNA nd nd
pppGpp guanosine-diphosphate
Name: pppGpp -> guanosine-diphosphate
Description: Transformation of pppGpp into guanosine-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: pppGpp / PPPGPPHYDRO-RXN / PPGPPSYN-RXN / guanosine-diphosphate
Components:
Function Name Type Evidence Reference(s)
product guanosine-diphosphate simple_molecule nd nd
reactant pppGpp simple_molecule nd nd



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