RegulonDB RegulonDB

GutR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-A-5-P D-fructose 6-phosphate mannitol-1-P D-mannitol_Ext ribulose-5P D-sorbitol 6-phosphate L-gulitol_Ext Glucitol GutM GutQ GutR HPr HPr - phosphorylated_Ext SrlA SrlB SrlD SrlE SrlR srlAEBD-gutM-srlR-gutQ srlAEBD-gutM-srlR-gutQ_mRNA GutR Glucitol SrlA SrlB SrlE HPr


Gensor Unit       
Name: GutR
Description: Molecular biology level
Detailed: In the absence of sorbitol, GutR negatively regulates the expression of genes required for sorbitol transport and catabolism. Under these conditions, GutR binds its target sites preventing the expression of its regulated genes. In the presence of sorbitol, GutR is modified to GutR-sorbitol, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of sorbitol, GutR negatively regulates the expression of genes needed for sorbitol transport and catabolic process.

Physiology level
Detailed: The presence of sorbitol induces the expression of genes involved with sorbitol transport and catabolic process. Under this condition the genes necessary for transport of sorbitol and its conversion to Fructose-6-phosphate are expressed. Conversely, the presence of sorbitol inhibits the expression of these genes.
Less detailed: The presence of sorbitol induces the expression of genes needful for sorbitol transport and its conversion to fructose-6-phosphate.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0042710 - biofilm formation
GO:1901135 - carbohydrate derivative metabolic process
GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0019294 - keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
GO:0045892 - negative regulation of transcription, DNA-templated
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cellular_component GO:0005737 - cytoplasm
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0019146 - arabinose-5-phosphate isomerase activity
GO:0097367 - carbohydrate derivative binding
GO:0042802 - identical protein binding
GO:0016301 - kinase activity
GO:0016491 - oxidoreductase activity
GO:0016773 - phosphotransferase activity, alcohol group as acceptor
GO:0090563 - protein-phosphocysteine-sugar phosphotransferase activity
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Components: Show/Hide Components Table (22 more...)
Function Name Type
protein GutM protein
protein GutQ protein
protein GutR protein
complex GutR-gulitol complex
simple_molecule HPr - phosphorylated_Ext simple_molecule
simple_molecule PtsH simple_molecule
protein SrlA protein
complex SrlA-SrlB-SrlE complex
protein SrlB protein
protein SrlD protein
protein SrlE protein
protein SrlR protein
simple_molecule aldehydo-arabinose-5P simple_molecule
simple_molecule fructose 6-phosphate simple_molecule
simple_molecule gulitol simple_molecule
simple_molecule gulitol_Ext simple_molecule
simple_molecule mannitol-1-P simple_molecule
simple_molecule mannitol_Ext simple_molecule
simple_molecule ribulose-5P simple_molecule
simple_molecule sorbitol 6-phosphate simple_molecule
gene srlAEBD-gutM-srlR-gutQ gene
RNA srlAEBD-gutM-srlR-gutQ_mRNA RNA


Reactions       
Showing 14 reactions
GutR srlAEBD-gutM-srlR-gutQ srlAEBD-gutM-srlR-gutQ_mRNA
Name: srlAEBD-gutM-srlR-gutQ -> srlAEBD-gutM-srlR-gutQ_mRNA
Description: Transcription of transcription unit srlAEBD-gutM-srlR-gutQ. Reaction inhibition by GutR.
Type: transcription
Pathway Components: srlAEBD-gutM-srlR-gutQ - GutR -> srlAEBD-gutM-srlR-gutQ_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GutR protein nd nd
reactant srlAEBD-gutM-srlR-gutQ gene nd nd
product srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
gulitol + GutR GutR-gulitol
Name: gulitol + GutR -> GutR-gulitol
Description: Reaction transforming gulitol, GutR into GutR-gulitol
Type: state transition
Pathway Components: gulitol + GutR -> GutR-gulitol
Components:
Function Name Type Evidence Reference(s)
reactant GutR protein nd nd
product GutR-gulitol complex nd nd
reactant gulitol simple_molecule nd nd
srlAEBD-gutM-srlR-gutQ_mRNA SrlA
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlA
Description: Translation of SrlA
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlA
Components:
Function Name Type Evidence Reference(s)
product SrlA protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
SrlB + SrlE + SrlA SrlA-SrlB-SrlE
Name: SrlB + SrlE + SrlA -> SrlA-SrlB-SrlE
Description: Reaction transforming SrlB, SrlE, SrlA into SrlA-SrlB-SrlE
Type: state transition
Pathway Components: SrlB + SrlE + SrlA -> SrlA-SrlB-SrlE
Components:
Function Name Type Evidence Reference(s)
reactant SrlA protein nd nd
product SrlA-SrlB-SrlE complex nd nd
reactant SrlB protein nd nd
reactant SrlE protein nd nd
SrlA-SrlB-SrlE HPr - phosphorylated_Ext + gulitol_Ext sorbitol 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + gulitol_Ext -> sorbitol 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, gulitol_Ext through a bacterial membrane, leading to the presence of sorbitol 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + gulitol_Ext - SrlA-SrlB-SrlE -> sorbitol 6-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
catalyzer SrlA-SrlB-SrlE complex nd nd
reactant gulitol_Ext simple_molecule nd nd
product sorbitol 6-phosphate simple_molecule nd nd
SrlA-SrlB-SrlE HPr - phosphorylated_Ext + mannitol_Ext mannitol-1-P + PtsH
Name: HPr - phosphorylated_Ext + mannitol_Ext -> mannitol-1-P + PtsH
Description: Transport of HPr - phosphorylated_Ext, mannitol_Ext through a bacterial membrane, leading to the presence of mannitol-1-P, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + mannitol_Ext - SrlA-SrlB-SrlE -> mannitol-1-P + PtsH
Components:
Function Name Type Evidence Reference(s)
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
catalyzer SrlA-SrlB-SrlE complex nd nd
product mannitol-1-P simple_molecule nd nd
reactant mannitol_Ext simple_molecule nd nd
srlAEBD-gutM-srlR-gutQ_mRNA SrlE
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlE
Description: Translation of SrlE
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlE
Components:
Function Name Type Evidence Reference(s)
product SrlE protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
srlAEBD-gutM-srlR-gutQ_mRNA SrlB
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlB
Description: Translation of SrlB
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlB
Components:
Function Name Type Evidence Reference(s)
product SrlB protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
srlAEBD-gutM-srlR-gutQ_mRNA SrlD
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlD
Description: Translation of SrlD
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlD
Components:
Function Name Type Evidence Reference(s)
product SrlD protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
SrlD sorbitol 6-phosphate fructose 6-phosphate
Name: sorbitol 6-phosphate -> fructose 6-phosphate
Description: Reaction transforming sorbitol 6-phosphate into fructose 6-phosphate
Type: state transition
Pathway Components: sorbitol 6-phosphate - SrlD -> fructose 6-phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer SrlD protein nd nd
product fructose 6-phosphate simple_molecule nd nd
reactant sorbitol 6-phosphate simple_molecule nd nd
srlAEBD-gutM-srlR-gutQ_mRNA GutM
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> GutM
Description: Translation of GutM
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> GutM
Components:
Function Name Type Evidence Reference(s)
product GutM protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
srlAEBD-gutM-srlR-gutQ_mRNA SrlR
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlR
Description: Translation of SrlR
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> SrlR
Components:
Function Name Type Evidence Reference(s)
product SrlR protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
srlAEBD-gutM-srlR-gutQ_mRNA GutQ
Name: srlAEBD-gutM-srlR-gutQ_mRNA -> GutQ
Description: Translation of GutQ
Type: translation
Pathway Components: srlAEBD-gutM-srlR-gutQ_mRNA -> GutQ
Components:
Function Name Type Evidence Reference(s)
product GutQ protein nd nd
reactant srlAEBD-gutM-srlR-gutQ_mRNA RNA nd nd
GutQ aldehydo-arabinose-5P ribulose-5P
Name: aldehydo-arabinose-5P -> ribulose-5P
Description: Reaction transforming aldehydo-arabinose-5P into ribulose-5P
Type: state transition
Pathway Components: aldehydo-arabinose-5P - GutQ -> ribulose-5P
Components:
Function Name Type Evidence Reference(s)
catalyzer GutQ protein nd nd
reactant aldehydo-arabinose-5P simple_molecule nd nd
product ribulose-5P simple_molecule nd nd



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