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GlpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-fructose 6-phosphate DL-glyceraldehyde DL-glyceraldehyde_Ext GlpA GlpB GlpC GlpD GlpF GlpK GlpQ GlpR GlpT GlpX Glycerol-3-phosphate glycerol-3-P-OR ROH an electron-transfer-related quinol an electron-transfer-related quinone an ubiquinol ubiquinone arsenite arsenite_Ext DHAP fructose-1,6-bisphosphate glpABC glpABC_mRNA glpD glpD_mRNA glpFKX glpFKX_mRNA glpTQ glpTQ_mRNA glycerol glycerol_Ext diglycerol phosphate glycine glycine_Ext phosphate phosphate_Ext sn-glycerol-3-phosphate sn-glycerol-3-phosphate_Ext urea urea_Ext GlpR Glycerol-3-phosphate GlpA GlpB GlpC sn-glycerol-3-phosphate sn-glycerol-3-phosphate phosphate


Gensor Unit       
Name: GlpR
Description: Molecular biology level
Detailed: In the absence of glycerol-3-phosphate, GlpR negatively regulates the expression of genes required for arsenite, urea, glycine and glycerol transport and metabolism, and glycerol-3-phosphate catabolic process. Under these conditions, GlpR binds its target sites preventing the expression of its regulated genes. In the presence of glycerol-3-phosphate, it is directly transported into cell or generated from glycerol transport and conversion to glycerol-3-phosphate, GlpR is modified to GlpR-glycerol-3-phosphate, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of glycerol-3-phosphate, GlpR negatively regulates the expression of genes needed for arsenite, urea, glycine and glycerol transport and metabolism, and glycerol-3-phosphate catabolic process.

Physiology level
Detailed: The presence of glycerol-3-phosphate induces the expression of genes involved with arsenite, urea, glycine and glycerol transport, and glycerol catabolic process. Under these conditions the genes necessary for transport of glycerol and glycerol-3-phosphate, conversion of diglycerol phosphate and glycerol to glycerol-3-phosphate (and DHAP), and the conversion of fructose-1,6-bisphosphate to D-fructose-6-phosphate, a gluconeogenesis intermediary, are expressed.
Less detailed: The presence of glycerol and glycerol-3-phosphate induces the expression of genes needful for transport of glycerol and glycerol-3-phosphate, conversion of diglycerol phosphate and glycerol to glycerol-3-phosphate (and DHAP), and the conversion of fructose-1,6-bisphosphate to D-fructose-6-phosphate, a gluconeogenesis intermediary. Read more >
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0009060 - aerobic respiration
GO:0009061 - anaerobic respiration
GO:0006974 - cellular response to DNA damage stimulus
GO:0071288 - cellular response to mercury ion
GO:0016311 - dephosphorylation
GO:0022900 - electron transport chain
Read more >
cellular_component GO:0005829 - cytosol
GO:0009331 - glycerol-3-phosphate dehydrogenase complex
GO:0005887 - integral component of plasma membrane
GO:0042597 - periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0071949 - FAD binding
GO:0010181 - FMN binding
GO:0005509 - calcium ion binding
GO:0009055 - electron transfer activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity
GO:0015254 - glycerol channel activity
Read more >
Components: Show/Hide Components Table (43 more...)
Function Name Type
simple_molecule DHAP simple_molecule
simple_molecule DL-glyceraldehyde simple_molecule
simple_molecule DL-glyceraldehyde_Ext simple_molecule
protein GlpA protein
complex GlpA-GlpB-GlpC complex
protein GlpB protein
protein GlpC protein
protein GlpD protein
protein GlpF protein
protein GlpK protein
protein GlpQ protein
protein GlpR protein
complex GlpR-glycerol-3-phosphate complex
protein GlpT protein
protein GlpX protein
simple_molecule alcohol simple_molecule
simple_molecule arsenite simple_molecule
simple_molecule arsenite_Ext simple_molecule
simple_molecule diglycerol phosphate simple_molecule
simple_molecule fructose 1,6-biphosphate simple_molecule
simple_molecule fructose-6-P simple_molecule
gene glpABC gene
RNA glpABC_mRNA RNA
gene glpD gene
RNA glpD_mRNA RNA
gene glpFKX gene
RNA glpFKX_mRNA RNA
gene glpTQ gene
RNA glpTQ_mRNA RNA
simple_molecule glycerol simple_molecule
simple_molecule glycerol-3-P-OR simple_molecule
simple_molecule glycerol-3-phosphate simple_molecule
simple_molecule glycerol-3-phosphate_Ext simple_molecule
simple_molecule glycerol_Ext simple_molecule
simple_molecule glycine simple_molecule
simple_molecule glycine_Ext simple_molecule
simple_molecule menaquinol simple_molecule
simple_molecule phosphate simple_molecule
simple_molecule ubiquinol simple_molecule
simple_molecule ubiquinone simple_molecule
simple_molecule urea simple_molecule
simple_molecule urea_Ext simple_molecule
simple_molecule vitamin K2 simple_molecule


Reactions       
Showing 27 reactions
GlpR glpABC glpABC_mRNA
Name: glpABC -> glpABC_mRNA
Description: Transcription of transcription unit glpABC. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpABC - GlpR -> glpABC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GlpR protein nd nd
reactant glpABC gene nd nd
product glpABC_mRNA RNA nd nd
GlpR glpD glpD_mRNA
Name: glpD -> glpD_mRNA
Description: Transcription of transcription unit glpD. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpD - GlpR -> glpD_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GlpR protein nd nd
reactant glpD gene nd nd
product glpD_mRNA RNA nd nd
GlpR glpFKX glpFKX_mRNA
Name: glpFKX -> glpFKX_mRNA
Description: Transcription of transcription unit glpFKX. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpFKX - GlpR -> glpFKX_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GlpR protein nd nd
reactant glpFKX gene nd nd
product glpFKX_mRNA RNA nd nd
GlpR glpTQ glpTQ_mRNA
Name: glpTQ -> glpTQ_mRNA
Description: Transcription of transcription unit glpTQ. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpTQ - GlpR -> glpTQ_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GlpR protein nd nd
reactant glpTQ gene nd nd
product glpTQ_mRNA RNA nd nd
glycerol-3-phosphate + GlpR GlpR-glycerol-3-phosphate
Name: glycerol-3-phosphate + GlpR -> GlpR-glycerol-3-phosphate
Description: Reaction transforming glycerol-3-phosphate, GlpR into GlpR-glycerol-3-phosphate
Type: state transition
Pathway Components: glycerol-3-phosphate + GlpR -> GlpR-glycerol-3-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant GlpR protein nd nd
product GlpR-glycerol-3-phosphate complex nd nd
reactant glycerol-3-phosphate simple_molecule nd nd
glpTQ_mRNA GlpT
Name: glpTQ_mRNA -> GlpT
Description: Translation of GlpT
Type: translation
Pathway Components: glpTQ_mRNA -> GlpT
Components:
Function Name Type Evidence Reference(s)
product GlpT protein nd nd
reactant glpTQ_mRNA RNA nd nd
GlpT glycerol-3-phosphate_Ext glycerol-3-phosphate
Name: glycerol-3-phosphate_Ext -> glycerol-3-phosphate
Description: Transport of glycerol-3-phosphate_Ext through a bacterial membrane, leading to the presence of glycerol-3-phosphate inside the cell.
Type: transport
Pathway Components: glycerol-3-phosphate_Ext - GlpT -> glycerol-3-phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpT protein nd nd
product glycerol-3-phosphate simple_molecule nd nd
reactant glycerol-3-phosphate_Ext simple_molecule nd nd
glpTQ_mRNA GlpQ
Name: glpTQ_mRNA -> GlpQ
Description: Translation of GlpQ
Type: translation
Pathway Components: glpTQ_mRNA -> GlpQ
Components:
Function Name Type Evidence Reference(s)
product GlpQ protein nd nd
reactant glpTQ_mRNA RNA nd nd
GlpQ glycerol-3-P-OR glycerol-3-phosphate + alcohol
Name: glycerol-3-P-OR -> glycerol-3-phosphate + alcohol
Description: Reaction transforming glycerol-3-P-OR into glycerol-3-phosphate, alcohol
Type: state transition
Pathway Components: glycerol-3-P-OR - GlpQ -> glycerol-3-phosphate + alcohol
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpQ protein nd nd
product alcohol simple_molecule nd nd
reactant glycerol-3-P-OR simple_molecule nd nd
product glycerol-3-phosphate simple_molecule nd nd
GlpQ diglycerol phosphate glycerol-3-phosphate + glycerol
Name: diglycerol phosphate -> glycerol-3-phosphate + glycerol
Description: Reaction transforming diglycerol phosphate into glycerol-3-phosphate, glycerol
Type: state transition
Pathway Components: diglycerol phosphate - GlpQ -> glycerol-3-phosphate + glycerol
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpQ protein nd nd
reactant diglycerol phosphate simple_molecule nd nd
product glycerol simple_molecule nd nd
product glycerol-3-phosphate simple_molecule nd nd
glpD_mRNA GlpD
Name: glpD_mRNA -> GlpD
Description: Translation of GlpD
Type: translation
Pathway Components: glpD_mRNA -> GlpD
Components:
Function Name Type Evidence Reference(s)
product GlpD protein nd nd
reactant glpD_mRNA RNA nd nd
DHAP GlpD glycerol-3-phosphate + ubiquinone ubiquinol + DHAP
Name: glycerol-3-phosphate + ubiquinone -> ubiquinol + DHAP
Description: Reaction transforming glycerol-3-phosphate, ubiquinone into ubiquinol, DHAP
Type: state transition
Pathway Components: glycerol-3-phosphate + ubiquinone - GlpD - DHAP -> ubiquinol + DHAP
Components:
Function Name Type Evidence Reference(s)
inhibitor DHAP simple_molecule nd nd
product DHAP simple_molecule nd nd
catalyzer GlpD protein nd nd
reactant glycerol-3-phosphate simple_molecule nd nd
product ubiquinol simple_molecule nd nd
reactant ubiquinone simple_molecule nd nd
glpFKX_mRNA GlpF
Name: glpFKX_mRNA -> GlpF
Description: Translation of GlpF
Type: translation
Pathway Components: glpFKX_mRNA -> GlpF
Components:
Function Name Type Evidence Reference(s)
product GlpF protein nd nd
reactant glpFKX_mRNA RNA nd nd
GlpF arsenite_Ext arsenite
Name: arsenite_Ext -> arsenite
Description: Transport of arsenite_Ext through a bacterial membrane, leading to the presence of arsenite inside the cell.
Type: transport
Pathway Components: arsenite_Ext - GlpF -> arsenite
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpF protein nd nd
product arsenite simple_molecule nd nd
reactant arsenite_Ext simple_molecule nd nd
GlpF glycine_Ext glycine
Name: glycine_Ext -> glycine
Description: Transport of glycine_Ext through a bacterial membrane, leading to the presence of glycine inside the cell.
Type: transport
Pathway Components: glycine_Ext - GlpF -> glycine
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpF protein nd nd
product glycine simple_molecule nd nd
reactant glycine_Ext simple_molecule nd nd
GlpF urea_Ext urea
Name: urea_Ext -> urea
Description: Transport of urea_Ext through a bacterial membrane, leading to the presence of urea inside the cell.
Type: transport
Pathway Components: urea_Ext - GlpF -> urea
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpF protein nd nd
product urea simple_molecule nd nd
reactant urea_Ext simple_molecule nd nd
GlpF DL-glyceraldehyde_Ext DL-glyceraldehyde
Name: DL-glyceraldehyde_Ext -> DL-glyceraldehyde
Description: Transport of DL-glyceraldehyde_Ext through a bacterial membrane, leading to the presence of DL-glyceraldehyde inside the cell.
Type: transport
Pathway Components: DL-glyceraldehyde_Ext - GlpF -> DL-glyceraldehyde
Components:
Function Name Type Evidence Reference(s)
product DL-glyceraldehyde simple_molecule nd nd
reactant DL-glyceraldehyde_Ext simple_molecule nd nd
catalyzer GlpF protein nd nd
GlpF glycerol_Ext glycerol
Name: glycerol_Ext -> glycerol
Description: Transport of glycerol_Ext through a bacterial membrane, leading to the presence of glycerol inside the cell.
Type: transport
Pathway Components: glycerol_Ext - GlpF -> glycerol
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpF protein nd nd
product glycerol simple_molecule nd nd
reactant glycerol_Ext simple_molecule nd nd
glpFKX_mRNA GlpK
Name: glpFKX_mRNA -> GlpK
Description: Translation of GlpK
Type: translation
Pathway Components: glpFKX_mRNA -> GlpK
Components:
Function Name Type Evidence Reference(s)
product GlpK protein nd nd
reactant glpFKX_mRNA RNA nd nd
GlpK fructose 1,6-biphosphate glycerol glycerol-3-phosphate glycerol glycerol-3-phosphate
Name: glycerol -> glycerol-3-phosphate
Description: Reaction transforming glycerol into glycerol-3-phosphate
Type: state transition
Pathway Components: glycerol - GlpK - fructose 1,6-biphosphate - glycerol - glycerol-3-phosphate -> glycerol-3-phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpK protein nd nd
inhibitor fructose 1,6-biphosphate simple_molecule nd nd
inhibitor glycerol simple_molecule nd nd
reactant glycerol simple_molecule nd nd
inhibitor glycerol-3-phosphate simple_molecule nd nd
product glycerol-3-phosphate simple_molecule nd nd
glpFKX_mRNA GlpX
Name: glpFKX_mRNA -> GlpX
Description: Translation of GlpX
Type: translation
Pathway Components: glpFKX_mRNA -> GlpX
Components:
Function Name Type Evidence Reference(s)
product GlpX protein nd nd
reactant glpFKX_mRNA RNA nd nd
GlpX fructose 1,6-biphosphate fructose-6-P + phosphate
Name: fructose 1,6-biphosphate -> fructose-6-P + phosphate
Description: Reaction transforming fructose 1,6-biphosphate into fructose-6-P, phosphate
Type: state transition
Pathway Components: fructose 1,6-biphosphate - GlpX -> fructose-6-P + phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlpX protein nd nd
reactant fructose 1,6-biphosphate simple_molecule nd nd
product fructose-6-P simple_molecule nd nd
product phosphate simple_molecule nd nd
glpABC_mRNA GlpA
Name: glpABC_mRNA -> GlpA
Description: Translation of GlpA
Type: translation
Pathway Components: glpABC_mRNA -> GlpA
Components:
Function Name Type Evidence Reference(s)
product GlpA protein nd nd
reactant glpABC_mRNA RNA nd nd
GlpC + GlpA + GlpB GlpA-GlpB-GlpC
Name: GlpC + GlpA + GlpB -> GlpA-GlpB-GlpC
Description: Reaction transforming GlpC, GlpA, GlpB into GlpA-GlpB-GlpC
Type: state transition
Pathway Components: GlpC + GlpA + GlpB -> GlpA-GlpB-GlpC
Components:
Function Name Type Evidence Reference(s)
reactant GlpA protein nd nd
product GlpA-GlpB-GlpC complex nd nd
reactant GlpB protein nd nd
reactant GlpC protein nd nd
GlpA-GlpB-GlpC glycerol-3-phosphate + vitamin K2 menaquinol + DHAP
Name: glycerol-3-phosphate + vitamin K2 -> menaquinol + DHAP
Description: Reaction transforming glycerol-3-phosphate, vitamin K2 into menaquinol, DHAP
Type: state transition
Pathway Components: glycerol-3-phosphate + vitamin K2 - GlpA-GlpB-GlpC -> menaquinol + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer GlpA-GlpB-GlpC complex nd nd
reactant glycerol-3-phosphate simple_molecule nd nd
product menaquinol simple_molecule nd nd
reactant vitamin K2 simple_molecule nd nd
glpABC_mRNA GlpB
Name: glpABC_mRNA -> GlpB
Description: Translation of GlpB
Type: translation
Pathway Components: glpABC_mRNA -> GlpB
Components:
Function Name Type Evidence Reference(s)
product GlpB protein nd nd
reactant glpABC_mRNA RNA nd nd
glpABC_mRNA GlpC
Name: glpABC_mRNA -> GlpC
Description: Translation of GlpC
Type: translation
Pathway Components: glpABC_mRNA -> GlpC
Components:
Function Name Type Evidence Reference(s)
product GlpC protein nd nd
reactant glpABC_mRNA RNA nd nd



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