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GntR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-4-hydroxy-2-oxoglutarate KDGP 5-ketogluconate 5-ketogluconate_Ext CO2 D-gluconate 6-p gluconate D-gluconate_Ext D-glyceraldehyde 3-phosphate Eda Edd Gluconate GntK GntR GntT GntU GntX IdnD IdnK IdnO IdnR IdnT L-idonate L-idonate_Ext NfuA edd-eda edd-eda_mRNA glyoxylate This Gensor Unit is not yet available This Gensor Unit is not yet available This Gensor Unit is not yet available This Gensor Unit is not yet available gntT gntT_mRNA gntX-nfuA gntX-nfuA_mRNA idnDOTR idnDOTR_mRNA idnK idnK_mRNA oxalacetate pyruvate GntR Gluconate


Gensor Unit       
Name: GntR
Description: Molecular biology level
Detailed: In the absence of gluconate, GntR negatively regulates the expression of genes required for gluconate and idonate transport and catabolic processes. Under these conditions, GntR binds its target sites preventing the expression of its regulated genes. In the presence of gluconate, GntR is modified to GntR-gluconate, unbinds its target sites enabling the expression of its regulated genes.
Less detailed:
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0046177 - D-gluconate catabolic process
GO:0019521 - D-gluconate metabolic process
GO:0046183 - L-idonate catabolic process
GO:0015726 - L-idonate transmembrane transport
GO:0046835 - carbohydrate phosphorylation
GO:0008643 - carbohydrate transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008675 - 2-dehydro-3-deoxy-phosphogluconate aldolase activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0008700 - 4-hydroxy-2-oxoglutarate aldolase activity
GO:0003677 - DNA binding
GO:0050572 - L-idonate 5-dehydrogenase activity
GO:0015568 - L-idonate transmembrane transporter activity
GO:0005402 - carbohydrate:cation symporter activity
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Components: Show/Hide Components Table (44 more...)
Function Name Type
simple_molecule 4-hydroxy-2-oxoglutarate simple_molecule
simple_molecule 5-ketogluconate simple_molecule
simple_molecule 5-ketogluconate_Ext simple_molecule
simple_molecule 6-p gluconate simple_molecule
simple_molecule CO2 simple_molecule
protein Eda protein
protein Edd protein
protein GntK protein
protein GntR protein
complex GntR-gluconate complex
protein GntT protein
protein GntU protein
protein GntX protein
protein IdnD protein
protein IdnK protein
protein IdnO protein
protein IdnR protein
protein IdnT protein
simple_molecule KDGP simple_molecule
protein NfuA protein
gene edd-eda gene
RNA edd-eda_mRNA RNA
simple_molecule gluconate simple_molecule
simple_molecule gluconate_Ext simple_molecule
simple_molecule glyceraldehyde-P simple_molecule
simple_molecule glyoxylate simple_molecule
gene gntK gene
gene gntKU gene
RNA gntKU_mRNA RNA
RNA gntK_mRNA RNA
gene gntRKU gene
RNA gntRKU_mRNA RNA
gene gntT gene
RNA gntT_mRNA RNA
gene gntX-nfuA gene
RNA gntX-nfuA_mRNA RNA
gene idnDOTR gene
RNA idnDOTR_mRNA RNA
gene idnK gene
RNA idnK_mRNA RNA
simple_molecule idonate simple_molecule
simple_molecule idonate_Ext simple_molecule
simple_molecule oxalacetate simple_molecule
simple_molecule pyruvate simple_molecule


Reactions       
Showing 37 reactions
GntR edd-eda edd-eda_mRNA
Name: edd-eda -> edd-eda_mRNA
Description: Transcription of transcription unit edd-eda. Reaction inhibition by GntR.
Type: transcription
Pathway Components: edd-eda - GntR -> edd-eda_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant edd-eda gene nd nd
product edd-eda_mRNA RNA nd nd
GntR gntRKU gntRKU_mRNA
Name: gntRKU -> gntRKU_mRNA
Description: Transcription of transcription unit gntRKU. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntRKU - GntR -> gntRKU_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant gntRKU gene nd nd
product gntRKU_mRNA RNA nd nd
GntR gntT gntT_mRNA
Name: gntT -> gntT_mRNA
Description: Transcription of transcription unit gntT. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntT - GntR -> gntT_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant gntT gene nd nd
product gntT_mRNA RNA nd nd
GntR gntX-nfuA gntX-nfuA_mRNA
Name: gntX-nfuA -> gntX-nfuA_mRNA
Description: Transcription of transcription unit gntX-nfuA. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntX-nfuA - GntR -> gntX-nfuA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant gntX-nfuA gene nd nd
product gntX-nfuA_mRNA RNA nd nd
GntR idnDOTR idnDOTR_mRNA
Name: idnDOTR -> idnDOTR_mRNA
Description: Transcription of transcription unit idnDOTR. Reaction inhibition by GntR.
Type: transcription
Pathway Components: idnDOTR - GntR -> idnDOTR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant idnDOTR gene nd nd
product idnDOTR_mRNA RNA nd nd
GntR idnK idnK_mRNA
Name: idnK -> idnK_mRNA
Description: Transcription of transcription unit idnK. Reaction inhibition by GntR.
Type: transcription
Pathway Components: idnK - GntR -> idnK_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant idnK gene nd nd
product idnK_mRNA RNA nd nd
gluconate + GntR GntR-gluconate
Name: gluconate + GntR -> GntR-gluconate
Description: Reaction transforming gluconate, GntR into GntR-gluconate
Type: state transition
Pathway Components: gluconate + GntR -> GntR-gluconate
Components:
Function Name Type Evidence Reference(s)
reactant GntR protein nd nd
product GntR-gluconate complex nd nd
reactant gluconate simple_molecule nd nd
GntR gntK gntK_mRNA
Name: gntK -> gntK_mRNA
Description: Transcription of transcription unit gntK. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntK - GntR -> gntK_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant gntK gene nd nd
product gntK_mRNA RNA nd nd
GntR gntKU gntKU_mRNA
Name: gntKU -> gntKU_mRNA
Description: Transcription of transcription unit gntKU. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntKU - GntR -> gntKU_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GntR protein nd nd
reactant gntKU gene nd nd
product gntKU_mRNA RNA nd nd
edd-eda_mRNA Edd
Name: edd-eda_mRNA -> Edd
Description: Translation of Edd
Type: translation
Pathway Components: edd-eda_mRNA -> Edd
Components:
Function Name Type Evidence Reference(s)
product Edd protein nd nd
reactant edd-eda_mRNA RNA nd nd
Edd 6-p gluconate KDGP
Name: 6-p gluconate -> KDGP
Description: Reaction transforming 6-p gluconate into KDGP
Type: state transition
Pathway Components: 6-p gluconate - Edd -> KDGP
Components:
Function Name Type Evidence Reference(s)
reactant 6-p gluconate simple_molecule nd nd
catalyzer Edd protein nd nd
product KDGP simple_molecule nd nd
edd-eda_mRNA Eda
Name: edd-eda_mRNA -> Eda
Description: Translation of Eda
Type: translation
Pathway Components: edd-eda_mRNA -> Eda
Components:
Function Name Type Evidence Reference(s)
product Eda protein nd nd
reactant edd-eda_mRNA RNA nd nd
Eda oxalacetate pyruvate + CO2
Name: oxalacetate -> pyruvate + CO2
Description: Reaction transforming oxalacetate into pyruvate, CO2
Type: state transition
Pathway Components: oxalacetate - Eda -> pyruvate + CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer Eda protein nd nd
reactant oxalacetate simple_molecule nd nd
product pyruvate simple_molecule nd nd
6-p gluconate Eda glyceraldehyde-P KDGP glyceraldehyde-P + pyruvate
Name: KDGP -> glyceraldehyde-P + pyruvate
Description: Reaction transforming KDGP into glyceraldehyde-P, pyruvate
Type: state transition
Pathway Components: KDGP - Eda - 6-p gluconate - glyceraldehyde-P -> glyceraldehyde-P + pyruvate
Components:
Function Name Type Evidence Reference(s)
inhibitor 6-p gluconate simple_molecule nd nd
catalyzer Eda protein nd nd
reactant KDGP simple_molecule nd nd
inhibitor glyceraldehyde-P simple_molecule nd nd
product glyceraldehyde-P simple_molecule nd nd
product pyruvate simple_molecule nd nd
Eda glyoxylate pyruvate 4-hydroxy-2-oxoglutarate glyoxylate + pyruvate
Name: 4-hydroxy-2-oxoglutarate -> glyoxylate + pyruvate
Description: Reaction transforming 4-hydroxy-2-oxoglutarate into glyoxylate, pyruvate
Type: state transition
Pathway Components: 4-hydroxy-2-oxoglutarate - Eda - glyoxylate - pyruvate -> glyoxylate + pyruvate
Components:
Function Name Type Evidence Reference(s)
reactant 4-hydroxy-2-oxoglutarate simple_molecule nd nd
catalyzer Eda protein nd nd
inhibitor glyoxylate simple_molecule nd nd
product glyoxylate simple_molecule nd nd
inhibitor pyruvate simple_molecule nd nd
product pyruvate simple_molecule nd nd
gntRKU_mRNA GntU
Name: gntRKU_mRNA -> GntU
Description: Translation of GntU
Type: translation
Pathway Components: gntRKU_mRNA -> GntU
Components:
Function Name Type Evidence Reference(s)
product GntU protein nd nd
reactant gntRKU_mRNA RNA nd nd
GntT GntU IdnT gluconate_Ext gluconate
Name: gluconate_Ext -> gluconate
Description: Transport of gluconate_Ext through a bacterial membrane, leading to the presence of gluconate inside the cell.
Type: transport
Pathway Components: gluconate_Ext - GntT - GntU - IdnT -> gluconate
Components:
Function Name Type Evidence Reference(s)
catalyzer GntT protein nd nd
catalyzer GntU protein nd nd
catalyzer IdnT protein nd nd
product gluconate simple_molecule nd nd
reactant gluconate_Ext simple_molecule nd nd
gntRKU_mRNA GntK
Name: gntRKU_mRNA -> GntK
Description: Translation of GntK
Type: translation
Pathway Components: gntRKU_mRNA -> GntK
Components:
Function Name Type Evidence Reference(s)
product GntK protein nd nd
reactant gntRKU_mRNA RNA nd nd
GntK IdnK gluconate 6-p gluconate
Name: gluconate -> 6-p gluconate
Description: Reaction transforming gluconate into 6-p gluconate
Type: state transition
Pathway Components: gluconate - GntK - IdnK -> 6-p gluconate
Components:
Function Name Type Evidence Reference(s)
product 6-p gluconate simple_molecule nd nd
catalyzer GntK protein nd nd
catalyzer IdnK protein nd nd
reactant gluconate simple_molecule nd nd
gntRKU_mRNA GntR
Name: gntRKU_mRNA -> GntR
Description: Translation of GntR
Type: translation
Pathway Components: gntRKU_mRNA -> GntR
Components:
Function Name Type Evidence Reference(s)
product GntR protein nd nd
reactant gntRKU_mRNA RNA nd nd
gntT_mRNA GntT
Name: gntT_mRNA -> GntT
Description: Translation of GntT
Type: translation
Pathway Components: gntT_mRNA -> GntT
Components:
Function Name Type Evidence Reference(s)
product GntT protein nd nd
reactant gntT_mRNA RNA nd nd
idnK_mRNA IdnK
Name: idnK_mRNA -> IdnK
Description: Translation of IdnK
Type: translation
Pathway Components: idnK_mRNA -> IdnK
Components:
Function Name Type Evidence Reference(s)
product IdnK protein nd nd
reactant idnK_mRNA RNA nd nd
idnDOTR_mRNA IdnD
Name: idnDOTR_mRNA -> IdnD
Description: Translation of IdnD
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnD
Components:
Function Name Type Evidence Reference(s)
product IdnD protein nd nd
reactant idnDOTR_mRNA RNA nd nd
IdnD idonate 5-ketogluconate
Name: idonate -> 5-ketogluconate
Description: Reaction transforming idonate into 5-ketogluconate
Type: state transition
Pathway Components: idonate - IdnD -> 5-ketogluconate
Components:
Function Name Type Evidence Reference(s)
product 5-ketogluconate simple_molecule nd nd
catalyzer IdnD protein nd nd
reactant idonate simple_molecule nd nd
idnDOTR_mRNA IdnO
Name: idnDOTR_mRNA -> IdnO
Description: Translation of IdnO
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnO
Components:
Function Name Type Evidence Reference(s)
product IdnO protein nd nd
reactant idnDOTR_mRNA RNA nd nd
IdnO gluconate 5-ketogluconate
Name: gluconate -> 5-ketogluconate
Description: Reaction transforming gluconate into 5-ketogluconate
Type: state transition
Pathway Components: gluconate - IdnO -> 5-ketogluconate
Components:
Function Name Type Evidence Reference(s)
product 5-ketogluconate simple_molecule nd nd
catalyzer IdnO protein nd nd
reactant gluconate simple_molecule nd nd
idnDOTR_mRNA IdnT
Name: idnDOTR_mRNA -> IdnT
Description: Translation of IdnT
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnT
Components:
Function Name Type Evidence Reference(s)
product IdnT protein nd nd
reactant idnDOTR_mRNA RNA nd nd
IdnT 5-ketogluconate_Ext 5-ketogluconate
Name: 5-ketogluconate_Ext -> 5-ketogluconate
Description: Transport of 5-ketogluconate_Ext through a bacterial membrane, leading to the presence of 5-ketogluconate inside the cell.
Type: transport
Pathway Components: 5-ketogluconate_Ext - IdnT -> 5-ketogluconate
Components:
Function Name Type Evidence Reference(s)
product 5-ketogluconate simple_molecule nd nd
reactant 5-ketogluconate_Ext simple_molecule nd nd
catalyzer IdnT protein nd nd
IdnT idonate_Ext idonate
Name: idonate_Ext -> idonate
Description: Transport of idonate_Ext through a bacterial membrane, leading to the presence of idonate inside the cell.
Type: transport
Pathway Components: idonate_Ext - IdnT -> idonate
Components:
Function Name Type Evidence Reference(s)
catalyzer IdnT protein nd nd
product idonate simple_molecule nd nd
reactant idonate_Ext simple_molecule nd nd
idnDOTR_mRNA IdnR
Name: idnDOTR_mRNA -> IdnR
Description: Translation of IdnR
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnR
Components:
Function Name Type Evidence Reference(s)
product IdnR protein nd nd
reactant idnDOTR_mRNA RNA nd nd
gntX-nfuA_mRNA GntX
Name: gntX-nfuA_mRNA -> GntX
Description: Translation of GntX
Type: translation
Pathway Components: gntX-nfuA_mRNA -> GntX
Components:
Function Name Type Evidence Reference(s)
product GntX protein nd nd
reactant gntX-nfuA_mRNA RNA nd nd
gntX-nfuA_mRNA NfuA
Name: gntX-nfuA_mRNA -> NfuA
Description: Translation of NfuA
Type: translation
Pathway Components: gntX-nfuA_mRNA -> NfuA
Components:
Function Name Type Evidence Reference(s)
product NfuA protein nd nd
reactant gntX-nfuA_mRNA RNA nd nd
gntKU_mRNA GntK
Name: gntKU_mRNA -> GntK
Description: Translation of GntK
Type: translation
Pathway Components: gntKU_mRNA -> GntK
Components:
Function Name Type Evidence Reference(s)
product GntK protein nd nd
reactant gntKU_mRNA RNA nd nd
gntKU_mRNA GntU
Name: gntKU_mRNA -> GntU
Description: Translation of GntU
Type: translation
Pathway Components: gntKU_mRNA -> GntU
Components:
Function Name Type Evidence Reference(s)
product GntU protein nd nd
reactant gntKU_mRNA RNA nd nd
gntK_mRNA GntK
Name: gntK_mRNA -> GntK
Description: Translation of GntK
Type: translation
Pathway Components: gntK_mRNA -> GntK
Components:
Function Name Type Evidence Reference(s)
product GntK protein nd nd
reactant gntK_mRNA RNA nd nd
5-ketogluconate gluconate
Name: 5-ketogluconate -> gluconate
Description: Transformation of 5-ketogluconate into gluconate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 5-ketogluconate / 1.1.1.215-RXN / gluconate
Components:
Function Name Type Evidence Reference(s)
reactant 5-ketogluconate simple_molecule nd nd
product gluconate simple_molecule nd nd
5-ketogluconate gluconate
Name: 5-ketogluconate -> gluconate
Description: Transformation of 5-ketogluconate into gluconate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 5-ketogluconate / gluconate
Components:
Function Name Type Evidence Reference(s)
reactant 5-ketogluconate simple_molecule nd nd
product gluconate simple_molecule nd nd



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