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GlcC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
GlcC lactate glcC GlcF glycolate_Ext acetyl-CoA GlcD GlcA glycolate 2-hydroxybutyrate coenzyme A A(H2) acetate GlcC GlcF GlcE glcDEFGBA_mRNA electron-transfer quinol glcDEFGBA acetate GlcC electron-transfer quinone acceptors malate glycolate lactate_Ext GlcD GlcB glyoxylate GlcE 2-hydroxybutyrate_Ext GlcG glcC_mRNA


Gensor Unit       
Name: GlcC
Description: Molecular biology level
Detailed: In the presence of glycolate, GlcC positively regulates the expression of genes required for lactate and glycolate transport and catabolic processes and negatively regulates its own expression. Under these conditions, GlcC is modified to GlcC-glycolate, binds its target sites enabling the expression of its regulated genes and preventing its own expression. In the absence of glycolate, GlcC unbinds its target sites, enabling in some cases and preventing in others the expression of its regulated genes.
Less detailed: In the presence of glycolate, GlcC positively regulates the expression of genes needed for lactate and glycolate transport and catabolic process and negatively regulates its own expression.

Physiology level
Detailed: The presence of glycolate induces the expression of genes involved with lactate and glycolate transport and catabolism. Under these conditions the genes necessary for glycolate and lactate transport into the cell and catabolism of glycolate to L-malate are expressed.
Less detailed: The presence of glycolate induces the expression of genes needful for transport of lactate and glycolate and its degration until L-malate.
Classification:
Groups: Transcription
Energy production and conversion
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0046296 - glycolate catabolic process
GO:0009436 - glyoxylate catabolic process
GO:0006097 - glyoxylate cycle
GO:0035873 - lactate transmembrane transport
GO:0015727 - lactate transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009339 - glycolate oxidase complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
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molecular_function GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0003824 - catalytic activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0019154 - glycolate dehydrogenase activity
GO:0008891 - glycolate oxidase activity
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Components:
  Function Name Type
  simple_molecule 2-hydroxybutyrate simple_molecule
  simple_molecule 2-hydroxybutyrate_Ext simple_molecule
  simple_molecule A(H2) simple_molecule
  protein GlcA protein
  protein GlcB protein
  protein GlcC protein
  complex GlcC-acetate complex
  complex GlcC-glycolate complex
  protein GlcD protein
  complex GlcD-GlcE-GlcF complex
  protein GlcE protein
  protein GlcF protein
  protein GlcG protein
  simple_molecule acceptors simple_molecule
  simple_molecule acetate simple_molecule
  simple_molecule acetyl-CoA simple_molecule
  simple_molecule coenzyme A simple_molecule
  simple_molecule electron-transfer quinol simple_molecule
  simple_molecule electron-transfer quinone simple_molecule
  gene glcC gene
  RNA glcC_mRNA RNA
  gene glcDEFGBA gene
  RNA glcDEFGBA_mRNA RNA
  simple_molecule glycolate simple_molecule
  simple_molecule glycolate_Ext simple_molecule
  simple_molecule glyoxylate simple_molecule
  simple_molecule lactate simple_molecule
  simple_molecule lactate_Ext simple_molecule
  simple_molecule malate simple_molecule


Reactions       
Showing 18 reactions
glycolate + GlcC GlcC-glycolate
Name: glycolate + GlcC -> GlcC-glycolate
Description: Reaction transforming glycolate, GlcC into GlcC-glycolate
Type: state transition
Pathway Components: glycolate + GlcC -> GlcC-glycolate
Components:
Function Name Type
reactant GlcC protein
product GlcC-glycolate complex
reactant glycolate simple_molecule
GlcC-glycolate glcDEFGBA glcDEFGBA_mRNA
Name: glcDEFGBA -> glcDEFGBA_mRNA
Description: Transcription of transcription unit glcDEFGBA. Reaction activation by GlcC-glycolate.
Type: transcription
Pathway Components: glcDEFGBA - GlcC-glycolate -> glcDEFGBA_mRNA
Components:
Function Name Type
activator GlcC-glycolate complex
reactant glcDEFGBA gene
product glcDEFGBA_mRNA RNA
GlcC-glycolate glcC glcC_mRNA
Name: glcC -> glcC_mRNA
Description: Transcription of transcription unit glcC. Reaction inhibition by GlcC-glycolate.
Type: transcription
Pathway Components: glcC - GlcC-glycolate -> glcC_mRNA
Components:
Function Name Type
inhibitor GlcC-glycolate complex
reactant glcC gene
product glcC_mRNA RNA
acetate + GlcC GlcC-acetate
Name: acetate + GlcC -> GlcC-acetate
Description: Reaction transforming acetate, GlcC into GlcC-acetate
Type: state transition
Pathway Components: acetate + GlcC -> GlcC-acetate
Components:
Function Name Type
reactant GlcC protein
product GlcC-acetate complex
reactant acetate simple_molecule
glcC_mRNA GlcC
Name: glcC_mRNA -> GlcC
Description: Translation of GlcC
Type: translation
Pathway Components: glcC_mRNA -> GlcC
Components:
Function Name Type
product GlcC protein
reactant glcC_mRNA RNA
glcDEFGBA_mRNA GlcD
Name: glcDEFGBA_mRNA -> GlcD
Description: Translation of GlcD
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcD
Components:
Function Name Type
product GlcD protein
reactant glcDEFGBA_mRNA RNA
GlcF + GlcE + GlcD GlcD-GlcE-GlcF
Name: GlcF + GlcE + GlcD -> GlcD-GlcE-GlcF
Description: Reaction transforming GlcF, GlcE, GlcD into GlcD-GlcE-GlcF
Type: state transition
Pathway Components: GlcF + GlcE + GlcD -> GlcD-GlcE-GlcF
Components:
Function Name Type
reactant GlcD protein
product GlcD-GlcE-GlcF complex
reactant GlcE protein
reactant GlcF protein
GlcD-GlcE-GlcF glycolate + acceptors glyoxylate + A(H2)
Name: glycolate + acceptors -> glyoxylate + A(H2)
Description: Reaction transforming glycolate, acceptors into glyoxylate, A(H2)
Type: state transition
Pathway Components: glycolate + acceptors - GlcD-GlcE-GlcF -> glyoxylate + A(H2)
Components:
Function Name Type
product A(H2) simple_molecule
catalyzer GlcD-GlcE-GlcF complex
reactant acceptors simple_molecule
reactant glycolate simple_molecule
product glyoxylate simple_molecule
GlcD-GlcE-GlcF electron-transfer quinone + glycolate electron-transfer quinol + glyoxylate
Name: electron-transfer quinone + glycolate -> electron-transfer quinol + glyoxylate
Description: Reaction transforming electron-transfer quinone, glycolate into electron-transfer quinol, glyoxylate
Type: state transition
Pathway Components: electron-transfer quinone + glycolate - GlcD-GlcE-GlcF -> electron-transfer quinol + glyoxylate
Components:
Function Name Type
catalyzer GlcD-GlcE-GlcF complex
product electron-transfer quinol simple_molecule
reactant electron-transfer quinone simple_molecule
reactant glycolate simple_molecule
product glyoxylate simple_molecule
glcDEFGBA_mRNA GlcE
Name: glcDEFGBA_mRNA -> GlcE
Description: Translation of GlcE
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcE
Components:
Function Name Type
product GlcE protein
reactant glcDEFGBA_mRNA RNA
glcDEFGBA_mRNA GlcF
Name: glcDEFGBA_mRNA -> GlcF
Description: Translation of GlcF
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcF
Components:
Function Name Type
product GlcF protein
reactant glcDEFGBA_mRNA RNA
glcDEFGBA_mRNA GlcG
Name: glcDEFGBA_mRNA -> GlcG
Description: Translation of GlcG
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcG
Components:
Function Name Type
product GlcG protein
reactant glcDEFGBA_mRNA RNA
glcDEFGBA_mRNA GlcB
Name: glcDEFGBA_mRNA -> GlcB
Description: Translation of GlcB
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcB
Components:
Function Name Type
product GlcB protein
reactant glcDEFGBA_mRNA RNA
GlcB glycolate acetyl-CoA + glyoxylate coenzyme A + malate
Name: acetyl-CoA + glyoxylate -> coenzyme A + malate
Description: Reaction transforming acetyl-CoA, glyoxylate into coenzyme A, malate
Type: state transition
Pathway Components: acetyl-CoA + glyoxylate - GlcB - glycolate -> coenzyme A + malate
Components:
Function Name Type
catalyzer GlcB protein
reactant acetyl-CoA simple_molecule
product coenzyme A simple_molecule
inhibitor glycolate simple_molecule
reactant glyoxylate simple_molecule
product malate simple_molecule
glcDEFGBA_mRNA GlcA
Name: glcDEFGBA_mRNA -> GlcA
Description: Translation of GlcA
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcA
Components:
Function Name Type
product GlcA protein
reactant glcDEFGBA_mRNA RNA
GlcA glycolate_Ext glycolate
Name: glycolate_Ext -> glycolate
Description: Transport of glycolate_Ext through a bacterial membrane, leading to the presence of glycolate inside the cell.
Type: transport
Pathway Components: glycolate_Ext - GlcA -> glycolate
Components:
Function Name Type
catalyzer GlcA protein
product glycolate simple_molecule
reactant glycolate_Ext simple_molecule
GlcA lactate_Ext lactate
Name: lactate_Ext -> lactate
Description: Transport of lactate_Ext through a bacterial membrane, leading to the presence of lactate inside the cell.
Type: transport
Pathway Components: lactate_Ext - GlcA -> lactate
Components:
Function Name Type
catalyzer GlcA protein
product lactate simple_molecule
reactant lactate_Ext simple_molecule
GlcA 2-hydroxybutyrate_Ext 2-hydroxybutyrate
Name: 2-hydroxybutyrate_Ext -> 2-hydroxybutyrate
Description: Transport of 2-hydroxybutyrate_Ext through a bacterial membrane, leading to the presence of 2-hydroxybutyrate inside the cell.
Type: transport
Pathway Components: 2-hydroxybutyrate_Ext - GlcA -> 2-hydroxybutyrate
Components:
Function Name Type
product 2-hydroxybutyrate simple_molecule
reactant 2-hydroxybutyrate_Ext simple_molecule
catalyzer GlcA protein
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