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GlcC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-lactate D-lactate_Ext L-lactate L-lactate_Ext L-malate GlcA GlcB GlcC GlcD GlcE GlcF GlcG a reduced electron acceptor ac-CoA an oxidized electron acceptor CoA glcC glcC_mRNA glcDEFGBA glcDEFGBA_mRNA glycolate glycolate_Ext glyoxylate GlcC glycolate GlcD GlcE GlcF


Gensor Unit       
Name: GlcC
Description: Molecular biology level
Detailed: In the presence of glycolate, GlcC positively regulates the expression of genes required for lactate and glycolate transport and catabolic processes and negatively regulates its own expression. Under these conditions, GlcC is modified to GlcC-glycolate, binds its target sites enabling the expression of its regulated genes and preventing its own expression. In the absence of glycolate, GlcC unbinds its target sites, enabling in some cases and preventing in others the expression of its regulated genes.
Less detailed: In the presence of glycolate, GlcC positively regulates the expression of genes needed for lactate and glycolate transport and catabolic process and negatively regulates its own expression.

Physiology level
Detailed: The presence of glycolate induces the expression of genes involved with lactate and glycolate transport and catabolism. Under these conditions the genes necessary for glycolate and lactate transport into the cell and catabolism of glycolate to L-malate are expressed.
Less detailed: The presence of glycolate induces the expression of genes needful for transport of lactate and glycolate and its degration until L-malate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0046296 - glycolate catabolic process
GO:0009436 - glyoxylate catabolic process
GO:0035873 - lactate transmembrane transport
GO:0006355 - regulation of transcription, DNA-templated
cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0019154 - glycolate dehydrogenase activity
GO:0043879 - glycolate transmembrane transporter activity
GO:0015129 - lactate transmembrane transporter activity
GO:0000287 - magnesium ion binding
GO:0004474 - malate synthase activity
GO:0005515 - protein binding
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Components: Show/Hide Components Table (25 more...)
Function Name Type
simple_molecule A(H2) simple_molecule
protein GlcA protein
protein GlcB protein
protein GlcC protein
complex GlcC-acetate complex
complex GlcC-glycolate complex
protein GlcD protein
complex GlcD-GlcE-GlcF complex
protein GlcE protein
protein GlcF protein
protein GlcG protein
simple_molecule acceptors simple_molecule
simple_molecule acetate simple_molecule
simple_molecule acetyl-CoA simple_molecule
simple_molecule coenzyme A simple_molecule
gene glcC gene
RNA glcC_mRNA RNA
gene glcDEFGBA gene
RNA glcDEFGBA_mRNA RNA
simple_molecule glycolate simple_molecule
simple_molecule glycolate_Ext simple_molecule
simple_molecule glyoxylate simple_molecule
simple_molecule lactate simple_molecule
simple_molecule lactate_Ext simple_molecule
simple_molecule malate simple_molecule


Reactions       
Showing 16 reactions
acetate + GlcC GlcC-acetate
Name: acetate + GlcC -> GlcC-acetate
Description: Reaction transforming acetate, GlcC into GlcC-acetate
Type: state transition
Pathway Components: acetate + GlcC -> GlcC-acetate
Components:
Function Name Type Evidence Reference(s)
reactant GlcC protein nd nd
product GlcC-acetate complex nd nd
reactant acetate simple_molecule nd nd
GlcC-acetate GlcC-glycolate glcDEFGBA glcDEFGBA_mRNA
Name: glcDEFGBA -> glcDEFGBA_mRNA
Description: Transcription of transcription unit glcDEFGBA. Reaction activation by GlcC-acetate, and GlcC-glycolate.
Type: transcription
Pathway Components: glcDEFGBA - GlcC-acetate - GlcC-glycolate -> glcDEFGBA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator GlcC-acetate complex nd nd
activator GlcC-glycolate complex nd nd
reactant glcDEFGBA gene nd nd
product glcDEFGBA_mRNA RNA nd nd
GlcC-acetate GlcC-glycolate glcC glcC_mRNA
Name: glcC -> glcC_mRNA
Description: Transcription of transcription unit glcC. Reaction inhibition by GlcC-acetate, and GlcC-glycolate.
Type: transcription
Pathway Components: glcC - GlcC-acetate - GlcC-glycolate -> glcC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GlcC-acetate complex nd nd
inhibitor GlcC-glycolate complex nd nd
reactant glcC gene nd nd
product glcC_mRNA RNA nd nd
glycolate + GlcC GlcC-glycolate
Name: glycolate + GlcC -> GlcC-glycolate
Description: Reaction transforming glycolate, GlcC into GlcC-glycolate
Type: state transition
Pathway Components: glycolate + GlcC -> GlcC-glycolate
Components:
Function Name Type Evidence Reference(s)
reactant GlcC protein nd nd
product GlcC-glycolate complex nd nd
reactant glycolate simple_molecule nd nd
glcDEFGBA_mRNA GlcD
Name: glcDEFGBA_mRNA -> GlcD
Description: Translation of GlcD
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcD
Components:
Function Name Type Evidence Reference(s)
product GlcD protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
GlcF + GlcE + GlcD GlcD-GlcE-GlcF
Name: GlcF + GlcE + GlcD -> GlcD-GlcE-GlcF
Description: Reaction transforming GlcF, GlcE, GlcD into GlcD-GlcE-GlcF
Type: state transition
Pathway Components: GlcF + GlcE + GlcD -> GlcD-GlcE-GlcF
Components:
Function Name Type Evidence Reference(s)
reactant GlcD protein nd nd
product GlcD-GlcE-GlcF complex nd nd
reactant GlcE protein nd nd
reactant GlcF protein nd nd
GlcD-GlcE-GlcF acceptors + glycolate glyoxylate + A(H2)
Name: acceptors + glycolate -> glyoxylate + A(H2)
Description: Reaction transforming acceptors, glycolate into glyoxylate, A(H2)
Type: state transition
Pathway Components: acceptors + glycolate - GlcD-GlcE-GlcF -> glyoxylate + A(H2)
Components:
Function Name Type Evidence Reference(s)
product A(H2) simple_molecule nd nd
catalyzer GlcD-GlcE-GlcF complex nd nd
reactant acceptors simple_molecule nd nd
reactant glycolate simple_molecule nd nd
product glyoxylate simple_molecule nd nd
glcDEFGBA_mRNA GlcE
Name: glcDEFGBA_mRNA -> GlcE
Description: Translation of GlcE
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcE
Components:
Function Name Type Evidence Reference(s)
product GlcE protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
glcDEFGBA_mRNA GlcF
Name: glcDEFGBA_mRNA -> GlcF
Description: Translation of GlcF
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcF
Components:
Function Name Type Evidence Reference(s)
product GlcF protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
glcDEFGBA_mRNA GlcG
Name: glcDEFGBA_mRNA -> GlcG
Description: Translation of GlcG
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcG
Components:
Function Name Type Evidence Reference(s)
product GlcG protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
glcDEFGBA_mRNA GlcB
Name: glcDEFGBA_mRNA -> GlcB
Description: Translation of GlcB
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcB
Components:
Function Name Type Evidence Reference(s)
product GlcB protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
GlcB glycolate acetyl-CoA + glyoxylate coenzyme A + malate
Name: acetyl-CoA + glyoxylate -> coenzyme A + malate
Description: Reaction transforming acetyl-CoA, glyoxylate into coenzyme A, malate
Type: state transition
Pathway Components: acetyl-CoA + glyoxylate - GlcB - glycolate -> coenzyme A + malate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlcB protein nd nd
reactant acetyl-CoA simple_molecule nd nd
product coenzyme A simple_molecule nd nd
inhibitor glycolate simple_molecule nd nd
reactant glyoxylate simple_molecule nd nd
product malate simple_molecule nd nd
glcDEFGBA_mRNA GlcA
Name: glcDEFGBA_mRNA -> GlcA
Description: Translation of GlcA
Type: translation
Pathway Components: glcDEFGBA_mRNA -> GlcA
Components:
Function Name Type Evidence Reference(s)
product GlcA protein nd nd
reactant glcDEFGBA_mRNA RNA nd nd
GlcA lactate_Ext lactate
Name: lactate_Ext -> lactate
Description: Transport of lactate_Ext through a bacterial membrane, leading to the presence of lactate inside the cell.
Type: transport
Pathway Components: lactate_Ext - GlcA -> lactate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlcA protein nd nd
product lactate simple_molecule nd nd
reactant lactate_Ext simple_molecule nd nd
GlcA glycolate_Ext glycolate
Name: glycolate_Ext -> glycolate
Description: Transport of glycolate_Ext through a bacterial membrane, leading to the presence of glycolate inside the cell.
Type: transport
Pathway Components: glycolate_Ext - GlcA -> glycolate
Components:
Function Name Type Evidence Reference(s)
catalyzer GlcA protein nd nd
product glycolate simple_molecule nd nd
reactant glycolate_Ext simple_molecule nd nd
glcC_mRNA GlcC
Name: glcC_mRNA -> GlcC
Description: Translation of GlcC
Type: translation
Pathway Components: glcC_mRNA -> GlcC
Components:
Function Name Type Evidence Reference(s)
product GlcC protein nd nd
reactant glcC_mRNA RNA nd nd



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