RegulonDB RegulonDB

GcvA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
5,10-methylenetetrahydrofolate CO2 GcvA This Gensor Unit is not yet available GcvH GcvP GcvT glycine Lpd Purine a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine ammonia gcvA gcvA_mRNA gcvB gcvB_mRNA gcvTHP gcvTHP_mRNA glycine THF GcvA Purine GcvA glycine Lpd GcvP GcvH GcvT


Gensor Unit       
Name: GcvA
Description: Molecular biology level
Detailed: In the absence of glycine and purine, GcvA negatively regulates its own expression, dually regulates the expression of genes required for glycine decarboxylation via glycine cleavage system and negatively regulates the expression of a small regulatory RNA. Under these conditions, GcvA remains unmodified, binds its target sites preventing its own expression, enabling the expression of a small regulatory RNA, and alternatively preventing and enabling the expression of other of its regulated genes.
Less detailed: In the absence of glycine and purine GcvA negatively regulates its own expression, positively regulates the expression of a small regulatory RNA, and dually regulates the expression of genes needed for glycine decarboxylation via glycine cleavage system.

Physiology level
Detailed: The presence of glycine and purine alternatively induces and inhibits the expression of genes involved with glycine decarboxylation via glycine cleavage system. Under these conditions the genes necessary for glycine decarboxylation through the H protein complex with release of CO2 and ammonia are dually expressed.
Less detailed: The presence of glycine and purine alternatively induces and inhibits the expression of genes needful for glycine decarboxylation through the H protein complex with release of CO2 and ammonia.
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): biological_process GO:0006546 - glycine catabolic process
GO:0019464 - glycine decarboxylation via glycine cleavage system
GO:0032259 - methylation
GO:0055114 - oxidation-reduction process
GO:0006355 - regulation of transcription, DNA-templated
GO:0009411 - response to UV
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005960 - glycine cleavage complex
molecular_function GO:0003700 - DNA binding transcription factor activity
GO:0004047 - aminomethyltransferase activity
GO:0016594 - glycine binding
GO:0004375 - glycine dehydrogenase (decarboxylating) activity
GO:0042802 - identical protein binding
GO:0031405 - lipoic acid binding
GO:0043565 - sequence-specific DNA binding
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Components: Show/Hide Components Table (24 more...)
Function Name Type
simple_molecule CO2 simple_molecule
protein GcvA protein
complex GcvA-glycine complex
complex GcvA-purine complex
protein GcvH protein
protein GcvP protein
protein GcvT protein
protein Lpd protein
complex Lpd-GcvP-GcvH-GcvT complex
protein RNA:GcvB protein
simple_molecule THF polyglutamate simple_molecule
simple_molecule [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule
simple_molecule [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule
simple_molecule [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule
simple_molecule ammonium simple_molecule
gene gcvA gene
RNA gcvA_mRNA RNA
gene gcvB gene
RNA gcvB_mRNA RNA
gene gcvTHP gene
RNA gcvTHP_mRNA RNA
simple_molecule glycine simple_molecule
simple_molecule methylene-H4PteGlu(n) simple_molecule
simple_molecule purine simple_molecule


Reactions       
Showing 16 reactions
GcvA gcvB gcvB_mRNA
Name: gcvB -> gcvB_mRNA
Description: Transcription of transcription unit gcvB. Reaction activation by GcvA.
Type: transcription
Pathway Components: gcvB - GcvA -> gcvB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator GcvA protein nd nd
reactant gcvB gene nd nd
product gcvB_mRNA RNA nd nd
GcvA GcvA gcvTHP gcvTHP_mRNA
Name: gcvTHP -> gcvTHP_mRNA
Description: Transcription of transcription unit gcvTHP. Reaction activation by GcvA. Reaction inhibition by GcvA.
Type: transcription
Pathway Components: gcvTHP - GcvA - GcvA -> gcvTHP_mRNA
Components:
Function Name Type Evidence Reference(s)
activator GcvA protein nd nd
inhibitor GcvA protein nd nd
reactant gcvTHP gene nd nd
product gcvTHP_mRNA RNA nd nd
GcvA gcvA gcvA_mRNA
Name: gcvA -> gcvA_mRNA
Description: Transcription of transcription unit gcvA. Reaction inhibition by GcvA.
Type: transcription
Pathway Components: gcvA - GcvA -> gcvA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GcvA protein nd nd
reactant gcvA gene nd nd
product gcvA_mRNA RNA nd nd
glycine + GcvA GcvA-glycine
Name: glycine + GcvA -> GcvA-glycine
Description: Reaction transforming glycine, GcvA into GcvA-glycine
Type: state transition
Pathway Components: glycine + GcvA -> GcvA-glycine
Components:
Function Name Type Evidence Reference(s)
reactant GcvA protein nd nd
product GcvA-glycine complex nd nd
reactant glycine simple_molecule nd nd
purine + GcvA GcvA-purine
Name: purine + GcvA -> GcvA-purine
Description: Reaction transforming purine, GcvA into GcvA-purine
Type: state transition
Pathway Components: purine + GcvA -> GcvA-purine
Components:
Function Name Type Evidence Reference(s)
reactant GcvA protein nd nd
product GcvA-purine complex nd nd
reactant purine simple_molecule nd nd
gcvB_mRNA RNA:GcvB
Name: gcvB_mRNA -> RNA:GcvB
Description: Translation of RNA:GcvB
Type: translation
Pathway Components: gcvB_mRNA -> RNA:GcvB
Components:
Function Name Type Evidence Reference(s)
product RNA:GcvB protein nd nd
reactant gcvB_mRNA RNA nd nd
gcvA_mRNA GcvA
Name: gcvA_mRNA -> GcvA
Description: Translation of GcvA
Type: translation
Pathway Components: gcvA_mRNA -> GcvA
Components:
Function Name Type Evidence Reference(s)
product GcvA protein nd nd
reactant gcvA_mRNA RNA nd nd
gcvTHP_mRNA GcvT
Name: gcvTHP_mRNA -> GcvT
Description: Translation of GcvT
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvT
Components:
Function Name Type Evidence Reference(s)
product GcvT protein nd nd
reactant gcvTHP_mRNA RNA nd nd
GcvP + GcvH + GcvT + Lpd Lpd-GcvP-GcvH-GcvT
Name: GcvP + GcvH + GcvT + Lpd -> Lpd-GcvP-GcvH-GcvT
Description: Reaction transforming GcvP, GcvH, GcvT, Lpd into Lpd-GcvP-GcvH-GcvT
Type: state transition
Pathway Components: GcvP + GcvH + GcvT + Lpd -> Lpd-GcvP-GcvH-GcvT
Components:
Function Name Type Evidence Reference(s)
reactant GcvH protein nd nd
reactant GcvP protein nd nd
reactant GcvT protein nd nd
reactant Lpd protein nd nd
product Lpd-GcvP-GcvH-GcvT complex nd nd
Lpd-GcvP-GcvH-GcvT THF polyglutamate + glycine methylene-H4PteGlu(n) + ammonium + CO2
Name: THF polyglutamate + glycine -> methylene-H4PteGlu(n) + ammonium + CO2
Description: Reaction transforming THF polyglutamate, glycine into methylene-H4PteGlu(n), ammonium , CO2
Type: state transition
Pathway Components: THF polyglutamate + glycine - Lpd-GcvP-GcvH-GcvT -> methylene-H4PteGlu(n) + ammonium + CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer Lpd-GcvP-GcvH-GcvT complex nd nd
reactant THF polyglutamate simple_molecule nd nd
product ammonium simple_molecule nd nd
reactant glycine simple_molecule nd nd
product methylene-H4PteGlu(n) simple_molecule nd nd
GcvP Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + glycine -> [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2
Description: Reaction transforming [glycine-cleavage complex H protein] N6-lipoyl-L-lysine, glycine into [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine, CO2
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + glycine - GcvP - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer GcvP protein nd nd
catalyzer Lpd-GcvP-GcvH-GcvT complex nd nd
product [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule nd nd
reactant [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule nd nd
reactant glycine simple_molecule nd nd
GcvT Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + THF polyglutamate -> [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + methylene-H4PteGlu(n) + ammonium
Description: Reaction transforming [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine, THF polyglutamate into [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine, methylene-H4PteGlu(n) , ammonium
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + THF polyglutamate - GcvT - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + methylene-H4PteGlu(n) + ammonium
Components:
Function Name Type Evidence Reference(s)
catalyzer GcvT protein nd nd
catalyzer Lpd-GcvP-GcvH-GcvT complex nd nd
reactant THF polyglutamate simple_molecule nd nd
reactant [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule nd nd
product [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule nd nd
product ammonium simple_molecule nd nd
product methylene-H4PteGlu(n) simple_molecule nd nd
Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine -> [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Description: Reaction transforming [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine into [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Components:
Function Name Type Evidence Reference(s)
catalyzer Lpd-GcvP-GcvH-GcvT complex nd nd
reactant [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule nd nd
product [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule nd nd
gcvTHP_mRNA GcvH
Name: gcvTHP_mRNA -> GcvH
Description: Translation of GcvH
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvH
Components:
Function Name Type Evidence Reference(s)
product GcvH protein nd nd
reactant gcvTHP_mRNA RNA nd nd
gcvTHP_mRNA GcvP
Name: gcvTHP_mRNA -> GcvP
Description: Translation of GcvP
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvP
Components:
Function Name Type Evidence Reference(s)
product GcvP protein nd nd
reactant gcvTHP_mRNA RNA nd nd
methylene-H4PteGlu(n) glycine
Name: methylene-H4PteGlu(n) -> glycine
Description: Transformation of methylene-H4PteGlu(n) into glycine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: methylene-H4PteGlu(n) / glycine
Components:
Function Name Type Evidence Reference(s)
product glycine simple_molecule nd nd
reactant methylene-H4PteGlu(n) simple_molecule nd nd



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