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GalR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
GalE GalK GalM GalP GalR GalS GalT MglA MglB MglC UDP-alpha-D-glucose UDP-alpha-D-galactose alpha-D-galactose alpha-D-galactose 1-phosphate alpha-D-glucose 1-phosphate beta-D-galactose beta-D-galactose_Ext galETKM galETKM_mRNA galP galP_mRNA galR galR_mRNA galS galS_mRNA galactose b-methyl-D-galactoside b-methyl-D-galactoside_Ext mglBAC mglBAC_mRNA phosphate GalR galactose MglA MglC MglB phosphate GalR


Gensor Unit       
Name: GalR
Description: Molecular biology level
Detailed: In the presence of galactose, GalR negatively regulates its own expression and the expression of genes required for galactose transport and regulation of transcription by galactose, and dually regulates the expression of genes required for galactose catabolic process via UDP-galactose. Under these conditions, GalR is modified to GalR-galactose, binds its target sites preventing its own expression and the expression of its regulated genes. In the absence of galactose, GalR binds its target sites preventing the expression of genes necessary for galactose and methylgalactoside transport and regulation of transcription by galactose.
Less detailed: GalR dually regulates the expression of genes required for galactose transport, galactose catabolic process via UDP-galactose and regulation of transcription by galactose in the presence of diverse levels of galactose.

Physiology level
Detailed: The presence of galactose inhibits the expression of genes involved with galactose transport and regulation of transcription by galactose and dually regulates the expression of the genes required for catabolism of galactose. Under these conditions, the genes necessary for the transport are not expressed and those genes necessary for the conversion of galactose to UDP-galactose are dually expressed.
Less detailed: The presence of galactose inhibits the expression of genes needful for galactose transport and regulation of transcription by galactose and dually regulates the expression of the genes required for catabolism of galactose. Read more >
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006935 - chemotaxis
GO:0009242 - colanic acid biosynthetic process
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
Read more >
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0070403 - NAD+ binding
GO:0003978 - UDP-glucose 4-epimerase activity
GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0004034 - aldose 1-epimerase activity
GO:0030246 - carbohydrate binding
Read more >
Components: Show/Hide Components Table (42 more...)
Function Name Type
simple_molecule α-D-galactose simple_molecule
simple_molecule D-glucose 1-phosphate simple_molecule
protein GalE protein
protein GalK protein
protein GalM protein
protein GalP protein
protein GalR protein
complex GalR-galactose complex
protein GalS protein
protein GalT protein
protein MglA protein
complex MglA-MglC-MglB complex
protein MglB protein
protein MglC protein
simple_molecule UDP-galactose simple_molecule
simple_molecule UDPG simple_molecule
simple_molecule b-methyl-D-galactoside simple_molecule
simple_molecule b-methyl-D-galactoside_Ext simple_molecule
simple_molecule beta-D-galactose simple_molecule
simple_molecule beta-D-galactose_Ext simple_molecule
gene galE gene
gene galET gene
gene galETK gene
gene galETKM gene
RNA galETKM_mRNA RNA
RNA galETK_mRNA RNA
RNA galET_mRNA RNA
RNA galE_mRNA RNA
gene galP gene
RNA galP_mRNA RNA
gene galR gene
RNA galR_mRNA RNA
gene galS gene
RNA galS_mRNA RNA
simple_molecule galactopyranose simple_molecule
simple_molecule galactopyranose_Ext simple_molecule
simple_molecule galactose simple_molecule
simple_molecule galactose-1-P simple_molecule
simple_molecule glucopyranose simple_molecule
simple_molecule glucopyranose_Ext simple_molecule
gene mglBAC gene
RNA mglBAC_mRNA RNA


Reactions       
Showing 34 reactions
GalR GalR galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction activation by GalR. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galETKM - GalR - GalR -> galETKM_mRNA
Components:
Function Name Type Evidence Reference(s)
activator GalR protein nd nd
inhibitor GalR protein nd nd
reactant galETKM gene nd nd
product galETKM_mRNA RNA nd nd
GalR galP galP_mRNA
Name: galP -> galP_mRNA
Description: Transcription of transcription unit galP. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galP - GalR -> galP_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galP gene nd nd
product galP_mRNA RNA nd nd
GalR galR galR_mRNA
Name: galR -> galR_mRNA
Description: Transcription of transcription unit galR. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galR - GalR -> galR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galR gene nd nd
product galR_mRNA RNA nd nd
GalR galS galS_mRNA
Name: galS -> galS_mRNA
Description: Transcription of transcription unit galS. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galS - GalR -> galS_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galS gene nd nd
product galS_mRNA RNA nd nd
GalR mglBAC mglBAC_mRNA
Name: mglBAC -> mglBAC_mRNA
Description: Transcription of transcription unit mglBAC. Reaction inhibition by GalR.
Type: transcription
Pathway Components: mglBAC - GalR -> mglBAC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant mglBAC gene nd nd
product mglBAC_mRNA RNA nd nd
galactose + GalR GalR-galactose
Name: galactose + GalR -> GalR-galactose
Description: Reaction transforming galactose, GalR into GalR-galactose
Type: state transition
Pathway Components: galactose + GalR -> GalR-galactose
Components:
Function Name Type Evidence Reference(s)
reactant GalR protein nd nd
product GalR-galactose complex nd nd
reactant galactose simple_molecule nd nd
GalR galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galE - GalR -> galE_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galE gene nd nd
product galE_mRNA RNA nd nd
GalR galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galET - GalR -> galET_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galET gene nd nd
product galET_mRNA RNA nd nd
GalR galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galETK - GalR -> galETK_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalR protein nd nd
reactant galETK gene nd nd
product galETK_mRNA RNA nd nd
galS_mRNA GalS
Name: galS_mRNA -> GalS
Description: Translation of GalS
Type: translation
Pathway Components: galS_mRNA -> GalS
Components:
Function Name Type Evidence Reference(s)
product GalS protein nd nd
reactant galS_mRNA RNA nd nd
galR_mRNA GalR
Name: galR_mRNA -> GalR
Description: Translation of GalR
Type: translation
Pathway Components: galR_mRNA -> GalR
Components:
Function Name Type Evidence Reference(s)
product GalR protein nd nd
reactant galR_mRNA RNA nd nd
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galETKM_mRNA RNA nd nd
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalE protein nd nd
product UDP-galactose simple_molecule nd nd
reactant UDPG simple_molecule nd nd
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galETKM_mRNA RNA nd nd
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type Evidence Reference(s)
product D-glucose 1-phosphate simple_molecule nd nd
catalyzer GalT protein nd nd
product UDP-galactose simple_molecule nd nd
reactant UDPG simple_molecule nd nd
reactant galactose-1-P simple_molecule nd nd
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type Evidence Reference(s)
product GalK protein nd nd
reactant galETKM_mRNA RNA nd nd
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type Evidence Reference(s)
reactant α-D-galactose simple_molecule nd nd
catalyzer GalK protein nd nd
product galactose-1-P simple_molecule nd nd
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type Evidence Reference(s)
product GalM protein nd nd
reactant galETKM_mRNA RNA nd nd
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type Evidence Reference(s)
product α-D-galactose simple_molecule nd nd
catalyzer GalM protein nd nd
reactant beta-D-galactose simple_molecule nd nd
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galET_mRNA RNA nd nd
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galET_mRNA RNA nd nd
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galETK_mRNA RNA nd nd
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galETK_mRNA RNA nd nd
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type Evidence Reference(s)
product GalK protein nd nd
reactant galETK_mRNA RNA nd nd
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galE_mRNA RNA nd nd
mglBAC_mRNA MglB
Name: mglBAC_mRNA -> MglB
Description: Translation of MglB
Type: translation
Pathway Components: mglBAC_mRNA -> MglB
Components:
Function Name Type Evidence Reference(s)
product MglB protein nd nd
reactant mglBAC_mRNA RNA nd nd
MglC + MglA + MglB MglA-MglC-MglB
Name: MglC + MglA + MglB -> MglA-MglC-MglB
Description: Reaction transforming MglC, MglA, MglB into MglA-MglC-MglB
Type: state transition
Pathway Components: MglC + MglA + MglB -> MglA-MglC-MglB
Components:
Function Name Type Evidence Reference(s)
reactant MglA protein nd nd
product MglA-MglC-MglB complex nd nd
reactant MglB protein nd nd
reactant MglC protein nd nd
MglA-MglC-MglB b-methyl-D-galactoside_Ext b-methyl-D-galactoside
Name: b-methyl-D-galactoside_Ext -> b-methyl-D-galactoside
Description: Transport of b-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext - MglA-MglC-MglB -> b-methyl-D-galactoside
Components:
Function Name Type Evidence Reference(s)
catalyzer MglA-MglC-MglB complex nd nd
product b-methyl-D-galactoside simple_molecule nd nd
reactant b-methyl-D-galactoside_Ext simple_molecule nd nd
MglA-MglC-MglB galactopyranose_Ext galactopyranose
Name: galactopyranose_Ext -> galactopyranose
Description: Transport of galactopyranose_Ext through a bacterial membrane, leading to the presence of galactopyranose inside the cell.
Type: transport
Pathway Components: galactopyranose_Ext - MglA-MglC-MglB -> galactopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer MglA-MglC-MglB complex nd nd
product galactopyranose simple_molecule nd nd
reactant galactopyranose_Ext simple_molecule nd nd
mglBAC_mRNA MglA
Name: mglBAC_mRNA -> MglA
Description: Translation of MglA
Type: translation
Pathway Components: mglBAC_mRNA -> MglA
Components:
Function Name Type Evidence Reference(s)
product MglA protein nd nd
reactant mglBAC_mRNA RNA nd nd
mglBAC_mRNA MglC
Name: mglBAC_mRNA -> MglC
Description: Translation of MglC
Type: translation
Pathway Components: mglBAC_mRNA -> MglC
Components:
Function Name Type Evidence Reference(s)
product MglC protein nd nd
reactant mglBAC_mRNA RNA nd nd
galP_mRNA GalP
Name: galP_mRNA -> GalP
Description: Translation of GalP
Type: translation
Pathway Components: galP_mRNA -> GalP
Components:
Function Name Type Evidence Reference(s)
product GalP protein nd nd
reactant galP_mRNA RNA nd nd
GalP glucopyranose_Ext glucopyranose
Name: glucopyranose_Ext -> glucopyranose
Description: Transport of glucopyranose_Ext through a bacterial membrane, leading to the presence of glucopyranose inside the cell.
Type: transport
Pathway Components: glucopyranose_Ext - GalP -> glucopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalP protein nd nd
product glucopyranose simple_molecule nd nd
reactant glucopyranose_Ext simple_molecule nd nd
GalP beta-D-galactose_Ext beta-D-galactose
Name: beta-D-galactose_Ext -> beta-D-galactose
Description: Transport of beta-D-galactose_Ext through a bacterial membrane, leading to the presence of beta-D-galactose inside the cell.
Type: transport
Pathway Components: beta-D-galactose_Ext - GalP -> beta-D-galactose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalP protein nd nd
product beta-D-galactose simple_molecule nd nd
reactant beta-D-galactose_Ext simple_molecule nd nd



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