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GatR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-glyceraldehyde 3-phosphate D-tagatofuranose 1,6-diphosphate D-tagatofuranose 6-phosphate GatA GatB GatC GatD GatR GatY GatZ HPr HPr - phosphorylated_Ext DHAP galactitol 1-phosphate dulcite_Ext gatYZABCD gatYZABCD_mRNA GatY GatZ GatC GatB GatA


Gensor Unit       
Name: GatR
Description: Molecular biology level
Detailed: GatR negatively regulates the expression of genes required for galactitol transport and catbolic process. GatR binds its target sites and prevents the expression of its regulated genes.
Less detailed: GatR negatively regulates the expression of genes needed for galactitol transport and catabolica processes.

Physiology level
Detailed: GatR inhibits the expression of genes involved with galactitol transport and catabolic process, the genes necessary for transport and conversion of galactitol to D-glyceraldehyde-3-phosphate and dihidroxyacetone phosphate are not expressed.
Less detailed: GatR inhibits the expression of genes needful for import of galactitol and its transformation to Glycerladehyde-3-phosphate and dihydroxyacetone phosphate.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0034219 - carbohydrate transmembrane transport
GO:0019404 - galactitol catabolic process
GO:0015796 - galactitol transport
GO:0055114 - oxidation-reduction process
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0008868 - galactitol-1-phosphate 5-dehydrogenase activity
GO:0042802 - identical protein binding
GO:0016491 - oxidoreductase activity
GO:0005515 - protein binding
GO:0090584 - protein-phosphocysteine-galactitol-phosphotransferase system transporter activity
GO:0090563 - protein-phosphocysteine-sugar phosphotransferase activity
GO:0051119 - sugar transmembrane transporter activity
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Components: Show/Hide Components Table (21 more...)
Function Name Type
simple_molecule DHAP simple_molecule
protein GatA protein
protein GatB protein
protein GatC protein
complex GatC-GatB-GatA complex
protein GatD protein
protein GatR protein
protein GatY protein
complex GatY-GatZ complex
protein GatZ protein
simple_molecule HPr - phosphorylated_Ext simple_molecule
simple_molecule PtsH simple_molecule
simple_molecule dulcite_Ext simple_molecule
simple_molecule galactitol 1-phosphate simple_molecule
gene gatYZABCD gene
RNA gatYZABCD_mRNA RNA
simple_molecule glyceraldehyde-P simple_molecule
simple_molecule gulitol_Ext simple_molecule
simple_molecule keto-L-tagatose 6-phosphate simple_molecule
simple_molecule sorbitol 6-phosphate simple_molecule
simple_molecule tagatofuranose 1,6-diphosphate simple_molecule


Reactions       
Showing 14 reactions
GatR gatYZABCD gatYZABCD_mRNA
Name: gatYZABCD -> gatYZABCD_mRNA
Description: Transcription of transcription unit gatYZABCD. Reaction inhibition by GatR.
Type: transcription
Pathway Components: gatYZABCD - GatR -> gatYZABCD_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GatR protein nd nd
reactant gatYZABCD gene nd nd
product gatYZABCD_mRNA RNA nd nd
gatYZABCD_mRNA GatY
Name: gatYZABCD_mRNA -> GatY
Description: Translation of GatY
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatY
Components:
Function Name Type Evidence Reference(s)
product GatY protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
GatY + GatZ GatY-GatZ
Name: GatY + GatZ -> GatY-GatZ
Description: Reaction transforming GatY, GatZ into GatY-GatZ
Type: state transition
Pathway Components: GatY + GatZ -> GatY-GatZ
Components:
Function Name Type Evidence Reference(s)
reactant GatY protein nd nd
product GatY-GatZ complex nd nd
reactant GatZ protein nd nd
GatY-GatZ tagatofuranose 1,6-diphosphate glyceraldehyde-P + DHAP
Name: tagatofuranose 1,6-diphosphate -> glyceraldehyde-P + DHAP
Description: Reaction transforming tagatofuranose 1,6-diphosphate into glyceraldehyde-P, DHAP
Type: state transition
Pathway Components: tagatofuranose 1,6-diphosphate - GatY-GatZ -> glyceraldehyde-P + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer GatY-GatZ complex nd nd
product glyceraldehyde-P simple_molecule nd nd
reactant tagatofuranose 1,6-diphosphate simple_molecule nd nd
gatYZABCD_mRNA GatZ
Name: gatYZABCD_mRNA -> GatZ
Description: Translation of GatZ
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatZ
Components:
Function Name Type Evidence Reference(s)
product GatZ protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
gatYZABCD_mRNA GatA
Name: gatYZABCD_mRNA -> GatA
Description: Translation of GatA
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatA
Components:
Function Name Type Evidence Reference(s)
product GatA protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
GatA + GatC + GatB GatC-GatB-GatA
Name: GatA + GatC + GatB -> GatC-GatB-GatA
Description: Reaction transforming GatA, GatC, GatB into GatC-GatB-GatA
Type: state transition
Pathway Components: GatA + GatC + GatB -> GatC-GatB-GatA
Components:
Function Name Type Evidence Reference(s)
reactant GatA protein nd nd
reactant GatB protein nd nd
reactant GatC protein nd nd
product GatC-GatB-GatA complex nd nd
GatC-GatB-GatA HPr - phosphorylated_Ext + dulcite_Ext galactitol 1-phosphate + PtsH
Name: HPr - phosphorylated_Ext + dulcite_Ext -> galactitol 1-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, dulcite_Ext through a bacterial membrane, leading to the presence of galactitol 1-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + dulcite_Ext - GatC-GatB-GatA -> galactitol 1-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer GatC-GatB-GatA complex nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
reactant dulcite_Ext simple_molecule nd nd
product galactitol 1-phosphate simple_molecule nd nd
GatC-GatB-GatA HPr - phosphorylated_Ext + gulitol_Ext sorbitol 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + gulitol_Ext -> sorbitol 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, gulitol_Ext through a bacterial membrane, leading to the presence of sorbitol 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + gulitol_Ext - GatC-GatB-GatA -> sorbitol 6-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer GatC-GatB-GatA complex nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
reactant gulitol_Ext simple_molecule nd nd
product sorbitol 6-phosphate simple_molecule nd nd
gatYZABCD_mRNA GatB
Name: gatYZABCD_mRNA -> GatB
Description: Translation of GatB
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatB
Components:
Function Name Type Evidence Reference(s)
product GatB protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
gatYZABCD_mRNA GatC
Name: gatYZABCD_mRNA -> GatC
Description: Translation of GatC
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatC
Components:
Function Name Type Evidence Reference(s)
product GatC protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
gatYZABCD_mRNA GatD
Name: gatYZABCD_mRNA -> GatD
Description: Translation of GatD
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatD
Components:
Function Name Type Evidence Reference(s)
product GatD protein nd nd
reactant gatYZABCD_mRNA RNA nd nd
GatD galactitol 1-phosphate keto-L-tagatose 6-phosphate
Name: galactitol 1-phosphate -> keto-L-tagatose 6-phosphate
Description: Reaction transforming galactitol 1-phosphate into keto-L-tagatose 6-phosphate
Type: state transition
Pathway Components: galactitol 1-phosphate - GatD -> keto-L-tagatose 6-phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer GatD protein nd nd
reactant galactitol 1-phosphate simple_molecule nd nd
product keto-L-tagatose 6-phosphate simple_molecule nd nd
keto-L-tagatose 6-phosphate tagatofuranose 1,6-diphosphate
Name: keto-L-tagatose 6-phosphate -> tagatofuranose 1,6-diphosphate
Description: Transformation of keto-L-tagatose 6-phosphate into tagatofuranose 1,6-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: keto-L-tagatose 6-phosphate / RXN-16992 / TAGAKIN-RXN / tagatofuranose 1,6-diphosphate
Components:
Function Name Type Evidence Reference(s)
reactant keto-L-tagatose 6-phosphate simple_molecule nd nd
product tagatofuranose 1,6-diphosphate simple_molecule nd nd



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