RegulonDB RegulonDB

GalS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
GalE GalK GalM GalP GalR GalS GalT MglA MglB MglC UDP-alpha-D-glucose UDP-alpha-D-galactose alpha-D-galactose alpha-D-galactose-1-P alpha-D-glucose-1-P beta-D-galactose beta-D-galactose_Ext galETKM galETKM_mRNA galP galP_mRNA galR galR_mRNA galS galS_mRNA beta-D-galactose b-methyl-D-galactoside b-methyl-D-galactoside_Ext mglBAC mglBAC_mRNA GalS beta-D-galactose MglA MglC MglB


Gensor Unit       
Name: GalS
Description: Molecular biology level
Detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes required for galactose degradation to UDP-galactose. Under different conditions of galactose availability, GalS remains unmodified or is modified to GalS-beta-D-galactose, binds to its target sites enabling or preventing the expression of its regulated genes.
Less detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes needed for galactose degradation to UDP-galactose to respond to different conditions of galactose availability.

Physiology level
Detailed: The presence of beta-D-galactose represses the expression of GalR and genes involved with Galactose uptake. Under this condition, the genes necessary for D-Galactose transport are not expressed. The presence of beta-D-galactose dually regulates the expression of genes required to UDP-D-galactose biosynthesis. Under this condition, the genes necessary for D-galactose conversion to UDP-D-galactose are expressed and not expressed. The absence of D-galactose repress its own expression and the expression of genes necessary for D-galactose and methyl-D-galactoside uptake. Under this condition, the genes necessary for D-galactose and D-methylgalactoside transport are not expressed.
Less detailed: The presence of beta-D-galactose represses the expression of genes needful for D-galactose transport and dually regulates the expression of genes related with D-galactose conversion to UDP-D-galactose. Read more >
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006935 - chemotaxis
GO:0009242 - colanic acid biosynthetic process
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
Read more >
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0070403 - NAD+ binding
GO:0003978 - UDP-glucose 4-epimerase activity
GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0004034 - aldose 1-epimerase activity
GO:0030246 - carbohydrate binding
Read more >
Components: Show/Hide Components Table (42 more...)
Function Name Type
simple_molecule α-D-galactose simple_molecule
simple_molecule D-glucose 1-phosphate simple_molecule
protein GalE protein
protein GalK protein
protein GalM protein
protein GalP protein
protein GalR protein
protein GalS protein
complex GalS-galactose complex
protein GalT protein
protein MglA protein
complex MglA-MglC-MglB complex
protein MglB protein
protein MglC protein
simple_molecule UDP-galactose simple_molecule
simple_molecule UDPG simple_molecule
simple_molecule b-methyl-D-galactoside simple_molecule
simple_molecule b-methyl-D-galactoside_Ext simple_molecule
simple_molecule beta-D-galactose simple_molecule
simple_molecule beta-D-galactose_Ext simple_molecule
gene galE gene
gene galET gene
gene galETK gene
gene galETKM gene
RNA galETKM_mRNA RNA
RNA galETK_mRNA RNA
RNA galET_mRNA RNA
RNA galE_mRNA RNA
gene galP gene
RNA galP_mRNA RNA
gene galR gene
RNA galR_mRNA RNA
gene galS gene
RNA galS_mRNA RNA
simple_molecule galactopyranose simple_molecule
simple_molecule galactopyranose_Ext simple_molecule
simple_molecule galactose simple_molecule
simple_molecule galactose-1-P simple_molecule
simple_molecule glucopyranose simple_molecule
simple_molecule glucopyranose_Ext simple_molecule
gene mglBAC gene
RNA mglBAC_mRNA RNA


Reactions       
Showing 34 reactions
GalS GalS galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction activation by GalS. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galETKM - GalS - GalS -> galETKM_mRNA
Components:
Function Name Type Evidence Reference(s)
activator GalS protein nd nd
inhibitor GalS protein nd nd
reactant galETKM gene nd nd
product galETKM_mRNA RNA nd nd
GalS galP galP_mRNA
Name: galP -> galP_mRNA
Description: Transcription of transcription unit galP. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galP - GalS -> galP_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galP gene nd nd
product galP_mRNA RNA nd nd
GalS galR galR_mRNA
Name: galR -> galR_mRNA
Description: Transcription of transcription unit galR. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galR - GalS -> galR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galR gene nd nd
product galR_mRNA RNA nd nd
GalS galS galS_mRNA
Name: galS -> galS_mRNA
Description: Transcription of transcription unit galS. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galS - GalS -> galS_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galS gene nd nd
product galS_mRNA RNA nd nd
GalS mglBAC mglBAC_mRNA
Name: mglBAC -> mglBAC_mRNA
Description: Transcription of transcription unit mglBAC. Reaction inhibition by GalS.
Type: transcription
Pathway Components: mglBAC - GalS -> mglBAC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant mglBAC gene nd nd
product mglBAC_mRNA RNA nd nd
galactose + GalS GalS-galactose
Name: galactose + GalS -> GalS-galactose
Description: Reaction transforming galactose, GalS into GalS-galactose
Type: state transition
Pathway Components: galactose + GalS -> GalS-galactose
Components:
Function Name Type Evidence Reference(s)
reactant GalS protein nd nd
product GalS-galactose complex nd nd
reactant galactose simple_molecule nd nd
GalS galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galE - GalS -> galE_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galE gene nd nd
product galE_mRNA RNA nd nd
GalS galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galET - GalS -> galET_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galET gene nd nd
product galET_mRNA RNA nd nd
GalS galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galETK - GalS -> galETK_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor GalS protein nd nd
reactant galETK gene nd nd
product galETK_mRNA RNA nd nd
galS_mRNA GalS
Name: galS_mRNA -> GalS
Description: Translation of GalS
Type: translation
Pathway Components: galS_mRNA -> GalS
Components:
Function Name Type Evidence Reference(s)
product GalS protein nd nd
reactant galS_mRNA RNA nd nd
galR_mRNA GalR
Name: galR_mRNA -> GalR
Description: Translation of GalR
Type: translation
Pathway Components: galR_mRNA -> GalR
Components:
Function Name Type Evidence Reference(s)
product GalR protein nd nd
reactant galR_mRNA RNA nd nd
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galETKM_mRNA RNA nd nd
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalE protein nd nd
product UDP-galactose simple_molecule nd nd
reactant UDPG simple_molecule nd nd
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galETKM_mRNA RNA nd nd
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type Evidence Reference(s)
product D-glucose 1-phosphate simple_molecule nd nd
catalyzer GalT protein nd nd
product UDP-galactose simple_molecule nd nd
reactant UDPG simple_molecule nd nd
reactant galactose-1-P simple_molecule nd nd
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type Evidence Reference(s)
product GalK protein nd nd
reactant galETKM_mRNA RNA nd nd
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type Evidence Reference(s)
reactant α-D-galactose simple_molecule nd nd
catalyzer GalK protein nd nd
product galactose-1-P simple_molecule nd nd
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type Evidence Reference(s)
product GalM protein nd nd
reactant galETKM_mRNA RNA nd nd
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type Evidence Reference(s)
product α-D-galactose simple_molecule nd nd
catalyzer GalM protein nd nd
reactant beta-D-galactose simple_molecule nd nd
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galET_mRNA RNA nd nd
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galET_mRNA RNA nd nd
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galETK_mRNA RNA nd nd
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type Evidence Reference(s)
product GalT protein nd nd
reactant galETK_mRNA RNA nd nd
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type Evidence Reference(s)
product GalK protein nd nd
reactant galETK_mRNA RNA nd nd
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type Evidence Reference(s)
product GalE protein nd nd
reactant galE_mRNA RNA nd nd
mglBAC_mRNA MglB
Name: mglBAC_mRNA -> MglB
Description: Translation of MglB
Type: translation
Pathway Components: mglBAC_mRNA -> MglB
Components:
Function Name Type Evidence Reference(s)
product MglB protein nd nd
reactant mglBAC_mRNA RNA nd nd
MglC + MglA + MglB MglA-MglC-MglB
Name: MglC + MglA + MglB -> MglA-MglC-MglB
Description: Reaction transforming MglC, MglA, MglB into MglA-MglC-MglB
Type: state transition
Pathway Components: MglC + MglA + MglB -> MglA-MglC-MglB
Components:
Function Name Type Evidence Reference(s)
reactant MglA protein nd nd
product MglA-MglC-MglB complex nd nd
reactant MglB protein nd nd
reactant MglC protein nd nd
MglA-MglC-MglB b-methyl-D-galactoside_Ext b-methyl-D-galactoside
Name: b-methyl-D-galactoside_Ext -> b-methyl-D-galactoside
Description: Transport of b-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext - MglA-MglC-MglB -> b-methyl-D-galactoside
Components:
Function Name Type Evidence Reference(s)
catalyzer MglA-MglC-MglB complex nd nd
product b-methyl-D-galactoside simple_molecule nd nd
reactant b-methyl-D-galactoside_Ext simple_molecule nd nd
MglA-MglC-MglB galactopyranose_Ext galactopyranose
Name: galactopyranose_Ext -> galactopyranose
Description: Transport of galactopyranose_Ext through a bacterial membrane, leading to the presence of galactopyranose inside the cell.
Type: transport
Pathway Components: galactopyranose_Ext - MglA-MglC-MglB -> galactopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer MglA-MglC-MglB complex nd nd
product galactopyranose simple_molecule nd nd
reactant galactopyranose_Ext simple_molecule nd nd
mglBAC_mRNA MglA
Name: mglBAC_mRNA -> MglA
Description: Translation of MglA
Type: translation
Pathway Components: mglBAC_mRNA -> MglA
Components:
Function Name Type Evidence Reference(s)
product MglA protein nd nd
reactant mglBAC_mRNA RNA nd nd
mglBAC_mRNA MglC
Name: mglBAC_mRNA -> MglC
Description: Translation of MglC
Type: translation
Pathway Components: mglBAC_mRNA -> MglC
Components:
Function Name Type Evidence Reference(s)
product MglC protein nd nd
reactant mglBAC_mRNA RNA nd nd
galP_mRNA GalP
Name: galP_mRNA -> GalP
Description: Translation of GalP
Type: translation
Pathway Components: galP_mRNA -> GalP
Components:
Function Name Type Evidence Reference(s)
product GalP protein nd nd
reactant galP_mRNA RNA nd nd
GalP glucopyranose_Ext glucopyranose
Name: glucopyranose_Ext -> glucopyranose
Description: Transport of glucopyranose_Ext through a bacterial membrane, leading to the presence of glucopyranose inside the cell.
Type: transport
Pathway Components: glucopyranose_Ext - GalP -> glucopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalP protein nd nd
product glucopyranose simple_molecule nd nd
reactant glucopyranose_Ext simple_molecule nd nd
GalP beta-D-galactose_Ext beta-D-galactose
Name: beta-D-galactose_Ext -> beta-D-galactose
Description: Transport of beta-D-galactose_Ext through a bacterial membrane, leading to the presence of beta-D-galactose inside the cell.
Type: transport
Pathway Components: beta-D-galactose_Ext - GalP -> beta-D-galactose
Components:
Function Name Type Evidence Reference(s)
catalyzer GalP protein nd nd
product beta-D-galactose simple_molecule nd nd
reactant beta-D-galactose_Ext simple_molecule nd nd



RegulonDB