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FucR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-1,2-propanediol D-ribulose D-ribulose-1-P FucA FucI FucK FucO FucP FucR FucU L-fucopyranose L-fucose L-fucose_Ext fuculose L-fuculose-1-P L-lactaldehyde alpha-L-fucose beta-L-fucose DHAP glycol fucAO fucAO_mRNA fucPIKUR fucPIKUR_mRNA glycoaldehyde D-arabinopyranose FucR L-fuculose-1-phosphate


Gensor Unit       
Name: FucR
Description: Molecular biology level
Detailed: In the presence of L-fuculose-1-phosphate, FucR positively regulates the expression of genes required for fucose transport and catabolic processes. Under these condition, FucR is modified to FucR-L-fuculose-1-phosphate, binds its target sites enabling the expression of its regulated genes. In the absence of L-fuculose-1-phosphate, FucR unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of L-fuculose-1-phosphate, FucR positively regulates the expression of genes needed for fucose transport and catabolic processes.

Physiology level
Detailed: The presence of L-fuculose-1-phosphate induces the expression of genes involved with fucose transport and catabolism. Under this conditions, the genes necessary for fucose transport and degradation to L-lactaldehyde and glycerone phosphate (that feeds glycolysis), are expressed.
Less detailed: The presence of L-fuculose-1-phosphate induces the expression of genes needful for transport of fucose and its degradation to L-lactaldehyde and glycerone phosphate.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0019571 - D-arabinose catabolic process
GO:0042355 - L-fucose catabolic process
GO:0015751 - arabinose transmembrane transport
GO:0046835 - carbohydrate phosphorylation
GO:0015755 - fructose transmembrane transport
GO:0015756 - fucose transmembrane transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005886 - plasma membrane
molecular_function GO:0008736 - L-fucose isomerase activity
GO:0008737 - L-fuculokinase activity
GO:0008738 - L-fuculose-phosphate aldolase activity
GO:0004022 - alcohol dehydrogenase (NAD) activity
GO:0016832 - aldehyde-lyase activity
GO:0008790 - arabinose isomerase activity
GO:0015518 - arabinose:proton symporter activity
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Components: Show/Hide Components Table (26 more...)
Function Name Type
simple_molecule α-L-fucose simple_molecule
simple_molecule 1,2-propanediol simple_molecule
simple_molecule DHAP simple_molecule
protein FucA protein
protein FucI protein
protein FucK protein
protein FucO protein
protein FucP protein
protein FucR protein
complex FucR-fuculose-1-P complex
protein FucU protein
simple_molecule arabinopyranose simple_molecule
simple_molecule beta-L-fucose simple_molecule
gene fucAO gene
RNA fucAO_mRNA RNA
gene fucPIKUR gene
RNA fucPIKUR_mRNA RNA
simple_molecule fucose simple_molecule
simple_molecule fucose_Ext simple_molecule
simple_molecule fuculose simple_molecule
simple_molecule fuculose-1-P simple_molecule
simple_molecule glycoaldehyde simple_molecule
simple_molecule glycol simple_molecule
simple_molecule lactaldehyde simple_molecule
simple_molecule ribulose simple_molecule
simple_molecule ribulose-1-P simple_molecule


Reactions       
Showing 20 reactions
fuculose-1-P + FucR FucR-fuculose-1-P
Name: fuculose-1-P + FucR -> FucR-fuculose-1-P
Description: Reaction transforming fuculose-1-P, FucR into FucR-fuculose-1-P
Type: state transition
Pathway Components: fuculose-1-P + FucR -> FucR-fuculose-1-P
Components:
Function Name Type Evidence Reference(s)
reactant FucR protein nd nd
product FucR-fuculose-1-P complex nd nd
reactant fuculose-1-P simple_molecule nd nd
FucR-fuculose-1-P fucAO fucAO_mRNA
Name: fucAO -> fucAO_mRNA
Description: Transcription of transcription unit fucAO. Reaction activation by FucR-fuculose-1-P.
Type: transcription
Pathway Components: fucAO - FucR-fuculose-1-P -> fucAO_mRNA
Components:
Function Name Type Evidence Reference(s)
activator FucR-fuculose-1-P complex nd nd
reactant fucAO gene nd nd
product fucAO_mRNA RNA nd nd
FucR-fuculose-1-P fucPIKUR fucPIKUR_mRNA
Name: fucPIKUR -> fucPIKUR_mRNA
Description: Transcription of transcription unit fucPIKUR. Reaction activation by FucR-fuculose-1-P.
Type: transcription
Pathway Components: fucPIKUR - FucR-fuculose-1-P -> fucPIKUR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator FucR-fuculose-1-P complex nd nd
reactant fucPIKUR gene nd nd
product fucPIKUR_mRNA RNA nd nd
fucAO_mRNA FucA
Name: fucAO_mRNA -> FucA
Description: Translation of FucA
Type: translation
Pathway Components: fucAO_mRNA -> FucA
Components:
Function Name Type Evidence Reference(s)
product FucA protein nd nd
reactant fucAO_mRNA RNA nd nd
FucA fuculose-1-P lactaldehyde + DHAP
Name: fuculose-1-P -> lactaldehyde + DHAP
Description: Reaction transforming fuculose-1-P into lactaldehyde, DHAP
Type: state transition
Pathway Components: fuculose-1-P - FucA -> lactaldehyde + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer FucA protein nd nd
reactant fuculose-1-P simple_molecule nd nd
product lactaldehyde simple_molecule nd nd
FucA ribulose-1-P glycoaldehyde + DHAP
Name: ribulose-1-P -> glycoaldehyde + DHAP
Description: Reaction transforming ribulose-1-P into glycoaldehyde, DHAP
Type: state transition
Pathway Components: ribulose-1-P - FucA -> glycoaldehyde + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer FucA protein nd nd
product glycoaldehyde simple_molecule nd nd
reactant ribulose-1-P simple_molecule nd nd
fucAO_mRNA FucO
Name: fucAO_mRNA -> FucO
Description: Translation of FucO
Type: translation
Pathway Components: fucAO_mRNA -> FucO
Components:
Function Name Type Evidence Reference(s)
product FucO protein nd nd
reactant fucAO_mRNA RNA nd nd
FucO glycol glycoaldehyde
Name: glycol -> glycoaldehyde
Description: Reaction transforming glycol into glycoaldehyde
Type: state transition
Pathway Components: glycol - FucO -> glycoaldehyde
Components:
Function Name Type Evidence Reference(s)
catalyzer FucO protein nd nd
product glycoaldehyde simple_molecule nd nd
reactant glycol simple_molecule nd nd
1,2-propanediol FucO 1,2-propanediol lactaldehyde
Name: 1,2-propanediol -> lactaldehyde
Description: Reaction transforming 1,2-propanediol into lactaldehyde
Type: state transition
Pathway Components: 1,2-propanediol - FucO - 1,2-propanediol -> lactaldehyde
Components:
Function Name Type Evidence Reference(s)
inhibitor 1,2-propanediol simple_molecule nd nd
reactant 1,2-propanediol simple_molecule nd nd
catalyzer FucO protein nd nd
product lactaldehyde simple_molecule nd nd
fucPIKUR_mRNA FucP
Name: fucPIKUR_mRNA -> FucP
Description: Translation of FucP
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucP
Components:
Function Name Type Evidence Reference(s)
product FucP protein nd nd
reactant fucPIKUR_mRNA RNA nd nd
FucP fucose_Ext fucose
Name: fucose_Ext -> fucose
Description: Transport of fucose_Ext through a bacterial membrane, leading to the presence of fucose inside the cell.
Type: transport
Pathway Components: fucose_Ext - FucP -> fucose
Components:
Function Name Type Evidence Reference(s)
catalyzer FucP protein nd nd
product fucose simple_molecule nd nd
reactant fucose_Ext simple_molecule nd nd
fucPIKUR_mRNA FucI
Name: fucPIKUR_mRNA -> FucI
Description: Translation of FucI
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucI
Components:
Function Name Type Evidence Reference(s)
product FucI protein nd nd
reactant fucPIKUR_mRNA RNA nd nd
FucI α-L-fucose fuculose
Name: α-L-fucose -> fuculose
Description: Reaction transforming α-L-fucose into fuculose
Type: state transition
Pathway Components: α-L-fucose - FucI -> fuculose
Components:
Function Name Type Evidence Reference(s)
reactant α-L-fucose simple_molecule nd nd
catalyzer FucI protein nd nd
product fuculose simple_molecule nd nd
FucI arabinopyranose ribulose
Name: arabinopyranose -> ribulose
Description: Reaction transforming arabinopyranose into ribulose
Type: state transition
Pathway Components: arabinopyranose - FucI -> ribulose
Components:
Function Name Type Evidence Reference(s)
catalyzer FucI protein nd nd
reactant arabinopyranose simple_molecule nd nd
product ribulose simple_molecule nd nd
fucPIKUR_mRNA FucK
Name: fucPIKUR_mRNA -> FucK
Description: Translation of FucK
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucK
Components:
Function Name Type Evidence Reference(s)
product FucK protein nd nd
reactant fucPIKUR_mRNA RNA nd nd
FucK fuculose fuculose-1-P
Name: fuculose -> fuculose-1-P
Description: Reaction transforming fuculose into fuculose-1-P
Type: state transition
Pathway Components: fuculose - FucK -> fuculose-1-P
Components:
Function Name Type Evidence Reference(s)
catalyzer FucK protein nd nd
reactant fuculose simple_molecule nd nd
product fuculose-1-P simple_molecule nd nd
FucK ribulose ribulose-1-P
Name: ribulose -> ribulose-1-P
Description: Reaction transforming ribulose into ribulose-1-P
Type: state transition
Pathway Components: ribulose - FucK -> ribulose-1-P
Components:
Function Name Type Evidence Reference(s)
catalyzer FucK protein nd nd
reactant ribulose simple_molecule nd nd
product ribulose-1-P simple_molecule nd nd
fucPIKUR_mRNA FucU
Name: fucPIKUR_mRNA -> FucU
Description: Translation of FucU
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucU
Components:
Function Name Type Evidence Reference(s)
product FucU protein nd nd
reactant fucPIKUR_mRNA RNA nd nd
FucU α-L-fucose beta-L-fucose
Name: α-L-fucose -> beta-L-fucose
Description: Reaction transforming α-L-fucose into beta-L-fucose
Type: state transition
Pathway Components: α-L-fucose - FucU -> beta-L-fucose
Components:
Function Name Type Evidence Reference(s)
reactant α-L-fucose simple_molecule nd nd
catalyzer FucU protein nd nd
product beta-L-fucose simple_molecule nd nd
fucPIKUR_mRNA FucR
Name: fucPIKUR_mRNA -> FucR
Description: Translation of FucR
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucR
Components:
Function Name Type Evidence Reference(s)
product FucR protein nd nd
reactant fucPIKUR_mRNA RNA nd nd



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