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FhlA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
CO2 FdhF FhlA FocB formate GDP GTP HycA HycB HycC HycD HycE HycF HycG HycH HycI HydN HyfA HyfB HyfC HyfD HyfE HyfF HyfG HyfH HyfI HyfJ HyfR HypA HypB HypC HypD HypE HypF C terminal 32 amino-acid peptide carbamoyl-P fdhF fdhF_mRNA formate hycABCDEFGHI hycABCDEFGHI_mRNA hydN-hypF hydN-hypF_mRNA hyfABCDEFGHIJR-focB hyfABCDEFGHIJR-focB_mRNA hypABCDE-fhlA hypABCDE-fhlA_mRNA FhlA formate HyfG HyfI HyfA HyfB HyfC HyfD HyfE HyfF HyfH FdhF HycE HycB HycG HycF HycC HycD HycD HycC HycF HycG HycB HycE H+ H2 HypE carboxamide HycE HycE precursor H+ H2


Gensor Unit       
Name: FhlA
Description: FhlA positively regulates the expression of genes involved in formate catabolism, in electron transfer, in proteolysis, and in carbamoylation processes, in the presence of formate. The presence of formate induces the expression of genes related to the degradation of formate to hydrogen and CO2, the proteolysis of the HycE precursor, and the carbamoylation of HypE.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:1902670 - carbon dioxide binding
GO:0008270 - zinc ion binding
GO:0003824 - catalytic activity
GO:0016020 - membrane
GO:0016491 - oxidoreductase activity
GO:0051287 - NAD binding
GO:0006464 - cellular protein modification process
GO:0005525 - GTP binding
GO:0009375 - ferredoxin hydrogenase complex
GO:0005887 - integral component of plasma membrane
GO:0015942 - formate metabolic process
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Components:
Function Name Type
RNA hypABCDE-fhlA_mRNA RNA


Reactions       
Showing 44 reactions
FhlA + Formate FhlA-Formate
Name: FhlA + Formate -> FhlA-Formate
Description: Reaction transforming FhlA, Formate into FhlA-Formate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant Formate simple molecule nd nd
reactant FhlA protein nd nd
product FhlA-Formate complex nd nd
fdhF fdhF_mRNA
Name: fdhF -> fdhF_mRNA
Description: Transcription of transcription unit fdhF; reaction activation by FhlA-Formate.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant fdhF gene nd nd
product fdhF_mRNA RNA nd nd
hycABCDEFGHI hycABCDEFGHI_mRNA
Name: hycABCDEFGHI -> hycABCDEFGHI_mRNA
Description: Transcription of transcription unit hycABCDEFGHI; reaction activation by FhlA-Formate.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product hycABCDEFGHI_mRNA RNA nd nd
reactant hycABCDEFGHI gene nd nd
hydN-hypF hydN-hypF_mRNA
Name: hydN-hypF -> hydN-hypF_mRNA
Description: Transcription of transcription unit hydN-hypF; reaction activation by FhlA-Formate.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product hydN-hypF_mRNA RNA nd nd
reactant hydN-hypF gene nd nd
hyfABCDEFGHIJR-focB hyfABCDEFGHIJR-focB_mRNA
Name: hyfABCDEFGHIJR-focB -> hyfABCDEFGHIJR-focB_mRNA
Description: Transcription of transcription unit hyfABCDEFGHIJR-focB; reaction activation by FhlA-Formate.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant hyfABCDEFGHIJR-focB gene nd nd
product hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hypABCDE-fhlA hypABCDE-fhlA_mRNA
Name: hypABCDE-fhlA -> hypABCDE-fhlA_mRNA
Description: Transcription of transcription unit hypABCDE-fhlA; reaction activation by FhlA-Formate.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product hypABCDE-fhlA_mRNA RNA nd nd
reactant hypABCDE-fhlA gene nd nd
hyfABCDEFGHIJR-focB_mRNA HyfI
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfI
Description: Translation of HyfI
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfI protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
HyfG + HyfI + HyfA + HyfB + HyfC + HyfD + HyfE + HyfF + HyfH HyfG-HyfI-HyfA-HyfB-HyfC-HyfD-HyfE-HyfF-HyfH
Name: HyfG + HyfI + HyfA + HyfB + HyfC + HyfD + HyfE + HyfF + HyfH -> HyfG-HyfI-HyfA-HyfB-HyfC-HyfD-HyfE-HyfF-HyfH
Description: Reaction transforming HyfG, HyfI, HyfA, HyfB, HyfC, HyfD, HyfE, HyfF, HyfH into HyfG-HyfI-HyfA-HyfB-HyfC-HyfD-HyfE-HyfF-HyfH
Type: state transition
Components: Show/Hide Components Table
Function Name Type Evidence Reference(s)
reactant HyfG protein nd nd
reactant HyfD protein nd nd
reactant HyfA protein nd nd
reactant HyfC protein nd nd
reactant HyfE protein nd nd
reactant HyfF protein nd nd
product HyfG-HyfI-HyfA-HyfB-HyfC-HyfD-HyfE-HyfF-HyfH complex nd nd
reactant HyfB protein nd nd
reactant HyfI protein nd nd
reactant HyfH protein nd nd
hycABCDEFGHI_mRNA HycA
Name: hycABCDEFGHI_mRNA -> HycA
Description: Translation of HycA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycA protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
hypABCDE-fhlA_mRNA HypD
Name: hypABCDE-fhlA_mRNA -> HypD
Description: Translation of HypD
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HypD protein nd nd
reactant hypABCDE-fhlA_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfH
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfH
Description: Translation of HyfH
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfH protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
fdhF_mRNA FdhF
Name: fdhF_mRNA -> FdhF
Description: Translation of FdhF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product FdhF protein nd nd
reactant fdhF_mRNA RNA nd nd
FdhF + HycE + HycB + HycG + HycF + HycC + HycD FdhF-HycE-HycB-HycG-HycF-HycC-HycD
Name: FdhF + HycE + HycB + HycG + HycF + HycC + HycD -> FdhF-HycE-HycB-HycG-HycF-HycC-HycD
Description: Reaction transforming FdhF, HycE, HycB, HycG, HycF, HycC, HycD into FdhF-HycE-HycB-HycG-HycF-HycC-HycD
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant FdhF protein nd nd
reactant HycB protein nd nd
reactant HycE protein nd nd
reactant HycD protein nd nd
reactant HycF protein nd nd
product FdhF-HycE-HycB-HycG-HycF-HycC-HycD complex nd nd
reactant HycG protein nd nd
reactant HycC protein nd nd
formate CO2 + H2
Name: formate -> CO2 + H2
Description: Reaction transforming formate into CO2, H2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product CO2 simple molecule nd nd
product H2 simple molecule nd nd
reactant formate simple molecule nd nd
hydN-hypF_mRNA HydN
Name: hydN-hypF_mRNA -> HydN
Description: Translation of HydN
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HydN protein nd nd
reactant hydN-hypF_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfF
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfF
Description: Translation of HyfF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfF protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycH
Name: hycABCDEFGHI_mRNA -> HycH
Description: Translation of HycH
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hycABCDEFGHI_mRNA RNA nd nd
product HycH protein nd nd
hydN-hypF_mRNA HypF
Name: hydN-hypF_mRNA -> HypF
Description: Translation of HypF
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hydN-hypF_mRNA RNA nd nd
product HypF protein nd nd
carbamoyl-phosphate + hydrogenase maturation protein, carbamoyl dehydratase HypE-carboxamide
Name: carbamoyl-phosphate + hydrogenase maturation protein, carbamoyl dehydratase -> HypE-carboxamide
Description: Reaction transforming carbamoyl-phosphate, hydrogenase maturation protein, carbamoyl dehydratase into HypE-carboxamide
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant carbamoyl-phosphate simple molecule nd nd
product HypE-carboxamide complex nd nd
reactant hydrogenase maturation protein, carbamoyl dehydratase simple molecule nd nd
hyfABCDEFGHIJR-focB_mRNA HyfR
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfR
Description: Translation of HyfR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfR protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycB
Name: hycABCDEFGHI_mRNA -> HycB
Description: Translation of HycB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycB protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
HycD + HycC + HycF + HycG + HycB + HycE HycD-HycC-HycF-HycG-HycB-HycE
Name: HycD + HycC + HycF + HycG + HycB + HycE -> HycD-HycC-HycF-HycG-HycB-HycE
Description: Reaction transforming HycD, HycC, HycF, HycG, HycB, HycE into HycD-HycC-HycF-HycG-HycB-HycE
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant HycF protein nd nd
reactant HycE protein nd nd
reactant HycC protein nd nd
product HycD-HycC-HycF-HycG-HycB-HycE complex nd nd
reactant HycD protein nd nd
reactant HycG protein nd nd
reactant HycB protein nd nd
hycABCDEFGHI_mRNA HycE
Name: hycABCDEFGHI_mRNA -> HycE
Description: Translation of HycE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycE protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA FocB
Name: hyfABCDEFGHIJR-focB_mRNA -> FocB
Description: Translation of FocB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product FocB protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hypABCDE-fhlA_mRNA FhlA
Name: hypABCDE-fhlA_mRNA -> FhlA
Description: Translation of FhlA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product FhlA protein nd nd
reactant hypABCDE-fhlA_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfD
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfD
Description: Translation of HyfD
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfD protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycF
Name: hycABCDEFGHI_mRNA -> HycF
Description: Translation of HycF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycF protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfE
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfE
Description: Translation of HyfE
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
product HyfE protein nd nd
hycABCDEFGHI_mRNA HycD
Name: hycABCDEFGHI_mRNA -> HycD
Description: Translation of HycD
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hycABCDEFGHI_mRNA RNA nd nd
product HycD protein nd nd
hyfABCDEFGHIJR-focB_mRNA HyfC
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfC
Description: Translation of HyfC
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfC protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycG
Name: hycABCDEFGHI_mRNA -> HycG
Description: Translation of HycG
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycG protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
hypABCDE-fhlA_mRNA HypB
Name: hypABCDE-fhlA_mRNA -> HypB
Description: Translation of HypB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hypABCDE-fhlA_mRNA RNA nd nd
product HypB protein nd nd
GTP GDP + phosphate
Name: GTP -> GDP + phosphate
Description: Reaction transforming GTP into GDP, phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product phosphate simple molecule nd nd
reactant GTP simple molecule nd nd
product GDP simple molecule nd nd
hypABCDE-fhlA_mRNA phosphate
Name: hypABCDE-fhlA_mRNA -> phosphate
Description: Translation of phosphate
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hypABCDE-fhlA_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfB
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfB
Description: Translation of HyfB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfB protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycI
Name: hycABCDEFGHI_mRNA -> HycI
Description: Translation of HycI
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HycI protein nd nd
reactant hycABCDEFGHI_mRNA RNA nd nd
hycABCDEFGHI_mRNA HycC
Name: hycABCDEFGHI_mRNA -> HycC
Description: Translation of HycC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hycABCDEFGHI_mRNA RNA nd nd
product HycC protein nd nd
hypABCDE-fhlA_mRNA HypC
Name: hypABCDE-fhlA_mRNA -> HypC
Description: Translation of HypC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hypABCDE-fhlA_mRNA RNA nd nd
product HypC protein nd nd
hyfABCDEFGHIJR-focB_mRNA HyfA
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfA
Description: Translation of HyfA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfA protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfJ
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfJ
Description: Translation of HyfJ
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
product HyfJ protein nd nd
hypABCDE-fhlA_mRNA HypA
Name: hypABCDE-fhlA_mRNA -> HypA
Description: Translation of HypA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HypA protein nd nd
reactant hypABCDE-fhlA_mRNA RNA nd nd
hyfABCDEFGHIJR-focB_mRNA HyfG
Name: hyfABCDEFGHIJR-focB_mRNA -> HyfG
Description: Translation of HyfG
Type: translation
Components:
Function Name Type Evidence Reference(s)
product HyfG protein nd nd
reactant hyfABCDEFGHIJR-focB_mRNA RNA nd nd
HycE precursor HycE
Name: HycE precursor -> HycE
Description: Reaction transforming HycE precursor into HycE
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product HycE protein nd nd
reactant HycE precursor protein nd nd
H+ H2
Name: H+ -> H2
Description: Reaction transforming H+ into H2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant H+ simple molecule nd nd
product H2 simple molecule nd nd



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