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FabR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
CO2 FabA FabR KASI beta-OH-acyl-ACP a (R)-3-hydroxy-cis-vaccenoyl-[acp] a (R)-3-hydroxybutanoyl-[acp] a (R)-3-hydroxydodecanoyl-[acp] a (R)-3-hydroxyoctanoyl-[acp] a 2,3,4-saturated fatty acyl-[acp] a 3-oxo-cis-Delta-5-dodecenoyl-[acp] a 3-oxo-cis-Delta-7-tetradecenoyl-[acp] a 3-oxo-cis-Delta-9-hexadecenoyl-[acp] a 3-oxo-decanoyl-[acp] a 3-oxo-dodecanoyl-[acp] a 3-oxo-hexanoyl-[acp] a 3-oxo-myristoyl-[acp] a 3-oxo-octanoyl-[acp] a 3-oxo-palmitoyl-[acp] a 3-ketopimelyl-[acp] methyl ester acetoacyl-ACP a 3R-hydroxy cis Delta-5-dodecenoyl-[acp] butanoyl-[acp] a cis-Delta-3-decenoyl-[acp] a cis-Delta-5-dodecenoyl-[acp] a cis-Delta-7-tetradecenoyl-[acp] a cis-vaccen-2-enoyl-[acp] a crotonyl-[acp] a decanoyl-[acp] a lauryl-[acp] a glutaryl-[acp] methyl ester a hexanoyl-[acp] acyl carrier protein malonyl-[ACP] a myristoyl-[acp] a trans dodec-2-enoyl-[acp] a trans hex-2-enoyl-[acp] a trans hexadecenoyl-[acp] a trans oct-2-enoyl-[acp] a trans tetradec-2-enoyl-[acp] a trans-Delta-2-decenoyl-[acp] a trans-Delta-3-cis-Delta-5-dodecenoyl-[acp] CH3(CH2)xCH=CHCO-S-ACP an (3R)-3-hydroxymyristoyl-[acp] an (R)-3-hydroxydecanoyl-[acp] an (R)-3-hydroxyhexanoyl-[acp] an (R)-3-hydroxypalmitoyl-[acp] an acetoacetyl-[acp] an acetyl-[acp] an octanoyl-[acp] fabA fabA_mRNA fabB fabB_mRNA acyl carrier protein malonyl-[ACP] CO2 acyl carrier protein CO2 malonyl-[ACP] malonyl-[ACP] acyl carrier protein CO2 acyl carrier protein malonyl-[ACP] CO2 malonyl-[ACP] acyl carrier protein CO2


Gensor Unit       
Name: FabR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0006631 - fatty acid metabolic process
GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008693 - 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:0016740 - transferase activity
GO:0008610 - lipid biosynthetic process
GO:0006633 - fatty acid biosynthetic process
GO:0016853 - isomerase activity
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Components:
Function Name Type
RNA fabB_mRNA RNA


Reactions       
Showing 29 reactions
fabA fabA_mRNA
Name: fabA -> fabA_mRNA
Description: Transcription of transcription unit fabA; reaction inhibition by FabR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product fabA_mRNA RNA nd nd
reactant fabA gene nd nd
fabB fabB_mRNA
Name: fabB -> fabB_mRNA
Description: Transcription of transcription unit fabB; reaction inhibition by FabR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant fabB gene nd nd
product fabB_mRNA RNA nd nd
fabA_mRNA FabA
Name: fabA_mRNA -> FabA
Description: Translation of FabA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fabA_mRNA RNA nd nd
product FabA protein nd nd
beta-OH-acyl-ACP CH3(CH2)xCH=CHCO-S-ACP
Name: beta-OH-acyl-ACP -> CH3(CH2)xCH=CHCO-S-ACP
Description: Reaction transforming beta-OH-acyl-ACP into CH3(CH2)xCH=CHCO-S-ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant beta-OH-acyl-ACP simple molecule nd nd
product CH3(CH2)xCH=CHCO-S-ACP simple molecule nd nd
an (3R)-3-hydroxymyristoyl-[acp] a trans tetradec-2-enoyl-[acp]
Name: an (3R)-3-hydroxymyristoyl-[acp] -> a trans tetradec-2-enoyl-[acp]
Description: Reaction transforming an (3R)-3-hydroxymyristoyl-[acp] into a trans tetradec-2-enoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a trans tetradec-2-enoyl-[acp] simple molecule nd nd
reactant an (3R)-3-hydroxymyristoyl-[acp] simple molecule nd nd
a (R)-3-hydroxydodecanoyl-[acp] a trans dodec-2-enoyl-[acp]
Name: a (R)-3-hydroxydodecanoyl-[acp] -> a trans dodec-2-enoyl-[acp]
Description: Reaction transforming a (R)-3-hydroxydodecanoyl-[acp] into a trans dodec-2-enoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a (R)-3-hydroxydodecanoyl-[acp] simple molecule nd nd
product a trans dodec-2-enoyl-[acp] simple molecule nd nd
an (R)-3-hydroxyhexanoyl-[acp] a trans hex-2-enoyl-[acp]
Name: an (R)-3-hydroxyhexanoyl-[acp] -> a trans hex-2-enoyl-[acp]
Description: Reaction transforming an (R)-3-hydroxyhexanoyl-[acp] into a trans hex-2-enoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant an (R)-3-hydroxyhexanoyl-[acp] simple molecule nd nd
product a trans hex-2-enoyl-[acp] simple molecule nd nd
a (R)-3-hydroxyoctanoyl-[acp] a trans oct-2-enoyl-[acp]
Name: a (R)-3-hydroxyoctanoyl-[acp] -> a trans oct-2-enoyl-[acp]
Description: Reaction transforming a (R)-3-hydroxyoctanoyl-[acp] into a trans oct-2-enoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a (R)-3-hydroxyoctanoyl-[acp] simple molecule nd nd
product a trans oct-2-enoyl-[acp] simple molecule nd nd
a (R)-3-hydroxy-cis-vaccenoyl-[acp] a cis-vaccen-2-enoyl-[acp]
Name: a (R)-3-hydroxy-cis-vaccenoyl-[acp] -> a cis-vaccen-2-enoyl-[acp]
Description: Reaction transforming a (R)-3-hydroxy-cis-vaccenoyl-[acp] into a cis-vaccen-2-enoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a (R)-3-hydroxy-cis-vaccenoyl-[acp] simple molecule nd nd
product a cis-vaccen-2-enoyl-[acp] simple molecule nd nd
an (R)-3-hydroxypalmitoyl-[acp] a trans hexadecenoyl-[acp]
Name: an (R)-3-hydroxypalmitoyl-[acp] -> a trans hexadecenoyl-[acp]
Description: Reaction transforming an (R)-3-hydroxypalmitoyl-[acp] into a trans hexadecenoyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant an (R)-3-hydroxypalmitoyl-[acp] simple molecule nd nd
product a trans hexadecenoyl-[acp] simple molecule nd nd
a (R)-3-hydroxybutanoyl-[acp] a crotonyl-[acp]
Name: a (R)-3-hydroxybutanoyl-[acp] -> a crotonyl-[acp]
Description: Reaction transforming a (R)-3-hydroxybutanoyl-[acp] into a crotonyl-[acp]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a (R)-3-hydroxybutanoyl-[acp] simple molecule nd nd
product a crotonyl-[acp] simple molecule nd nd
fabB_mRNA KASI
Name: fabB_mRNA -> KASI
Description: Translation of KASI
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant fabB_mRNA RNA nd nd
product KASI protein nd nd
a glutaryl-[acp] methyl ester + malonyl-[ACP] a 3-ketopimelyl-[acp] methyl ester + CO2 + ACP
Name: a glutaryl-[acp] methyl ester + malonyl-[ACP] -> a 3-ketopimelyl-[acp] methyl ester + CO2 + ACP
Description: Reaction transforming a glutaryl-[acp] methyl ester, malonyl-[ACP] into a 3-ketopimelyl-[acp] methyl ester, CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a glutaryl-[acp] methyl ester simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
product CO2 simple molecule nd nd
product ACP simple molecule nd nd
product a 3-ketopimelyl-[acp] methyl ester simple molecule nd nd
butanoyl-[acp] + malonyl-[ACP] a 3-oxo-hexanoyl-[acp] + CO2 + ACP
Name: butanoyl-[acp] + malonyl-[ACP] -> a 3-oxo-hexanoyl-[acp] + CO2 + ACP
Description: Reaction transforming butanoyl-[acp], malonyl-[ACP] into a 3-oxo-hexanoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant butanoyl-[acp] simple molecule nd nd
product ACP simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
product CO2 simple molecule nd nd
product a 3-oxo-hexanoyl-[acp] simple molecule nd nd
malonyl-[ACP] + an acetyl-[acp] ACP + an acetoacetyl-[acp] + CO2
Name: malonyl-[ACP] + an acetyl-[acp] -> ACP + an acetoacetyl-[acp] + CO2
Description: Reaction transforming malonyl-[ACP], an acetyl-[acp] into ACP, an acetoacetyl-[acp] , CO2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant an acetyl-[acp] simple molecule nd nd
product an acetoacetyl-[acp] simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
product CO2 simple molecule nd nd
product ACP simple molecule nd nd
malonyl-[ACP] + a 2,3,4-saturated fatty acyl-[acp] ACP + acetoacyl-ACP + CO2
Name: malonyl-[ACP] + a 2,3,4-saturated fatty acyl-[acp] -> ACP + acetoacyl-ACP + CO2
Description: Reaction transforming malonyl-[ACP], a 2,3,4-saturated fatty acyl-[acp] into ACP, acetoacyl-ACP , CO2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product CO2 simple molecule nd nd
reactant a 2,3,4-saturated fatty acyl-[acp] simple molecule nd nd
product ACP simple molecule nd nd
product acetoacyl-ACP simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
a myristoyl-[acp] + malonyl-[ACP] a 3-oxo-palmitoyl-[acp] + CO2 + ACP
Name: a myristoyl-[acp] + malonyl-[ACP] -> a 3-oxo-palmitoyl-[acp] + CO2 + ACP
Description: Reaction transforming a myristoyl-[acp], malonyl-[ACP] into a 3-oxo-palmitoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a 3-oxo-palmitoyl-[acp] simple molecule nd nd
product CO2 simple molecule nd nd
product ACP simple molecule nd nd
reactant a myristoyl-[acp] simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
a hexanoyl-[acp] + malonyl-[ACP] a 3-oxo-octanoyl-[acp] + CO2 + ACP
Name: a hexanoyl-[acp] + malonyl-[ACP] -> a 3-oxo-octanoyl-[acp] + CO2 + ACP
Description: Reaction transforming a hexanoyl-[acp], malonyl-[ACP] into a 3-oxo-octanoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a hexanoyl-[acp] simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
product ACP simple molecule nd nd
product a 3-oxo-octanoyl-[acp] simple molecule nd nd
product CO2 simple molecule nd nd
an octanoyl-[acp] + malonyl-[ACP] a 3-oxo-decanoyl-[acp] + CO2 + ACP
Name: an octanoyl-[acp] + malonyl-[ACP] -> a 3-oxo-decanoyl-[acp] + CO2 + ACP
Description: Reaction transforming an octanoyl-[acp], malonyl-[ACP] into a 3-oxo-decanoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant malonyl-[ACP] simple molecule nd nd
reactant an octanoyl-[acp] simple molecule nd nd
product ACP simple molecule nd nd
product CO2 simple molecule nd nd
product a 3-oxo-decanoyl-[acp] simple molecule nd nd
a decanoyl-[acp] + malonyl-[ACP] a 3-oxo-dodecanoyl-[acp] + CO2 + ACP
Name: a decanoyl-[acp] + malonyl-[ACP] -> a 3-oxo-dodecanoyl-[acp] + CO2 + ACP
Description: Reaction transforming a decanoyl-[acp], malonyl-[ACP] into a 3-oxo-dodecanoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a decanoyl-[acp] simple molecule nd nd
product CO2 simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
product a 3-oxo-dodecanoyl-[acp] simple molecule nd nd
product ACP simple molecule nd nd
a lauryl-[acp] + malonyl-[ACP] a 3-oxo-myristoyl-[acp] + CO2 + ACP
Name: a lauryl-[acp] + malonyl-[ACP] -> a 3-oxo-myristoyl-[acp] + CO2 + ACP
Description: Reaction transforming a lauryl-[acp], malonyl-[ACP] into a 3-oxo-myristoyl-[acp], CO2 , ACP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant malonyl-[ACP] simple molecule nd nd
product ACP simple molecule nd nd
reactant a lauryl-[acp] simple molecule nd nd
product CO2 simple molecule nd nd
product a 3-oxo-myristoyl-[acp] simple molecule nd nd
malonyl-[ACP] an acetyl-[acp] + CO2
Name: malonyl-[ACP] -> an acetyl-[acp] + CO2
Description: Reaction transforming malonyl-[ACP] into an acetyl-[acp], CO2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product an acetyl-[acp] simple molecule nd nd
product CO2 simple molecule nd nd
reactant malonyl-[ACP] simple molecule nd nd
an acetoacetyl-[acp] acetoacyl-ACP
Name: an acetoacetyl-[acp] -> acetoacyl-ACP
Description: Transformation of an acetoacetyl-[acp] into acetoacyl-ACP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant an acetoacetyl-[acp] simple molecule nd nd
product acetoacyl-ACP simple molecule nd nd
acetoacyl-ACP beta-OH-acyl-ACP
Name: acetoacyl-ACP -> beta-OH-acyl-ACP
Description: Transformation of acetoacyl-ACP into beta-OH-acyl-ACP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant acetoacyl-ACP simple molecule nd nd
product beta-OH-acyl-ACP simple molecule nd nd
CH3(CH2)xCH=CHCO-S-ACP a 2,3,4-saturated fatty acyl-[acp]
Name: CH3(CH2)xCH=CHCO-S-ACP -> a 2,3,4-saturated fatty acyl-[acp]
Description: Transformation of CH3(CH2)xCH=CHCO-S-ACP into a 2,3,4-saturated fatty acyl-[acp] by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product a 2,3,4-saturated fatty acyl-[acp] simple molecule nd nd
reactant CH3(CH2)xCH=CHCO-S-ACP simple molecule nd nd
a 3-oxo-decanoyl-[acp] an (R)-3-hydroxydecanoyl-[acp]
Name: a 3-oxo-decanoyl-[acp] -> an (R)-3-hydroxydecanoyl-[acp]
Description: Transformation of a 3-oxo-decanoyl-[acp] into an (R)-3-hydroxydecanoyl-[acp] by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product an (R)-3-hydroxydecanoyl-[acp] simple molecule nd nd
reactant a 3-oxo-decanoyl-[acp] simple molecule nd nd
a 3-oxo-octanoyl-[acp] an octanoyl-[acp]
Name: a 3-oxo-octanoyl-[acp] -> an octanoyl-[acp]
Description: Transformation of a 3-oxo-octanoyl-[acp] into an octanoyl-[acp] by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product an octanoyl-[acp] simple molecule nd nd
reactant a 3-oxo-octanoyl-[acp] simple molecule nd nd
a 3-oxo-hexanoyl-[acp] a hexanoyl-[acp]
Name: a 3-oxo-hexanoyl-[acp] -> a hexanoyl-[acp]
Description: Transformation of a 3-oxo-hexanoyl-[acp] into a hexanoyl-[acp] by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant a 3-oxo-hexanoyl-[acp] simple molecule nd nd
product a hexanoyl-[acp] simple molecule nd nd
a 3-oxo-dodecanoyl-[acp] a lauryl-[acp]
Name: a 3-oxo-dodecanoyl-[acp] -> a lauryl-[acp]
Description: Transformation of a 3-oxo-dodecanoyl-[acp] into a lauryl-[acp] by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant a 3-oxo-dodecanoyl-[acp] simple molecule nd nd
product a lauryl-[acp] simple molecule nd nd



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