RegulonDB RegulonDB

EvgA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AcrA AcrD CO2 EmrK EmrY EvgA EvgS Frc GadE MdtE MdtF Oxc phosphate SafA TolC YdeO YdeP YegR YfdE YfdV YfdX a drug a drug_Ext acrD acrD_mRNA emrKY emrKY_mRNA evgAS evgAS_mRNA formate formyl-CoA frc frc_mRNA gadE-mdtEF gadE-mdtEF_mRNA oxalate oxalyl-CoA safA-ydeO safA-ydeO_mRNA ydeP ydeP_mRNA yegRZ yegRZ_mRNA yfdX-frc-oxc-yfdVE yfdX-frc-oxc-yfdVE_mRNA EvgA phosphate EmrK EmrY TolC AcrD AcrA TolC TolC MdtE MdtF


Gensor Unit       
Name: EvgA
Signal name: acidified medium.
Classification:
Groups: GUs related to the two-component system
Gene Ontology Terms (GO): biological_process GO:0015721 - bile acid and bile salt transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0071468 - cellular response to acidic pH
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
Read more >
cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
GO:0031226 - intrinsic component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
Read more >
molecular_function GO:0043531 - ADP binding
GO:0003677 - DNA binding
GO:0003700 - DNA binding transcription factor activity
GO:0036412 - acetyl-CoA:oxalate CoA-transferase
GO:0016830 - carbon-carbon lyase activity
GO:0015238 - drug transmembrane transporter activity
GO:0015307 - drug:proton antiporter activity
Read more >
Components: Show/Hide Components Table (54 more...)
Function Name Type
protein AcrA protein
protein AcrD protein
complex AcrD-AcrA-TolC complex
simple_molecule CO2 simple_molecule
protein EmrK protein
complex EmrK-EmrY-TolC complex
protein EmrY protein
protein EvgA protein
complex EvgA-phosphate complex
protein EvgS protein
protein Frc protein
protein GadE protein
protein MdtE protein
protein MdtF protein
protein NP protein
protein Oxc protein
protein RcsB protein
complex RcsB-GadE complex
protein SafA protein
protein TolC protein
complex TolC-MdtE-MdtF complex
protein YdeO protein
protein YdeP protein
protein YegR protein
protein YfdE protein
protein YfdV protein
protein YfdX protein
simple_molecule acetate simple_molecule
simple_molecule acetyl-CoA simple_molecule
gene acrD gene
RNA acrD_mRNA RNA
simple_molecule drug simple_molecule
simple_molecule drug_Ext simple_molecule
gene emrKY gene
RNA emrKY_mRNA RNA
gene evgAS gene
RNA evgAS_mRNA RNA
simple_molecule formate simple_molecule
simple_molecule formyl-CoA simple_molecule
gene frc gene
RNA frc_mRNA RNA
gene gadE-mdtEF gene
RNA gadE-mdtEF_mRNA RNA
simple_molecule oxalate simple_molecule
simple_molecule oxalyl-CoA simple_molecule
simple_molecule phosphate simple_molecule
gene safA-ydeO gene
RNA safA-ydeO_mRNA RNA
gene ydeP gene
RNA ydeP_mRNA RNA
gene yegRZ gene
RNA yegRZ_mRNA RNA
gene yfdX-frc-oxc-yfdVE gene
RNA yfdX-frc-oxc-yfdVE_mRNA RNA


Reactions       
Showing 37 reactions
phosphate + EvgA EvgA-phosphate
Name: phosphate + EvgA -> EvgA-phosphate
Description: Reaction transforming phosphate, EvgA into EvgA-phosphate
Type: state transition
Pathway Components: phosphate + EvgA -> EvgA-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant EvgA protein nd nd
product EvgA-phosphate complex nd nd
reactant phosphate simple_molecule nd nd
EvgA-phosphate acrD acrD_mRNA
Name: acrD -> acrD_mRNA
Description: Transcription of transcription unit acrD. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: acrD - EvgA-phosphate -> acrD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant acrD gene nd nd
product acrD_mRNA RNA nd nd
EvgA-phosphate emrKY emrKY_mRNA
Name: emrKY -> emrKY_mRNA
Description: Transcription of transcription unit emrKY. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: emrKY - EvgA-phosphate -> emrKY_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant emrKY gene nd nd
product emrKY_mRNA RNA nd nd
EvgA-phosphate evgAS evgAS_mRNA
Name: evgAS -> evgAS_mRNA
Description: Transcription of transcription unit evgAS. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: evgAS - EvgA-phosphate -> evgAS_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant evgAS gene nd nd
product evgAS_mRNA RNA nd nd
EvgA-phosphate gadE-mdtEF gadE-mdtEF_mRNA
Name: gadE-mdtEF -> gadE-mdtEF_mRNA
Description: Transcription of transcription unit gadE-mdtEF. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: gadE-mdtEF - EvgA-phosphate -> gadE-mdtEF_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant gadE-mdtEF gene nd nd
product gadE-mdtEF_mRNA RNA nd nd
EvgA-phosphate safA-ydeO safA-ydeO_mRNA
Name: safA-ydeO -> safA-ydeO_mRNA
Description: Transcription of transcription unit safA-ydeO. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: safA-ydeO - EvgA-phosphate -> safA-ydeO_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant safA-ydeO gene nd nd
product safA-ydeO_mRNA RNA nd nd
EvgA-phosphate ydeP ydeP_mRNA
Name: ydeP -> ydeP_mRNA
Description: Transcription of transcription unit ydeP. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: ydeP - EvgA-phosphate -> ydeP_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant ydeP gene nd nd
product ydeP_mRNA RNA nd nd
EvgA-phosphate yegRZ yegRZ_mRNA
Name: yegRZ -> yegRZ_mRNA
Description: Transcription of transcription unit yegRZ. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: yegRZ - EvgA-phosphate -> yegRZ_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant yegRZ gene nd nd
product yegRZ_mRNA RNA nd nd
EvgA-phosphate yfdX-frc-oxc-yfdVE yfdX-frc-oxc-yfdVE_mRNA
Name: yfdX-frc-oxc-yfdVE -> yfdX-frc-oxc-yfdVE_mRNA
Description: Transcription of transcription unit yfdX-frc-oxc-yfdVE. Reaction activation by EvgA-phosphate.
Type: transcription
Pathway Components: yfdX-frc-oxc-yfdVE - EvgA-phosphate -> yfdX-frc-oxc-yfdVE_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA-phosphate complex nd nd
reactant yfdX-frc-oxc-yfdVE gene nd nd
product yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
EvgA frc frc_mRNA
Name: frc -> frc_mRNA
Description: Transcription of transcription unit frc. Reaction activation by EvgA.
Type: transcription
Pathway Components: frc - EvgA -> frc_mRNA
Components:
Function Name Type Evidence Reference(s)
activator EvgA protein nd nd
reactant frc gene nd nd
product frc_mRNA RNA nd nd
ydeP_mRNA YdeP
Name: ydeP_mRNA -> YdeP
Description: Translation of YdeP
Type: translation
Pathway Components: ydeP_mRNA -> YdeP
Components:
Function Name Type Evidence Reference(s)
product YdeP protein nd nd
reactant ydeP_mRNA RNA nd nd
yegRZ_mRNA YegR
Name: yegRZ_mRNA -> YegR
Description: Translation of YegR
Type: translation
Pathway Components: yegRZ_mRNA -> YegR
Components:
Function Name Type Evidence Reference(s)
product YegR protein nd nd
reactant yegRZ_mRNA RNA nd nd
yegRZ_mRNA NP
Name: yegRZ_mRNA -> NP
Description: Translation of NP
Type: translation
Pathway Components: yegRZ_mRNA -> NP
Components:
Function Name Type Evidence Reference(s)
product NP protein nd nd
reactant yegRZ_mRNA RNA nd nd
safA-ydeO_mRNA SafA
Name: safA-ydeO_mRNA -> SafA
Description: Translation of SafA
Type: translation
Pathway Components: safA-ydeO_mRNA -> SafA
Components:
Function Name Type Evidence Reference(s)
product SafA protein nd nd
reactant safA-ydeO_mRNA RNA nd nd
safA-ydeO_mRNA YdeO
Name: safA-ydeO_mRNA -> YdeO
Description: Translation of YdeO
Type: translation
Pathway Components: safA-ydeO_mRNA -> YdeO
Components:
Function Name Type Evidence Reference(s)
product YdeO protein nd nd
reactant safA-ydeO_mRNA RNA nd nd
gadE-mdtEF_mRNA GadE
Name: gadE-mdtEF_mRNA -> GadE
Description: Translation of GadE
Type: translation
Pathway Components: gadE-mdtEF_mRNA -> GadE
Components:
Function Name Type Evidence Reference(s)
product GadE protein nd nd
reactant gadE-mdtEF_mRNA RNA nd nd
RcsB + GadE RcsB-GadE
Name: RcsB + GadE -> RcsB-GadE
Description: Reaction transforming RcsB, GadE into RcsB-GadE
Type: state transition
Pathway Components: RcsB + GadE -> RcsB-GadE
Components:
Function Name Type Evidence Reference(s)
reactant GadE protein nd nd
reactant RcsB protein nd nd
product RcsB-GadE complex nd nd
gadE-mdtEF_mRNA MdtE
Name: gadE-mdtEF_mRNA -> MdtE
Description: Translation of MdtE
Type: translation
Pathway Components: gadE-mdtEF_mRNA -> MdtE
Components:
Function Name Type Evidence Reference(s)
product MdtE protein nd nd
reactant gadE-mdtEF_mRNA RNA nd nd
MdtF + MdtE + TolC TolC-MdtE-MdtF
Name: MdtF + MdtE + TolC -> TolC-MdtE-MdtF
Description: Reaction transforming MdtF, MdtE, TolC into TolC-MdtE-MdtF
Type: state transition
Pathway Components: MdtF + MdtE + TolC -> TolC-MdtE-MdtF
Components:
Function Name Type Evidence Reference(s)
reactant MdtE protein nd nd
reactant MdtF protein nd nd
reactant TolC protein nd nd
product TolC-MdtE-MdtF complex nd nd
AcrD-AcrA-TolC EmrK-EmrY-TolC TolC-MdtE-MdtF drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrD-AcrA-TolC - EmrK-EmrY-TolC - TolC-MdtE-MdtF -> drug
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrD-AcrA-TolC complex nd nd
catalyzer EmrK-EmrY-TolC complex nd nd
catalyzer TolC-MdtE-MdtF complex nd nd
product drug simple_molecule nd nd
reactant drug_Ext simple_molecule nd nd
gadE-mdtEF_mRNA MdtF
Name: gadE-mdtEF_mRNA -> MdtF
Description: Translation of MdtF
Type: translation
Pathway Components: gadE-mdtEF_mRNA -> MdtF
Components:
Function Name Type Evidence Reference(s)
product MdtF protein nd nd
reactant gadE-mdtEF_mRNA RNA nd nd
frc_mRNA Frc
Name: frc_mRNA -> Frc
Description: Translation of Frc
Type: translation
Pathway Components: frc_mRNA -> Frc
Components:
Function Name Type Evidence Reference(s)
product Frc protein nd nd
reactant frc_mRNA RNA nd nd
Frc acetyl-CoA oxalate formyl-CoA + oxalate oxalyl-CoA + formate
Name: formyl-CoA + oxalate -> oxalyl-CoA + formate
Description: Reaction transforming formyl-CoA, oxalate into oxalyl-CoA, formate
Type: state transition
Pathway Components: formyl-CoA + oxalate - Frc - acetyl-CoA - oxalate -> oxalyl-CoA + formate
Components:
Function Name Type Evidence Reference(s)
catalyzer Frc protein nd nd
inhibitor acetyl-CoA simple_molecule nd nd
product formate simple_molecule nd nd
reactant formyl-CoA simple_molecule nd nd
inhibitor oxalate simple_molecule nd nd
reactant oxalate simple_molecule nd nd
product oxalyl-CoA simple_molecule nd nd
evgAS_mRNA EvgA
Name: evgAS_mRNA -> EvgA
Description: Translation of EvgA
Type: translation
Pathway Components: evgAS_mRNA -> EvgA
Components:
Function Name Type Evidence Reference(s)
product EvgA protein nd nd
reactant evgAS_mRNA RNA nd nd
evgAS_mRNA EvgS
Name: evgAS_mRNA -> EvgS
Description: Translation of EvgS
Type: translation
Pathway Components: evgAS_mRNA -> EvgS
Components:
Function Name Type Evidence Reference(s)
product EvgS protein nd nd
reactant evgAS_mRNA RNA nd nd
acrD_mRNA AcrD
Name: acrD_mRNA -> AcrD
Description: Translation of AcrD
Type: translation
Pathway Components: acrD_mRNA -> AcrD
Components:
Function Name Type Evidence Reference(s)
product AcrD protein nd nd
reactant acrD_mRNA RNA nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
reactant TolC protein nd nd
yfdX-frc-oxc-yfdVE_mRNA YfdX
Name: yfdX-frc-oxc-yfdVE_mRNA -> YfdX
Description: Translation of YfdX
Type: translation
Pathway Components: yfdX-frc-oxc-yfdVE_mRNA -> YfdX
Components:
Function Name Type Evidence Reference(s)
product YfdX protein nd nd
reactant yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
yfdX-frc-oxc-yfdVE_mRNA Frc
Name: yfdX-frc-oxc-yfdVE_mRNA -> Frc
Description: Translation of Frc
Type: translation
Pathway Components: yfdX-frc-oxc-yfdVE_mRNA -> Frc
Components:
Function Name Type Evidence Reference(s)
product Frc protein nd nd
reactant yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
yfdX-frc-oxc-yfdVE_mRNA Oxc
Name: yfdX-frc-oxc-yfdVE_mRNA -> Oxc
Description: Translation of Oxc
Type: translation
Pathway Components: yfdX-frc-oxc-yfdVE_mRNA -> Oxc
Components:
Function Name Type Evidence Reference(s)
product Oxc protein nd nd
reactant yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
Oxc oxalyl-CoA formyl-CoA + CO2
Name: oxalyl-CoA -> formyl-CoA + CO2
Description: Reaction transforming oxalyl-CoA into formyl-CoA, CO2
Type: state transition
Pathway Components: oxalyl-CoA - Oxc -> formyl-CoA + CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer Oxc protein nd nd
product formyl-CoA simple_molecule nd nd
reactant oxalyl-CoA simple_molecule nd nd
yfdX-frc-oxc-yfdVE_mRNA YfdV
Name: yfdX-frc-oxc-yfdVE_mRNA -> YfdV
Description: Translation of YfdV
Type: translation
Pathway Components: yfdX-frc-oxc-yfdVE_mRNA -> YfdV
Components:
Function Name Type Evidence Reference(s)
product YfdV protein nd nd
reactant yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
yfdX-frc-oxc-yfdVE_mRNA YfdE
Name: yfdX-frc-oxc-yfdVE_mRNA -> YfdE
Description: Translation of YfdE
Type: translation
Pathway Components: yfdX-frc-oxc-yfdVE_mRNA -> YfdE
Components:
Function Name Type Evidence Reference(s)
product YfdE protein nd nd
reactant yfdX-frc-oxc-yfdVE_mRNA RNA nd nd
YfdE acetyl-CoA + oxalate oxalyl-CoA + acetate
Name: acetyl-CoA + oxalate -> oxalyl-CoA + acetate
Description: Reaction transforming acetyl-CoA, oxalate into oxalyl-CoA, acetate
Type: state transition
Pathway Components: acetyl-CoA + oxalate - YfdE -> oxalyl-CoA + acetate
Components:
Function Name Type Evidence Reference(s)
catalyzer YfdE protein nd nd
product acetate simple_molecule nd nd
reactant acetyl-CoA simple_molecule nd nd
reactant oxalate simple_molecule nd nd
product oxalyl-CoA simple_molecule nd nd
emrKY_mRNA EmrK
Name: emrKY_mRNA -> EmrK
Description: Translation of EmrK
Type: translation
Pathway Components: emrKY_mRNA -> EmrK
Components:
Function Name Type Evidence Reference(s)
product EmrK protein nd nd
reactant emrKY_mRNA RNA nd nd
EmrK + TolC + EmrY EmrK-EmrY-TolC
Name: EmrK + TolC + EmrY -> EmrK-EmrY-TolC
Description: Reaction transforming EmrK, TolC, EmrY into EmrK-EmrY-TolC
Type: state transition
Pathway Components: EmrK + TolC + EmrY -> EmrK-EmrY-TolC
Components:
Function Name Type Evidence Reference(s)
reactant EmrK protein nd nd
product EmrK-EmrY-TolC complex nd nd
reactant EmrY protein nd nd
reactant TolC protein nd nd
emrKY_mRNA EmrY
Name: emrKY_mRNA -> EmrY
Description: Translation of EmrY
Type: translation
Pathway Components: emrKY_mRNA -> EmrY
Components:
Function Name Type Evidence Reference(s)
product EmrY protein nd nd
reactant emrKY_mRNA RNA nd nd



RegulonDB