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EnvR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AcrA AcrB AcrD EnvR TolC a drug a drug_Ext acrAB acrAB_mRNA AcrA TolC AcrB AcrD AcrA TolC


Gensor Unit       
Name: EnvR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0015721 - bile acid and bile salt transport
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0046677 - response to antibiotic
GO:0042493 - response to drug
cellular_component GO:1990281 - efflux pump complex
GO:0005887 - integral component of plasma membrane
GO:0031226 - intrinsic component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0015238 - drug transmembrane transporter activity
GO:0015307 - drug:proton antiporter activity
GO:0042802 - identical protein binding
GO:0005515 - protein binding
GO:0005215 - transporter activity
Components: Show/Hide Components Table (13 more...)
Function Name Type
protein AcrA protein
complex AcrA-TolC-AcrB complex
protein AcrB protein
protein AcrD protein
complex AcrD-AcrA-TolC complex
protein EnvR protein
protein TolC protein
gene acrAB gene
RNA acrAB_mRNA RNA
simple_molecule chenodiol simple_molecule
simple_molecule chenodiol_Ext simple_molecule
simple_molecule drug simple_molecule
simple_molecule drug_Ext simple_molecule


Reactions       
Showing 7 reactions
EnvR acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB. Reaction inhibition by EnvR.
Type: transcription
Pathway Components: acrAB - EnvR -> acrAB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor EnvR protein nd nd
reactant acrAB gene nd nd
product acrAB_mRNA RNA nd nd
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Pathway Components: acrAB_mRNA -> AcrA
Components:
Function Name Type Evidence Reference(s)
product AcrA protein nd nd
reactant acrAB_mRNA RNA nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
reactant TolC protein nd nd
AcrA-TolC-AcrB AcrD-AcrA-TolC drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrA-TolC-AcrB - AcrD-AcrA-TolC -> drug
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrA-TolC-AcrB complex nd nd
catalyzer AcrD-AcrA-TolC complex nd nd
product drug simple_molecule nd nd
reactant drug_Ext simple_molecule nd nd
AcrB + AcrA + TolC AcrA-TolC-AcrB
Name: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Description: Reaction transforming AcrB, AcrA, TolC into AcrA-TolC-AcrB
Type: state transition
Pathway Components: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
product AcrA-TolC-AcrB complex nd nd
reactant AcrB protein nd nd
reactant TolC protein nd nd
AcrA-TolC-AcrB chenodiol_Ext chenodiol
Name: chenodiol_Ext -> chenodiol
Description: Transport of chenodiol_Ext through a bacterial membrane, leading to the presence of chenodiol inside the cell.
Type: transport
Pathway Components: chenodiol_Ext - AcrA-TolC-AcrB -> chenodiol
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrA-TolC-AcrB complex nd nd
product chenodiol simple_molecule nd nd
reactant chenodiol_Ext simple_molecule nd nd
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Pathway Components: acrAB_mRNA -> AcrB
Components:
Function Name Type Evidence Reference(s)
product AcrB protein nd nd
reactant acrAB_mRNA RNA nd nd



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