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DpiA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
dpiBA_mRNA GlcA_Ext exuT adenine diphosphate appY_mRNA GlcA CitF CitE DpiA CitE ExuT appY exuT_mRNA CitG citCDEFXG Mdh citrate lyase [a citrate-lyase acyl-carrier protein] malate AppY CitF oxalacetate 3-dephospho-CoA DpiB dpiBA 2-5-triphosphoribosyl-3-dephospho-CoA galaturonate acetate phosphate mdh_mRNA [a holo citrate lyase acyl-carrier protein] CitX DpiA galaturonate_Ext mdh citCDEFXG_mRNA CitD phosphate CitD CitC


Gensor Unit       
Name: DpiA
Signal name: citrate and anaerobiosis (reduced conditions).
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Energy production and conversion
Signal transduction mechanisms
Coenzyme transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0006084 - acetyl-CoA metabolic process
GO:0009061 - anaerobic respiration
GO:0009058 - biosynthetic process
GO:0005975 - carbohydrate metabolic process
GO:0019752 - carboxylic acid metabolic process
GO:0006464 - cellular protein modification process
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cellular_component GO:0009346 - citrate lyase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019898 - extrinsic component of membrane
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
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molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0030060 - L-malate dehydrogenase activity
GO:0008080 - N-acetyltransferase activity
GO:0008771 - [citrate (pro-3S)-lyase] ligase activity
GO:0003824 - catalytic activity
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Components:
  Function Name Type
  simple_molecule 2-5-triphosphoribosyl-3-dephospho-CoA simple_molecule
  simple_molecule 3-dephospho-CoA simple_molecule
  protein AppY protein
  protein CitC protein
  protein CitD protein
  complex CitD-CitF-CitE complex
  protein CitE protein
  protein CitF protein
  protein CitG protein
  protein CitX protein
  protein DpiA protein
  complex DpiA-phosphate complex
  protein DpiB protein
  protein ExuT protein
  simple_molecule GlcA simple_molecule
  simple_molecule GlcA_Ext simple_molecule
  protein Mdh protein
  simple_molecule [a citrate-lyase acyl-carrier protein] simple_molecule
  simple_molecule [a holo citrate lyase acyl-carrier protein] simple_molecule
  simple_molecule acetate simple_molecule
  simple_molecule adenine simple_molecule
  gene appY gene
  RNA appY_mRNA RNA
  gene citCDEFXG gene
  RNA citCDEFXG_mRNA RNA
  simple_molecule citrate lyase simple_molecule
  simple_molecule diphosphate simple_molecule
  gene dpiBA gene
  RNA dpiBA_mRNA RNA
  gene exuT gene
  RNA exuT_mRNA RNA
  simple_molecule galaturonate simple_molecule
  simple_molecule galaturonate_Ext simple_molecule
  simple_molecule malate simple_molecule
  gene mdh gene
  RNA mdh_mRNA RNA
  simple_molecule oxalacetate simple_molecule
  simple_molecule phosphate simple_molecule


Reactions       
Showing 24 reactions
phosphate + DpiA DpiA-phosphate
Name: phosphate + DpiA -> DpiA-phosphate
Description: Reaction transforming phosphate, DpiA into DpiA-phosphate
Type: state transition
Pathway Components: phosphate + DpiA -> DpiA-phosphate
Components:
Function Name Type
reactant DpiA protein
product DpiA-phosphate complex
reactant phosphate simple_molecule
DpiA-phosphate citCDEFXG citCDEFXG_mRNA
Name: citCDEFXG -> citCDEFXG_mRNA
Description: Transcription of transcription unit citCDEFXG. Reaction activation by DpiA-phosphate.
Type: transcription
Pathway Components: citCDEFXG - DpiA-phosphate -> citCDEFXG_mRNA
Components:
Function Name Type
activator DpiA-phosphate complex
reactant citCDEFXG gene
product citCDEFXG_mRNA RNA
DpiA-phosphate dpiBA dpiBA_mRNA
Name: dpiBA -> dpiBA_mRNA
Description: Transcription of transcription unit dpiBA. Reaction activation by DpiA-phosphate.
Type: transcription
Pathway Components: dpiBA - DpiA-phosphate -> dpiBA_mRNA
Components:
Function Name Type
activator DpiA-phosphate complex
reactant dpiBA gene
product dpiBA_mRNA RNA
DpiA-phosphate exuT exuT_mRNA
Name: exuT -> exuT_mRNA
Description: Transcription of transcription unit exuT. Reaction activation by DpiA-phosphate.
Type: transcription
Pathway Components: exuT - DpiA-phosphate -> exuT_mRNA
Components:
Function Name Type
activator DpiA-phosphate complex
reactant exuT gene
product exuT_mRNA RNA
DpiA-phosphate mdh mdh_mRNA
Name: mdh -> mdh_mRNA
Description: Transcription of transcription unit mdh. Reaction activation by DpiA-phosphate.
Type: transcription
Pathway Components: mdh - DpiA-phosphate -> mdh_mRNA
Components:
Function Name Type
activator DpiA-phosphate complex
reactant mdh gene
product mdh_mRNA RNA
DpiA-phosphate appY appY_mRNA
Name: appY -> appY_mRNA
Description: Transcription of transcription unit appY. Reaction inhibition by DpiA-phosphate.
Type: transcription
Pathway Components: appY - DpiA-phosphate -> appY_mRNA
Components:
Function Name Type
inhibitor DpiA-phosphate complex
reactant appY gene
product appY_mRNA RNA
mdh_mRNA Mdh
Name: mdh_mRNA -> Mdh
Description: Translation of Mdh
Type: translation
Pathway Components: mdh_mRNA -> Mdh
Components:
Function Name Type
product Mdh protein
reactant mdh_mRNA RNA
Mdh malate oxalacetate
Name: malate -> oxalacetate
Description: Reaction transforming malate into oxalacetate
Type: state transition
Pathway Components: malate - Mdh -> oxalacetate
Components:
Function Name Type
catalyzer Mdh protein
reactant malate simple_molecule
product oxalacetate simple_molecule
appY_mRNA AppY
Name: appY_mRNA -> AppY
Description: Translation of AppY
Type: translation
Pathway Components: appY_mRNA -> AppY
Components:
Function Name Type
product AppY protein
reactant appY_mRNA RNA
dpiBA_mRNA DpiB
Name: dpiBA_mRNA -> DpiB
Description: Translation of DpiB
Type: translation
Pathway Components: dpiBA_mRNA -> DpiB
Components:
Function Name Type
product DpiB protein
reactant dpiBA_mRNA RNA
dpiBA_mRNA DpiA
Name: dpiBA_mRNA -> DpiA
Description: Translation of DpiA
Type: translation
Pathway Components: dpiBA_mRNA -> DpiA
Components:
Function Name Type
product DpiA protein
reactant dpiBA_mRNA RNA
citCDEFXG_mRNA CitC
Name: citCDEFXG_mRNA -> CitC
Description: Translation of CitC
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitC
Components:
Function Name Type
product CitC protein
reactant citCDEFXG_mRNA RNA
CitC Reactants citrate lyase + diphosphate
Name: [a holo citrate lyase acyl-carrier protein] + acetate -> citrate lyase + diphosphate
Description: Reaction transforming [a holo citrate lyase acyl-carrier protein], acetate into citrate lyase, diphosphate
Type: state transition
Pathway Components: [a holo citrate lyase acyl-carrier protein] + acetate - CitC -> citrate lyase + diphosphate
Components:
Function Name Type
catalyzer CitC protein
reactant [a holo citrate lyase acyl-carrier protein] simple_molecule
reactant acetate simple_molecule
product citrate lyase simple_molecule
product diphosphate simple_molecule
citCDEFXG_mRNA CitD
Name: citCDEFXG_mRNA -> CitD
Description: Translation of CitD
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitD
Components:
Function Name Type
product CitD protein
reactant citCDEFXG_mRNA RNA
CitD + CitF + CitE CitD-CitF-CitE
Name: CitD + CitF + CitE -> CitD-CitF-CitE
Description: Reaction transforming CitD, CitF, CitE into CitD-CitF-CitE
Type: state transition
Pathway Components: CitD + CitF + CitE -> CitD-CitF-CitE
Components:
Function Name Type
reactant CitD protein
product CitD-CitF-CitE complex
reactant CitE protein
reactant CitF protein
citCDEFXG_mRNA CitE
Name: citCDEFXG_mRNA -> CitE
Description: Translation of CitE
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitE
Components:
Function Name Type
product CitE protein
reactant citCDEFXG_mRNA RNA
citCDEFXG_mRNA CitF
Name: citCDEFXG_mRNA -> CitF
Description: Translation of CitF
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitF
Components:
Function Name Type
product CitF protein
reactant citCDEFXG_mRNA RNA
citCDEFXG_mRNA CitX
Name: citCDEFXG_mRNA -> CitX
Description: Translation of CitX
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitX
Components:
Function Name Type
product CitX protein
reactant citCDEFXG_mRNA RNA
CitX Reactants Products
Name: [a citrate-lyase acyl-carrier protein] + 2-5-triphosphoribosyl-3-dephospho-CoA -> [a holo citrate lyase acyl-carrier protein] + diphosphate
Description: Reaction transforming [a citrate-lyase acyl-carrier protein], 2-5-triphosphoribosyl-3-dephospho-CoA into [a holo citrate lyase acyl-carrier protein], diphosphate
Type: state transition
Pathway Components: [a citrate-lyase acyl-carrier protein] + 2-5-triphosphoribosyl-3-dephospho-CoA - CitX -> [a holo citrate lyase acyl-carrier protein] + diphosphate
Components:
Function Name Type
reactant 2-5-triphosphoribosyl-3-dephospho-CoA simple_molecule
catalyzer CitX protein
reactant [a citrate-lyase acyl-carrier protein] simple_molecule
product [a holo citrate lyase acyl-carrier protein] simple_molecule
product diphosphate simple_molecule
citCDEFXG_mRNA CitG
Name: citCDEFXG_mRNA -> CitG
Description: Translation of CitG
Type: translation
Pathway Components: citCDEFXG_mRNA -> CitG
Components:
Function Name Type
product CitG protein
reactant citCDEFXG_mRNA RNA
CitG 3-dephospho-CoA 2-5-triphosphoribosyl-3-dephospho-CoA + adenine
Name: 3-dephospho-CoA -> 2-5-triphosphoribosyl-3-dephospho-CoA + adenine
Description: Reaction transforming 3-dephospho-CoA into 2-5-triphosphoribosyl-3-dephospho-CoA, adenine
Type: state transition
Pathway Components: 3-dephospho-CoA - CitG -> 2-5-triphosphoribosyl-3-dephospho-CoA + adenine
Components:
Function Name Type
product 2-5-triphosphoribosyl-3-dephospho-CoA simple_molecule
reactant 3-dephospho-CoA simple_molecule
catalyzer CitG protein
product adenine simple_molecule
exuT_mRNA ExuT
Name: exuT_mRNA -> ExuT
Description: Translation of ExuT
Type: translation
Pathway Components: exuT_mRNA -> ExuT
Components:
Function Name Type
product ExuT protein
reactant exuT_mRNA RNA
ExuT galaturonate_Ext galaturonate
Name: galaturonate_Ext -> galaturonate
Description: Transport of galaturonate_Ext through a bacterial membrane, leading to the presence of galaturonate inside the cell.
Type: transport
Pathway Components: galaturonate_Ext - ExuT -> galaturonate
Components:
Function Name Type
catalyzer ExuT protein
product galaturonate simple_molecule
reactant galaturonate_Ext simple_molecule
ExuT GlcA_Ext GlcA
Name: GlcA_Ext -> GlcA
Description: Transport of GlcA_Ext through a bacterial membrane, leading to the presence of GlcA inside the cell.
Type: transport
Pathway Components: GlcA_Ext - ExuT -> GlcA
Components:
Function Name Type
catalyzer ExuT protein
product GlcA simple_molecule
reactant GlcA_Ext simple_molecule



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