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DpiA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-malate 2'-(5-triphosphoribosyl)-3'-dephospho-CoA AppY CitC CitD CitE CitF CitG CitX galaturonate galaturonate_Ext GlcA GlcA_Ext DpiA DpiB ExuT Mdh phosphate a [citrate-lyase] (acetyl form) a [citrate-lyase] (citryl form) a [citrate-lyase] (thiol form) a citrate lyase apo-[acyl-carrier protein] a citrate lyase holo-[acyl-carrier protein] acetate adenine appY appY_mRNA citCDEFXG citCDEFXG_mRNA cit dephospho-CoA PP dpiBA dpiBA_mRNA exuT exuT_mRNA mdh mdh_mRNA oxalacetate DpiA phosphate CitD CitF CitE


Gensor Unit       
Name: DpiA
Classification:
Groups: GUs related to the two-component system
Gene Ontology Terms (GO): GO:0071310 - cellular response to organic substance
GO:0044262 - cellular carbohydrate metabolic process
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0003824 - catalytic activity
GO:0009346 - citrate lyase complex
GO:0008814 - citrate CoA-transferase activity
GO:0016615 - malate dehydrogenase activity
GO:0006099 - tricarboxylic acid cycle
GO:0016020 - membrane
GO:0016491 - oxidoreductase activity
GO:0008080 - N-acetyltransferase activity
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Components:
Function Name Type
simple molecule oxalacetate simple molecule


Reactions       
Showing 27 reactions
DpiA + phosphate DpiA-Pasp
Name: DpiA + phosphate -> DpiA-Pasp
Description: Reaction transforming DpiA, phosphate into DpiA-Pasp
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product DpiA-Pasp complex nd nd
reactant phosphate simple molecule nd nd
reactant DpiA protein nd nd
appY appY_mRNA
Name: appY -> appY_mRNA
Description: Transcription of transcription unit appY; reaction inhibition by DpiA-Pasp.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant appY gene nd nd
product appY_mRNA RNA nd nd
citCDEFXG citCDEFXG_mRNA
Name: citCDEFXG -> citCDEFXG_mRNA
Description: Transcription of transcription unit citCDEFXG; reaction activation by DpiA-Pasp.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product citCDEFXG_mRNA RNA nd nd
reactant citCDEFXG gene nd nd
dpiBA dpiBA_mRNA
Name: dpiBA -> dpiBA_mRNA
Description: Transcription of transcription unit dpiBA; reaction activation by DcuR-Phosphorylated.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant dpiBA gene nd nd
product dpiBA_mRNA RNA nd nd
exuT exuT_mRNA
Name: exuT -> exuT_mRNA
Description: Transcription of transcription unit exuT; reaction activation by DpiA-Pasp.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product exuT_mRNA RNA nd nd
reactant exuT gene nd nd
mdh mdh_mRNA
Name: mdh -> mdh_mRNA
Description: Transcription of transcription unit mdh; reaction activation by DpiA-Pasp.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product mdh_mRNA RNA nd nd
reactant mdh gene nd nd
citCDEFXG_mRNA CitC
Name: citCDEFXG_mRNA -> CitC
Description: Translation of CitC
Type: translation
Components:
Function Name Type Evidence Reference(s)
product CitC protein nd nd
reactant citCDEFXG_mRNA RNA nd nd
a [citrate-lyase] (thiol form) + acetate a [citrate-lyase] (acetyl form) + PP
Name: a [citrate-lyase] (thiol form) + acetate -> a [citrate-lyase] (acetyl form) + PP
Description: Reaction transforming a [citrate-lyase] (thiol form), acetate into a [citrate-lyase] (acetyl form), PP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a [citrate-lyase] (acetyl form) simple molecule nd nd
reactant a [citrate-lyase] (thiol form) simple molecule nd nd
product PP simple molecule nd nd
reactant acetate simple molecule nd nd
mdh_mRNA Mdh
Name: mdh_mRNA -> Mdh
Description: Translation of Mdh
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Mdh protein nd nd
reactant mdh_mRNA RNA nd nd
L-malate oxalacetate
Name: L-malate -> oxalacetate
Description: Reaction transforming L-malate into oxalacetate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product oxalacetate simple molecule nd nd
reactant L-malate simple molecule nd nd
citCDEFXG_mRNA CitF
Name: citCDEFXG_mRNA -> CitF
Description: Translation of CitF
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant citCDEFXG_mRNA RNA nd nd
product CitF protein nd nd
CitD + CitF + CitE CitD-CitF-CitE
Name: CitD + CitF + CitE -> CitD-CitF-CitE
Description: Reaction transforming CitD, CitF, CitE into CitD-CitF-CitE
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product CitD-CitF-CitE complex nd nd
reactant CitE protein nd nd
reactant CitD protein nd nd
reactant CitF protein nd nd
cit acetate + oxalacetate
Name: cit -> acetate + oxalacetate
Description: Reaction transforming cit into acetate, oxalacetate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant cit simple molecule nd nd
product oxalacetate simple molecule nd nd
product acetate simple molecule nd nd
a [citrate-lyase] (acetyl form) + cit a [citrate-lyase] (citryl form) + acetate
Name: a [citrate-lyase] (acetyl form) + cit -> a [citrate-lyase] (citryl form) + acetate
Description: Reaction transforming a [citrate-lyase] (acetyl form), cit into a [citrate-lyase] (citryl form), acetate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a [citrate-lyase] (acetyl form) simple molecule nd nd
reactant cit simple molecule nd nd
product acetate simple molecule nd nd
product a [citrate-lyase] (citryl form) simple molecule nd nd
a [citrate-lyase] (citryl form) oxalacetate + a [citrate-lyase] (acetyl form)
Name: a [citrate-lyase] (citryl form) -> oxalacetate + a [citrate-lyase] (acetyl form)
Description: Reaction transforming a [citrate-lyase] (citryl form) into oxalacetate, a [citrate-lyase] (acetyl form)
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product oxalacetate simple molecule nd nd
product a [citrate-lyase] (acetyl form) simple molecule nd nd
reactant a [citrate-lyase] (citryl form) simple molecule nd nd
dpiBA_mRNA DpiA
Name: dpiBA_mRNA -> DpiA
Description: Translation of DpiA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product DpiA protein nd nd
reactant dpiBA_mRNA RNA nd nd
exuT_mRNA ExuT
Name: exuT_mRNA -> ExuT
Description: Translation of ExuT
Type: translation
Components:
Function Name Type Evidence Reference(s)
product ExuT protein nd nd
reactant exuT_mRNA RNA nd nd
galaturonate_Ext galaturonate
Name: galaturonate_Ext -> galaturonate
Description: Transport of galaturonate_Ext through a bacterial membrane, leading to the presence of galaturonate inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product galaturonate simple molecule nd nd
reactant galaturonate_Ext simple molecule nd nd
GlcA_Ext GlcA
Name: GlcA_Ext -> GlcA
Description: Transport of GlcA_Ext through a bacterial membrane, leading to the presence of GlcA inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product GlcA simple molecule nd nd
reactant GlcA_Ext simple molecule nd nd
citCDEFXG_mRNA CitD
Name: citCDEFXG_mRNA -> CitD
Description: Translation of CitD
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant citCDEFXG_mRNA RNA nd nd
product CitD protein nd nd
citCDEFXG_mRNA CitX
Name: citCDEFXG_mRNA -> CitX
Description: Translation of CitX
Type: translation
Components:
Function Name Type Evidence Reference(s)
product CitX protein nd nd
reactant citCDEFXG_mRNA RNA nd nd
2-5-triphosphoribosyl-3-dephospho-CoA + a citrate lyase apo-[acyl-carrier protein] a citrate lyase holo-[acyl-carrier protein] + PP
Name: 2-5-triphosphoribosyl-3-dephospho-CoA + a citrate lyase apo-[acyl-carrier protein] -> a citrate lyase holo-[acyl-carrier protein] + PP
Description: Reaction transforming 2-5-triphosphoribosyl-3-dephospho-CoA, a citrate lyase apo-[acyl-carrier protein] into a citrate lyase holo-[acyl-carrier protein], PP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a citrate lyase holo-[acyl-carrier protein] simple molecule nd nd
reactant 2-5-triphosphoribosyl-3-dephospho-CoA simple molecule nd nd
reactant a citrate lyase apo-[acyl-carrier protein] simple molecule nd nd
product PP simple molecule nd nd
citCDEFXG_mRNA CitG
Name: citCDEFXG_mRNA -> CitG
Description: Translation of CitG
Type: translation
Components:
Function Name Type Evidence Reference(s)
product CitG protein nd nd
reactant citCDEFXG_mRNA RNA nd nd
dephospho-CoA 2-5-triphosphoribosyl-3-dephospho-CoA + adenine
Name: dephospho-CoA -> 2-5-triphosphoribosyl-3-dephospho-CoA + adenine
Description: Reaction transforming dephospho-CoA into 2-5-triphosphoribosyl-3-dephospho-CoA, adenine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product adenine simple molecule nd nd
reactant dephospho-CoA simple molecule nd nd
product 2-5-triphosphoribosyl-3-dephospho-CoA simple molecule nd nd
dpiBA_mRNA DpiB
Name: dpiBA_mRNA -> DpiB
Description: Translation of DpiB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant dpiBA_mRNA RNA nd nd
product DpiB protein nd nd
citCDEFXG_mRNA CitE
Name: citCDEFXG_mRNA -> CitE
Description: Translation of CitE
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant citCDEFXG_mRNA RNA nd nd
product CitE protein nd nd
appY_mRNA AppY
Name: appY_mRNA -> AppY
Description: Translation of AppY
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant appY_mRNA RNA nd nd
product AppY protein nd nd



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