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DnaA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-lactate ATP AldA CDP DNA(n) DnaA DnaN GDP GMP GuaA GuaB IMP glutamate glutamine L-lactaldehyde NrdA NrdB PolA This Gensor Unit is not yet available RecF RecO RecR RpoH UDP XMP YfaE YjeV nucleoside 5'-phosphate deoxyribonucleoside triphosphate a double stranded DNA deoxyribonucleoside 5'-phosphate reduced thioredoxin a single stranded DNA a stabilized RecA filament-DNA complex aldA aldA_mRNA ammonia oxidized thioredoxin an unstable RecA filament-DNA complex dADP dCDP dGDP dUDP DNA(n+1) dnaAN-recF dnaAN-recF_mRNA glycoaldehyde glycolate guaBA guaBA_mRNA nrdAB-yfaE nrdAB-yfaE_mRNA polA polA_mRNA rpoH rpoH_mRNA yjeV yjeV_mRNA DnaA ATP RecF RecR RecO NrdA NrdB oxidized thioredoxin ADP reduced thioredoxin XMP DNA(n-1)


Gensor Unit       
Name: DnaA
Description: DnaA dually regulates the expression of genes involved in DNA replication and oxidation-reduction processes, and it positively regulates the polA gene, in the presence of ATP. DnaA negatively regulates the expression of genes involved in the catabolism of sugars and in the stress response in the presence of ATP. The presence of ATP inhibits the expression of genes related to the transformation of lactaldehyde to L-lactate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0003688 - DNA replication origin binding
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0008270 - zinc ion binding
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016491 - oxidoreductase activity
GO:0003824 - catalytic activity
GO:0009186 - deoxyribonucleoside diphosphate metabolic process
GO:0004777 - succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0016987 - sigma factor activity
GO:0019301 - rhamnose catabolic process
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Components:
Function Name Type
RNA yjeV_mRNA RNA


Reactions       
Showing 38 reactions
DnaA + ATP DnaA-ATP
Name: DnaA + ATP -> DnaA-ATP
Description: Reaction transforming DnaA, ATP into DnaA-ATP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product DnaA-ATP complex nd nd
reactant ATP simple molecule nd nd
reactant DnaA protein nd nd
aldA aldA_mRNA
Name: aldA -> aldA_mRNA
Description: Transcription of transcription unit aldA; reaction inhibition by DnaA-ATP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant aldA gene nd nd
product aldA_mRNA RNA nd nd
dnaAN-recF dnaAN-recF_mRNA
Name: dnaAN-recF -> dnaAN-recF_mRNA
Description: Transcription of transcription unit dnaAN-recF; reaction activation by ArgP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product dnaAN-recF_mRNA RNA nd nd
reactant dnaAN-recF gene nd nd
guaBA guaBA_mRNA
Name: guaBA -> guaBA_mRNA
Description: Transcription of transcription unit guaBA; reaction inhibition by DnaA-ATP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product guaBA_mRNA RNA nd nd
reactant guaBA gene nd nd
nrdAB-yfaE nrdAB-yfaE_mRNA
Name: nrdAB-yfaE -> nrdAB-yfaE_mRNA
Description: Transcription of transcription unit nrdAB-yfaE; reaction activation by ArgP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product nrdAB-yfaE_mRNA RNA nd nd
reactant nrdAB-yfaE gene nd nd
polA polA_mRNA
Name: polA -> polA_mRNA
Description: Transcription of transcription unit polA; reaction activation by DnaA-ATP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product polA_mRNA RNA nd nd
reactant polA gene nd nd
rpoH rpoH_mRNA
Name: rpoH -> rpoH_mRNA
Description: Transcription of transcription unit rpoH; reaction activation by CpxR-Phosphorylated.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant rpoH gene nd nd
product rpoH_mRNA RNA nd nd
yjeV yjeV_mRNA
Name: yjeV -> yjeV_mRNA
Description: Transcription of transcription unit yjeV; reaction inhibition by DnaA-ATP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product yjeV_mRNA RNA nd nd
reactant yjeV gene nd nd
aldA_mRNA AldA
Name: aldA_mRNA -> AldA
Description: Translation of AldA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AldA protein nd nd
reactant aldA_mRNA RNA nd nd
glycolaldehyde glycolate
Name: glycolaldehyde -> glycolate
Description: Reaction transforming glycolaldehyde into glycolate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product glycolate simple molecule nd nd
reactant glycolaldehyde simple molecule nd nd
L-lactaldehyde (S)-lactate
Name: L-lactaldehyde -> (S)-lactate
Description: Reaction transforming L-lactaldehyde into (S)-lactate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product (S)-lactate simple molecule nd nd
reactant L-lactaldehyde simple molecule nd nd
dnaAN-recF_mRNA RecF
Name: dnaAN-recF_mRNA -> RecF
Description: Translation of RecF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product RecF protein nd nd
reactant dnaAN-recF_mRNA RNA nd nd
RecF + RecR + RecO RecF-RecR-RecO
Name: RecF + RecR + RecO -> RecF-RecR-RecO
Description: Reaction transforming RecF, RecR, RecO into RecF-RecR-RecO
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant RecR protein nd nd
reactant RecF protein nd nd
product RecF-RecR-RecO complex nd nd
reactant RecO protein nd nd
an unstable RecA filament-DNA complex a stabilized RecA filament-DNA complex
Name: an unstable RecA filament-DNA complex -> a stabilized RecA filament-DNA complex
Description: Reaction transforming an unstable RecA filament-DNA complex into a stabilized RecA filament-DNA complex
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a stabilized RecA filament-DNA complex simple molecule nd nd
reactant an unstable RecA filament-DNA complex simple molecule nd nd
polA_mRNA PolA
Name: polA_mRNA -> PolA
Description: Translation of PolA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant polA_mRNA RNA nd nd
product PolA protein nd nd
a double stranded DNA a single stranded DNA + a 5′-phosphomononucleotide
Name: a double stranded DNA -> a single stranded DNA + a 5′-phosphomononucleotide
Description: Reaction transforming a double stranded DNA into a single stranded DNA, a 5′-phosphomononucleotide
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product a 5′-phosphomononucleotide simple molecule nd nd
product a single stranded DNA simple molecule nd nd
reactant a double stranded DNA simple molecule nd nd
DNAn a nucleoside monophosphate
Name: DNAn -> a nucleoside monophosphate
Description: Reaction transforming DNAn into a nucleoside monophosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant DNAn simple molecule nd nd
product a nucleoside monophosphate simple molecule nd nd
a deoxyribonucleoside triphosphate + DNAn DNAn
Name: a deoxyribonucleoside triphosphate + DNAn -> DNAn
Description: Reaction transforming a deoxyribonucleoside triphosphate, DNAn into DNAn
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product DNAn simple molecule nd nd
reactant a deoxyribonucleoside triphosphate simple molecule nd nd
reactant DNAn simple molecule nd nd
rpoH_mRNA RpoH
Name: rpoH_mRNA -> RpoH
Description: Translation of RpoH
Type: translation
Components:
Function Name Type Evidence Reference(s)
product RpoH protein nd nd
reactant rpoH_mRNA RNA nd nd
rpoH_mRNA RNA polymerase sigma 32
Name: rpoH_mRNA -> RNA polymerase sigma 32
Description: Translation of RNA polymerase sigma 32
Type: translation
Components:
Function Name Type Evidence Reference(s)
product RNA polymerase sigma 32 RNA nd nd
reactant rpoH_mRNA RNA nd nd
dnaAN-recF_mRNA DnaA
Name: dnaAN-recF_mRNA -> DnaA
Description: Translation of DnaA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant dnaAN-recF_mRNA RNA nd nd
product DnaA protein nd nd
nrdAB-yfaE_mRNA YfaE
Name: nrdAB-yfaE_mRNA -> YfaE
Description: Translation of YfaE
Type: translation
Components:
Function Name Type Evidence Reference(s)
product YfaE protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
yjeV_mRNA YjeV
Name: yjeV_mRNA -> YjeV
Description: Translation of YjeV
Type: translation
Components:
Function Name Type Evidence Reference(s)
product YjeV protein nd nd
reactant yjeV_mRNA RNA nd nd
dnaAN-recF_mRNA DnaN
Name: dnaAN-recF_mRNA -> DnaN
Description: Translation of DnaN
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant dnaAN-recF_mRNA RNA nd nd
product DnaN protein nd nd
guaBA_mRNA GuaA
Name: guaBA_mRNA -> GuaA
Description: Translation of GuaA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant guaBA_mRNA RNA nd nd
product GuaA protein nd nd
L-glutamine + XMP L-glutamate + GMP
Name: L-glutamine + XMP -> L-glutamate + GMP
Description: Reaction transforming L-glutamine, XMP into L-glutamate, GMP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-glutamine simple molecule nd nd
reactant XMP simple molecule nd nd
product L-glutamate simple molecule nd nd
product GMP simple molecule nd nd
XMP + ammonia GMP
Name: XMP + ammonia -> GMP
Description: Reaction transforming XMP, ammonia into GMP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product GMP simple molecule nd nd
reactant XMP simple molecule nd nd
reactant ammonia simple molecule nd nd
nrdAB-yfaE_mRNA NrdB
Name: nrdAB-yfaE_mRNA -> NrdB
Description: Translation of NrdB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdB protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
NrdA + NrdB NrdA-NrdB
Name: NrdA + NrdB -> NrdA-NrdB
Description: Reaction transforming NrdA, NrdB into NrdA-NrdB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant NrdB protein nd nd
reactant NrdA protein nd nd
product NrdA-NrdB complex nd nd
CDP + a reduced thioredoxin dCDP + an oxidized thioredoxin
Name: CDP + a reduced thioredoxin -> dCDP + an oxidized thioredoxin
Description: Reaction transforming CDP, a reduced thioredoxin into dCDP, an oxidized thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a reduced thioredoxin simple molecule nd nd
product an oxidized thioredoxin simple molecule nd nd
product dCDP simple molecule nd nd
reactant CDP simple molecule nd nd
UDP + a reduced thioredoxin dUDP + an oxidized thioredoxin
Name: UDP + a reduced thioredoxin -> dUDP + an oxidized thioredoxin
Description: Reaction transforming UDP, a reduced thioredoxin into dUDP, an oxidized thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product an oxidized thioredoxin simple molecule nd nd
reactant a reduced thioredoxin simple molecule nd nd
product dUDP simple molecule nd nd
reactant UDP simple molecule nd nd
ADP + a reduced thioredoxin dADP + an oxidized thioredoxin
Name: ADP + a reduced thioredoxin -> dADP + an oxidized thioredoxin
Description: Reaction transforming ADP, a reduced thioredoxin into dADP, an oxidized thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product an oxidized thioredoxin simple molecule nd nd
reactant ADP simple molecule nd nd
reactant a reduced thioredoxin simple molecule nd nd
product dADP simple molecule nd nd
GDP + a reduced thioredoxin dGDP + an oxidized thioredoxin
Name: GDP + a reduced thioredoxin -> dGDP + an oxidized thioredoxin
Description: Reaction transforming GDP, a reduced thioredoxin into dGDP, an oxidized thioredoxin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant a reduced thioredoxin simple molecule nd nd
reactant GDP simple molecule nd nd
product an oxidized thioredoxin simple molecule nd nd
product dGDP simple molecule nd nd
nrdAB-yfaE_mRNA NrdA
Name: nrdAB-yfaE_mRNA -> NrdA
Description: Translation of NrdA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NrdA protein nd nd
reactant nrdAB-yfaE_mRNA RNA nd nd
guaBA_mRNA GuaB
Name: guaBA_mRNA -> GuaB
Description: Translation of GuaB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product GuaB protein nd nd
reactant guaBA_mRNA RNA nd nd
IMP XMP
Name: IMP -> XMP
Description: Reaction transforming IMP into XMP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant IMP simple molecule nd nd
product XMP simple molecule nd nd
GMP GDP
Name: GMP -> GDP
Description: Transformation of GMP into GDP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant GMP simple molecule nd nd
product GDP simple molecule nd nd
UDP CDP
Name: UDP -> CDP
Description: Transformation of UDP into CDP by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant UDP simple molecule nd nd
product CDP simple molecule nd nd



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