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DsdC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-serine D-serine_Ext DsdA DsdC DsdX ammonia This Gensor Unit is not yet available This Gensor Unit is not yet available dsdC dsdC_mRNA dsdXA dsdXA_mRNA pyruvate DsdC D-serine


Gensor Unit       
Name: DsdC
Description: Molecular biology level
Detailed: In presence of serine, DsdC positively regulates the expression of genes invol required for serine transportation and catabolism and negatively regulates its own expression. Under this condition, DsdC is modified to DsdC-D-serine, binds its target sites preventing its own expression and enabling the expression of its regulated genes.
Less detailed: In the presence of serine, DsdC positively regulates the expression of genes needed for serine transportation and catabolism and negatively regulates its own expression.

Physiology level
Detailed: The presence of serine induces the expression of genes involved the assimilation of serine. Under this condition the genes necessary for serine uptake and degradation to pyruvate and ammonium, are expressed.
Less detailed: The presence of serine induces the expression of genes needful for the transport and degradation of serine to pyruvate and ammonium.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0036088 - D-serine catabolic process
GO:0070178 - D-serine metabolic process
GO:0042942 - D-serine transport
GO:0006565 - L-serine catabolic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0051410 - detoxification of nitrogen compound
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0008721 - D-serine ammonia-lyase activity
GO:0042945 - D-serine transmembrane transporter activity
GO:0003700 - DNA binding transcription factor activity
GO:0003941 - L-serine ammonia-lyase activity
GO:0004794 - L-threonine ammonia-lyase activity
GO:0015128 - gluconate transmembrane transporter activity
GO:0016836 - hydro-lyase activity
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Components: Show/Hide Components Table (13 more...)
Function Name Type
protein DsdA protein
protein DsdC protein
complex DsdC-serine complex
protein DsdX protein
simple_molecule dehydroalanine simple_molecule
gene dsdA gene
RNA dsdA_mRNA RNA
gene dsdC gene
RNA dsdC_mRNA RNA
gene dsdXA gene
RNA dsdXA_mRNA RNA
simple_molecule serine simple_molecule
simple_molecule serine_Ext simple_molecule


Reactions       
Showing 10 reactions
DsdC DsdC-serine dsdXA dsdXA_mRNA
Name: dsdXA -> dsdXA_mRNA
Description: Transcription of transcription unit dsdXA. Reaction activation by DsdC, and DsdC-serine.
Type: transcription
Pathway Components: dsdXA - DsdC - DsdC-serine -> dsdXA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DsdC protein nd nd
activator DsdC-serine complex nd nd
reactant dsdXA gene nd nd
product dsdXA_mRNA RNA nd nd
DsdC DsdC-serine dsdC dsdC_mRNA
Name: dsdC -> dsdC_mRNA
Description: Transcription of transcription unit dsdC. Reaction inhibition by DsdC, and DsdC-serine.
Type: transcription
Pathway Components: dsdC - DsdC - DsdC-serine -> dsdC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor DsdC protein nd nd
inhibitor DsdC-serine complex nd nd
reactant dsdC gene nd nd
product dsdC_mRNA RNA nd nd
serine + DsdC DsdC-serine
Name: serine + DsdC -> DsdC-serine
Description: Reaction transforming serine, DsdC into DsdC-serine
Type: state transition
Pathway Components: serine + DsdC -> DsdC-serine
Components:
Function Name Type Evidence Reference(s)
reactant DsdC protein nd nd
product DsdC-serine complex nd nd
reactant serine simple_molecule nd nd
DsdC dsdA dsdA_mRNA
Name: dsdA -> dsdA_mRNA
Description: Transcription of transcription unit dsdA. Reaction activation by DsdC.
Type: transcription
Pathway Components: dsdA - DsdC -> dsdA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DsdC protein nd nd
reactant dsdA gene nd nd
product dsdA_mRNA RNA nd nd
dsdXA_mRNA DsdX
Name: dsdXA_mRNA -> DsdX
Description: Translation of DsdX
Type: translation
Pathway Components: dsdXA_mRNA -> DsdX
Components:
Function Name Type Evidence Reference(s)
product DsdX protein nd nd
reactant dsdXA_mRNA RNA nd nd
DsdX serine_Ext serine
Name: serine_Ext -> serine
Description: Transport of serine_Ext through a bacterial membrane, leading to the presence of serine inside the cell.
Type: transport
Pathway Components: serine_Ext - DsdX -> serine
Components:
Function Name Type Evidence Reference(s)
catalyzer DsdX protein nd nd
product serine simple_molecule nd nd
reactant serine_Ext simple_molecule nd nd
dsdXA_mRNA DsdA
Name: dsdXA_mRNA -> DsdA
Description: Translation of DsdA
Type: translation
Pathway Components: dsdXA_mRNA -> DsdA
Components:
Function Name Type Evidence Reference(s)
product DsdA protein nd nd
reactant dsdXA_mRNA RNA nd nd
DsdA serine dehydroalanine
Name: serine -> dehydroalanine
Description: Reaction transforming serine into dehydroalanine
Type: state transition
Pathway Components: serine - DsdA -> dehydroalanine
Components:
Function Name Type Evidence Reference(s)
catalyzer DsdA protein nd nd
product dehydroalanine simple_molecule nd nd
reactant serine simple_molecule nd nd
dsdC_mRNA DsdC
Name: dsdC_mRNA -> DsdC
Description: Translation of DsdC
Type: translation
Pathway Components: dsdC_mRNA -> DsdC
Components:
Function Name Type Evidence Reference(s)
product DsdC protein nd nd
reactant dsdC_mRNA RNA nd nd
dsdA_mRNA DsdA
Name: dsdA_mRNA -> DsdA
Description: Translation of DsdA
Type: translation
Pathway Components: dsdA_mRNA -> DsdA
Components:
Function Name Type Evidence Reference(s)
product DsdA protein nd nd
reactant dsdA_mRNA RNA nd nd



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