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DeoR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
d-cytidine_Ext thymine 2-deoxy-D-ribose 5-phosphate DeoR deoCABD_mRNA deoxyuridine purine base nucleoside DeoC ribose-5P cytidine tsx_mRNA NupG DeoR deoxyinosine_Ext inosine nupG_mRNA thymidine DeoB ribose-1-phosphate DeoD deoxyadenosine_Ext adenosine 2-deoxy-D-ribose 5-phosphate cytidine_Ext deoxyguanosine guanine hypoxanthine DeoA uracil xanthosine_Ext deoxyadenosine nucleoside_Ext guanosine ethanal Tsx d-cytidine uridine_Ext xanthosine deoCABD uridine inosine_Ext adenosine_Ext glyceraldehyde-P thymidine_Ext adenine deoxyinosine nupG deoxyuridine_Ext tsx nebularine deoxy-D-ribose 1-phosphate ribose-1-phosphate adenine inosine adenosine adenosine deoxy-D-ribose 1-phosphate phosphate ribose-1-phosphate ribose-1-phosphate phosphate guanine deoxy-D-ribose 1-phosphate phosphate hypoxanthine ribose-1-phosphate ribose-1-phosphate phosphate


Gensor Unit       
Name: DeoR
Description: Molecular biology level
Detailed: In the absence of deoxyadenosine, DeoR negatively regulates the expression of genes required for nucleoside transport and metabolic process and deoxyribonucleotide catabolic process. Under these conditions, DeoR remains unmodified, binds its target sites preventing the expression of its regulated genes. In the presence of deoxyadenosine, DeoR is modified to DeoR-Deoxyribose-5-phosphate, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of deoxyadenosine, DeoR negatively regulates the expression of genes needed for nucleoside transport and metabolic process and deoxyribonucleotide catabolic process.

Physiology level
Detailed: The presence of deoxyadenosine induces the expression of genes involved with nucleoside transport and metabolic process and deoxyribonucleotide catabolic process. Under these conditions, the genes necessary for nucleoside transport into cell and conversion to nucleobases, and conversion of deoxyadenosine to deoxyribose-5-phosphate are expressed.
Less detailed: The presence of deoxyadenosine induces the expression of genes needful for nucleoside transport into cell and conversion to nucleobases, and conversion of deoxyadenosine to deoxyribose-5-phosphate.
Classification:
Groups: Carbohydrate transport and metabolism
Cell wall/membrane/envelope biogenesis
Nucleotide transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process
GO:0032238 - adenosine transport
GO:0016052 - carbohydrate catabolic process
GO:0043094 - cellular metabolic compound salvage
GO:0006974 - cellular response to DNA damage stimulus
GO:0015861 - cytidine transport
Read more >
cellular_component GO:0009279 - cell outer membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
Read more >
molecular_function GO:0004645 - 1,4-alpha-oligoglucan phosphorylase activity
GO:0003824 - catalytic activity
GO:0015212 - cytidine transmembrane transporter activity
GO:0004139 - deoxyribose-phosphate aldolase activity
GO:0042802 - identical protein binding
GO:0016853 - isomerase activity
GO:0016829 - lyase activity
Read more >
Components:
  Function Name Type
  simple_molecule 2-deoxy-D-ribose 5-phosphate simple_molecule
  protein DeoA protein
  protein DeoB protein
  protein DeoC protein
  protein DeoD protein
  protein DeoR protein
  complex DeoR-2-deoxy-D-ribose 5-phosphate complex
  protein NupG protein
  protein Tsx protein
  simple_molecule adenine simple_molecule
  simple_molecule adenosine simple_molecule
  simple_molecule adenosine_Ext simple_molecule
  simple_molecule cytidine simple_molecule
  simple_molecule cytidine_Ext simple_molecule
  simple_molecule d-cytidine simple_molecule
  simple_molecule d-cytidine_Ext simple_molecule
  gene deoCABD gene
  RNA deoCABD_mRNA RNA
  simple_molecule deoxy-D-ribose 1-phosphate simple_molecule
  simple_molecule deoxyadenosine simple_molecule
  simple_molecule deoxyadenosine_Ext simple_molecule
  simple_molecule deoxyguanosine simple_molecule
  simple_molecule deoxyinosine simple_molecule
  simple_molecule deoxyinosine_Ext simple_molecule
  simple_molecule deoxyuridine simple_molecule
  simple_molecule deoxyuridine_Ext simple_molecule
  simple_molecule ethanal simple_molecule
  simple_molecule glyceraldehyde-P simple_molecule
  simple_molecule guanine simple_molecule
  simple_molecule guanosine simple_molecule
  simple_molecule hypoxanthine simple_molecule
  simple_molecule inosine simple_molecule
  simple_molecule inosine_Ext simple_molecule
  simple_molecule nebularine simple_molecule
  simple_molecule nucleoside simple_molecule
  simple_molecule nucleoside_Ext simple_molecule
  gene nupG gene
  RNA nupG_mRNA RNA
  simple_molecule phosphate simple_molecule
  simple_molecule purine base simple_molecule
  simple_molecule ribose-1-phosphate simple_molecule
  simple_molecule ribose-5P simple_molecule
  simple_molecule thymidine simple_molecule
  simple_molecule thymidine_Ext simple_molecule
  simple_molecule thymine simple_molecule
  gene tsx gene
  RNA tsx_mRNA RNA
  simple_molecule uracil simple_molecule
  simple_molecule uridine simple_molecule
  simple_molecule uridine_Ext simple_molecule
  simple_molecule xanthosine simple_molecule
  simple_molecule xanthosine_Ext simple_molecule


Reactions       
Showing 35 reactions
DeoR deoCABD deoCABD_mRNA
Name: deoCABD -> deoCABD_mRNA
Description: Transcription of transcription unit deoCABD. Reaction inhibition by DeoR.
Type: transcription
Pathway Components: deoCABD - DeoR -> deoCABD_mRNA
Components:
Function Name Type
inhibitor DeoR protein
reactant deoCABD gene
product deoCABD_mRNA RNA
DeoR nupG nupG_mRNA
Name: nupG -> nupG_mRNA
Description: Transcription of transcription unit nupG. Reaction inhibition by DeoR.
Type: transcription
Pathway Components: nupG - DeoR -> nupG_mRNA
Components:
Function Name Type
inhibitor DeoR protein
reactant nupG gene
product nupG_mRNA RNA
DeoR tsx tsx_mRNA
Name: tsx -> tsx_mRNA
Description: Transcription of transcription unit tsx. Reaction inhibition by DeoR.
Type: transcription
Pathway Components: tsx - DeoR -> tsx_mRNA
Components:
Function Name Type
inhibitor DeoR protein
reactant tsx gene
product tsx_mRNA RNA
2-deoxy-D-ribose 5-phosphate + DeoR DeoR-2-deoxy-D-ribose 5-phosphate
Name: 2-deoxy-D-ribose 5-phosphate + DeoR -> DeoR-2-deoxy-D-ribose 5-phosphate
Description: Reaction transforming 2-deoxy-D-ribose 5-phosphate, DeoR into DeoR-2-deoxy-D-ribose 5-phosphate
Type: state transition
Pathway Components: 2-deoxy-D-ribose 5-phosphate + DeoR -> DeoR-2-deoxy-D-ribose 5-phosphate
Components:
Function Name Type
reactant 2-deoxy-D-ribose 5-phosphate simple_molecule
reactant DeoR protein
product DeoR-2-deoxy-D-ribose 5-phosphate complex
deoCABD_mRNA DeoC
Name: deoCABD_mRNA -> DeoC
Description: Translation of DeoC
Type: translation
Pathway Components: deoCABD_mRNA -> DeoC
Components:
Function Name Type
product DeoC protein
reactant deoCABD_mRNA RNA
DeoC 2-deoxy-D-ribose 5-phosphate glyceraldehyde-P + ethanal
Name: 2-deoxy-D-ribose 5-phosphate -> glyceraldehyde-P + ethanal
Description: Reaction transforming 2-deoxy-D-ribose 5-phosphate into glyceraldehyde-P, ethanal
Type: state transition
Pathway Components: 2-deoxy-D-ribose 5-phosphate - DeoC -> glyceraldehyde-P + ethanal
Components:
Function Name Type
reactant 2-deoxy-D-ribose 5-phosphate simple_molecule
catalyzer DeoC protein
product ethanal simple_molecule
product glyceraldehyde-P simple_molecule
deoCABD_mRNA DeoA
Name: deoCABD_mRNA -> DeoA
Description: Translation of DeoA
Type: translation
Pathway Components: deoCABD_mRNA -> DeoA
Components:
Function Name Type
product DeoA protein
reactant deoCABD_mRNA RNA
DeoA ribose-1-phosphate thymine phosphate + thymidine deoxy-D-ribose 1-phosphate + thymine
Name: phosphate + thymidine -> deoxy-D-ribose 1-phosphate + thymine
Description: Reaction transforming phosphate, thymidine into deoxy-D-ribose 1-phosphate, thymine
Type: state transition
Pathway Components: phosphate + thymidine - DeoA - ribose-1-phosphate - thymine -> deoxy-D-ribose 1-phosphate + thymine
Components:
Function Name Type
catalyzer DeoA protein
product deoxy-D-ribose 1-phosphate simple_molecule
reactant phosphate simple_molecule
inhibitor ribose-1-phosphate simple_molecule
reactant thymidine simple_molecule
inhibitor thymine simple_molecule
product thymine simple_molecule
DeoA deoxyuridine + phosphate deoxy-D-ribose 1-phosphate + uracil
Name: deoxyuridine + phosphate -> deoxy-D-ribose 1-phosphate + uracil
Description: Reaction transforming deoxyuridine, phosphate into deoxy-D-ribose 1-phosphate, uracil
Type: state transition
Pathway Components: deoxyuridine + phosphate - DeoA -> deoxy-D-ribose 1-phosphate + uracil
Components:
Function Name Type
catalyzer DeoA protein
product deoxy-D-ribose 1-phosphate simple_molecule
reactant deoxyuridine simple_molecule
reactant phosphate simple_molecule
product uracil simple_molecule
deoCABD_mRNA DeoB
Name: deoCABD_mRNA -> DeoB
Description: Translation of DeoB
Type: translation
Pathway Components: deoCABD_mRNA -> DeoB
Components:
Function Name Type
product DeoB protein
reactant deoCABD_mRNA RNA
DeoB deoxy-D-ribose 1-phosphate 2-deoxy-D-ribose 5-phosphate
Name: deoxy-D-ribose 1-phosphate -> 2-deoxy-D-ribose 5-phosphate
Description: Reaction transforming deoxy-D-ribose 1-phosphate into 2-deoxy-D-ribose 5-phosphate
Type: state transition
Pathway Components: deoxy-D-ribose 1-phosphate - DeoB -> 2-deoxy-D-ribose 5-phosphate
Components:
Function Name Type
product 2-deoxy-D-ribose 5-phosphate simple_molecule
catalyzer DeoB protein
reactant deoxy-D-ribose 1-phosphate simple_molecule
DeoB ribose-1-phosphate ribose-5P
Name: ribose-1-phosphate -> ribose-5P
Description: Reaction transforming ribose-1-phosphate into ribose-5P
Type: state transition
Pathway Components: ribose-1-phosphate - DeoB -> ribose-5P
Components:
Function Name Type
catalyzer DeoB protein
reactant ribose-1-phosphate simple_molecule
product ribose-5P simple_molecule
deoCABD_mRNA DeoD
Name: deoCABD_mRNA -> DeoD
Description: Translation of DeoD
Type: translation
Pathway Components: deoCABD_mRNA -> DeoD
Components:
Function Name Type
product DeoD protein
reactant deoCABD_mRNA RNA
DeoD nebularine + phosphate ribose-1-phosphate + purine base
Name: nebularine + phosphate -> ribose-1-phosphate + purine base
Description: Reaction transforming nebularine, phosphate into ribose-1-phosphate, purine base
Type: state transition
Pathway Components: nebularine + phosphate - DeoD -> ribose-1-phosphate + purine base
Components:
Function Name Type
catalyzer DeoD protein
reactant nebularine simple_molecule
reactant phosphate simple_molecule
product purine base simple_molecule
product ribose-1-phosphate simple_molecule
DeoD phosphate + guanosine ribose-1-phosphate + guanine
Name: phosphate + guanosine -> ribose-1-phosphate + guanine
Description: Reaction transforming phosphate, guanosine into ribose-1-phosphate, guanine
Type: state transition
Pathway Components: phosphate + guanosine - DeoD -> ribose-1-phosphate + guanine
Components:
Function Name Type
catalyzer DeoD protein
product guanine simple_molecule
reactant guanosine simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
DeoD adenosine deoxyguanosine + phosphate deoxy-D-ribose 1-phosphate + guanine
Name: deoxyguanosine + phosphate -> deoxy-D-ribose 1-phosphate + guanine
Description: Reaction transforming deoxyguanosine, phosphate into deoxy-D-ribose 1-phosphate, guanine
Type: state transition
Pathway Components: deoxyguanosine + phosphate - DeoD - adenosine -> deoxy-D-ribose 1-phosphate + guanine
Components:
Function Name Type
catalyzer DeoD protein
inhibitor adenosine simple_molecule
product deoxy-D-ribose 1-phosphate simple_molecule
reactant deoxyguanosine simple_molecule
product guanine simple_molecule
reactant phosphate simple_molecule
DeoD phosphate + inosine ribose-1-phosphate + hypoxanthine
Name: phosphate + inosine -> ribose-1-phosphate + hypoxanthine
Description: Reaction transforming phosphate, inosine into ribose-1-phosphate, hypoxanthine
Type: state transition
Pathway Components: phosphate + inosine - DeoD -> ribose-1-phosphate + hypoxanthine
Components:
Function Name Type
catalyzer DeoD protein
product hypoxanthine simple_molecule
reactant inosine simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
DeoD deoxyinosine + phosphate deoxy-D-ribose 1-phosphate + hypoxanthine
Name: deoxyinosine + phosphate -> deoxy-D-ribose 1-phosphate + hypoxanthine
Description: Reaction transforming deoxyinosine, phosphate into deoxy-D-ribose 1-phosphate, hypoxanthine
Type: state transition
Pathway Components: deoxyinosine + phosphate - DeoD -> deoxy-D-ribose 1-phosphate + hypoxanthine
Components:
Function Name Type
catalyzer DeoD protein
product deoxy-D-ribose 1-phosphate simple_molecule
reactant deoxyinosine simple_molecule
product hypoxanthine simple_molecule
reactant phosphate simple_molecule
DeoD phosphate + adenosine ribose-1-phosphate + adenine
Name: phosphate + adenosine -> ribose-1-phosphate + adenine
Description: Reaction transforming phosphate, adenosine into ribose-1-phosphate, adenine
Type: state transition
Pathway Components: phosphate + adenosine - DeoD -> ribose-1-phosphate + adenine
Components:
Function Name Type
catalyzer DeoD protein
product adenine simple_molecule
reactant adenosine simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
DeoD deoxyadenosine + phosphate deoxy-D-ribose 1-phosphate + adenine
Name: deoxyadenosine + phosphate -> deoxy-D-ribose 1-phosphate + adenine
Description: Reaction transforming deoxyadenosine, phosphate into deoxy-D-ribose 1-phosphate, adenine
Type: state transition
Pathway Components: deoxyadenosine + phosphate - DeoD -> deoxy-D-ribose 1-phosphate + adenine
Components:
Function Name Type
catalyzer DeoD protein
product adenine simple_molecule
product deoxy-D-ribose 1-phosphate simple_molecule
reactant deoxyadenosine simple_molecule
reactant phosphate simple_molecule
tsx_mRNA Tsx
Name: tsx_mRNA -> Tsx
Description: Translation of Tsx
Type: translation
Pathway Components: tsx_mRNA -> Tsx
Components:
Function Name Type
product Tsx protein
reactant tsx_mRNA RNA
NupG Tsx nucleoside_Ext nucleoside
Name: nucleoside_Ext -> nucleoside
Description: Transport of nucleoside_Ext through a bacterial membrane, leading to the presence of nucleoside inside the cell.
Type: transport
Pathway Components: nucleoside_Ext - NupG - Tsx -> nucleoside
Components:
Function Name Type
catalyzer NupG protein
catalyzer Tsx protein
product nucleoside simple_molecule
reactant nucleoside_Ext simple_molecule
nupG_mRNA NupG
Name: nupG_mRNA -> NupG
Description: Translation of NupG
Type: translation
Pathway Components: nupG_mRNA -> NupG
Components:
Function Name Type
product NupG protein
reactant nupG_mRNA RNA
NupG uridine_Ext uridine
Name: uridine_Ext -> uridine
Description: Transport of uridine_Ext through a bacterial membrane, leading to the presence of uridine inside the cell.
Type: transport
Pathway Components: uridine_Ext - NupG -> uridine
Components:
Function Name Type
catalyzer NupG protein
product uridine simple_molecule
reactant uridine_Ext simple_molecule
NupG thymidine_Ext thymidine
Name: thymidine_Ext -> thymidine
Description: Transport of thymidine_Ext through a bacterial membrane, leading to the presence of thymidine inside the cell.
Type: transport
Pathway Components: thymidine_Ext - NupG -> thymidine
Components:
Function Name Type
catalyzer NupG protein
product thymidine simple_molecule
reactant thymidine_Ext simple_molecule
NupG inosine_Ext inosine
Name: inosine_Ext -> inosine
Description: Transport of inosine_Ext through a bacterial membrane, leading to the presence of inosine inside the cell.
Type: transport
Pathway Components: inosine_Ext - NupG -> inosine
Components:
Function Name Type
catalyzer NupG protein
product inosine simple_molecule
reactant inosine_Ext simple_molecule
NupG deoxyuridine_Ext deoxyuridine
Name: deoxyuridine_Ext -> deoxyuridine
Description: Transport of deoxyuridine_Ext through a bacterial membrane, leading to the presence of deoxyuridine inside the cell.
Type: transport
Pathway Components: deoxyuridine_Ext - NupG -> deoxyuridine
Components:
Function Name Type
catalyzer NupG protein
product deoxyuridine simple_molecule
reactant deoxyuridine_Ext simple_molecule
NupG deoxyinosine_Ext deoxyinosine
Name: deoxyinosine_Ext -> deoxyinosine
Description: Transport of deoxyinosine_Ext through a bacterial membrane, leading to the presence of deoxyinosine inside the cell.
Type: transport
Pathway Components: deoxyinosine_Ext - NupG -> deoxyinosine
Components:
Function Name Type
catalyzer NupG protein
product deoxyinosine simple_molecule
reactant deoxyinosine_Ext simple_molecule
NupG d-cytidine_Ext d-cytidine
Name: d-cytidine_Ext -> d-cytidine
Description: Transport of d-cytidine_Ext through a bacterial membrane, leading to the presence of d-cytidine inside the cell.
Type: transport
Pathway Components: d-cytidine_Ext - NupG -> d-cytidine
Components:
Function Name Type
catalyzer NupG protein
product d-cytidine simple_molecule
reactant d-cytidine_Ext simple_molecule
NupG deoxyadenosine_Ext deoxyadenosine
Name: deoxyadenosine_Ext -> deoxyadenosine
Description: Transport of deoxyadenosine_Ext through a bacterial membrane, leading to the presence of deoxyadenosine inside the cell.
Type: transport
Pathway Components: deoxyadenosine_Ext - NupG -> deoxyadenosine
Components:
Function Name Type
catalyzer NupG protein
product deoxyadenosine simple_molecule
reactant deoxyadenosine_Ext simple_molecule
NupG cytidine_Ext cytidine
Name: cytidine_Ext -> cytidine
Description: Transport of cytidine_Ext through a bacterial membrane, leading to the presence of cytidine inside the cell.
Type: transport
Pathway Components: cytidine_Ext - NupG -> cytidine
Components:
Function Name Type
catalyzer NupG protein
product cytidine simple_molecule
reactant cytidine_Ext simple_molecule
NupG adenosine_Ext adenosine
Name: adenosine_Ext -> adenosine
Description: Transport of adenosine_Ext through a bacterial membrane, leading to the presence of adenosine inside the cell.
Type: transport
Pathway Components: adenosine_Ext - NupG -> adenosine
Components:
Function Name Type
catalyzer NupG protein
product adenosine simple_molecule
reactant adenosine_Ext simple_molecule
NupG xanthosine_Ext xanthosine
Name: xanthosine_Ext -> xanthosine
Description: Transport of xanthosine_Ext through a bacterial membrane, leading to the presence of xanthosine inside the cell.
Type: transport
Pathway Components: xanthosine_Ext - NupG -> xanthosine
Components:
Function Name Type
catalyzer NupG protein
product xanthosine simple_molecule
reactant xanthosine_Ext simple_molecule
xanthosine ribose-1-phosphate
Name: xanthosine -> ribose-1-phosphate
Description: Transformation of xanthosine into ribose-1-phosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: xanthosine / XANTHOSINEPHOSPHORY-RXN / ribose-1-phosphate
Components:
Function Name Type
product ribose-1-phosphate simple_molecule
reactant xanthosine simple_molecule
adenosine inosine
Name: adenosine -> inosine
Description: Transformation of adenosine into inosine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: adenosine / ADENODEAMIN-RXN / inosine
Components:
Function Name Type
reactant adenosine simple_molecule
product inosine simple_molecule



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