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DcuR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-malate D-malate_Ext L-malate L-malate_Ext D-tartrate D-tartrate_Ext DctA DcuB DcuR DpiA DpiB FrdA FrdB FrdC FrdD FumB asp asp_Ext phosphate a C4-dicarboxylate a C4-dicarboxylate_Ext a menaquinol menaquinone dctA dctA_mRNA dcuB-fumB dcuB-fumB_mRNA dpiBA dpiBA_mRNA frdABCD frdABCD_mRNA fumarate fumarate_Ext orotate orotate_Ext oxalacetate succinate DcuR phosphate succinate succinate_Ext succinate fumarate succinate FrdA FrdB FrdC FrdD


Gensor Unit       
Name: DcuR
Signal name: C4-dicarboxylates (fumarate
succinate).
Classification:
Groups: GUs related to the two-component system
Gene Ontology Terms (GO): biological_process GO:0015740 - C4-dicarboxylate transport
GO:0070778 - L-aspartate transmembrane transport
GO:0009061 - anaerobic respiration
GO:0044780 - bacterial-type flagellum assembly
GO:0071973 - bacterial-type flagellum-dependent cell motility
GO:0042710 - biofilm formation
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0045284 - plasma membrane fumarate reductase complex
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molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0051538 - 3 iron, 4 sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0015556 - C4-dicarboxylate transmembrane transporter activity
GO:0047808 - D(-)-tartrate dehydratase activity
GO:0003677 - DNA binding
GO:0071949 - FAD binding
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Components: Show/Hide Components Table (38 more...)
Function Name Type
simple_molecule C4-dicarboxylate simple_molecule
simple_molecule C4-dicarboxylate_Ext simple_molecule
protein DctA protein
protein DcuB protein
protein DcuR protein
complex DcuR-phosphate complex
protein DpiA protein
protein DpiB protein
protein FrdA protein
complex FrdA-FrdB-FrdC-FrdD complex
protein FrdB protein
protein FrdC protein
protein FrdD protein
protein FumB protein
simple_molecule aspartate simple_molecule
simple_molecule aspartate_Ext simple_molecule
gene dctA gene
RNA dctA_mRNA RNA
gene dcuB-fumB gene
RNA dcuB-fumB_mRNA RNA
gene dpiBA gene
RNA dpiBA_mRNA RNA
gene frdABCD gene
RNA frdABCD_mRNA RNA
simple_molecule fumarate simple_molecule
simple_molecule fumarate_Ext simple_molecule
simple_molecule malate simple_molecule
simple_molecule malate_Ext simple_molecule
simple_molecule menaquinol simple_molecule
simple_molecule orotate simple_molecule
simple_molecule orotate_Ext simple_molecule
simple_molecule oxalacetate simple_molecule
simple_molecule phosphate simple_molecule
simple_molecule succinate simple_molecule
simple_molecule succinate_Ext simple_molecule
simple_molecule tartrate simple_molecule
simple_molecule tartrate_Ext simple_molecule
simple_molecule vitamin K2 simple_molecule


Reactions       
Showing 28 reactions
phosphate + DcuR DcuR-phosphate
Name: phosphate + DcuR -> DcuR-phosphate
Description: Reaction transforming phosphate, DcuR into DcuR-phosphate
Type: state transition
Pathway Components: phosphate + DcuR -> DcuR-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant DcuR protein nd nd
product DcuR-phosphate complex nd nd
reactant phosphate simple_molecule nd nd
DcuR-phosphate dctA dctA_mRNA
Name: dctA -> dctA_mRNA
Description: Transcription of transcription unit dctA. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dctA - DcuR-phosphate -> dctA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DcuR-phosphate complex nd nd
reactant dctA gene nd nd
product dctA_mRNA RNA nd nd
DcuR-phosphate dcuB-fumB dcuB-fumB_mRNA
Name: dcuB-fumB -> dcuB-fumB_mRNA
Description: Transcription of transcription unit dcuB-fumB. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dcuB-fumB - DcuR-phosphate -> dcuB-fumB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DcuR-phosphate complex nd nd
reactant dcuB-fumB gene nd nd
product dcuB-fumB_mRNA RNA nd nd
DcuR-phosphate dpiBA dpiBA_mRNA
Name: dpiBA -> dpiBA_mRNA
Description: Transcription of transcription unit dpiBA. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dpiBA - DcuR-phosphate -> dpiBA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DcuR-phosphate complex nd nd
reactant dpiBA gene nd nd
product dpiBA_mRNA RNA nd nd
DcuR-phosphate frdABCD frdABCD_mRNA
Name: frdABCD -> frdABCD_mRNA
Description: Transcription of transcription unit frdABCD. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: frdABCD - DcuR-phosphate -> frdABCD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DcuR-phosphate complex nd nd
reactant frdABCD gene nd nd
product frdABCD_mRNA RNA nd nd
dpiBA_mRNA DpiB
Name: dpiBA_mRNA -> DpiB
Description: Translation of DpiB
Type: translation
Pathway Components: dpiBA_mRNA -> DpiB
Components:
Function Name Type Evidence Reference(s)
product DpiB protein nd nd
reactant dpiBA_mRNA RNA nd nd
dpiBA_mRNA DpiA
Name: dpiBA_mRNA -> DpiA
Description: Translation of DpiA
Type: translation
Pathway Components: dpiBA_mRNA -> DpiA
Components:
Function Name Type Evidence Reference(s)
product DpiA protein nd nd
reactant dpiBA_mRNA RNA nd nd
frdABCD_mRNA FrdA
Name: frdABCD_mRNA -> FrdA
Description: Translation of FrdA
Type: translation
Pathway Components: frdABCD_mRNA -> FrdA
Components:
Function Name Type Evidence Reference(s)
product FrdA protein nd nd
reactant frdABCD_mRNA RNA nd nd
FrdA + FrdD + FrdB + FrdC FrdA-FrdB-FrdC-FrdD
Name: FrdA + FrdD + FrdB + FrdC -> FrdA-FrdB-FrdC-FrdD
Description: Reaction transforming FrdA, FrdD, FrdB, FrdC into FrdA-FrdB-FrdC-FrdD
Type: state transition
Pathway Components: FrdA + FrdD + FrdB + FrdC -> FrdA-FrdB-FrdC-FrdD
Components:
Function Name Type Evidence Reference(s)
reactant FrdA protein nd nd
product FrdA-FrdB-FrdC-FrdD complex nd nd
reactant FrdB protein nd nd
reactant FrdC protein nd nd
reactant FrdD protein nd nd
FrdA-FrdB-FrdC-FrdD oxalacetate menaquinol + fumarate vitamin K2 + succinate
Name: menaquinol + fumarate -> vitamin K2 + succinate
Description: Reaction transforming menaquinol, fumarate into vitamin K2, succinate
Type: state transition
Pathway Components: menaquinol + fumarate - FrdA-FrdB-FrdC-FrdD - oxalacetate -> vitamin K2 + succinate
Components:
Function Name Type Evidence Reference(s)
catalyzer FrdA-FrdB-FrdC-FrdD complex nd nd
reactant fumarate simple_molecule nd nd
reactant menaquinol simple_molecule nd nd
inhibitor oxalacetate simple_molecule nd nd
product succinate simple_molecule nd nd
product vitamin K2 simple_molecule nd nd
frdABCD_mRNA FrdB
Name: frdABCD_mRNA -> FrdB
Description: Translation of FrdB
Type: translation
Pathway Components: frdABCD_mRNA -> FrdB
Components:
Function Name Type Evidence Reference(s)
product FrdB protein nd nd
reactant frdABCD_mRNA RNA nd nd
frdABCD_mRNA FrdC
Name: frdABCD_mRNA -> FrdC
Description: Translation of FrdC
Type: translation
Pathway Components: frdABCD_mRNA -> FrdC
Components:
Function Name Type Evidence Reference(s)
product FrdC protein nd nd
reactant frdABCD_mRNA RNA nd nd
frdABCD_mRNA FrdD
Name: frdABCD_mRNA -> FrdD
Description: Translation of FrdD
Type: translation
Pathway Components: frdABCD_mRNA -> FrdD
Components:
Function Name Type Evidence Reference(s)
product FrdD protein nd nd
reactant frdABCD_mRNA RNA nd nd
dctA_mRNA DctA
Name: dctA_mRNA -> DctA
Description: Translation of DctA
Type: translation
Pathway Components: dctA_mRNA -> DctA
Components:
Function Name Type Evidence Reference(s)
product DctA protein nd nd
reactant dctA_mRNA RNA nd nd
DctA DcuB C4-dicarboxylate_Ext C4-dicarboxylate
Name: C4-dicarboxylate_Ext -> C4-dicarboxylate
Description: Transport of C4-dicarboxylate_Ext through a bacterial membrane, leading to the presence of C4-dicarboxylate inside the cell.
Type: transport
Pathway Components: C4-dicarboxylate_Ext - DctA - DcuB -> C4-dicarboxylate
Components:
Function Name Type Evidence Reference(s)
product C4-dicarboxylate simple_molecule nd nd
reactant C4-dicarboxylate_Ext simple_molecule nd nd
catalyzer DctA protein nd nd
catalyzer DcuB protein nd nd
DctA malate_Ext malate
Name: malate_Ext -> malate
Description: Transport of malate_Ext through a bacterial membrane, leading to the presence of malate inside the cell.
Type: transport
Pathway Components: malate_Ext - DctA -> malate
Components:
Function Name Type Evidence Reference(s)
catalyzer DctA protein nd nd
product malate simple_molecule nd nd
reactant malate_Ext simple_molecule nd nd
DctA aspartate_Ext aspartate
Name: aspartate_Ext -> aspartate
Description: Transport of aspartate_Ext through a bacterial membrane, leading to the presence of aspartate inside the cell.
Type: transport
Pathway Components: aspartate_Ext - DctA -> aspartate
Components:
Function Name Type Evidence Reference(s)
catalyzer DctA protein nd nd
product aspartate simple_molecule nd nd
reactant aspartate_Ext simple_molecule nd nd
DctA orotate_Ext orotate
Name: orotate_Ext -> orotate
Description: Transport of orotate_Ext through a bacterial membrane, leading to the presence of orotate inside the cell.
Type: transport
Pathway Components: orotate_Ext - DctA -> orotate
Components:
Function Name Type Evidence Reference(s)
catalyzer DctA protein nd nd
product orotate simple_molecule nd nd
reactant orotate_Ext simple_molecule nd nd
DctA fumarate_Ext fumarate
Name: fumarate_Ext -> fumarate
Description: Transport of fumarate_Ext through a bacterial membrane, leading to the presence of fumarate inside the cell.
Type: transport
Pathway Components: fumarate_Ext - DctA -> fumarate
Components:
Function Name Type Evidence Reference(s)
catalyzer DctA protein nd nd
product fumarate simple_molecule nd nd
reactant fumarate_Ext simple_molecule nd nd
DctA succinate_Ext succinate
Name: succinate_Ext -> succinate
Description: Transport of succinate_Ext through a bacterial membrane, leading to the presence of succinate inside the cell.
Type: transport
Pathway Components: succinate_Ext - DctA -> succinate
Components:
Function Name Type Evidence Reference(s)
catalyzer DctA protein nd nd
product succinate simple_molecule nd nd
reactant succinate_Ext simple_molecule nd nd
dcuB-fumB_mRNA DcuB
Name: dcuB-fumB_mRNA -> DcuB
Description: Translation of DcuB
Type: translation
Pathway Components: dcuB-fumB_mRNA -> DcuB
Components:
Function Name Type Evidence Reference(s)
product DcuB protein nd nd
reactant dcuB-fumB_mRNA RNA nd nd
DcuB succinate_Ext + tartrate_Ext succinate + tartrate
Name: succinate_Ext + tartrate_Ext -> succinate + tartrate
Description: Transport of succinate_Ext, tartrate_Ext through a bacterial membrane, leading to the presence of succinate, tartrate inside the cell.
Type: transport
Pathway Components: succinate_Ext + tartrate_Ext - DcuB -> succinate + tartrate
Components:
Function Name Type Evidence Reference(s)
catalyzer DcuB protein nd nd
product succinate simple_molecule nd nd
reactant succinate_Ext simple_molecule nd nd
product tartrate simple_molecule nd nd
reactant tartrate_Ext simple_molecule nd nd
DcuB succinate_Ext + malate_Ext succinate + malate
Name: succinate_Ext + malate_Ext -> succinate + malate
Description: Transport of succinate_Ext, malate_Ext through a bacterial membrane, leading to the presence of succinate, malate inside the cell.
Type: transport
Pathway Components: succinate_Ext + malate_Ext - DcuB -> succinate + malate
Components:
Function Name Type Evidence Reference(s)
catalyzer DcuB protein nd nd
product malate simple_molecule nd nd
reactant malate_Ext simple_molecule nd nd
product succinate simple_molecule nd nd
reactant succinate_Ext simple_molecule nd nd
DcuB succinate_Ext + aspartate_Ext succinate + aspartate
Name: succinate_Ext + aspartate_Ext -> succinate + aspartate
Description: Transport of succinate_Ext, aspartate_Ext through a bacterial membrane, leading to the presence of succinate, aspartate inside the cell.
Type: transport
Pathway Components: succinate_Ext + aspartate_Ext - DcuB -> succinate + aspartate
Components:
Function Name Type Evidence Reference(s)
catalyzer DcuB protein nd nd
product aspartate simple_molecule nd nd
reactant aspartate_Ext simple_molecule nd nd
product succinate simple_molecule nd nd
reactant succinate_Ext simple_molecule nd nd
DcuB succinate_Ext + fumarate_Ext succinate + fumarate
Name: succinate_Ext + fumarate_Ext -> succinate + fumarate
Description: Transport of succinate_Ext, fumarate_Ext through a bacterial membrane, leading to the presence of succinate, fumarate inside the cell.
Type: transport
Pathway Components: succinate_Ext + fumarate_Ext - DcuB -> succinate + fumarate
Components:
Function Name Type Evidence Reference(s)
catalyzer DcuB protein nd nd
product fumarate simple_molecule nd nd
reactant fumarate_Ext simple_molecule nd nd
product succinate simple_molecule nd nd
reactant succinate_Ext simple_molecule nd nd
dcuB-fumB_mRNA FumB
Name: dcuB-fumB_mRNA -> FumB
Description: Translation of FumB
Type: translation
Pathway Components: dcuB-fumB_mRNA -> FumB
Components:
Function Name Type Evidence Reference(s)
product FumB protein nd nd
reactant dcuB-fumB_mRNA RNA nd nd
FumB malate fumarate
Name: malate -> fumarate
Description: Reaction transforming malate into fumarate
Type: state transition
Pathway Components: malate - FumB -> fumarate
Components:
Function Name Type Evidence Reference(s)
catalyzer FumB protein nd nd
product fumarate simple_molecule nd nd
reactant malate simple_molecule nd nd
FumB tartrate oxalacetate
Name: tartrate -> oxalacetate
Description: Reaction transforming tartrate into oxalacetate
Type: state transition
Pathway Components: tartrate - FumB -> oxalacetate
Components:
Function Name Type Evidence Reference(s)
catalyzer FumB protein nd nd
product oxalacetate simple_molecule nd nd
reactant tartrate simple_molecule nd nd



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