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DcuR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
dctA_mRNA FrdD frdABCD C4-dicarboxylate_Ext menaquinol malate_Ext DpiB FrdD orotate DcuB tartrate DcuR dctA aspartate dpiBA_mRNA FrdC malate C4-dicarboxylate DctA succinate fumarate aspartate_Ext orotate_Ext dcuB-fumB_mRNA oxalacetate phosphate fumarate_Ext DpiA FrdA FumB dcuB-fumB FrdB frdABCD_mRNA FrdB tartrate_Ext phosphate dpiBA DcuR succinate_Ext vitamin K2 FrdA FrdC fumarate malate_Ext fumarate_Ext succinate succinate fumarate malate


Gensor Unit       
Name: DcuR
Signal name: C4-dicarboxylates (fumarate
succinate).
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Energy production and conversion
Signal transduction mechanisms
Gene Ontology Terms (GO): biological_process GO:0015740 - C4-dicarboxylate transport
GO:0070778 - L-aspartate transmembrane transport
GO:0009061 - anaerobic respiration
GO:0044780 - bacterial-type flagellum assembly
GO:0042710 - biofilm formation
GO:0006974 - cellular response to DNA damage stimulus
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
GO:0016020 - membrane
GO:0005886 - plasma membrane
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molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0051538 - 3 iron, 4 sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0015556 - C4-dicarboxylate transmembrane transporter activity
GO:0047808 - D(-)-tartrate dehydratase activity
GO:0003677 - DNA binding
Read more >
Components:
  Function Name Type
  simple_molecule C4-dicarboxylate simple_molecule
  simple_molecule C4-dicarboxylate_Ext simple_molecule
  protein DctA protein
  protein DcuB protein
  protein DcuR protein
  complex DcuR-phosphate complex
  protein DpiA protein
  protein DpiB protein
  protein FrdA protein
  complex FrdA-FrdB-FrdC-FrdD complex
  protein FrdB protein
  protein FrdC protein
  protein FrdD protein
  protein FumB protein
  simple_molecule aspartate simple_molecule
  simple_molecule aspartate_Ext simple_molecule
  gene dctA gene
  RNA dctA_mRNA RNA
  gene dcuB-fumB gene
  RNA dcuB-fumB_mRNA RNA
  gene dpiBA gene
  RNA dpiBA_mRNA RNA
  gene frdABCD gene
  RNA frdABCD_mRNA RNA
  simple_molecule fumarate simple_molecule
  simple_molecule fumarate_Ext simple_molecule
  simple_molecule malate simple_molecule
  simple_molecule malate_Ext simple_molecule
  simple_molecule menaquinol simple_molecule
  simple_molecule orotate simple_molecule
  simple_molecule orotate_Ext simple_molecule
  simple_molecule oxalacetate simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule succinate simple_molecule
  simple_molecule succinate_Ext simple_molecule
  simple_molecule tartrate simple_molecule
  simple_molecule tartrate_Ext simple_molecule
  simple_molecule vitamin K2 simple_molecule


Reactions       
Showing 28 reactions
phosphate + DcuR DcuR-phosphate
Name: phosphate + DcuR -> DcuR-phosphate
Description: Reaction transforming phosphate, DcuR into DcuR-phosphate
Type: state transition
Pathway Components: phosphate + DcuR -> DcuR-phosphate
Components:
Function Name Type
reactant DcuR protein
product DcuR-phosphate complex
reactant phosphate simple_molecule
DcuR-phosphate dctA dctA_mRNA
Name: dctA -> dctA_mRNA
Description: Transcription of transcription unit dctA. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dctA - DcuR-phosphate -> dctA_mRNA
Components:
Function Name Type
activator DcuR-phosphate complex
reactant dctA gene
product dctA_mRNA RNA
DcuR-phosphate dcuB-fumB dcuB-fumB_mRNA
Name: dcuB-fumB -> dcuB-fumB_mRNA
Description: Transcription of transcription unit dcuB-fumB. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dcuB-fumB - DcuR-phosphate -> dcuB-fumB_mRNA
Components:
Function Name Type
activator DcuR-phosphate complex
reactant dcuB-fumB gene
product dcuB-fumB_mRNA RNA
DcuR-phosphate dpiBA dpiBA_mRNA
Name: dpiBA -> dpiBA_mRNA
Description: Transcription of transcription unit dpiBA. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: dpiBA - DcuR-phosphate -> dpiBA_mRNA
Components:
Function Name Type
activator DcuR-phosphate complex
reactant dpiBA gene
product dpiBA_mRNA RNA
DcuR-phosphate frdABCD frdABCD_mRNA
Name: frdABCD -> frdABCD_mRNA
Description: Transcription of transcription unit frdABCD. Reaction activation by DcuR-phosphate.
Type: transcription
Pathway Components: frdABCD - DcuR-phosphate -> frdABCD_mRNA
Components:
Function Name Type
activator DcuR-phosphate complex
reactant frdABCD gene
product frdABCD_mRNA RNA
dpiBA_mRNA DpiB
Name: dpiBA_mRNA -> DpiB
Description: Translation of DpiB
Type: translation
Pathway Components: dpiBA_mRNA -> DpiB
Components:
Function Name Type
product DpiB protein
reactant dpiBA_mRNA RNA
dpiBA_mRNA DpiA
Name: dpiBA_mRNA -> DpiA
Description: Translation of DpiA
Type: translation
Pathway Components: dpiBA_mRNA -> DpiA
Components:
Function Name Type
product DpiA protein
reactant dpiBA_mRNA RNA
dctA_mRNA DctA
Name: dctA_mRNA -> DctA
Description: Translation of DctA
Type: translation
Pathway Components: dctA_mRNA -> DctA
Components:
Function Name Type
product DctA protein
reactant dctA_mRNA RNA
DctA C4-dicarboxylate_Ext C4-dicarboxylate
Name: C4-dicarboxylate_Ext -> C4-dicarboxylate
Description: Transport of C4-dicarboxylate_Ext through a bacterial membrane, leading to the presence of C4-dicarboxylate inside the cell.
Type: transport
Pathway Components: C4-dicarboxylate_Ext - DctA -> C4-dicarboxylate
Components:
Function Name Type
product C4-dicarboxylate simple_molecule
reactant C4-dicarboxylate_Ext simple_molecule
catalyzer DctA protein
DctA aspartate_Ext aspartate
Name: aspartate_Ext -> aspartate
Description: Transport of aspartate_Ext through a bacterial membrane, leading to the presence of aspartate inside the cell.
Type: transport
Pathway Components: aspartate_Ext - DctA -> aspartate
Components:
Function Name Type
catalyzer DctA protein
product aspartate simple_molecule
reactant aspartate_Ext simple_molecule
DctA succinate_Ext succinate
Name: succinate_Ext -> succinate
Description: Transport of succinate_Ext through a bacterial membrane, leading to the presence of succinate inside the cell.
Type: transport
Pathway Components: succinate_Ext - DctA -> succinate
Components:
Function Name Type
catalyzer DctA protein
product succinate simple_molecule
reactant succinate_Ext simple_molecule
DctA DcuB fumarate_Ext fumarate
Name: fumarate_Ext -> fumarate
Description: Transport of fumarate_Ext through a bacterial membrane, leading to the presence of fumarate inside the cell.
Type: transport
Pathway Components: fumarate_Ext - DctA - DcuB -> fumarate
Components:
Function Name Type
catalyzer DctA protein
catalyzer DcuB protein
product fumarate simple_molecule
reactant fumarate_Ext simple_molecule
DctA malate_Ext malate
Name: malate_Ext -> malate
Description: Transport of malate_Ext through a bacterial membrane, leading to the presence of malate inside the cell.
Type: transport
Pathway Components: malate_Ext - DctA -> malate
Components:
Function Name Type
catalyzer DctA protein
product malate simple_molecule
reactant malate_Ext simple_molecule
DctA orotate_Ext orotate
Name: orotate_Ext -> orotate
Description: Transport of orotate_Ext through a bacterial membrane, leading to the presence of orotate inside the cell.
Type: transport
Pathway Components: orotate_Ext - DctA -> orotate
Components:
Function Name Type
catalyzer DctA protein
product orotate simple_molecule
reactant orotate_Ext simple_molecule
dcuB-fumB_mRNA DcuB
Name: dcuB-fumB_mRNA -> DcuB
Description: Translation of DcuB
Type: translation
Pathway Components: dcuB-fumB_mRNA -> DcuB
Components:
Function Name Type
product DcuB protein
reactant dcuB-fumB_mRNA RNA
DcuB succinate_Ext + fumarate_Ext succinate + fumarate
Name: succinate_Ext + fumarate_Ext -> succinate + fumarate
Description: Transport of succinate_Ext, fumarate_Ext through a bacterial membrane, leading to the presence of succinate, fumarate inside the cell.
Type: transport
Pathway Components: succinate_Ext + fumarate_Ext - DcuB -> succinate + fumarate
Components:
Function Name Type
catalyzer DcuB protein
product fumarate simple_molecule
reactant fumarate_Ext simple_molecule
product succinate simple_molecule
reactant succinate_Ext simple_molecule
DcuB succinate_Ext + malate_Ext succinate + malate
Name: succinate_Ext + malate_Ext -> succinate + malate
Description: Transport of succinate_Ext, malate_Ext through a bacterial membrane, leading to the presence of succinate, malate inside the cell.
Type: transport
Pathway Components: succinate_Ext + malate_Ext - DcuB -> succinate + malate
Components:
Function Name Type
catalyzer DcuB protein
product malate simple_molecule
reactant malate_Ext simple_molecule
product succinate simple_molecule
reactant succinate_Ext simple_molecule
DcuB aspartate_Ext + succinate_Ext succinate + aspartate
Name: aspartate_Ext + succinate_Ext -> succinate + aspartate
Description: Transport of aspartate_Ext, succinate_Ext through a bacterial membrane, leading to the presence of succinate, aspartate inside the cell.
Type: transport
Pathway Components: aspartate_Ext + succinate_Ext - DcuB -> succinate + aspartate
Components:
Function Name Type
catalyzer DcuB protein
product aspartate simple_molecule
reactant aspartate_Ext simple_molecule
product succinate simple_molecule
reactant succinate_Ext simple_molecule
DcuB succinate_Ext + tartrate_Ext succinate + tartrate
Name: succinate_Ext + tartrate_Ext -> succinate + tartrate
Description: Transport of succinate_Ext, tartrate_Ext through a bacterial membrane, leading to the presence of succinate, tartrate inside the cell.
Type: transport
Pathway Components: succinate_Ext + tartrate_Ext - DcuB -> succinate + tartrate
Components:
Function Name Type
catalyzer DcuB protein
product succinate simple_molecule
reactant succinate_Ext simple_molecule
product tartrate simple_molecule
reactant tartrate_Ext simple_molecule
dcuB-fumB_mRNA FumB
Name: dcuB-fumB_mRNA -> FumB
Description: Translation of FumB
Type: translation
Pathway Components: dcuB-fumB_mRNA -> FumB
Components:
Function Name Type
product FumB protein
reactant dcuB-fumB_mRNA RNA
FumB malate fumarate
Name: malate -> fumarate
Description: Reaction transforming malate into fumarate
Type: state transition
Pathway Components: malate - FumB -> fumarate
Components:
Function Name Type
catalyzer FumB protein
product fumarate simple_molecule
reactant malate simple_molecule
FumB tartrate oxalacetate
Name: tartrate -> oxalacetate
Description: Reaction transforming tartrate into oxalacetate
Type: state transition
Pathway Components: tartrate - FumB -> oxalacetate
Components:
Function Name Type
catalyzer FumB protein
product oxalacetate simple_molecule
reactant tartrate simple_molecule
frdABCD_mRNA FrdA
Name: frdABCD_mRNA -> FrdA
Description: Translation of FrdA
Type: translation
Pathway Components: frdABCD_mRNA -> FrdA
Components:
Function Name Type
product FrdA protein
reactant frdABCD_mRNA RNA
FrdA + FrdB + FrdD + FrdC FrdA-FrdB-FrdC-FrdD
Name: FrdA + FrdB + FrdD + FrdC -> FrdA-FrdB-FrdC-FrdD
Description: Reaction transforming FrdA, FrdB, FrdD, FrdC into FrdA-FrdB-FrdC-FrdD
Type: state transition
Pathway Components: FrdA + FrdB + FrdD + FrdC -> FrdA-FrdB-FrdC-FrdD
Components:
Function Name Type
reactant FrdA protein
product FrdA-FrdB-FrdC-FrdD complex
reactant FrdB protein
reactant FrdC protein
reactant FrdD protein
FrdA-FrdB-FrdC-FrdD oxalacetate menaquinol + fumarate vitamin K2 + succinate
Name: menaquinol + fumarate -> vitamin K2 + succinate
Description: Reaction transforming menaquinol, fumarate into vitamin K2, succinate
Type: state transition
Pathway Components: menaquinol + fumarate - FrdA-FrdB-FrdC-FrdD - oxalacetate -> vitamin K2 + succinate
Components:
Function Name Type
catalyzer FrdA-FrdB-FrdC-FrdD complex
reactant fumarate simple_molecule
reactant menaquinol simple_molecule
inhibitor oxalacetate simple_molecule
product succinate simple_molecule
product vitamin K2 simple_molecule
frdABCD_mRNA FrdB
Name: frdABCD_mRNA -> FrdB
Description: Translation of FrdB
Type: translation
Pathway Components: frdABCD_mRNA -> FrdB
Components:
Function Name Type
product FrdB protein
reactant frdABCD_mRNA RNA
frdABCD_mRNA FrdC
Name: frdABCD_mRNA -> FrdC
Description: Translation of FrdC
Type: translation
Pathway Components: frdABCD_mRNA -> FrdC
Components:
Function Name Type
product FrdC protein
reactant frdABCD_mRNA RNA
frdABCD_mRNA FrdD
Name: frdABCD_mRNA -> FrdD
Description: Translation of FrdD
Type: translation
Pathway Components: frdABCD_mRNA -> FrdD
Components:
Function Name Type
product FrdD protein
reactant frdABCD_mRNA RNA



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