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CytR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2'-deoxy-alpha-D-ribose 1-phosphate 2'-deoxyadenosine 2'-deoxyadenosine_Ext 2'-deoxycytidine 2'-deoxycytidine_Ext 2'-deoxyguanosine 2'-deoxyinosine 2'-deoxyinosine_Ext 2'-deoxyuridine 2'-deoxyuridine_Ext 2-deoxy-D-ribose-5-phosphate Cdd CytR cytidine D-glyceraldehyde 3-phosphate ribose-5P DeoA DeoB DeoC DeoD NupC NupG PpiA RpoH Tsx Udp YcdZ nucleoside nucleoside_Ext acetaldehyde adenine adenosine adenosine_Ext alpha-D-ribose 1-phosphate ammonia cdd cdd_mRNA cytR cytR_mRNA cytidine cytidine_Ext deoCABD deoCABD_mRNA guanine guanosine hypoxanthine inosine inosine_Ext nupC nupC_mRNA nupG nupG_mRNA peptidylproline (omega = 0) peptidylproline (omega = 180) ppiA ppiA_mRNA rpoH rpoH_mRNA thymidine thymidine_Ext thymine tsx tsx_mRNA udp udp_mRNA uracil uridine uridine_Ext xanthosine xanthosine_Ext ycdZ ycdZ_mRNA CytR cytidine alpha-D-ribose 1-phosphate 2'-deoxy-alpha-D-ribose 1-phosphate uracil uridine ammonia 2'-deoxy-alpha-D-ribose 1-phosphate adenine hypoxanthine alpha-D-ribose 1-phosphate alpha-D-ribose 1-phosphate


Gensor Unit       
Name: CytR
Description: CytR negatively regulates the expression of genes involved in nucleoside and nucleotide transport and catabolic processes, in the absence of cytidine. The presence of cytidine induces the expression of genes related to the transport of nucleosides and nucleotides (e.g., uridine, inosine, 2′-deoxyuridine, etc.) and their transformation to ribose, ammonia, acetaldehyde, and glyceraldehyde-3-P.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0045892 - negative regulation of transcription, DNA-templated
GO:0046930 - pore complex
GO:0047844 - deoxycytidine deaminase activity
GO:0044206 - UMP salvage
GO:0008270 - zinc ion binding
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0003824 - catalytic activity
GO:0015212 - cytidine transmembrane transporter activity
GO:0015214 - pyrimidine nucleoside transmembrane transporter activity
GO:0016020 - membrane
GO:0009032 - thymidine phosphorylase activity
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Components:
Function Name Type
RNA ycdZ_mRNA RNA


Reactions       
Showing 52 reactions
cdd cdd_mRNA
Name: cdd -> cdd_mRNA
Description: Transcription of transcription unit cdd; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product cdd_mRNA RNA nd nd
reactant cdd gene nd nd
cytR cytR_mRNA
Name: cytR -> cytR_mRNA
Description: Transcription of transcription unit cytR; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product cytR_mRNA RNA nd nd
reactant cytR gene nd nd
deoCABD deoCABD_mRNA
Name: deoCABD -> deoCABD_mRNA
Description: Transcription of transcription unit deoCABD; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product deoCABD_mRNA RNA nd nd
reactant deoCABD gene nd nd
nupC nupC_mRNA
Name: nupC -> nupC_mRNA
Description: Transcription of transcription unit nupC; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product nupC_mRNA RNA nd nd
reactant nupC gene nd nd
nupG nupG_mRNA
Name: nupG -> nupG_mRNA
Description: Transcription of transcription unit nupG; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant nupG gene nd nd
product nupG_mRNA RNA nd nd
ppiA ppiA_mRNA
Name: ppiA -> ppiA_mRNA
Description: Transcription of transcription unit ppiA; reaction activation by CpxR-Phosphorylated.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant ppiA gene nd nd
product ppiA_mRNA RNA nd nd
rpoH rpoH_mRNA
Name: rpoH -> rpoH_mRNA
Description: Transcription of transcription unit rpoH; reaction activation by CpxR-Phosphorylated.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant rpoH gene nd nd
product rpoH_mRNA RNA nd nd
tsx tsx_mRNA
Name: tsx -> tsx_mRNA
Description: Transcription of transcription unit tsx; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant tsx gene nd nd
product tsx_mRNA RNA nd nd
udp udp_mRNA
Name: udp -> udp_mRNA
Description: Transcription of transcription unit udp; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product udp_mRNA RNA nd nd
reactant udp gene nd nd
ycdZ ycdZ_mRNA
Name: ycdZ -> ycdZ_mRNA
Description: Transcription of transcription unit ycdZ; reaction inhibition by CytR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant ycdZ gene nd nd
product ycdZ_mRNA RNA nd nd
CytR + Cytidine CytR-Cytidine
Name: CytR + Cytidine -> CytR-Cytidine
Description: Reaction transforming CytR, Cytidine into CytR-Cytidine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant Cytidine simple molecule nd nd
product CytR-Cytidine complex nd nd
reactant CytR protein nd nd
deoCABD_mRNA DeoB
Name: deoCABD_mRNA -> DeoB
Description: Translation of DeoB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant deoCABD_mRNA RNA nd nd
product DeoB protein nd nd
2′-deoxy-alpha-D-ribose 1-phosphate 2-deoxy-D-ribose-5-phosphate
Name: 2′-deoxy-alpha-D-ribose 1-phosphate -> 2-deoxy-D-ribose-5-phosphate
Description: Reaction transforming 2′-deoxy-alpha-D-ribose 1-phosphate into 2-deoxy-D-ribose-5-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
product 2-deoxy-D-ribose-5-phosphate simple molecule nd nd
alpha-D-ribose-1-phosphate D-ribose 5-phosphate
Name: alpha-D-ribose-1-phosphate -> D-ribose 5-phosphate
Description: Reaction transforming alpha-D-ribose-1-phosphate into D-ribose 5-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product D-ribose 5-phosphate simple molecule nd nd
reactant alpha-D-ribose-1-phosphate simple molecule nd nd
cdd_mRNA Cdd
Name: cdd_mRNA -> Cdd
Description: Translation of Cdd
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Cdd protein nd nd
reactant cdd_mRNA RNA nd nd
cytidine ammonia + uridine
Name: cytidine -> ammonia + uridine
Description: Reaction transforming cytidine into ammonia, uridine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product uridine simple molecule nd nd
product ammonia simple molecule nd nd
reactant cytidine simple molecule nd nd
2′-deoxycytidine ammonia + 2′-deoxyuridine
Name: 2′-deoxycytidine -> ammonia + 2′-deoxyuridine
Description: Reaction transforming 2′-deoxycytidine into ammonia, 2′-deoxyuridine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxyuridine simple molecule nd nd
reactant 2′-deoxycytidine simple molecule nd nd
product ammonia simple molecule nd nd
nupG_mRNA NupG
Name: nupG_mRNA -> NupG
Description: Translation of NupG
Type: translation
Components:
Function Name Type Evidence Reference(s)
product NupG protein nd nd
reactant nupG_mRNA RNA nd nd
a nucleoside_Ext a nucleoside
Name: a nucleoside_Ext -> a nucleoside
Description: Transport of a nucleoside_Ext through a bacterial membrane, leading to the presence of a nucleoside inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant a nucleoside_Ext simple molecule nd nd
product a nucleoside simple molecule nd nd
cytidine_Ext cytidine
Name: cytidine_Ext -> cytidine
Description: Transport of cytidine_Ext through a bacterial membrane, leading to the presence of cytidine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product cytidine simple molecule nd nd
reactant cytidine_Ext simple molecule nd nd
uridine_Ext uridine
Name: uridine_Ext -> uridine
Description: Transport of uridine_Ext through a bacterial membrane, leading to the presence of uridine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product uridine simple molecule nd nd
reactant uridine_Ext simple molecule nd nd
thymidine_Ext thymidine
Name: thymidine_Ext -> thymidine
Description: Transport of thymidine_Ext through a bacterial membrane, leading to the presence of thymidine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product thymidine simple molecule nd nd
reactant thymidine_Ext simple molecule nd nd
2′-deoxyuridine_Ext 2′-deoxyuridine
Name: 2′-deoxyuridine_Ext -> 2′-deoxyuridine
Description: Transport of 2′-deoxyuridine_Ext through a bacterial membrane, leading to the presence of 2′-deoxyuridine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxyuridine simple molecule nd nd
reactant 2′-deoxyuridine_Ext simple molecule nd nd
2′-deoxycytidine_Ext 2′-deoxycytidine
Name: 2′-deoxycytidine_Ext -> 2′-deoxycytidine
Description: Transport of 2′-deoxycytidine_Ext through a bacterial membrane, leading to the presence of 2′-deoxycytidine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant 2′-deoxycytidine_Ext simple molecule nd nd
product 2′-deoxycytidine simple molecule nd nd
2′-deoxyinosine_Ext 2′-deoxyinosine
Name: 2′-deoxyinosine_Ext -> 2′-deoxyinosine
Description: Transport of 2′-deoxyinosine_Ext through a bacterial membrane, leading to the presence of 2′-deoxyinosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant 2′-deoxyinosine_Ext simple molecule nd nd
product 2′-deoxyinosine simple molecule nd nd
2′-deoxyadenosine_Ext 2′-deoxyadenosine
Name: 2′-deoxyadenosine_Ext -> 2′-deoxyadenosine
Description: Transport of 2′-deoxyadenosine_Ext through a bacterial membrane, leading to the presence of 2′-deoxyadenosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxyadenosine simple molecule nd nd
reactant 2′-deoxyadenosine_Ext simple molecule nd nd
xanthosine_Ext xanthosine
Name: xanthosine_Ext -> xanthosine
Description: Transport of xanthosine_Ext through a bacterial membrane, leading to the presence of xanthosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product xanthosine simple molecule nd nd
reactant xanthosine_Ext simple molecule nd nd
inosine_Ext inosine
Name: inosine_Ext -> inosine
Description: Transport of inosine_Ext through a bacterial membrane, leading to the presence of inosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant inosine_Ext simple molecule nd nd
product inosine simple molecule nd nd
adenosine_Ext adenosine
Name: adenosine_Ext -> adenosine
Description: Transport of adenosine_Ext through a bacterial membrane, leading to the presence of adenosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product adenosine simple molecule nd nd
reactant adenosine_Ext simple molecule nd nd
rpoH_mRNA RpoH
Name: rpoH_mRNA -> RpoH
Description: Translation of RpoH
Type: translation
Components:
Function Name Type Evidence Reference(s)
product RpoH protein nd nd
reactant rpoH_mRNA RNA nd nd
deoCABD_mRNA DeoA
Name: deoCABD_mRNA -> DeoA
Description: Translation of DeoA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant deoCABD_mRNA RNA nd nd
product DeoA protein nd nd
thymidine 2′-deoxy-alpha-D-ribose 1-phosphate + thymine
Name: thymidine -> 2′-deoxy-alpha-D-ribose 1-phosphate + thymine
Description: Reaction transforming thymidine into 2′-deoxy-alpha-D-ribose 1-phosphate, thymine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product thymine simple molecule nd nd
product 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
reactant thymidine simple molecule nd nd
2′-deoxyuridine 2′-deoxy-alpha-D-ribose 1-phosphate + uracil
Name: 2′-deoxyuridine -> 2′-deoxy-alpha-D-ribose 1-phosphate + uracil
Description: Reaction transforming 2′-deoxyuridine into 2′-deoxy-alpha-D-ribose 1-phosphate, uracil
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product uracil simple molecule nd nd
reactant 2′-deoxyuridine simple molecule nd nd
product 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
nupC_mRNA NupC
Name: nupC_mRNA -> NupC
Description: Translation of NupC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant nupC_mRNA RNA nd nd
product NupC protein nd nd
deoCABD_mRNA DeoD
Name: deoCABD_mRNA -> DeoD
Description: Translation of DeoD
Type: translation
Components:
Function Name Type Evidence Reference(s)
product DeoD protein nd nd
reactant deoCABD_mRNA RNA nd nd
guanosine alpha-D-ribose-1-phosphate + guanine
Name: guanosine -> alpha-D-ribose-1-phosphate + guanine
Description: Reaction transforming guanosine into alpha-D-ribose-1-phosphate, guanine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product alpha-D-ribose-1-phosphate simple molecule nd nd
product guanine simple molecule nd nd
reactant guanosine simple molecule nd nd
2′-deoxyguanosine guanine + 2′-deoxy-alpha-D-ribose 1-phosphate
Name: 2′-deoxyguanosine -> guanine + 2′-deoxy-alpha-D-ribose 1-phosphate
Description: Reaction transforming 2′-deoxyguanosine into guanine, 2′-deoxy-alpha-D-ribose 1-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 2′-deoxyguanosine simple molecule nd nd
product guanine simple molecule nd nd
product 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
inosine alpha-D-ribose-1-phosphate + hypoxanthine
Name: inosine -> alpha-D-ribose-1-phosphate + hypoxanthine
Description: Reaction transforming inosine into alpha-D-ribose-1-phosphate, hypoxanthine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product hypoxanthine simple molecule nd nd
product alpha-D-ribose-1-phosphate simple molecule nd nd
reactant inosine simple molecule nd nd
2′-deoxyinosine hypoxanthine + 2′-deoxy-alpha-D-ribose 1-phosphate
Name: 2′-deoxyinosine -> hypoxanthine + 2′-deoxy-alpha-D-ribose 1-phosphate
Description: Reaction transforming 2′-deoxyinosine into hypoxanthine, 2′-deoxy-alpha-D-ribose 1-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
product hypoxanthine simple molecule nd nd
reactant 2′-deoxyinosine simple molecule nd nd
adenosine alpha-D-ribose-1-phosphate + adenine
Name: adenosine -> alpha-D-ribose-1-phosphate + adenine
Description: Reaction transforming adenosine into alpha-D-ribose-1-phosphate, adenine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product alpha-D-ribose-1-phosphate simple molecule nd nd
product adenine simple molecule nd nd
reactant adenosine simple molecule nd nd
2′-deoxyadenosine adenine + 2′-deoxy-alpha-D-ribose 1-phosphate
Name: 2′-deoxyadenosine -> adenine + 2′-deoxy-alpha-D-ribose 1-phosphate
Description: Reaction transforming 2′-deoxyadenosine into adenine, 2′-deoxy-alpha-D-ribose 1-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxy-alpha-D-ribose 1-phosphate simple molecule nd nd
product adenine simple molecule nd nd
reactant 2′-deoxyadenosine simple molecule nd nd
deoCABD_mRNA DeoC
Name: deoCABD_mRNA -> DeoC
Description: Translation of DeoC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant deoCABD_mRNA RNA nd nd
product DeoC protein nd nd
2-deoxy-D-ribose-5-phosphate acetaldehyde + D-glyceraldehyde 3-phosphate
Name: 2-deoxy-D-ribose-5-phosphate -> acetaldehyde + D-glyceraldehyde 3-phosphate
Description: Reaction transforming 2-deoxy-D-ribose-5-phosphate into acetaldehyde, D-glyceraldehyde 3-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product D-glyceraldehyde 3-phosphate simple molecule nd nd
product acetaldehyde simple molecule nd nd
reactant 2-deoxy-D-ribose-5-phosphate simple molecule nd nd
cytR_mRNA CytR
Name: cytR_mRNA -> CytR
Description: Translation of CytR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product CytR protein nd nd
reactant cytR_mRNA RNA nd nd
tsx_mRNA Tsx
Name: tsx_mRNA -> Tsx
Description: Translation of Tsx
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Tsx protein nd nd
reactant tsx_mRNA RNA nd nd
udp_mRNA Udp
Name: udp_mRNA -> Udp
Description: Translation of Udp
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Udp protein nd nd
reactant udp_mRNA RNA nd nd
uridine alpha-D-ribose-1-phosphate + uracil
Name: uridine -> alpha-D-ribose-1-phosphate + uracil
Description: Reaction transforming uridine into alpha-D-ribose-1-phosphate, uracil
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product alpha-D-ribose-1-phosphate simple molecule nd nd
product uracil simple molecule nd nd
reactant uridine simple molecule nd nd
ycdZ_mRNA YcdZ
Name: ycdZ_mRNA -> YcdZ
Description: Translation of YcdZ
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant ycdZ_mRNA RNA nd nd
product YcdZ protein nd nd
ppiA_mRNA PpiA
Name: ppiA_mRNA -> PpiA
Description: Translation of PpiA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product PpiA protein nd nd
reactant ppiA_mRNA RNA nd nd
peptidylproline (ω = 180) peptidylproline (ω = 0)
Name: peptidylproline (ω = 180) -> peptidylproline (ω = 0)
Description: Reaction transforming peptidylproline (ω = 180) into peptidylproline (ω = 0)
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product peptidylproline (ω = 0) simple molecule nd nd
reactant peptidylproline (ω = 180) simple molecule nd nd
2′-deoxyadenosine 2′-deoxyinosine
Name: 2′-deoxyadenosine -> 2′-deoxyinosine
Description: Transformation of 2′-deoxyadenosine into 2′-deoxyinosine by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product 2′-deoxyinosine simple molecule nd nd
reactant 2′-deoxyadenosine simple molecule nd nd
adenosine inosine
Name: adenosine -> inosine
Description: Transformation of adenosine into inosine by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant adenosine simple molecule nd nd
product inosine simple molecule nd nd



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