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DhaR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
DhaK DhaL DhaM DhaR dhaKLM dhaKLM_mRNA dhaR dhaR_mRNA dihydroxyacetone DHAP PEP pyruvate DhaR DhaK DhaM DhaK DhaL


Gensor Unit       
Name: DhaR
Description: Molecular biology level
Detailed: In the absence of DhaK, DhaR positively regulates the expression of genes required for glycerol catabolic process and negatively regulates its own expression. Under this condition, DhaR binds its target sites, hindering its own expression, but enabling the expression of genes necessary for glycerol catabolism. In the presence of DhaK, DhaR is modified to DhaR-DhaK, unbinds its target sites, allowing its own expression but preventing the expression of its regulated genes.
Less detailed: In the absence of DhaK, DhaR positively regulates the expression of genes needed for glycerol catabolic process and negatively regulates its own expression.

Physiology level
Detailed: The presence of DhaK inhibits the expression of genes involved with glycerol catabolic process. Under this condition, the genes necessary for conversion from dihydroxyacetone to dihydroxyacetone phosphate (DHAP), a reaction that is part of the glycerol degradation pathway, are repressed (or not expressed).
Less detailed: The presence of DhaK inhibits the expression of genes needful for the conversion from dihydroxyacetone to dihydroxyacetone phosphate (DHAP), a reaction that is part of the glycerol degradation pathway.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0019563 - glycerol catabolic process
GO:0061610 - glycerol to glycerone phosphate metabolic process
GO:0042182 - ketone catabolic process
GO:0046365 - monosaccharide catabolic process
GO:0034983 - peptidyl-lysine deacetylation
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cellular_component GO:0005829 - cytosol
molecular_function GO:0043531 - ADP binding
GO:0004371 - glycerone kinase activity
GO:0016787 - hydrolase activity
GO:0000287 - magnesium ion binding
GO:0047324 - phosphoenolpyruvate-glycerone phosphotransferase activity
GO:0005515 - protein binding
GO:0033558 - protein deacetylase activity
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Components: Show/Hide Components Table (14 more...)
Function Name Type
simple_molecule DHAP simple_molecule
protein DhaK protein
protein DhaL protein
protein DhaM protein
complex DhaM-DhaK-DhaL complex
protein DhaR protein
complex DhaR-DhaK complex
simple_molecule P-enol-pyruvate simple_molecule
gene dhaKLM gene
RNA dhaKLM_mRNA RNA
gene dhaR gene
RNA dhaR_mRNA RNA
simple_molecule glycerone simple_molecule
simple_molecule pyruvate simple_molecule


Reactions       
Showing 9 reactions
DhaR dhaKLM dhaKLM_mRNA
Name: dhaKLM -> dhaKLM_mRNA
Description: Transcription of transcription unit dhaKLM. Reaction activation by DhaR.
Type: transcription
Pathway Components: dhaKLM - DhaR -> dhaKLM_mRNA
Components:
Function Name Type Evidence Reference(s)
activator DhaR protein nd nd
reactant dhaKLM gene nd nd
product dhaKLM_mRNA RNA nd nd
DhaR dhaR dhaR_mRNA
Name: dhaR -> dhaR_mRNA
Description: Transcription of transcription unit dhaR. Reaction inhibition by DhaR.
Type: transcription
Pathway Components: dhaR - DhaR -> dhaR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor DhaR protein nd nd
reactant dhaR gene nd nd
product dhaR_mRNA RNA nd nd
DhaK + DhaR DhaR-DhaK
Name: DhaK + DhaR -> DhaR-DhaK
Description: Reaction transforming DhaK, DhaR into DhaR-DhaK
Type: state transition
Pathway Components: DhaK + DhaR -> DhaR-DhaK
Components:
Function Name Type Evidence Reference(s)
reactant DhaK protein nd nd
reactant DhaR protein nd nd
product DhaR-DhaK complex nd nd
dhaR_mRNA DhaR
Name: dhaR_mRNA -> DhaR
Description: Translation of DhaR
Type: translation
Pathway Components: dhaR_mRNA -> DhaR
Components:
Function Name Type Evidence Reference(s)
product DhaR protein nd nd
reactant dhaR_mRNA RNA nd nd
dhaKLM_mRNA DhaK
Name: dhaKLM_mRNA -> DhaK
Description: Translation of DhaK
Type: translation
Pathway Components: dhaKLM_mRNA -> DhaK
Components:
Function Name Type Evidence Reference(s)
product DhaK protein nd nd
reactant dhaKLM_mRNA RNA nd nd
DhaK + DhaL + DhaM DhaM-DhaK-DhaL
Name: DhaK + DhaL + DhaM -> DhaM-DhaK-DhaL
Description: Reaction transforming DhaK, DhaL, DhaM into DhaM-DhaK-DhaL
Type: state transition
Pathway Components: DhaK + DhaL + DhaM -> DhaM-DhaK-DhaL
Components:
Function Name Type Evidence Reference(s)
reactant DhaK protein nd nd
reactant DhaL protein nd nd
reactant DhaM protein nd nd
product DhaM-DhaK-DhaL complex nd nd
DhaM-DhaK-DhaL P-enol-pyruvate + glycerone pyruvate + DHAP
Name: P-enol-pyruvate + glycerone -> pyruvate + DHAP
Description: Reaction transforming P-enol-pyruvate, glycerone into pyruvate, DHAP
Type: state transition
Pathway Components: P-enol-pyruvate + glycerone - DhaM-DhaK-DhaL -> pyruvate + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer DhaM-DhaK-DhaL complex nd nd
reactant P-enol-pyruvate simple_molecule nd nd
reactant glycerone simple_molecule nd nd
product pyruvate simple_molecule nd nd
dhaKLM_mRNA DhaL
Name: dhaKLM_mRNA -> DhaL
Description: Translation of DhaL
Type: translation
Pathway Components: dhaKLM_mRNA -> DhaL
Components:
Function Name Type Evidence Reference(s)
product DhaL protein nd nd
reactant dhaKLM_mRNA RNA nd nd
dhaKLM_mRNA DhaM
Name: dhaKLM_mRNA -> DhaM
Description: Translation of DhaM
Type: translation
Pathway Components: dhaKLM_mRNA -> DhaM
Components:
Function Name Type Evidence Reference(s)
product DhaM protein nd nd
reactant dhaKLM_mRNA RNA nd nd



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