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CynR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
CO2 CynR CynS CynT CynX carbonate carbamate cyanate cyanate_Ext cynR cynR_mRNA cynTS cynTSX cynTSX_mRNA cynTS_mRNA CynR cyanate


Gensor Unit       
Name: CynR
Description: Molecular biology level
Detailed: In the presence of cyanate, CynR positively regulates the expression of genes required for cyanate catabolic process. Under these conditions, CynR is modified to CynR-cyanate, binds its targets sites enabling the expression of its regulated genes. In the absence of cynate, CynR binds its own promoter preventing its own expression.
Less detailed: In the presence of cyanate, CynR positively regulates the expression of genes needed for cyanate catabolic process. In the absence of cyanate, CynR negatively autoregulates its own expression.

Physiology level
Detailed: The presence of cyanate induces the expression of genes required for cyanate catabolic process. Under these conditions the genes necessary for conversion of cyanate and carbonate to carmabate and carbon dioxide are expressed.
Less detailed: The presence of cyanate induces the expression of genes needful for the conversion of cyanate and carbonate to carbamate and carbon dioxide.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0009440 - cyanate catabolic process
GO:0055085 - transmembrane transport
cellular_component GO:0005737 - cytoplasm
GO:0016021 - integral component of membrane
GO:0005886 - plasma membrane
molecular_function GO:0004089 - carbonate dehydratase activity
GO:0008824 - cyanate hydratase activity
GO:0042802 - identical protein binding
GO:0022857 - transmembrane transporter activity
GO:0008270 - zinc ion binding
Components: Show/Hide Components Table (16 more...)
Function Name Type
simple_molecule CO2 simple_molecule
protein CynR protein
complex CynR-cyanate complex
protein CynS protein
protein CynT protein
protein CynX protein
simple_molecule carbamate simple_molecule
simple_molecule carbonate simple_molecule
simple_molecule cyanate simple_molecule
simple_molecule cyanate_Ext simple_molecule
gene cynR gene
RNA cynR_mRNA RNA
gene cynTS gene
gene cynTSX gene
RNA cynTSX_mRNA RNA
RNA cynTS_mRNA RNA


Reactions       
Showing 14 reactions
cyanate + CynR CynR-cyanate
Name: cyanate + CynR -> CynR-cyanate
Description: Reaction transforming cyanate, CynR into CynR-cyanate
Type: state transition
Pathway Components: cyanate + CynR -> CynR-cyanate
Components:
Function Name Type Evidence Reference(s)
reactant CynR protein nd nd
product CynR-cyanate complex nd nd
reactant cyanate simple_molecule nd nd
CynR-cyanate cynTSX cynTSX_mRNA
Name: cynTSX -> cynTSX_mRNA
Description: Transcription of transcription unit cynTSX. Reaction activation by CynR-cyanate.
Type: transcription
Pathway Components: cynTSX - CynR-cyanate -> cynTSX_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CynR-cyanate complex nd nd
reactant cynTSX gene nd nd
product cynTSX_mRNA RNA nd nd
CynR-cyanate cynR cynR_mRNA
Name: cynR -> cynR_mRNA
Description: Transcription of transcription unit cynR. Reaction inhibition by CynR-cyanate.
Type: transcription
Pathway Components: cynR - CynR-cyanate -> cynR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor CynR-cyanate complex nd nd
reactant cynR gene nd nd
product cynR_mRNA RNA nd nd
CynR cynTS cynTS_mRNA
Name: cynTS -> cynTS_mRNA
Description: Transcription of transcription unit cynTS. Reaction activation by CynR.
Type: transcription
Pathway Components: cynTS - CynR -> cynTS_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CynR protein nd nd
reactant cynTS gene nd nd
product cynTS_mRNA RNA nd nd
cynTSX_mRNA CynT
Name: cynTSX_mRNA -> CynT
Description: Translation of CynT
Type: translation
Pathway Components: cynTSX_mRNA -> CynT
Components:
Function Name Type Evidence Reference(s)
product CynT protein nd nd
reactant cynTSX_mRNA RNA nd nd
CynT cyanate carbonate CO2
Name: carbonate -> CO2
Description: Reaction transforming carbonate into CO2
Type: state transition
Pathway Components: carbonate - CynT - cyanate -> CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer CynT protein nd nd
reactant carbonate simple_molecule nd nd
inhibitor cyanate simple_molecule nd nd
cynTSX_mRNA CynS
Name: cynTSX_mRNA -> CynS
Description: Translation of CynS
Type: translation
Pathway Components: cynTSX_mRNA -> CynS
Components:
Function Name Type Evidence Reference(s)
product CynS protein nd nd
reactant cynTSX_mRNA RNA nd nd
CynS carbonate cyanate carbonate + cyanate carbamate + CO2
Name: carbonate + cyanate -> carbamate + CO2
Description: Reaction transforming carbonate, cyanate into carbamate, CO2
Type: state transition
Pathway Components: carbonate + cyanate - CynS - carbonate - cyanate -> carbamate + CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
catalyzer CynS protein nd nd
product carbamate simple_molecule nd nd
inhibitor carbonate simple_molecule nd nd
reactant carbonate simple_molecule nd nd
inhibitor cyanate simple_molecule nd nd
reactant cyanate simple_molecule nd nd
cynTSX_mRNA CynX
Name: cynTSX_mRNA -> CynX
Description: Translation of CynX
Type: translation
Pathway Components: cynTSX_mRNA -> CynX
Components:
Function Name Type Evidence Reference(s)
product CynX protein nd nd
reactant cynTSX_mRNA RNA nd nd
CynX cyanate_Ext cyanate
Name: cyanate_Ext -> cyanate
Description: Transport of cyanate_Ext through a bacterial membrane, leading to the presence of cyanate inside the cell.
Type: transport
Pathway Components: cyanate_Ext - CynX -> cyanate
Components:
Function Name Type Evidence Reference(s)
catalyzer CynX protein nd nd
product cyanate simple_molecule nd nd
reactant cyanate_Ext simple_molecule nd nd
cynR_mRNA CynR
Name: cynR_mRNA -> CynR
Description: Translation of CynR
Type: translation
Pathway Components: cynR_mRNA -> CynR
Components:
Function Name Type Evidence Reference(s)
product CynR protein nd nd
reactant cynR_mRNA RNA nd nd
cynTS_mRNA CynT
Name: cynTS_mRNA -> CynT
Description: Translation of CynT
Type: translation
Pathway Components: cynTS_mRNA -> CynT
Components:
Function Name Type Evidence Reference(s)
product CynT protein nd nd
reactant cynTS_mRNA RNA nd nd
cynTS_mRNA CynS
Name: cynTS_mRNA -> CynS
Description: Translation of CynS
Type: translation
Pathway Components: cynTS_mRNA -> CynS
Components:
Function Name Type Evidence Reference(s)
product CynS protein nd nd
reactant cynTS_mRNA RNA nd nd
carbamate CO2
Name: carbamate -> CO2
Description: Transformation of carbamate into CO2 by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: carbamate / RXN0-5222 / CO2
Components:
Function Name Type Evidence Reference(s)
product CO2 simple_molecule nd nd
reactant carbamate simple_molecule nd nd



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