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CynR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
cynTSX_mRNA CynX cyanate carbonate cynTS_mRNA cyanate CynS cynR_mRNA CynR CynR cynR cynTSX CO2 CynT carbamate cyanate_Ext cynTS


Gensor Unit       
Name: CynR
Description: Molecular biology level
Detailed: In the presence of cyanate, CynR positively regulates the expression of genes required for cyanate catabolic process. Under these conditions, CynR is modified to CynR-cyanate, binds its targets sites enabling the expression of its regulated genes. In the absence of cynate, CynR binds its own promoter preventing its own expression.
Less detailed: In the presence of cyanate, CynR positively regulates the expression of genes needed for cyanate catabolic process. In the absence of cyanate, CynR negatively autoregulates its own expression.

Physiology level
Detailed: The presence of cyanate induces the expression of genes required for cyanate catabolic process. Under these conditions the genes necessary for conversion of cyanate and carbonate to carmabate and carbon dioxide are expressed.
Less detailed: The presence of cyanate induces the expression of genes needful for the conversion of cyanate and carbonate to carbamate and carbon dioxide.
Classification:
Groups: Inorganic ion transport and metabolism
Transcription
Gene Ontology Terms (GO): biological_process GO:0015976 - carbon utilization
GO:0009440 - cyanate catabolic process
GO:0009439 - cyanate metabolic process
GO:0006355 - regulation of transcription, DNA-templated
GO:0006351 - transcription, DNA-templated
GO:0055085 - transmembrane transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004089 - carbonate dehydratase activity
GO:0008824 - cyanate hydratase activity
GO:0042802 - identical protein binding
GO:0016829 - lyase activity
GO:0046872 - metal ion binding
Read more >
Components:
  Function Name Type
  simple_molecule CO2 simple_molecule
  protein CynR protein
  complex CynR-cyanate complex
  protein CynS protein
  protein CynT protein
  protein CynX protein
  simple_molecule carbamate simple_molecule
  simple_molecule carbonate simple_molecule
  simple_molecule cyanate simple_molecule
  simple_molecule cyanate_Ext simple_molecule
  gene cynR gene
  RNA cynR_mRNA RNA
  gene cynTS gene
  gene cynTSX gene
  RNA cynTSX_mRNA RNA
  RNA cynTS_mRNA RNA


Reactions       
Showing 14 reactions
CynR cynR cynR_mRNA
Name: cynR -> cynR_mRNA
Description: Transcription of transcription unit cynR. Reaction inhibition by CynR.
Type: transcription
Pathway Components: cynR - CynR -> cynR_mRNA
Components:
Function Name Type
inhibitor CynR protein
reactant cynR gene
product cynR_mRNA RNA
cyanate + CynR CynR-cyanate
Name: cyanate + CynR -> CynR-cyanate
Description: Reaction transforming cyanate, CynR into CynR-cyanate
Type: state transition
Pathway Components: cyanate + CynR -> CynR-cyanate
Components:
Function Name Type
reactant CynR protein
product CynR-cyanate complex
reactant cyanate simple_molecule
CynR-cyanate cynTS cynTS_mRNA
Name: cynTS -> cynTS_mRNA
Description: Transcription of transcription unit cynTS. Reaction activation by CynR-cyanate.
Type: transcription
Pathway Components: cynTS - CynR-cyanate -> cynTS_mRNA
Components:
Function Name Type
activator CynR-cyanate complex
reactant cynTS gene
product cynTS_mRNA RNA
CynR-cyanate cynTSX cynTSX_mRNA
Name: cynTSX -> cynTSX_mRNA
Description: Transcription of transcription unit cynTSX. Reaction activation by CynR-cyanate.
Type: transcription
Pathway Components: cynTSX - CynR-cyanate -> cynTSX_mRNA
Components:
Function Name Type
activator CynR-cyanate complex
reactant cynTSX gene
product cynTSX_mRNA RNA
cynR_mRNA CynR
Name: cynR_mRNA -> CynR
Description: Translation of CynR
Type: translation
Pathway Components: cynR_mRNA -> CynR
Components:
Function Name Type
product CynR protein
reactant cynR_mRNA RNA
cynTS_mRNA CynT
Name: cynTS_mRNA -> CynT
Description: Translation of CynT
Type: translation
Pathway Components: cynTS_mRNA -> CynT
Components:
Function Name Type
product CynT protein
reactant cynTS_mRNA RNA
CynT cyanate carbonate CO2
Name: carbonate -> CO2
Description: Reaction transforming carbonate into CO2
Type: state transition
Pathway Components: carbonate - CynT - cyanate -> CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer CynT protein
reactant carbonate simple_molecule
inhibitor cyanate simple_molecule
cynTS_mRNA CynS
Name: cynTS_mRNA -> CynS
Description: Translation of CynS
Type: translation
Pathway Components: cynTS_mRNA -> CynS
Components:
Function Name Type
product CynS protein
reactant cynTS_mRNA RNA
CynS carbonate cyanate carbonate + cyanate carbamate + CO2
Name: carbonate + cyanate -> carbamate + CO2
Description: Reaction transforming carbonate, cyanate into carbamate, CO2
Type: state transition
Pathway Components: carbonate + cyanate - CynS - carbonate - cyanate -> carbamate + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer CynS protein
product carbamate simple_molecule
inhibitor carbonate simple_molecule
reactant carbonate simple_molecule
inhibitor cyanate simple_molecule
reactant cyanate simple_molecule
cynTSX_mRNA CynT
Name: cynTSX_mRNA -> CynT
Description: Translation of CynT
Type: translation
Pathway Components: cynTSX_mRNA -> CynT
Components:
Function Name Type
product CynT protein
reactant cynTSX_mRNA RNA
cynTSX_mRNA CynS
Name: cynTSX_mRNA -> CynS
Description: Translation of CynS
Type: translation
Pathway Components: cynTSX_mRNA -> CynS
Components:
Function Name Type
product CynS protein
reactant cynTSX_mRNA RNA
cynTSX_mRNA CynX
Name: cynTSX_mRNA -> CynX
Description: Translation of CynX
Type: translation
Pathway Components: cynTSX_mRNA -> CynX
Components:
Function Name Type
product CynX protein
reactant cynTSX_mRNA RNA
CynX cyanate_Ext cyanate
Name: cyanate_Ext -> cyanate
Description: Transport of cyanate_Ext through a bacterial membrane, leading to the presence of cyanate inside the cell.
Type: transport
Pathway Components: cyanate_Ext - CynX -> cyanate
Components:
Function Name Type
catalyzer CynX protein
product cyanate simple_molecule
reactant cyanate_Ext simple_molecule
carbamate CO2
Name: carbamate -> CO2
Description: Transformation of carbamate into CO2 by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: carbamate / RXN0-5222 / CO2
Components:
Function Name Type
product CO2 simple_molecule
reactant carbamate simple_molecule



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