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CusR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
silver silver_Ext Cu(I) Cu(I)_Ext CusA CusB CusC CusF CusR CusS phosphate cusCFBA cusCFBA_mRNA cusRS cusRS_mRNA CusR phosphate CusC CusB CusF CusA


Gensor Unit       
Name: CusR
Signal name: increased cooper concentration.
Classification:
Groups: GUs related to the two-component system
Gene Ontology Terms (GO): biological_process GO:0042773 - ATP synthesis coupled electron transport
GO:0019646 - aerobic electron transport chain
GO:0009060 - aerobic respiration
GO:0006878 - cellular copper ion homeostasis
GO:0045333 - cellular respiration
GO:0071280 - cellular response to copper ion
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cellular_component GO:0009279 - cell outer membrane
GO:0009319 - cytochrome o ubiquinol oxidase complex
GO:0005829 - cytosol
GO:0071575 - integral component of external side of plasma membrane
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
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molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA binding transcription factor activity
GO:0001216 - bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO:0016531 - copper chaperone activity
GO:0005507 - copper ion binding
GO:0005375 - copper ion transmembrane transporter activity
GO:0009486 - cytochrome bo3 ubiquinol oxidase activity
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Components: Show/Hide Components Table (35 more...)
Function Name Type
simple_molecule Cu(I) simple_molecule
simple_molecule Cu(I)_Ext simple_molecule
protein CusA protein
protein CusB protein
protein CusC protein
complex CusC-CusB-CusF-CusA complex
protein CusF protein
protein CusR protein
complex CusR-phosphate complex
protein CusS protein
protein CyoA protein
protein CyoB protein
protein CyoC protein
protein CyoD protein
complex CyoD-CyoA-CyoB-CyoC complex
protein CyoE protein
protein YedX protein
gene cusCFBA gene
RNA cusCFBA_mRNA RNA
gene cusRS gene
RNA cusRS_mRNA RNA
gene cyoABCDE gene
RNA cyoABCDE_mRNA RNA
simple_molecule diphosphate simple_molecule
simple_molecule farnesyl-PP simple_molecule
simple_molecule ferroheme o simple_molecule
simple_molecule oxygen_Ext simple_molecule
simple_molecule phosphate simple_molecule
simple_molecule protoheme IX simple_molecule
simple_molecule silver simple_molecule
simple_molecule silver_Ext simple_molecule
simple_molecule ubiquinol_Ext simple_molecule
simple_molecule ubiquinone simple_molecule
gene yedX gene
RNA yedX_mRNA RNA


Reactions       
Showing 23 reactions
phosphate + CusR CusR-phosphate
Name: phosphate + CusR -> CusR-phosphate
Description: Reaction transforming phosphate, CusR into CusR-phosphate
Type: state transition
Pathway Components: phosphate + CusR -> CusR-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant CusR protein nd nd
product CusR-phosphate complex nd nd
reactant phosphate simple_molecule nd nd
CusR-phosphate cusCFBA cusCFBA_mRNA
Name: cusCFBA -> cusCFBA_mRNA
Description: Transcription of transcription unit cusCFBA. Reaction activation by CusR-phosphate.
Type: transcription
Pathway Components: cusCFBA - CusR-phosphate -> cusCFBA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CusR-phosphate complex nd nd
reactant cusCFBA gene nd nd
product cusCFBA_mRNA RNA nd nd
CusR-phosphate cusRS cusRS_mRNA
Name: cusRS -> cusRS_mRNA
Description: Transcription of transcription unit cusRS. Reaction activation by CusR-phosphate.
Type: transcription
Pathway Components: cusRS - CusR-phosphate -> cusRS_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CusR-phosphate complex nd nd
reactant cusRS gene nd nd
product cusRS_mRNA RNA nd nd
CusR-phosphate cyoABCDE cyoABCDE_mRNA
Name: cyoABCDE -> cyoABCDE_mRNA
Description: Transcription of transcription unit cyoABCDE. Reaction activation by CusR-phosphate.
Type: transcription
Pathway Components: cyoABCDE - CusR-phosphate -> cyoABCDE_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CusR-phosphate complex nd nd
reactant cyoABCDE gene nd nd
product cyoABCDE_mRNA RNA nd nd
CusR-phosphate yedX yedX_mRNA
Name: yedX -> yedX_mRNA
Description: Transcription of transcription unit yedX. Reaction activation by CusR-phosphate.
Type: transcription
Pathway Components: yedX - CusR-phosphate -> yedX_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CusR-phosphate complex nd nd
reactant yedX gene nd nd
product yedX_mRNA RNA nd nd
yedX_mRNA YedX
Name: yedX_mRNA -> YedX
Description: Translation of YedX
Type: translation
Pathway Components: yedX_mRNA -> YedX
Components:
Function Name Type Evidence Reference(s)
product YedX protein nd nd
reactant yedX_mRNA RNA nd nd
cusRS_mRNA CusR
Name: cusRS_mRNA -> CusR
Description: Translation of CusR
Type: translation
Pathway Components: cusRS_mRNA -> CusR
Components:
Function Name Type Evidence Reference(s)
product CusR protein nd nd
reactant cusRS_mRNA RNA nd nd
cusRS_mRNA CusS
Name: cusRS_mRNA -> CusS
Description: Translation of CusS
Type: translation
Pathway Components: cusRS_mRNA -> CusS
Components:
Function Name Type Evidence Reference(s)
product CusS protein nd nd
reactant cusRS_mRNA RNA nd nd
cusCFBA_mRNA CusC
Name: cusCFBA_mRNA -> CusC
Description: Translation of CusC
Type: translation
Pathway Components: cusCFBA_mRNA -> CusC
Components:
Function Name Type Evidence Reference(s)
product CusC protein nd nd
reactant cusCFBA_mRNA RNA nd nd
CusB + CusC + CusA + CusF CusC-CusB-CusF-CusA
Name: CusB + CusC + CusA + CusF -> CusC-CusB-CusF-CusA
Description: Reaction transforming CusB, CusC, CusA, CusF into CusC-CusB-CusF-CusA
Type: state transition
Pathway Components: CusB + CusC + CusA + CusF -> CusC-CusB-CusF-CusA
Components:
Function Name Type Evidence Reference(s)
reactant CusA protein nd nd
reactant CusB protein nd nd
reactant CusC protein nd nd
product CusC-CusB-CusF-CusA complex nd nd
reactant CusF protein nd nd
CusC-CusB-CusF-CusA Cu(I)_Ext Cu(I)
Name: Cu(I)_Ext -> Cu(I)
Description: Transport of Cu(I)_Ext through a bacterial membrane, leading to the presence of Cu(I) inside the cell.
Type: transport
Pathway Components: Cu(I)_Ext - CusC-CusB-CusF-CusA -> Cu(I)
Components:
Function Name Type Evidence Reference(s)
product Cu(I) simple_molecule nd nd
reactant Cu(I)_Ext simple_molecule nd nd
catalyzer CusC-CusB-CusF-CusA complex nd nd
CusC-CusB-CusF-CusA silver_Ext silver
Name: silver_Ext -> silver
Description: Transport of silver_Ext through a bacterial membrane, leading to the presence of silver inside the cell.
Type: transport
Pathway Components: silver_Ext - CusC-CusB-CusF-CusA -> silver
Components:
Function Name Type Evidence Reference(s)
catalyzer CusC-CusB-CusF-CusA complex nd nd
product silver simple_molecule nd nd
reactant silver_Ext simple_molecule nd nd
cusCFBA_mRNA CusF
Name: cusCFBA_mRNA -> CusF
Description: Translation of CusF
Type: translation
Pathway Components: cusCFBA_mRNA -> CusF
Components:
Function Name Type Evidence Reference(s)
product CusF protein nd nd
reactant cusCFBA_mRNA RNA nd nd
cusCFBA_mRNA CusB
Name: cusCFBA_mRNA -> CusB
Description: Translation of CusB
Type: translation
Pathway Components: cusCFBA_mRNA -> CusB
Components:
Function Name Type Evidence Reference(s)
product CusB protein nd nd
reactant cusCFBA_mRNA RNA nd nd
cusCFBA_mRNA CusA
Name: cusCFBA_mRNA -> CusA
Description: Translation of CusA
Type: translation
Pathway Components: cusCFBA_mRNA -> CusA
Components:
Function Name Type Evidence Reference(s)
product CusA protein nd nd
reactant cusCFBA_mRNA RNA nd nd
cyoABCDE_mRNA CyoA
Name: cyoABCDE_mRNA -> CyoA
Description: Translation of CyoA
Type: translation
Pathway Components: cyoABCDE_mRNA -> CyoA
Components:
Function Name Type Evidence Reference(s)
product CyoA protein nd nd
reactant cyoABCDE_mRNA RNA nd nd
CyoC + CyoA + CyoD + CyoB CyoD-CyoA-CyoB-CyoC
Name: CyoC + CyoA + CyoD + CyoB -> CyoD-CyoA-CyoB-CyoC
Description: Reaction transforming CyoC, CyoA, CyoD, CyoB into CyoD-CyoA-CyoB-CyoC
Type: state transition
Pathway Components: CyoC + CyoA + CyoD + CyoB -> CyoD-CyoA-CyoB-CyoC
Components:
Function Name Type Evidence Reference(s)
reactant CyoA protein nd nd
reactant CyoB protein nd nd
reactant CyoC protein nd nd
reactant CyoD protein nd nd
product CyoD-CyoA-CyoB-CyoC complex nd nd
CyoD-CyoA-CyoB-CyoC ubiquinol_Ext + oxygen_Ext ubiquinone
Name: ubiquinol_Ext + oxygen_Ext -> ubiquinone
Description: Transport of ubiquinol_Ext, oxygen_Ext through a bacterial membrane, leading to the presence of ubiquinone inside the cell.
Type: transport
Pathway Components: ubiquinol_Ext + oxygen_Ext - CyoD-CyoA-CyoB-CyoC -> ubiquinone
Components:
Function Name Type Evidence Reference(s)
catalyzer CyoD-CyoA-CyoB-CyoC complex nd nd
reactant oxygen_Ext simple_molecule nd nd
reactant ubiquinol_Ext simple_molecule nd nd
product ubiquinone simple_molecule nd nd
cyoABCDE_mRNA CyoB
Name: cyoABCDE_mRNA -> CyoB
Description: Translation of CyoB
Type: translation
Pathway Components: cyoABCDE_mRNA -> CyoB
Components:
Function Name Type Evidence Reference(s)
product CyoB protein nd nd
reactant cyoABCDE_mRNA RNA nd nd
cyoABCDE_mRNA CyoC
Name: cyoABCDE_mRNA -> CyoC
Description: Translation of CyoC
Type: translation
Pathway Components: cyoABCDE_mRNA -> CyoC
Components:
Function Name Type Evidence Reference(s)
product CyoC protein nd nd
reactant cyoABCDE_mRNA RNA nd nd
cyoABCDE_mRNA CyoD
Name: cyoABCDE_mRNA -> CyoD
Description: Translation of CyoD
Type: translation
Pathway Components: cyoABCDE_mRNA -> CyoD
Components:
Function Name Type Evidence Reference(s)
product CyoD protein nd nd
reactant cyoABCDE_mRNA RNA nd nd
cyoABCDE_mRNA CyoE
Name: cyoABCDE_mRNA -> CyoE
Description: Translation of CyoE
Type: translation
Pathway Components: cyoABCDE_mRNA -> CyoE
Components:
Function Name Type Evidence Reference(s)
product CyoE protein nd nd
reactant cyoABCDE_mRNA RNA nd nd
CyoE protoheme IX + farnesyl-PP diphosphate + ferroheme o
Name: protoheme IX + farnesyl-PP -> diphosphate + ferroheme o
Description: Reaction transforming protoheme IX, farnesyl-PP into diphosphate, ferroheme o
Type: state transition
Pathway Components: protoheme IX + farnesyl-PP - CyoE -> diphosphate + ferroheme o
Components:
Function Name Type Evidence Reference(s)
catalyzer CyoE protein nd nd
product diphosphate simple_molecule nd nd
reactant farnesyl-PP simple_molecule nd nd
product ferroheme o simple_molecule nd nd
reactant protoheme IX simple_molecule nd nd



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