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CueR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2,3-dihydroxybenzoate 2-carboxymuconate CopA Cu(I) Cu(I)_Ext Cu(II) CueO CueR Fe(II) Fe(III) GTP MoaA MoaB MoaC MoaD MoaE small subunit of molybdopterin synthase thiocarboxylated small subunit of molybdopterin synthase copA copA_mRNA cueO cueO_mRNA cyclic pyranopterin phosphate moaABCDE moaABCDE_mRNA molybdopterin CueR Cu(I) MoaD MoaE


Gensor Unit       
Name: CueR
Description: Molecular biology level
Detailed: In the presence of Cu(I), CueR positively regulates the expression of genes required for phenol oxidation of iron siderophores, ferroxidation, and efflux of monovalent copper and negatively regulates the expression of genes involved in conversion from guanosine-triphosphate to molybdopterin. Under this condition, CueR is modified to CueR-Cu(I), binds its target sites and enables the expression of some of its regulated genes and prevents the expression of other of its regulated genes.
Less detailed: In the presence of Cu(I).CueR positively regulates the expression of genes needed for cellular response to copper ion and negatively regulates the expression of genes involved in synthesis of molybdopterin guanine dinucleotide, a cofactor for many enzymes.

Physiology level
Detailed: The presence of Cu(I) induces genes necessary for cellular response to copper and repress the expression of genes involved with synthesis of molybdopterin. Under these conditions, the genes necessary for copper detoxification and iron homeostasis are expressed whereas that the genes necessary for synthesis of molybdopterin guanine dinucleotide, a cofactor for many enzymes, are not expressed.
Less detailed: The presence of Cu(I) induces genes needful for copper detoxification and iron homeostasis and repress the expression of genes necessary for synthesis of molybdopterin.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0099132 - ATP hydrolysis coupled cation transmembrane transport
GO:0099131 - ATP hydrolysis coupled ion transmembrane transport
GO:0006777 - Mo-molybdopterin cofactor biosynthetic process
GO:0071280 - cellular response to copper ion
GO:0071292 - cellular response to silver ion
GO:0060003 - copper ion export
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cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0031224 - intrinsic component of membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
GO:0005886 - plasma membrane
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molecular_function GO:0016887 - ATPase activity
GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0061798 - GTP 3',8'-cyclase activity
GO:0005507 - copper ion binding
GO:0061799 - cyclic pyranopterin monophosphate synthase activity
GO:0004322 - ferroxidase activity
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (34 more...)
Function Name Type
simple_molecule 2-carboxymuconate simple_molecule
simple_molecule 2-pyrocatechuate simple_molecule
protein CopA protein
simple_molecule Cu(I) simple_molecule
simple_molecule Cu(I)_Ext simple_molecule
simple_molecule Cu(II) simple_molecule
protein CueO protein
protein CueR protein
complex CueR-Cu(I) complex
complex CueR-gold complex
complex CueR-silver complex
simple_molecule Fe+2 simple_molecule
simple_molecule H2Dtpp-mP simple_molecule
protein MoaA protein
protein MoaB protein
protein MoaC protein
protein MoaD protein
complex MoaD-MoaE complex
protein MoaE protein
simple_molecule cPMP simple_molecule
gene copA gene
RNA copA_mRNA RNA
gene cueO gene
RNA cueO_mRNA RNA
simple_molecule diphosphate simple_molecule
simple_molecule fe(iii) simple_molecule
simple_molecule gold simple_molecule
simple_molecule guanosine-triphosphate simple_molecule
gene moaABCDE gene
RNA moaABCDE_mRNA RNA
simple_molecule oxygen simple_molecule
simple_molecule silver simple_molecule
simple_molecule small subunit of molybdopterin synthase simple_molecule
simple_molecule thiocarboxylated small subunit of molybdopterin synthase simple_molecule


Reactions       
Showing 20 reactions
silver + CueR CueR-silver
Name: silver + CueR -> CueR-silver
Description: Reaction transforming silver, CueR into CueR-silver
Type: state transition
Pathway Components: silver + CueR -> CueR-silver
Components:
Function Name Type Evidence Reference(s)
reactant CueR protein nd nd
product CueR-silver complex nd nd
reactant silver simple_molecule nd nd
CueR-Cu(I) CueR-gold CueR-silver copA copA_mRNA
Name: copA -> copA_mRNA
Description: Transcription of transcription unit copA. Reaction activation by CueR-Cu(I), CueR-gold, and CueR-silver.
Type: transcription
Pathway Components: copA - CueR-Cu(I) - CueR-gold - CueR-silver -> copA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CueR-Cu(I) complex nd nd
activator CueR-gold complex nd nd
activator CueR-silver complex nd nd
reactant copA gene nd nd
product copA_mRNA RNA nd nd
CueR-Cu(I) CueR-gold CueR-silver cueO cueO_mRNA
Name: cueO -> cueO_mRNA
Description: Transcription of transcription unit cueO. Reaction activation by CueR-Cu(I), CueR-gold, and CueR-silver.
Type: transcription
Pathway Components: cueO - CueR-Cu(I) - CueR-gold - CueR-silver -> cueO_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CueR-Cu(I) complex nd nd
activator CueR-gold complex nd nd
activator CueR-silver complex nd nd
reactant cueO gene nd nd
product cueO_mRNA RNA nd nd
CueR-Cu(I) CueR-gold CueR-silver moaABCDE moaABCDE_mRNA
Name: moaABCDE -> moaABCDE_mRNA
Description: Transcription of transcription unit moaABCDE. Reaction inhibition by CueR-Cu(I), CueR-gold, and CueR-silver.
Type: transcription
Pathway Components: moaABCDE - CueR-Cu(I) - CueR-gold - CueR-silver -> moaABCDE_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor CueR-Cu(I) complex nd nd
inhibitor CueR-gold complex nd nd
inhibitor CueR-silver complex nd nd
reactant moaABCDE gene nd nd
product moaABCDE_mRNA RNA nd nd
Cu(I) + CueR CueR-Cu(I)
Name: Cu(I) + CueR -> CueR-Cu(I)
Description: Reaction transforming Cu(I), CueR into CueR-Cu(I)
Type: state transition
Pathway Components: Cu(I) + CueR -> CueR-Cu(I)
Components:
Function Name Type Evidence Reference(s)
reactant Cu(I) simple_molecule nd nd
reactant CueR protein nd nd
product CueR-Cu(I) complex nd nd
gold + CueR CueR-gold
Name: gold + CueR -> CueR-gold
Description: Reaction transforming gold, CueR into CueR-gold
Type: state transition
Pathway Components: gold + CueR -> CueR-gold
Components:
Function Name Type Evidence Reference(s)
reactant CueR protein nd nd
product CueR-gold complex nd nd
reactant gold simple_molecule nd nd
moaABCDE_mRNA MoaA
Name: moaABCDE_mRNA -> MoaA
Description: Translation of MoaA
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaA
Components:
Function Name Type Evidence Reference(s)
product MoaA protein nd nd
reactant moaABCDE_mRNA RNA nd nd
MoaA guanosine-triphosphate diphosphate + cPMP
Name: guanosine-triphosphate -> diphosphate + cPMP
Description: Reaction transforming guanosine-triphosphate into diphosphate, cPMP
Type: state transition
Pathway Components: guanosine-triphosphate - MoaA -> diphosphate + cPMP
Components:
Function Name Type Evidence Reference(s)
catalyzer MoaA protein nd nd
product cPMP simple_molecule nd nd
product diphosphate simple_molecule nd nd
reactant guanosine-triphosphate simple_molecule nd nd
moaABCDE_mRNA MoaB
Name: moaABCDE_mRNA -> MoaB
Description: Translation of MoaB
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaB
Components:
Function Name Type Evidence Reference(s)
product MoaB protein nd nd
reactant moaABCDE_mRNA RNA nd nd
moaABCDE_mRNA MoaC
Name: moaABCDE_mRNA -> MoaC
Description: Translation of MoaC
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaC
Components:
Function Name Type Evidence Reference(s)
product MoaC protein nd nd
reactant moaABCDE_mRNA RNA nd nd
moaABCDE_mRNA MoaD
Name: moaABCDE_mRNA -> MoaD
Description: Translation of MoaD
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaD
Components:
Function Name Type Evidence Reference(s)
product MoaD protein nd nd
reactant moaABCDE_mRNA RNA nd nd
MoaD + MoaE MoaD-MoaE
Name: MoaD + MoaE -> MoaD-MoaE
Description: Reaction transforming MoaD, MoaE into MoaD-MoaE
Type: state transition
Pathway Components: MoaD + MoaE -> MoaD-MoaE
Components:
Function Name Type Evidence Reference(s)
reactant MoaD protein nd nd
product MoaD-MoaE complex nd nd
reactant MoaE protein nd nd
MoaD-MoaE Reactants Products
Name: thiocarboxylated small subunit of molybdopterin synthase + cPMP -> small subunit of molybdopterin synthase + H2Dtpp-mP
Description: Reaction transforming thiocarboxylated small subunit of molybdopterin synthase, cPMP into small subunit of molybdopterin synthase, H2Dtpp-mP
Type: state transition
Pathway Components: thiocarboxylated small subunit of molybdopterin synthase + cPMP - MoaD-MoaE -> small subunit of molybdopterin synthase + H2Dtpp-mP
Components:
Function Name Type Evidence Reference(s)
product H2Dtpp-mP simple_molecule nd nd
catalyzer MoaD-MoaE complex nd nd
reactant cPMP simple_molecule nd nd
product small subunit of molybdopterin synthase simple_molecule nd nd
reactant thiocarboxylated small subunit of molybdopterin synthase simple_molecule nd nd
moaABCDE_mRNA MoaE
Name: moaABCDE_mRNA -> MoaE
Description: Translation of MoaE
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaE
Components:
Function Name Type Evidence Reference(s)
product MoaE protein nd nd
reactant moaABCDE_mRNA RNA nd nd
copA_mRNA CopA
Name: copA_mRNA -> CopA
Description: Translation of CopA
Type: translation
Pathway Components: copA_mRNA -> CopA
Components:
Function Name Type Evidence Reference(s)
product CopA protein nd nd
reactant copA_mRNA RNA nd nd
CopA Cu(I)_Ext Cu(I)
Name: Cu(I)_Ext -> Cu(I)
Description: Transport of Cu(I)_Ext through a bacterial membrane, leading to the presence of Cu(I) inside the cell.
Type: transport
Pathway Components: Cu(I)_Ext - CopA -> Cu(I)
Components:
Function Name Type Evidence Reference(s)
catalyzer CopA protein nd nd
product Cu(I) simple_molecule nd nd
reactant Cu(I)_Ext simple_molecule nd nd
cueO_mRNA CueO
Name: cueO_mRNA -> CueO
Description: Translation of CueO
Type: translation
Pathway Components: cueO_mRNA -> CueO
Components:
Function Name Type Evidence Reference(s)
product CueO protein nd nd
reactant cueO_mRNA RNA nd nd
CueO oxygen + Cu(I) Cu(II)
Name: oxygen + Cu(I) -> Cu(II)
Description: Reaction transforming oxygen, Cu(I) into Cu(II)
Type: state transition
Pathway Components: oxygen + Cu(I) - CueO -> Cu(II)
Components:
Function Name Type Evidence Reference(s)
reactant Cu(I) simple_molecule nd nd
product Cu(II) simple_molecule nd nd
catalyzer CueO protein nd nd
reactant oxygen simple_molecule nd nd
CueO 2-pyrocatechuate + oxygen 2-carboxymuconate
Name: 2-pyrocatechuate + oxygen -> 2-carboxymuconate
Description: Reaction transforming 2-pyrocatechuate, oxygen into 2-carboxymuconate
Type: state transition
Pathway Components: 2-pyrocatechuate + oxygen - CueO -> 2-carboxymuconate
Components:
Function Name Type Evidence Reference(s)
product 2-carboxymuconate simple_molecule nd nd
reactant 2-pyrocatechuate simple_molecule nd nd
catalyzer CueO protein nd nd
reactant oxygen simple_molecule nd nd
CueO oxygen + Fe+2 fe(iii)
Name: oxygen + Fe+2 -> fe(iii)
Description: Reaction transforming oxygen, Fe+2 into fe(iii)
Type: state transition
Pathway Components: oxygen + Fe+2 - CueO -> fe(iii)
Components:
Function Name Type Evidence Reference(s)
catalyzer CueO protein nd nd
reactant Fe+2 simple_molecule nd nd
product fe(iii) simple_molecule nd nd
reactant oxygen simple_molecule nd nd



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