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CspA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
CspA GyrA GyrB Hns a double stranded DNA a negatively supercoiled DNA gyrA gyrA_mRNA hns hns_mRNA phosphate GyrA GyrB


Gensor Unit       
Name: CspA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006265 - DNA topological change
GO:0016458 - gene silencing
GO:0006417 - regulation of translation
GO:0042493 - response to drug
GO:0006351 - transcription, DNA-templated
cellular_component GO:0009330 - DNA topoisomerase complex (ATP-hydrolyzing)
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0009295 - nucleoid
GO:0032993 - protein-DNA complex
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0034335 - DNA supercoiling activity
GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0008094 - DNA-dependent ATPase activity
GO:0003723 - RNA binding
GO:0001217 - bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
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Components: Show/Hide Components Table (12 more...)
Function Name Type
protein CspA protein
protein GyrA protein
complex GyrA-GyrB complex
protein GyrB protein
protein Hns protein
simple_molecule double stranded DNA simple_molecule
gene gyrA gene
RNA gyrA_mRNA RNA
gene hns gene
RNA hns_mRNA RNA
simple_molecule negatively supercoiled DNA simple_molecule
simple_molecule phosphate simple_molecule


Reactions       
Showing 6 reactions
CspA gyrA gyrA_mRNA
Name: gyrA -> gyrA_mRNA
Description: Transcription of transcription unit gyrA. Reaction activation by CspA.
Type: transcription
Pathway Components: gyrA - CspA -> gyrA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CspA protein nd nd
reactant gyrA gene nd nd
product gyrA_mRNA RNA nd nd
CspA hns hns_mRNA
Name: hns -> hns_mRNA
Description: Transcription of transcription unit hns. Reaction activation by CspA.
Type: transcription
Pathway Components: hns - CspA -> hns_mRNA
Components:
Function Name Type Evidence Reference(s)
activator CspA protein nd nd
reactant hns gene nd nd
product hns_mRNA RNA nd nd
gyrA_mRNA GyrA
Name: gyrA_mRNA -> GyrA
Description: Translation of GyrA
Type: translation
Pathway Components: gyrA_mRNA -> GyrA
Components:
Function Name Type Evidence Reference(s)
product GyrA protein nd nd
reactant gyrA_mRNA RNA nd nd
GyrA + GyrB GyrA-GyrB
Name: GyrA + GyrB -> GyrA-GyrB
Description: Reaction transforming GyrA, GyrB into GyrA-GyrB
Type: state transition
Pathway Components: GyrA + GyrB -> GyrA-GyrB
Components:
Function Name Type Evidence Reference(s)
reactant GyrA protein nd nd
product GyrA-GyrB complex nd nd
reactant GyrB protein nd nd
GyrA-GyrB double stranded DNA negatively supercoiled DNA + phosphate
Name: double stranded DNA -> negatively supercoiled DNA + phosphate
Description: Reaction transforming double stranded DNA into negatively supercoiled DNA, phosphate
Type: state transition
Pathway Components: double stranded DNA - GyrA-GyrB -> negatively supercoiled DNA + phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer GyrA-GyrB complex nd nd
reactant double stranded DNA simple_molecule nd nd
product negatively supercoiled DNA simple_molecule nd nd
product phosphate simple_molecule nd nd
hns_mRNA Hns
Name: hns_mRNA -> Hns
Description: Translation of Hns
Type: translation
Pathway Components: hns_mRNA -> Hns
Components:
Function Name Type Evidence Reference(s)
product Hns protein nd nd
reactant hns_mRNA RNA nd nd



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